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A Look Back at 2021: Progress Towards the Treatment of Aging as a Medical Condition
Well, here we are again, at the end of another pandemic year, a year older and - hopefully - a year wiser and more knowledgeable. I said all that really needs to be said on the topic of COVID-19 as an age-related condition at the end of last year. We might hope that, given widespread vaccination, the pandemic will become a topic of diminishing importance as the year ahead progresses, even given the present round of variants, fears, and reintroduction of restrictions. Advocacy for Aging Research Have we finally made significant progress in convincing the world that aging is the cause of age-related disease, th...
Source: Fight Aging! - December 31, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 15th 2021
This article will review the relationship between diabetes mellitus and AD as it relates to tau pathology. More understanding of the link between diabetes mellitus and AD could change the approach researchers and clinicians take toward both diseases, potentially leading to new treatments and preventative strategies in the future. Signaling from White Fat Tissue Contributes to Age-Related Hair Follicle Dysfunction https://www.fightaging.org/archives/2021/11/signaling-from-white-fat-tissue-contributes-to-age-related-hair-follicle-dysfunction/ Changes in fat tissue behavior in the skin take place with age, ...
Source: Fight Aging! - November 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reflections on HLTH2021: The Lens of the Patient and Carepartner
By GRACE CORDOVANO Attending HLTH 2021 in-person in Boston solidified that there is no comparison between attending live vs. virtual conferences.  While content and presentations can be solid both virtually or in-person, it is the energy of the connections that are made between scheduled presentations and the conversations that are shared throughout that move the needle. Kudos to the organizers of HLTH 2021 for prioritizing the safety of all in-person attendees with COVID-19 vaccination requirements, proof of negative PCR testing within 3 days of arrival, and mask requirements on-site. After reflecting on all th...
Source: The Health Care Blog - November 3, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Grace Cordovano HLTH Patient advocates patient centered innovation Source Type: blogs

Extremely high HDL – beneficial or harmful?
This study showed extremely high HDL was associated with lower risks for all-cause mortality and cardiovascular events compared to low HDL. But they had higher risks compared to very high HDL. Paradoxically high all-cause mortality in those with extremely high HDL has also been reported in another study of 52 268 men and 64 240 women [5]. Though most of these studies showed a negative role for extremely high HDL, there is recent study from Korea which showed that extremely high HDL was not associated with increased risk of mortality, myocardial infarction and stroke [6]. That study with 343,687 subjects also defined extrem...
Source: Cardiophile MD - October 20, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Wristband to Detect Strokes: Interview with Sandra Saldana, CEO of Alva Health
Alva Health, a medtech startup based in Connecticut, is developing a wristband that can detect the signs of stroke and promptly alert the wearer and/or healthcare staff. The technology is intended for those at high risk of stroke, such as stroke surv...
Source: Medgadget - October 18, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Neurosurgery alvahealth stroke Source Type: blogs

Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice. To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Jekyll And Hyde Emotion? Research On Anger, Digested
This study provided evidence of “the important role of anger in the psychological process underlying moral courage,” the team wrote. Of course, a person’s individual moral framework is crucial here, though. If the sight of women venturing outdoors alone or going to work, say, deeply offends you, then your resulting outrage will likely propel you to action, too. Expressing anger can also make you seem more authentic and sincere. At least, this was suggested by a 2021 study of Kickstarter pitch videos. Entrepreneurs are often encouraged to be only positive about their ventures, commented the researchers. But they fo...
Source: BPS RESEARCH DIGEST - October 12, 2021 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Anger Source Type: blogs

EvoWalk Digital Therapy Platform: Interview with Pierluigi Mantovani, CEO at Evolution Devices
Evolution Devices, a company based in California, created a functional electrical stimulation device to assist people with foot drop to walk more freely. Foot drop is caused by muscle weakness/paralysis, and those affected struggle to lift the front ...
Source: Medgadget - October 5, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Rehab evolutiondevices evowalk Source Type: blogs

Fight Aging! Newsletter, October 4th 2021
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them. Extending Life Without Extending Health: Vast Effort Directed to the Wrong Goals https://www...
Source: Fight Aging! - October 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Genetic Variants Associated with Visceral Fat Accumulation Correlate with Longevity
It is well established that excess visceral fat is harmful. This tissue is metabolically active, and generates increased chronic inflammation through numerous mechanisms: a greater number of senescent cells; signaling by fat cells that appears similar to that produced by infected cells; increased debris from dead and dying fat cells that provokes the immune system. Overweight and obese people have a shorter life expectancy, greater incidence of age-related disease, and higher lifetime medical costs, with these disadvantages increasing with a larger burden of visceral fat tissue. It is not surprising, therefore, to find tha...
Source: Fight Aging! - October 1, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 27th 2021
This study provides causal evidence of a lipoprotein-Aß /capillary axis for onset and progression of a neurodegenerative process. The Staggering Ongoing Cost of Failing to Aggressively Pursue the Development of Rejuvenation Therapies https://www.fightaging.org/archives/2021/09/the-staggering-ongoing-cost-of-failing-to-aggressively-pursue-the-development-of-rejuvenation-therapies/ No feasible amount of funding that could be devoted to the research and development of rejuvenation therapies would be too much. If near all other projects were dropped, and institutions radically retooled on a short term basis...
Source: Fight Aging! - September 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Staggering Ongoing Cost of Failing to Aggressively Pursue the Development of Rejuvenation Therapies
No feasible amount of funding that could be devoted to the research and development of rejuvenation therapies would be too much. If near all other projects were dropped, and institutions radically retooled on a short term basis, then the world might be able to devote $300 billion per year into medical research and development aimed at aging. That is an unachievable upper bound, of course. Given a few decades in which to train new researchers while rapidly and radically expanding existing institutions, then humanity might start to approach that scale of expenditure. Realistically it will take 20-30 years following the first...
Source: Fight Aging! - September 24, 2021 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Fight Aging! Newsletter, September 20th 2021
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients. NANOG Expression versus Cellular Senescence https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/ Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living an...
Source: Fight Aging! - September 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs