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Fight Aging! Newsletter, September 13th 2021
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - September 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
George Halvorson HIMSS Changemaker Lifetime Achievement Award Acceptance Speech, Part 1
Former Kaiser Permanente CEO George Halvorson has written on THCB on and off over the years, most notably last year with his proposal for Medicare Advantage for All post-COVID. This month he was given a lifetime achievement award by HIMSS and we are running his acceptance speech in two parts. Here’s part one — Matthew Holt
Thank you for giving me this first ever HIMSS Changemaker In Health Care Lifetime Achievement Award.
You are honoring an extremely impressive set of other current changemakers at this particular national meeting for 2021 and I am very honored and pleased to be the first person to b...
Source: The Health Care Blog - August 18, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology George Halvorson HIMSS Changemaker Lifetime Achievement Award Source Type: blogs
We Need to Open Up the AI Black Box
To convince physicians and nurses that deep learning algorithms are worth using in everyday practice, developers need to explain how they work in plain clinical English.Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, and John Halamka, M.D., president, Mayo Clinic Platform, wrote this article.AI ’s so-called black box refers to the fact that much of the underlying technology behind machine learning-enhanced algorithms isprobability/statistics without a human readable explanation.Oftentimes that ’s the case because the advanced math or the data science behind the algorithms is t...
Source: Life as a Healthcare CIO - August 17, 2021 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflamm...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Alcohol, Smoking, Drugs: How Technology Can Help
The global statistics on substance use are disquieting. Globally, about 3 million people die every year from alcohol abuse. Tobacco kills up to half of its users – over 8 million people annually. And the UN’s 2021 World Drug Report estimated that around 275 million people used drugs worldwide in 2020, while over 36 million people suffered from drug use disorders.
Disruptive technologies could act only as additional tools for managing preventive or reactive treatment for both victims and physicians next to therapy. Alcohol content-measuring wristbands, smart lighters, nicotine tracking wearables, stop smoking apps, virt...
Source: The Medical Futurist - July 15, 2021 Category: Information Technology Authors: berci.mesko Tags: E-Patients Future of Medicine Future of Pharma Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy Telemedicine & Smartphones Virtual Reality alcohol digital health Innovation smoking technology VR health Source Type: blogs
Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future.
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Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in the Context of Aging, Metabolism, and Epigenetics
The accumulation of senescent cells is clearly an important contribution to the progression of degenerative aging. This was firmly established to be the case not by the careful examination of mechanisms, because it is very challenging to assign relative significance to the many different processes involved in aging, but rather by the selective removal of senescent cells in mice. The best way, and possibly the only practical way at the present time, to establish the relevance of a mechanism to aging and disease is to very selectively block just that mechanism and then observe the results.
In the case of senescent cel...
Source: Fight Aging! - July 7, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Drinking Straw Device for Hiccups Treatment
Researchers at the University of Texas Health Science Center at San Antonio have developed a device to treat hiccups. The drinking straw-like device allows a user to apply forceful suction to draw water into it, with subsequent swallowing triggering ...
Source: Medgadget - June 21, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Anxiety During Social Outings May Have Worsened for People with Dementia
Photo image Sander Weeteling
Dear Carol: My husband is only 56 but he has early-onset Alzheimer’s. I’ve done my best during COVID to keep him interested in activities and Zoom calls with the kids and friends. Now that we’re vaccinated, he could go out more but I’m having trouble finding the line between giving him the social exposure that’s recommended and pushing him into anxiety. Since he’s still in the earlier stage of dementia, the doctor wants to wait before trying antianxiety medications. Our kids think now that it’s safer I should have him out more. In a way they are right, but he can’t seem t...
Source: Minding Our Elders - June 6, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells caus...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stressed Caregiver Can Increase Anxiety in Someone with Dementia
Photo credit Tim Doerfler
Dear Carol: My mom’s been living with Alzheimer’s for several years and Dad refuses to get any help with her. My sister and I have begged him to place Mom in memory care because the facilities where they live are good, but he has always adored her and feels like he must be her protector. We’re afraid for both of them because while he means well, her care is getting too difficult. He still says the right words, but his body language shows his stress level is high and he’s becoming impatient which is unlike him. I’m sure his stress is affecting Mom, too, and making her more anxious. That, ...
Source: Minding Our Elders - May 30, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Arts Improve Quality of life for Stroke Survivors and People with Alzheimer's
Photo credit Crystal de Passille
Research continues to show that the arts enhance the quality of life for people who have health problems, including Alzheimer's disease and strokes. New research, presented at the 12th Annual Spring Meeting on Cardiovascular Nursing, in Copenhagen, Denmark, reported on the importance of the arts, stating: "Patients who appreciated music, painting and theatre recovered better from their stroke than patients who did not"...
Continue reading on HealthCentral to learn more about how art can help people who've had a stroke recover:
Minding Our Elders: Caregivers Share Their Personal Storie...
Source: Minding Our Elders - May 29, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Epistemology VI: Epidemiology
Epidemiology originally largely meant studying how infectious diseases spread, and that ' s still a major concern of epidemiologists. However, it also includes the study of any and every environmental or behavioral factor affecting human health. For example, the finding that smoking tobacco causes lung cancer (not to mention a bazillion other diseases) is an epidemiological finding. Epidemiology is largely an observational science, given the ethical prohibition against exposing humans to potentially hazardous conditions for experimental purposes. That ' s not to say it hasn ' t been done, with the victims being ...
Source: Stayin' Alive - May 17, 2021 Category: American Health Source Type: blogs
