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Unveiling the vulnerabilities of synthetic lethality in triple-negative breast cancer
AbstractTriple-negative breast cancer (TNBC) is the most invasive molecular subtype of breast cancer (BC), accounting for about nearly 15% of all BC cases reported annually. The absence of the three major BC hormone receptors, Estrogen (ER), Progesterone (PR), and Human Epidermal Growth Factor 2 (HER2) receptor, accounts for the characteristic “Triple negative” phraseology. The absence of these marked receptors makes this cancer insensitive to classical endocrine therapeutic approaches. Hence, the available treatment options remain solemnly limited to only conventional realms of chemotherapy and radiation therapy. More...
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research

Love and Sex in the Nursing Home? Ethicist Says, ' Why Not? ' Love and Sex in the Nursing Home? Ethicist Says, ' Why Not? '
Art Caplan, PhD, discusses when to intervene and when to stay out of it regarding sexual relationships in a nursing home.Medscape Business of Medicine
Source: Medscape Allergy Headlines - September 21, 2023 Category: Allergy & Immunology Tags: Family Medicine/Primary Care Commentary Source Type: news

which unis should i apply to?
Discussions Megathread Other application years: Graduate Entry Medicine 2025 Entry Official Undergraduate Medicine 2025 Entry Useful Articles: GCSE Requirements for Medicine Everything you need to know about the BMAT Work Experience as a Graduate or Mature student Medicine Personal Statement Advice Medicine Personal Statement Advice (Graduate Entry) Interview Frequently Asked Questions MMI Medicine Interview Tips What to do after an unsuccessful first application If your query is answered by one of the Megathreads or articles linked above, and yotu would like us to close this thread for you, please reply to this thread ...
Source: The Student Room - September 21, 2023 Category: Universities & Medical Training Authors: aggeth_ Tags: Medicine Source Type: forums

US Employers to See Biggest Healthcare Cost Jump in a Decade US Employers to See Biggest Healthcare Cost Jump in a Decade
US employers are bracing for the largest increase in health insurance costs in a decade next year, according forecasts from healthcare consultants.Reuters Health Information
Source: Medscape Medical News Headlines - September 21, 2023 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

Fluticasone Furoate Does Not Cut Time to COVID-19 Symptom Resolution
THURSDAY, Sept. 21, 2023 -- For outpatients with mild-to-moderate COVID-19, inhaled fluticasone furoate does not shorten time to symptom resolution, according to a study published in the Sept. 21 issue of the New England Journal of Medicine. David...
Source: Drugs.com - Pharma News - September 21, 2023 Category: Pharmaceuticals Source Type: news

The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series
Condition:   Postpartum Depression Interventions:   Behavioral: interpersonal psychotherapy (IPT);   Drug: Ketamine Sponsor:   Washington University School of Medicine Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

The Effect of State and Trait Anxiety on Pain-pressure Threshold
Conditions:   Pain;   Anxiety;   Musculoskeletal Pain;   Sensitisation Intervention:   Other: No intervention Sponsor:   Philadelphia College of Osteopathic Medicine Recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Adaptation and Feasibility of the Community-Based Anxiety Program Tailored for Autism (CAPTA)
Conditions:   Anxiety;   Autism Spectrum Disorder;   Separation Anxiety;   Generalized Anxiety Disorder;   Social Anxiety Disorder of Childhood Interventions:   Behavioral: Cognitive Behavioral Therapy;   Other: Treatment as Usual Sponsors:   Baylor College of Medicine;   University of Pennsylvania Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

The Effect of State and Trait Anxiety on Pain-pressure Threshold
Conditions:   Pain;   Anxiety;   Musculoskeletal Pain;   Sensitisation Intervention:   Other: No intervention Sponsor:   Philadelphia College of Osteopathic Medicine Recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series
Condition:   Postpartum Depression Interventions:   Behavioral: interpersonal psychotherapy (IPT);   Drug: Ketamine Sponsor:   Washington University School of Medicine Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Adaptation and Feasibility of the Community-Based Anxiety Program Tailored for Autism (CAPTA)
Conditions:   Anxiety;   Autism Spectrum Disorder;   Separation Anxiety;   Generalized Anxiety Disorder;   Social Anxiety Disorder of Childhood Interventions:   Behavioral: Cognitive Behavioral Therapy;   Other: Treatment as Usual Sponsors:   Baylor College of Medicine;   University of Pennsylvania Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

The Effect of State and Trait Anxiety on Pain-pressure Threshold
Conditions:   Pain;   Anxiety;   Musculoskeletal Pain;   Sensitisation Intervention:   Other: No intervention Sponsor:   Philadelphia College of Osteopathic Medicine Recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series
Condition:   Postpartum Depression Interventions:   Behavioral: interpersonal psychotherapy (IPT);   Drug: Ketamine Sponsor:   Washington University School of Medicine Not yet recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

It ' s Not Easy Saying No to Weight Loss Drugs It ' s Not Easy Saying No to Weight Loss Drugs
Misuse of some GLP-1 receptor agonists is already being reported. How do you handle the patient who wants the drug but doesn ' t qualify for it?Medscape Family Medicine
Source: Medscape Today Headlines - September 21, 2023 Category: Consumer Health News Tags: Family Medicine/Primary Care Clinical Case Source Type: news

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