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Cancers, Vol. 15, Pages 4130: How Reliable Is Fluorescence-Guided Surgery in Low-Grade Gliomas? A Systematic Review Concerning Different Fluorophores
Conclusions: The current evidence does not support the routine use of 5-aminolevulinic acid or sodium fluorescein with a standard operating microscope because of the low fluorescence rates. New molecules, including tozuleristide, and new techniques for fluorescence detection have shown promising results; however, their use still needs to be clinically validated on a large scale.
Source: Cancers - August 16, 2023 Category: Cancer & Oncology Authors: Andrea Bianconi Marta Bonada Pietro Zeppa Stefano Colonna Fulvio Tartara Antonio Melcarne Diego Garbossa Fabio Cofano Tags: Systematic Review Source Type: research
Machine learning-based identification of glycosyltransferase-related mRNAs for improving outcomes and the anti-tumor therapeutic response of gliomas
Conclusion: The GRMS may act as a powerful and promising biomarker for improving the clinical prognosis of glioma patients.
Source: Frontiers in Pharmacology - August 16, 2023 Category: Drugs & Pharmacology Source Type: research
Vanadium(V) pyridine-containing Schiff base catecholate complexes are novel lipophilic, redox-active and selectively cytotoxic in glioblastoma (T98g) cells
Chemistry. 2023 Aug 15:e202302271. doi: 10.1002/chem.202302271. Online ahead of print.ABSTRACTTwo new series of complexes with pyridine-containing Schiff bases, [VVO(SALIEP)L] and [VVO(Cl-SALIEP)L] (SALIEP = N-(salicylideneaminato)-2-(2-aminoethylpyridine; Cl-SALIEP = N-(5-chlorosalicylideneaminato)-2-(2-aminoethylpyridine, L = catecholato(2-) ligand) were synthesized. Characterization by 1H and 51V NMR and UV-Vis spectroscopies confirmed that: 1) most complexes form two major geometric isomers in solution, and [VVO(SALIEP)(DTB)] (DTB = di-tert-butylcatecholato(2-)) forms two isomers that equilibrate in solution; and 2) te...
Source: Chemistry - August 15, 2023 Category: Chemistry Authors: Kateryna Kostenkova Aviva Levina Drew Walters Heide A Murakami Peter A Lay Debbie C Crans Source Type: research
Overexpression of CD99 is associated with tumor adaptiveness and indicates the tumor recurrence and therapeutic responses in gliomas
Transl Oncol. 2023 Aug 12;37:101759. doi: 10.1016/j.tranon.2023.101759. Online ahead of print.ABSTRACTGlioma undergoes adaptive changes, leading to poor prognosis and resistance to treatment. CD99 influences the migration and invasion of glioma cells and plays an oncogene role. However, whether CD99 can affect the adaptiveness of gliomas is still lacking in research, making its clinical value underestimated. Here, we enrolled our in-house and public multiomics datasets for bioinformatic analysis and conducted immunohistochemistry staining to investigate the role of CD99 in glioma adaptive response and its clinical implicat...
Source: Translational Oncology - August 14, 2023 Category: Cancer & Oncology Authors: Erfei Shang Shanyue Sun Ruolan Zhang Zehui Cao Qingwang Chen Leming Shi Jinsong Wu Shuai Wu Yingchao Liu Yuanting Zheng Source Type: research
RPA3 promotes the proliferation, migration, and invasion of gliomas by activating the PI3K-AKT-mTOR pathway
In conclusion, RPA3 is highly expressed in gliomas and promotes the proliferation, migration and invasion of gliomas by activating the PI3K-AKT-mTOR pathway. Therefore, RPA3 may be a prognostic biomarker and therapeutic target for gliomas.PMID:37571896 | DOI:10.14715/cmb/2023.69.5.14
Source: Cellular and Molecular Biology - August 12, 2023 Category: Molecular Biology Authors: Liang Liang Zongmao Zhao Qianxu Jin Shiyang Zhang Zijun Zhao Xin Li Source Type: research
