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Cancer Survivors Exhibit a Significantly Higher Risk of Cardiovascular Disease
The dominant cancer therapies of chemotherapy and radiotherapy have not yet been replaced by immunotherapies for more than a handful of cancer types. These classes of therapy produce a significantly increased burden of senescent cells in patients; one of the goals of cancer therapy is to drive cancerous cells into senescence, those that cannot be killed. These additional senescent cells in turn accelerate the progression of degenerative aging. The advent of senolytic therapies to clear senescent cells from aged tissues will make a sizable difference to these patients. More effort should be undertaken today to enable patien...
Source: Fight Aging! - July 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Hunting Disease-Causing Genetic Variants
Dr. Miriam Meisler. Credit: University of Michigan Medical School. “In my lab, we’ve been gene hunters—starting with visible phenotypes, or characteristics, and searching for the responsible genes,” says Miriam Meisler, Ph.D., the Myron Levine Distinguished University Professor at the University of Michigan Medical School in Ann Arbor. During her career, Dr. Meisler has identified the functions of multiple genes and has shown how genetic variants, or mutations, can impact human health. Becoming a Scientist Dr. Meisler had a strong interest in science as a child, which she credits to “growing up at the tim...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 29, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Genes Injury and Illness Diseases DNA Profiles Research Organisms Scientific Process Source Type: blogs

Lifestyle Medicine Could Be The Key To Digital Health Adoption
I’ve been wearing several generations and types of smartwatches for a couple of years and I only remove my watch when I shower. I use it to track my sleep and its smart alarm wakes me up at the optimal time every morning. With the pocketable Kardia, I regularly check my ECG at home to detect any anomalies. For an in-depth analysis of what my genetic makeup predisposes me to, I had my whole genome sequenced. And I bring relevant data to my general practitioner during my checkups so that we can decide on preventive measures. In short, I’m trying to live like the patient of the future, using lifestyle medicine to prev...
Source: The Medical Futurist - June 29, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Lifestyle medicine E-Patients Health Sensors & Trackers Healthcare Design Medical Education Personalized Medicine sleep stress food scanner sleep apnea Apple Watch Dr. Vernes Baylor ACLM Source Type: blogs

Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree Towards Scaffold-Based Regeneration of Dental Pulp https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/ Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth h...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Inflammaging as a Contributing Factor in the Development of Cardiovascular Disease
Inflammaging is the name given to the decline of the aging immune system into a state of constant, unresolved inflammation. Inflammatory signaling in the aged body arises in part because of an increased burden of senescent cells. These cells secrete a potent mix of pro-inflammatory signals, disrupting tissue function. This is one of the reasons why removal of lingering senescent cells produces such rapid rejuvenation, as these errant cells actively maintain a portion of the degradation of function and environment in aged tissues. Beyond senescent cells, the broad molecular damage and cellular dysfunction of aging produces ...
Source: Fight Aging! - June 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, June 13th 2022
In conclusion, long-term cumulative BP was associated with subsequent cognitive decline, dementia risk, and all-cause mortality in cognitively healthy adults aged ≥50 years. Efforts are required to control long-term systolic BP and pulse pressure and to maintain adequate diastolic BP. Longer-Lived Mammals Tend to Have Lower Expression of Inflammation-Related Genes https://www.fightaging.org/archives/2022/06/longer-lived-mammals-tend-to-have-lower-expression-of-inflammation-related-genes/ Researchers here make a few interesting observations on gene expression data from a range of mammalian species with ...
Source: Fight Aging! - June 12, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Is this Myo-pericarditis? Or OMI with subsequent pericarditis? Does the angiogram always explain the ECG findings?
Conclusion: Although at 1st glance, it looked like the ECG picture in Figure-1 might be suggestive of acute pericarditis — on further inspection, there are significant ECG features against the diagnosis of acute uncomplicated pericarditis.As per the superb discussion above by Dr. Smith — evolution of this case (including the ECG picture on serial tracings) — are consistent with what probably occurred in today ' s case, namely the combination of acute OMI from LCx occlusion, followed by development of post-infarction regional pericarditis.
Source: Dr. Smith's ECG Blog - June 11, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs

Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology. Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 9th 2022
In conclusion, although several favorable effects are obtained in our heterochronic non-myeloablative transplantation model, additional optimization is needed for better rejuvenation effects. More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells https://www.fightaging.org/archives/2022/05/more-on-gpnmb-as-a-target-for-senolytic-therapies-to-clear-senescent-cells/ You might recall that researchers recently demonstrated that vaccination against GPNMB is a senolytic strategy, reducing the harmful burden of senescent cells in aged tissues by directing the immune system to destroy these c...
Source: Fight Aging! - May 8, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Profiling Michael Greve ' s Fund, Kizoo Technology Ventures
Philanthropist and investor Michael Greve directs funds into advocacy, research, and commercial development of SENS-like projects aimed at repair of underlying mechanisms of aging. His Forever Healthy Foundation undertakes a range of useful activities, such as reviewing existing therapies that may address aspects of aging, and running the Undoing Aging conference series. His venture fund, Kizoo, has invested in a range of biotech companies developing interventions for aging, most of which are in some way connected to the SENS outline for rejuvenation biotechnology. Kizoo is investing €300 million in a portfolio ...
Source: Fight Aging! - May 6, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

International health care outcomes index 2022
Civitas -This comparison of global health systems places the UK second to bottom across a series of major health care outcomes, including life expectancy and survival rates from cancer, strokes and heart attacks. The comparative study ranks the performance of the UK health care system with that of 18 comparable countries since 2000 or the earliest year for which data is available. It covers the level of health spending, overall life expectancy, the health care outcomes of the major diseases and the outcomes for treatable mortality and childbirth.ReportCivitas - publications
Source: Health Management Specialist Library - April 27, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: NHS performance and productivity Source Type: blogs

Fight Aging! Newsletter, April 11th 2022
In conclusion, plasma levels of IGHA2, APOA and HPT are associated with subclinical atherosclerosis independently of traditional risk factors and offers potential to predict this disease. The panel could improve primary prevention strategies in areas where imaging is not available. A Lesser Diversity of Circulating Antibodies in the Aging Killifish Immune System https://www.fightaging.org/archives/2022/04/a-lesser-diversity-of-circulating-antibodies-in-the-aging-killifish-immune-system/ Short-lived killifish are one of the more recently adopted animal models of aging. All such models are a trade-off betw...
Source: Fight Aging! - April 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Home Care and In-Home Care: What's Covered, What's Not?
Home care can be helpful in supporting individuals of all ages to safely live at home for as long as possible and/or to recover from an unexpected health crisis. Additionally, home care can be a welcome source of support when family members can no longer provide care alone. These care providers are available for anything from simple household chores and companionship to complex care. But what exactly is meant by the terms “home care” and “in-home care," and what will your insurance cover? Continue reading on HealthCentral for more about in-home care and insurance coverage:  Minding Our Elders: Careg...
Source: Minding Our Elders - April 5, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Should You Care for Aging Parents Who Neglected or Abused You in Childhood
Photo credit Berhard Grossgasteiger Years ago, a journalist (we’ll call her Nancy) requested an interview with me to discuss common caregiving issues for an article she was writing. We bonded during our chat, and Nancy shared some of her own experiences trying to cope with her aging parents’ needs. In addition to notoriously difficult decisions that come with caregiving, like whether Dad should continue driving or if Mom needs more help at home, Nancy was also struggling with years and years of toxic family history. Initially, she felt that her experience was unusual. After all, we mostly hear about family caregi...
Source: Minding Our Elders - March 31, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Balancing Elder Care with Other Relationships Is Challenging
Photo credit Alex Iby Becoming a family caregiver is often something that either happens very suddenly or slowly sneaks up on a person. When a loved one has a health setback or begins needing more assistance, we tend to go into “crisis mode” and haphazardly shift our priorities around to ensure their immediate needs are met. Most family caregivers take on these responsibilities thinking they will be short-term commitments and that life will soon return to “normal.” But the reality is that caregiving can drag on for weeks, months, and even years. Without any solid plans or reprioritizing, things that were once at th...
Source: Minding Our Elders - March 30, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs