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Personalized Medicine's Coming of Age: One Drug, One Patient
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2194. Online ahead of print.ABSTRACTA dendritic cell/myeloma fusion vaccine, given with lenalidomide and GM-CSF, did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating multiple myeloma-reactive lymphocytes indicative of tumor-specific immunity.PMID:37733765 | DOI:10.1158/1078-0432.CCR-23-2194
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Muzaffar H Qazilbash Larry W Kwak Source Type: research
Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering
Ann Biomed Eng. 2023 Sep 20. doi: 10.1007/s10439-023-03370-3. Online ahead of print.ABSTRACTTendon and ligament injuries account for a substantial proportion of disorders in the musculoskeletal system. While non-operative and operative treatment strategies have advanced, the restoration of native tendon and ligament structures after injury is still challenging due to its innate limited regenerative ability. Cell sheet technology is an innovative tool for tissue fabrication and cell transplantation in regenerative medicine. In this review, we first summarize different harvesting procedures and advantages of cell sheet techn...
Source: Annals of Biomedical Engineering - September 21, 2023 Category: Biomedical Engineering Authors: Yexin Li Ting Deng Dilihumaer Aili Yang Chen Weihong Zhu Qian Liu Source Type: research
Aggressive variant prostate cancer: A case report and literature review
CONCLUSION: We should reach consensus definitions of the AVPC and other androgen receptor-independent subtypes of PCA and develop new biomarkers to identify groups of high-risk variants. It is crucial to complete a puncture biopsy of the tumor or metastatic lesion as soon as possible in patients with advanced PCA who exhibit clinical features such as low Prostate-specific antigen levels, high carcinoembryonic antigen levels, and insensitivity to hormones to determine the pathological histological type and to create a more aggressive monitoring and treatment regimens.PMID:37731555 | PMC:PMC10507546 | DOI:10.12998/wjcc.v11.i26.6213
Source: Clinical Prostate Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Xiang-Tao Weng Wen-Li Lin Qi-Man Pan Tao-Fen Chen Si-Yi Li Chi-Ming Gu Source Type: research
Retracted IQGAP1 ‑siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines
Mol Med Rep. 2023 Nov;28(5):207. doi: 10.3892/mmr.2023.13094. Epub 2023 Sep 21.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blotting data shown in Fig. 1C, and other western blotting data included in Figs. 2D and 7C and D, were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published elsewhere, prior to its s...
Source: Molecular Medicine Reports - September 21, 2023 Category: Molecular Biology Authors: Bo Diao Ying Liu Yi Zhang Jing Yu Jun Xie Guo-Zheng Xu Source Type: research
Britanin inhibits titanium wear particle ‑induced osteolysis and osteoclastogenesis
Mol Med Rep. 2023 Nov;28(5):205. doi: 10.3892/mmr.2023.13092. Epub 2023 Sep 21.ABSTRACTWear particle‑induced osteolysis is a serious complication that occurs in individuals with titanium (Ti)‑based implants following long‑term usage due to loosening of the implants. The control of excessive osteoclast differentiation and inflammation is essential for protecting against wear particle‑induced osteolysis. The present study evaluated the effect of britanin, a pseudoguaianolide sesquiterpene isolated from Inula japonica, on osteoclastogenesis in vitro and Ti particle‑induced osteolysis in vivo. The effect of britanin ...
Source: Molecular Medicine Reports - September 21, 2023 Category: Molecular Biology Authors: Ju Ang Kim Soomin Lim Hye Jung Ihn Jung-Eun Kim Kyungmoo Yea Jimin Moon Hyukjae Choi Eui Kyun Park Source Type: research
Oxalate ‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling < em > in  vitro < /em > and < em > in  vivo < /em >
Mol Med Rep. 2023 Nov;28(5):209. doi: 10.3892/mmr.2023.13096. Epub 2023 Sep 21.ABSTRACTCalcium oxalate kidney stone has become an urgent issue due to its high incidence and recurrence rate. Thus, it is necessary to explore for mechanisms of calcium oxalate stones formation. Previous studies demonstrated that oxalate crystals could induce the activation of nucleotide‑binding domain and leucine‑rich repeat‑containing family pyrin domain‑containing 3 (NLRP3) inflammasome and change the renal tubular epithelium adhesion. However, the type and molecular mechanism of NLRP3 inflammasome‑mediated calcium oxalate stones f...
Source: Molecular Medicine Reports - September 21, 2023 Category: Molecular Biology Authors: Yue Chen Shushuai Yang Hailong Kong Qi Wang Shiqun Chen Xingyu Wang Liqun Chen Shiyong Qi Source Type: research
Alteration of relative telomere length and telomerase reverse transcriptase expression in the granulosa cells of women during aging and assessment of < em > in vitro < /em > fertilization outcomes
Mol Med Rep. 2023 Nov;28(5):206. doi: 10.3892/mmr.2023.13093. Epub 2023 Sep 21.ABSTRACTTelomere attrition plays a critical role in the reproductive aging process in humans. Telomere length (TL) is typically regulated by telomerase, the main component of which is telomerase reverse transcriptase (TERT). The aim of the present study was to investigate the changes of relative TL (RTL) and TERT expression in granulosa cells (GCs) during aging and its association with reproduction. Clinical data on the frozen‑thawed embryo transfer cycles of older (>35 year old) and younger (≤35 year old) women from a single center over ...
