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Total 21938 results found since Jan 2013.
Higher Mixed lineage Kinase Domain-like protein (MLKL) is associated with worst overall survival in adult-type diffuse glioma patients
by Guilherme Afonso Vergara, Gisele Cristine Eugenio, Suzana Maria Fleury Malheiros, Elivane da Silva Victor, Ricardo Weinlich
IntroductionRecently, the search for novel molecular markers in adult-type diffuse gliomas has grown substantially, yet with few novel breakthroughs. As the presence of a necrotic center is a differential diagnosis for more aggressive entities, we hypothesized that genes involved in necroptosis may play a role in tumor progression. AimGiven that MLKL is the executioner of the necroptotic pathway, we evaluated whether this gene would help to predict prognosis of adult gliomas patients. MethodsWe ana...
Source: PLoS One - August 31, 2023 Category: Biomedical Science Authors: Guilherme Afonso Vergara Source Type: research
Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection
Condition: Brain Gliomas Intervention: Biological: Allogenic B7H3 CAR-γδT cell Sponsor: Dushu Lake Hospital Affiliated to Soochow University Recruiting
Source: ClinicalTrials.gov - August 30, 2023 Category: Research Source Type: clinical trials
Deep-learning and conventional radiomics to predict IDH genotyping status based on magnetic resonance imaging data in adult diffuse glioma
ConclusionIn IDH genotyping, LR is a promising machine-learning classification model. Compared with CR features, DL signatures exhibit markedly superior prediction values and discriminative capability.
Source: Frontiers in Oncology - August 30, 2023 Category: Cancer & Oncology Source Type: research
