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Freezing a Moment in Time: Snapshots of Cryo-EM Research
To get a look at cell components that are too small to see with a normal light microscope, scientists often use cryo-electron microscopy (cryo-EM). As the prefix cryo- means “cold” or “freezing,” cryo-EM involves rapidly freezing a cell, virus, molecular complex, or other structure to prevent water molecules from forming crystals. This preserves the sample in its natural state and keeps it still so that it can be imaged with an electron microscope, which uses beams of electrons instead of light. Some electrons are scattered by the sample, while others pass through it and through magnetic lenses to land on a detecto...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 4, 2020 Category: Research Authors: Chrissa Chverchko Tags: Molecular Structures Tools and Techniques Cellular Imaging Cellular Processes Cool Tools/Techniques Cryo-Electron Microscopy Research Roundup Source Type: blogs

Fatigue and Weakness and a computer interpretation of STEMI
This case was sent by David Carroll, a 2nd year EM resident, and his attending physician Brad Caloia.A 60-something male presented to the ED with weakness and fatigue.  He was diagnosed with a viral syndrome anddischarged.  He returned later and had a lab and ECG workup.  He had no cardiac history.  There was no chest pain or shortness of breath.Here is his ECG:The computer interpretation:Rate: 93 | PR 146 | QRSD 112 | QT/QTc(Bazett) 353/439Normal sinus rhythmAnterolateral infarct, acute / ***ACUTE MI*** What do you think?Dr. Carroll astutely realized something was amiss: what is it?There...
Source: Dr. Smith's ECG Blog - October 30, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs

Aspirin and breast cancer risk: How a wonder drug may become more wonderful
Aspirin has been called a wonder drug. And it’s easy to see why. It’s inexpensive, its side effects are well-known and generally minor. And since it was developed in the 1890s, it’s been shown to provide a number of potential benefits, such as relieving pain, bringing down a fever, and preventing heart attacks and strokes. Over the last 20 years or so, the list of aspirin’s potential benefits has been growing. And it might be about to get even longer: did you know that aspirin may lower your risk of several types of cancer? Studies of aspirin and cancer A number of studies suggest that aspirin can lower the risk of...
Source: Harvard Health Blog - October 23, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Breast Cancer Health Source Type: blogs

Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others. A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/ The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of the...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected. This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Diagnostics: recovery and renewal
This report recommends that community diagnostic hubs or ‘one stop shops’ should be created across the country, away from hospitals, so that patients can receive life-saving checks close to their homes. It argues that these proposals will help save lives and improve people’s quality of life including for cancer, stroke, heart disease and respiratory conditions.ReportNHS England - news
Source: Health Management Specialist Library - October 6, 2020 Category: UK Health Authors: The King ' s Fund Library Tags: NHS finances and productivity Patient involvement, experience and feedback Quality of care and clinical outcomes Source Type: blogs

Reductio ad absurdum
The new Supreme Court nominee believes that a zygote -- the single cell that results from the merger of a sperm cell and an ovum -- is a human being just like you and your Aunt Fannie, and entitled to all of the rights, dignity and respect due accordingly. Can you guess what is wrong with this idea? As I have noted previously, it most certainly does not come from the Bible, not from the Old Testament or any saying ascribed to Jesus or Paul. Nobody actually knew what conception was until the 20th Century, actually, but people knew that pregnancy resulted from sexual intercourse and that it didn ' t become apparent unti...
Source: Stayin' Alive - October 1, 2020 Category: American Health Source Type: blogs

Death is personal for this physician
An excerpt from Dying with Ease: A Compassionate Guide for Making Wiser End-of-Life Decisions. Used by permission of the publisher Rowman& Littlefield. All rights reserved. In 2017, there were 2,813,503 deaths in the United States. About a quarter of Americans die of heart disease, some 22 percent from cancer, and about one in twenty […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - September 26, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jeff-speiss" rel="tag" > Jeff Speiss, MD < /a > < /span > Tags: Physician Oncology/Hematology Palliative Care Source Type: blogs