Source: Molecular Medicine Reports - September 21, 2023 Category: Molecular Biology Authors: Yan Hao Mingrong Lv Jing Peng Dan Kuang Zhihua Zhang Zhou Zhang Tingting Wang Bo Yang Zhaolian Wei Ping Zhou Zhiguo Zhang Yunxia Cao Source Type: research
Catechin hydrate ameliorates cerulein ‑induced chronic pancreatitis via the inactivation of TGF‑β/Smad2 signaling
Mol Med Rep. 2023 Nov;28(5):208. doi: 10.3892/mmr.2023.13095. Epub 2023 Sep 21.ABSTRACTChronic pancreatitis (CP) is a pancreatic inflammatory disease associated with histological changes, including fibrosis, acinar cell loss and immune cell infiltration, and leads to damage of the pancreas, which results in pain, weight loss and loss of pancreas function. Catechin or catechin hydrate (CH) has antioxidant, anticancer and immune‑regulatory effects. However, unlike other catechins, the antifibrotic effects of (+)‑CH have not been widely studied in many diseases, including CP. Therefore, the anti‑fibrotic effects of (+)â...
Source: Molecular Medicine Reports - September 21, 2023 Category: Molecular Biology Authors: Bitna Kweon Dong-Uk Kim Jin-Young Oh Sung-Joo Park Gi-Sang Bae Source Type: research
Early diagnosis of chronic kidney disease in patients with diabetes in France: multidisciplinary expert opinion, prevention value and practical recommendations
This article provides an overview of critical laboratory evidence of CKD and their limitations, such as estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR), Kidney Failure Risk Equation (KFRE), and serum potassium. eGFR is estimated using the CKD-EPI 2009 formula, more relevant in Europe, from the calibrated dosage of plasma creatinine. The estimation formula and the diagnostic thresholds have been the subject of recent controversies. Recent guidelines emphasized the combined equation using both creatinine and cystatin for improved estimation of GFR. UACR on a spot urine sample is a simple...
Source: Postgraduate Medicine - September 21, 2023 Category: Internal Medicine Authors: Thierry Hannedouche Patrick Rossignol Patrice Darmon Jean-Michel Halimi Patrick Vuattoux Albert Hagege Ludivine Videloup Francis Guinard Source Type: research
An analysis of cardiology consultation requests in infants presented to the pediatric emergency department of a tertiary children's hospital
CONCLUSION: In conclusion, congenital heart disease is usually diagnosed in the neonatal period, but some patients may be missed due to a variety of symptoms and findings. Infants with feeding problems and jaundice, especially those with cardiomegaly on chest radiographs, should be carefully evaluated for underlying serious congenital heart disease.PMID:37731167 | DOI:10.1080/00325481.2023.2261356
Source: Postgraduate Medicine - September 21, 2023 Category: Internal Medicine Authors: Bet ül Öztürk Mustafa Muhammed G üneyli Oğlu Raziye Merve Yaradilmi ş Orkun Ayd ın Deniz Yasar Ali G üngör I Lknur Bodur Ayta ç Göktuğ I Lker Ufuk Sayici Utku Arman Örün Can Demir Karacan Nilden Tuygun Source Type: research
Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey
CONCLUSIONS: EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.PMID:37731370 | DOI:10.1080/03007995.2023.2258777
Source: Current Medical Research and Opinion - September 21, 2023 Category: Research Authors: Georg Seifert Laura Upstone Christopher P Watling Christian Vogelberg Source Type: research
Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico
Conclusions: Data suggest combined ibogaine and 5-MeO-DMT assisted therapy has potential to provide rapid and robust changes in mental health functioning with a signal of durable therapeutic effects up to 6-months. Future research in controlled settings is warranted.PMID:37734158 | DOI:10.1080/00952990.2023.2220874
Source: The American Journal of Drug and Alcohol Abuse - September 21, 2023 Category: Addiction Authors: Alan Kooi Davis Yitong Xin Nathan Sepeda Lynnette A Averill Source Type: research
Meeting Report: 11th and 12th Annual Meetings of the Society of Anesthesia and Sleep Medicine: Taking Sleep Health Into the Next Decade
Anesth Analg. 2023 Sep 21. doi: 10.1213/ANE.0000000000006632. Online ahead of print.NO ABSTRACTPMID:37733625 | DOI:10.1213/ANE.0000000000006632
Source: Anesthesia and Analgesia - September 21, 2023 Category: Anesthesiology Authors: Ameya Pappu Satya Krishna Ramachandran Dennis Auckley Christine Won Bhargavi Gali Mary Hargett Olubukola Nafiu Jennifer Dominguez Mandeep Singh Source Type: research
Development and evaluation of a predictive algorithm and telehealth intervention to reduce suicidal behavior among university students
CONCLUSIONS: Predictive risk algorithms embedded into universal screening, coupled with telehealth intervention, offer significant potential as a suicide prevention approach for students.PMID:37732419 | DOI:10.1017/S0033291723002714
Source: Psychological Medicine - September 21, 2023 Category: Psychiatry Authors: Penelope A Hasking Kealagh Robinson Peter McEvoy Glenn Melvin Ronny Bruffaerts Mark E Boyes Randy P Auerbach Delia Hendrie Matthew K Nock David A Preece Clare Rees Ronald C Kessler Source Type: research
Personalized Medicine's Coming of Age: One Drug, One Patient
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2194. Online ahead of print.ABSTRACTA dendritic cell/myeloma fusion vaccine, given with lenalidomide and GM-CSF, did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating multiple myeloma-reactive lymphocytes indicative of tumor-specific immunity.PMID:37733765 | DOI:10.1158/1078-0432.CCR-23-2194
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Muzaffar H Qazilbash Larry W Kwak Source Type: research
