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Total 21938 results found since Jan 2013.
Caveolin-1 promotes glioma progression and maintains its mitochondrial inhibition resistance
ConclusionTherefore, we identified a key gene CAV1 and deciphered its function in glioma progression and prognosis, proposing that CAV1 may be a therapeutic target for gliomas.Graphical Abstract
Source: Hormones and Cancer - August 29, 2023 Category: Cancer & Oncology Source Type: research
Interactions between microglia and glioma in tumor microenvironment
Gliomas, the most prevalent primary tumors in the central nervous system, are marked by their immunosuppressive properties and consequent poor patient prognosis. Current evidence emphasizes the pivotal role of the tumor microenvironment in the progression of gliomas, largely attributed to tumor-associated macrophages (brain-resident microglia and bone marrow-derived macrophages) that create a tumor microenvironment conducive to the growth and invasion of tumor cells. Yet, distinguishing between these two cell subgroups remains a challenge. Thus, our review starts by analyzing the heterogeneity between these two cell subset...
Source: Frontiers in Oncology - August 28, 2023 Category: Cancer & Oncology Source Type: research
Tyrosine kinase receptor gene fusion: A series of four cases of infantile-type hemispheric glioma
CONCLUSION: Infant-type hemispheric gliomas are rare and present as large cerebral hemispheric tumors in very young children. Searching for a tyrosine kinase gene fusion should be systematic when dealing with a high-grade glioma in an infant. Importantly, these gene fusions are therapeutic targets. The impact of targeted therapies on patient survival should be evaluated in future prospective studies.PMID:37635016 | DOI:10.1016/j.annpat.2023.07.003
Source: Annales de Pathologie - August 27, 2023 Category: Pathology Authors: Baptiste Sourty La ëtitia Basset Sophie Michalak Estelle Colin Merzouka Zidane-Marinnes Matthieu Delion Emilie de Carli Audrey Rousseau Source Type: research
Chinese Dietary Indices and Glioma: New Insights of a Case-Control Study in the Chinese Population
Nutrients. 2023 Aug 17;15(16):3602. doi: 10.3390/nu15163602.ABSTRACTIdentifying modifiable factors in primary prevention strategies is a typical goal of glioma epidemiology. Among many glioma risk factors, diet was always considered as one. Most of the relevant studies thus far were concentrated on the West. It was crucial to investigate the connection between the Chinese diet and gliomas given the stark variations between western and eastern diets. A food frequency questionnaire including 114 items was used to investigate the food intake of the study subjects. The Chinese Dietary Quality Index (CDQI), the Chinese Dietary ...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Weichunbai Zhang Yongqi He Feng Chen Ce Wang Xun Kang Yue Peng Wenbin Li Source Type: research
Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma
CONCLUSIONS: Our findings indicate that SIRT2 inhibition selectively targets ATRX-deficient gliomas for senescence through global chromatin remodeling, while demonstrating more broadly a viable approach to combat complex epigenetic rewiring in cancer.PMID:37625115 | DOI:10.1093/neuonc/noad155
Source: Ann Oncol - August 25, 2023 Category: Cancer & Oncology Authors: Prit Benny Malgulwar Carla Danussi Sharvari Dharmaiah William Johnson Anand Singh Kunal Rai Arvind Rao Jason T Huse Source Type: research
Genes, Vol. 14, Pages 1693: TERTmonitor & mdash;qPCR Detection of TERTp Mutations in Glioma
In this study, we evaluated the performance of TERTmonitor for TERTp genotyping in a series of 185 gliomas in comparison to the traditional method, Sanger sequencing. Against the gold-standard Sanger method, TERTmonitor performed with a 97.8% accuracy. Inaccuracy was mainly due to the over-detection of variants in negative cases (by Sanger) and the presence of variants that can modify the chemistry of the probe detection. The distribution of the mutations was comparable to other series, with the −124 being the most represented (38.92% for Sanger and TERTmonitor) and more prevalent in the higher-grade tumours,...
Source: Genes - August 25, 2023 Category: Genetics & Stem Cells Authors: Br ás Jesus Prazeres Lima Soares Vinagre Tags: Article Source Type: research
The evolving role of reirradiation in the management of recurrent brain tumors
AbstractDespite aggressive management consisting of surgery, radiation therapy (RT), and systemic therapy given alone or in combination, a significant proportion of patients with brain tumors will experience tumor recurrence. For these patients, no standard of care exists and management of either primary or metastatic recurrent tumors remains challenging.Advances in imaging and RT technology have enabled more precise tumor localization and dose delivery, leading to a reduction in the volume of health brain tissue exposed to high radiation doses. Radiation techniques have evolved from three-dimensional (3-D) conformal RT to...
Source: Journal of Neuro-Oncology - August 25, 2023 Category: Cancer & Oncology Source Type: research
Genes, Vol. 14, Pages 1683: Optical Genome Mapping: Integrating Structural Variations for Precise Homologous Recombination Deficiency Score Calculation
This study reveals HRD signatures that are cryptic to current standard of care (SOC) methods used for assessing the HRD phenotype and presents OGM as an attractive alternative with higher resolution and sensitivity to accurately assess the HRD phenotype.
Source: Genes - August 25, 2023 Category: Genetics & Stem Cells Authors: Nikhil Shri Sahajpal Ashis K. Mondal Ashutosh Vashisht Harmanpreet Singh Andy Wing Chun Pang Daniel Saul Omar Nivin Benjamin Hilton Barbara R. DuPont Vamsi Kota Natasha M. Savage Alex R. Hastie Alka Chaubey Ravindra Kolhe Tags: Article Source Type: research
An active learning approach to train a deep learning algorithm for tumor segmentation from brain MR images
ConclusionThe active learning approach when applied to model training can drastically reduce the time and labor spent on preparation of ground truth training data.Critical relevance statementActive learning concepts were applied to a deep learning-assisted segmentation of brain gliomas from MR images to assess their viability in reducing the required amount of manually annotated ground truth data in model training.Key points• This study focuses on assessing the performance of active learning techniques to train a brain MRI glioma segmentation model.• The active learning approach for manual segmentation can lead to comp...
Source: Insights into Imaging - August 25, 2023 Category: Radiology Source Type: research
Efficacy of apatinib combined with temozolomide in the treatment of recurrent high ‑grade glioma: A meta‑analysis
In conclusion, apatinib combined with temozolomide has the effect that, compared with traditional Bevacizumab treatment, it can improve the efficacy in the treatment of recurrent high-grade glioma and improve prognosis. When combining with dose-dense temozolomide, the effect may be better than that of the conventional 5/28 regimen.PMID:37614429 | PMC:PMC10443066 | DOI:10.3892/etm.2023.12151
Source: Experimental and Therapeutic Medicine - August 24, 2023 Category: General Medicine Authors: Guanglie Li Xiwei Xu Jianqi Cui Fan Zhang Siyang Wang Source Type: research