Too much licorice may kill you
This morning, thanks to a friend’s post on Facebook, I read an Associated Press article, picked up and published by NBC News, that REALLY shocked me. Here’s the link: https://www.nbcnews.com/news/us-news/daily-black-licorice-habit-kills-massachusetts-construction-worker-n1240902?fbclid=IwAR1kiMGaCEQGdDrGjyVkkdy1l0MT8nNSAByFBnzqdYQFxkqYGAuQIjNgrcM Is it possible for someone to DIE from eating too much licorice??? The incredible answer is…yes. It happened to a 54-year-old man in Massachusetts, U.S.A. He had been eating A LOT of licorice, a bag and a half apparently!!!, every day for a few weeks before he co...
Source: Margaret's Corner - September 25, 2020 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll death licorice. glycyrrhizic acid Source Type: blogs

Lifestyle medicine for all: Healthy food comes first
“Lifestyle medicine is only for rich people, right?” a colleague asked me several years ago, questioning my involvement in this relatively new field of medicine that guides people toward healthy habits. This has been a common misperception, for sure. But across the US, a revitalized brand of health activism is intent on bringing lifestyle medicine to a broader range of people. This is backed by a new effort from the American College of Lifestyle Medicine to engage communities most affected by chronic disease. The first pillar of healthy lifestyle: Food is medicine Lifestyle medicine is an evidence-based practice of hel...
Source: Harvard Health Blog - September 24, 2020 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Food as medicine Health Health care disparities Healthy Eating Source Type: blogs

General examination – hands and feet
General examination – hands and feet Cyanosis and pallor can be noted in the tips of the digits in both central and peripheral cyanosis. Severe jaundice may be visible in the palms and soles, especially in small infants. Clubbing of digits may be noted in cyanotic heart diseases as well many other non cardiac conditions. In clubbing, initially there is fluctuation of nail bed (Grade 1) followed by obliteration of angle between nail and adjacent skin fold (Lovibond angle – Grade 2). Later there is curvature of the nails (parrot beaking – Grade 3). Grade 4 or hypertrophic osteoarthropathy is not common in cardiova...
Source: Cardiophile MD - September 22, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: HBC Heberden’s nodes Janeway lesions Lovibond angle Osler’s nodes Pitting edema Polydactyly Source Type: blogs

Discrimination, high blood pressure, and health disparities in African Americans
Over the past few months, we have all seen the results of significant disruption to daily life due to the COVID-19 pandemic, high levels of unemployment, and civil unrest driven by chronic racial injustice. These overlapping waves of societal insult have begun to bring necessary attention to the importance of health care disparities in the United States. Direct links between stress, discrimination, racial injustice, and health outcomes occurring over one’s lifespan have not been well studied. But a recently published article in the journal Hypertension has looked at the connection between discrimination and increased ris...
Source: Harvard Health Blog - September 21, 2020 Category: Consumer Health News Authors: Chester Hedgepeth, III, MD, PhD Tags: Health care disparities Hypertension and Stroke Source Type: blogs

Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Doctors Urge Caution in Interpretation of Research in Times of COVID-19
September 9, 2020 To:       American College of Cardiology American College of Chest Physicians American College of Physicians American College of Radiology American Heart Association American Society of Echocardiography American Thoracic Society European Association of Cardiovascular Imaging European Society of Cardiology European Society of Radiology Heart Rhythm Society Infectious Disease Society of America North American Society of Cardiovascular Imaging Radiologic Society of North America Society of Cardiovascular Magnetic Resonance Soci...
Source: The Health Care Blog - September 17, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Patients Physicians myocarditis Saurabh Jha Source Type: blogs

Lowered Body Temperature is Important in the Beneficial Calorie Restriction Response
Calorie restriction lowers body temperature in mammals, but most research on how reduced calorie intake produces benefits to long-term health and longevity has focused on nutrient sensing as the primary trigger for the upregulation of stress responses and other helpful changes to cellular metabolism. Here, researchers demonstrate that reduced body temperature is in fact an important trigger mechanism, possible more so than nutrient sensing, as keeping calorie restricted mice warm eliminates much of the beneficial metabolic adaptation to reduced nutrient levels. Cutting calories significantly may not be an easy tas...
Source: Fight Aging! - September 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs