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Keeping Older Adults Active and and Engaged
Photo credit Bret Meliti As family caregivers, we strive to meet all our loved ones’ needs. We give medication reminders, cook meals, manage doctor’s appointments and keep schedules. Our daily tasks can be challenging, but one, in particular, gives families a lot of grief: ensuring our loved ones are stimulated and entertained. If a senior’s abilities have waned, it can be challenging to find ways to adapt or replace the pastimes they once loved. Sometimes, though, our loved ones simply lose their motivation to participate in life. They may complain, nag us, or spend all day sleeping or watching television. What is a...
Source: Minding Our Elders - March 29, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Arts Improve Quality of life for Stroke Survivors and People with Alzheimer's
Photo credit Crystal de Pasille Chabot "Patients who appreciated music, painting and theatre recovered better from their stroke than patients who did not"Patients interested in art had better general health, found it easier to walk, and had more energy. They were also happier, less anxious or depressed, and felt calmer. They had better memory and were superior communicators (speaking with other people, understanding what people said, naming people and objects correctly)." Read more on HealthCentral about how the arts can improve quality of life for stroke survivors: Minding Our Elders: Caregivers Share Their Personal Stori...
Source: Minding Our Elders - March 28, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 21st 2022
This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions. "This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise." Variations in Biological Age Across Organs in Younger Individuals https://...
Source: Fight Aging! - March 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Combination of Situational and Anticipatory Greif Understandable Caregiver Emotions
Photo credit Danie Franco Dear Carol: While my dad has suffered due to a stroke and subsequent vascular dementia, it’s cancer that’s killing him. Hospice care has been a blessing, but watching this once large, hearty man waste away is devasting. Even though Dad mostly sleeps, I can see the emotional suffering in his face during the brief times he does wake. I long for this to end yet I’m desperate not to lose him. I ask myself what purpose is served with so much suffering and it strains my faith. How do people cope with these complicated feelings? – HD Continue reading in Inforum about these different types and how...
Source: Minding Our Elders - March 20, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

A Combination of Situational and Anticipatory Grief Understandable Caregiver Emotions
Photo credit Danie Franco Dear Carol: While my dad has suffered due to a stroke and subsequent vascular dementia, it’s cancer that’s killing him. Hospice care has been a blessing, but watching this once large, hearty man waste away is devasting. Even though Dad mostly sleeps, I can see the emotional suffering in his face during the brief times he does wake. I long for this to end yet I’m desperate not to lose him. I ask myself what purpose is served with so much suffering and it strains my faith. How do people cope with these complicated feelings? – HD Continue reading in Inforum about these different types and how...
Source: Minding Our Elders - March 20, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

The (sort of, partial) Father mRNA Vaccines Who Now Spreads Vaccine Misinformation (Part 1)
By DAVID WARMFLASH, MD Robert W. Malone, MD MS, is a physician-scientist who will live in infamy, thanks to the Joe Rogan Experience Podcast boosting his visibility this past December regarding his criticism of COVID-19 vaccines, particularly the mRNA vaccines (Moderna and Pfizer-BioNTech). Subsequently, Malone was banned from Twitter, which further boosted his celebrity status. Describing himself as the inventor of mRNA vaccine technology, he has been reaching a growing number of people with a narrative that makes COVID-19 vaccination sound scary. We cannot embed clips from the Rogan interview, which lasted about three...
Source: The Health Care Blog - March 17, 2022 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Health Policy antivaxxer COVID-19 vaccine David Warmflash Joe Rogan Robert Malone Source Type: blogs

What Has A.I. In Medicine Ever Done For Us? At Least 50 Things!
Remember Monty Python’s brilliant Life of Brian movie scene where the Judean Jewish insurgent commando, planning the abduction of Pilate’s wife in return for all the horrors they had to endure from the Roman Empire, asks the rhetorical question: what have the Romans ever done for us? With the hype and overmarketing, not to speak about the fears around A.I, we asked the same question. What has A.I. in medicine ever done for us? Well, we found at least 50 things. I have 50 responses to the pressing question on everyone’s mind who is interested in healthcare but tired of the hype or the doomsday scenarios around A.I....
Source: The Medical Futurist - March 1, 2022 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Medicine AI cancer diagnostics digital health Healthcare Innovation medical Radiology technology medical imaging treatment administration digital health technology Source Type: blogs

Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty. Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/ Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying re...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far. Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/ In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and here...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 14th 2022
In conclusion, this first examination of the effects of age and the ageing process on the small intestinal microbiome demonstrates that the duodenal microbiome changes with increasing age, with significant decreases in duodenal microbial diversity due to increased prevalence of phylum Proteobacteria, particularly coliforms and anaerobic taxa. Given the key roles of small intestinal microbes in nutrient absorption and host metabolism, these changes may be clinically relevant for human health during the ageing process. Naked Mole Rats Exhibit Minimal Cardiac Aging https://www.fightaging.org/archives/2022/02/naked...
Source: Fight Aging! - February 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity. This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction. Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/ Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning an...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols. FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice. Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs