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A Unique Grief: How Caregivers Grieve the cognitive Decline Of Someone They Cherish
Photo credit Claudia But underneath, often unnoticed, there's a knot in our hearts. We're grieving the loss – the loss of function that made our parent need to ask for help. Weren't they the ones who helped us? Weren't they the ones in charge? Generally, these changes are subtle, the grief sneaky. I remember watching my parents age in a normal fashion. I'd occasionally look at them and be startled by the realization that they were aging. But that was all I acknowledged. I never intentionally thought about loss and pain. It dwelled beneath my consciousness. Read the full article on Agingcare about how we who watch l...
Source: Minding Our Elders - August 5, 2019 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

What should you do if your blood pressure medication has been recalled?
Over the past several months, you may have heard that the FDA has recalled certain lots of angiotensin II receptor blocker (ARB) medications due to the presence of impurities. These contaminants — nitrosamine impurities — may occur as a byproduct of the manufacturing process. They include N-Nitrosodiethylamine (NDEA) and N-Nitrosodimethylamine (NDMA), which can potentially cause cancer. These substances are found in the environment as well in meats, dairy products, and water, but their presence in medications is not acceptable. Therefore, the FDA sets acceptable safety limits on the presence of these impurities in drug...
Source: Harvard Health Blog - August 5, 2019 Category: Consumer Health News Authors: James Yeh, MD, MPH Tags: Drugs and Supplements Health Hypertension and Stroke Source Type: blogs

Hospice Care Can Help Throughout the End Stages of Life
Photo credit Mikhail Rakityanskiy ...For weeks, each time I walked into Dad's room in the nursing home, he would be rigid in bed, up on one elbow and slamming his fist against his hand. Pow! Pow! Pow! Over and over, he pounded fist against hand. I would try to get him to relax; to lie back. He couldn't comprehend. Pow! Pow! Pow! He was trying to knock out the pain. Read the full article on Agingcare about how hospice care can improve the quality of life for people nearing death:   Carol Bradley Bursack is the Candid Caregiver MedicareFAQ – Medicare Resource Center Support a caregiver or jump-start discussion in sup...
Source: Minding Our Elders - August 4, 2019 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

How To Minimize Grief for a Surviving Spouse Living with Dementia
Photo credit Jeremy Wong Dementia and the loss of a spouse are sad and challenging enough on their own, but when they coincide, the result can be truly heartbreaking. For many adult children, deciding whether to inform a cognitively impaired parent that their spouse has died is a serious and often recurring struggle. For someone who has not experienced such a dilemma, this would appear to be a no-brainer. However, as with many dementia-related quandaries, the question and answer are far more complex for those facing this reality. Read the full article on Agingcare to learn more about how you can try to minimize grief for y...
Source: Minding Our Elders - August 2, 2019 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

How to Refresh Your Caregiving Routine Any Time Of Year
Photo credit Sydney Sims We repeatedly read articles about caregiver burnout and how we must practice self-care. I've written countless articles on that topic myself. Sometimes, I feel like a hypocrite because I know that caregivers often have few choices when it comes to change, and the choices they do have are likely not very attractive. Still, I'd like to suggest some steps that may help some people to think through the year and consider some adjustments. The following are two places that we could possibly make progress: Read the full article on HealthCentral to learn more about how to refresh your caregiving routine to...
Source: Minding Our Elders - August 1, 2019 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Quality of life for Stroke Survivors and People with Alzheimer's Improved Through the Arts
Photo credit Matthieu-a-b ..."Patients who appreciated music, painting and theatre recovered better from their stroke than patients who did not"Patients interested in art had better general health, found it easier to walk, and had more energy. They were also happier, less anxious or depressed, and felt calmer. They had better memory and were superior communicators (speaking with other people, understanding what people said, naming people and objects correctly)." Read the full article on HealthCentral to learn more about how music can improve life quality for people who have had a stroke or who live with dementia:  &#...
Source: Minding Our Elders - August 1, 2019 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, July 29th 2019
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - July 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Commentary on the Developing UK Government Position on Healthy Longevity
One option for patient advocacy for the treatment of aging as a medical condition is to petition governments and large international organizations such as the World Health Organization to adjust their positions on research funding and goals in medicine. This a fairly popular path, for all that I think it not terribly effective at speeding up the cutting edge of research and development. Large organizations of any sort are inherently conservative, and tend to get meaningfully involved in new fields of human endeavor only long after their support would have been truly influential. Nonetheless, numerous examples of gov...
Source: Fight Aging! - July 26, 2019 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs

Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Mainstream View of the Longevity Industry
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - July 17, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Why medical writing is essential to medicine
I wasn’t as happy as I expected to be when I walked out of the hospital on my last day in medical school. But then again, there was little to celebrate— my last few patients had terminal cancer, a stroke, and end-stage liver disease from alcoholism. I signed off my patients to my resident, […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - July 11, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/steven-zhang" rel="tag" > Steven Zhang, MD < /a > < /span > Tags: Education Hospital-Based Medicine Primary Care Source Type: blogs

Landmark Results Achieved in Aging and Chronic Disease: Danish Group Extends Disease-free Life by 8 Years
By WILLIAM H. BESTERMANN JR., MD New Scientific Breakthroughs Can Provide a Longer Healthier Life Twenty-one years of follow-up comparing usual care with a protocol-driven team-based intervention in diabetes proved that healthy life in humans can be prolonged by 8 years. These results were achieved at a lower per patient per year cost. Aging researchers have been confident that we will soon be able to prolong healthy life. This landmark study shows this ambitious goal can be achieved now with lifestyle intervention and a few highly effective proven medications. These medications interfere with the core molecular biol...
Source: The Health Care Blog - July 11, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients aging chronic disease Denmark Diabetes William Bestermann Source Type: blogs

More opioids, more pain: Fueling the fire
For more than a century, clinicians have noticed a paradoxical phenomenon: certain patients who are taking opioids (which are supposed to numb pain) become more sensitive to pain than those who are not taking opioids. The earliest observation of this phenomenon can be traced back to the British physician Sir Clifford Allbutt, who, in 1870, described it: “at such times I have certainly felt it a great responsibility to say that pain, which I know is an evil, is less injurious than morphia, which may be an evil. Does morphia tend to encourage the very pain it pretends to relieve?” Research studies and clinical observatio...
Source: Harvard Health Blog - July 8, 2019 Category: Consumer Health News Authors: Shafik Boyaji, MD Tags: Pain Management Source Type: blogs

Fight Aging! Newsletter, July 8th 2019
In this study, we identify a link between members of the genus Veillonella and exercise performance. We observed an increase in Veillonella relative abundance in marathon runners postmarathon and isolated a strain of Veillonella atypica from stool samples. Inoculation of this strain into mice significantly increased exhaustive treadmill run time. Veillonella utilize lactate as their sole carbon source, which prompted us to perform a shotgun metagenomic analysis in a cohort of elite athletes, finding that every gene in a major pathway metabolizing lactate to propionate is at higher relative abundance postexercise. Us...
Source: Fight Aging! - July 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

First Cryopreservation Following Use of Assisted Death Legislation in California
Simple human dignity and self-ownership demands the right to end one's own life on one's own terms, and to be able to help others achieve this goal where they are not capable of doing so themselves. Yet these acts remain forbidden to most people in most parts of the world. Painless, effective euthanasia requires medical assistance, and providing that service remains largely illegal. This state of affairs is slowly starting to change in the US, however, and so late last year the first cryopreservation following voluntary euthanasia took place. Cryopreservation is the only presently available end of life option that o...
Source: Fight Aging! - July 3, 2019 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs