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Graph Attention Network based mapping of knowledge relations between chemical spaces of Nuclear factor kappa B and Centella asiatica
This study aims to explore the regulatory nature of the molecules from the inhibition and activation of the NF-κB bioassay data set and map this information for a knowledge-based analysis against the molecules of CA, a low-growing tropical plant. This finding has led to a new direction in the field, transitioning from the conventional active-inactive framework to a more comprehensive active-inactive-regulatory model. This approach can be thoroughly explored by leveraging a graph-based deep learning system. The study presents an innovative approach using a Graph Attention Network (GAT) to rank CA molecules in chemical spac...
Source: Computational Biology and Chemistry - September 21, 2023 Category: Bioinformatics Authors: Vivek P Mithun Mohanan Shajil U K Sandesh E Pa Jaleel U C A Source Type: research
Integration and sharing of traditional Chinese medicine treatment for children with functional constipation: 3-Year graded diagnosis and treatment experience
Asian J Surg. 2023 Sep 19:S1015-9584(23)01381-7. doi: 10.1016/j.asjsur.2023.08.208. Online ahead of print.NO ABSTRACTPMID:37734986 | DOI:10.1016/j.asjsur.2023.08.208
Source: Asian Journal of Surgery - September 21, 2023 Category: Surgery Authors: Jian Shen Bimeng Zhang Xiajun Xie Jiajia Lv Source Type: research
Development of critical thinking skills in human anatomy and physiology
Adv Physiol Educ. 2023 Sep 21. doi: 10.1152/advan.00131.2023. Online ahead of print.ABSTRACTApplication of knowledge skills are highly valued in clinical medicine as indicated by recent changes to licensure and entrance exams for nursing and physician programs (i.e., the NCLEX and MCAT). Such emphasis should be both welcomed and supported by approaches to teaching human anatomy and physiology that emphasize critical thinking skills built upon logic, reasoning, and judgement. The argument for development of these skills is not simply philosophical, rather, such emphasis is strongly supported by a 2016 Johns Hopkins study1 t...
Source: Advances in Physiology Education - September 21, 2023 Category: Physiology Authors: Erik P Silldorff Gerald D Robinson Source Type: research
Brain-Penetrant Cyanoindane and Cyanotetralin Inhibitors of G2019S-LRRK2 Kinase Activity
We report the discovery of a series of cyanoindane and cyanotetralin kinase inhibitors culminating in compound 34 that demonstrated selective inhibition of phosphorylation of LRRK2 in the mouse brain. These novel inhibitors may further enable the precision medicine path for future PD therapeutics.PMID:37734423 | DOI:10.1016/j.bmcl.2023.129487
Source: Bioorganic and Medicinal Chemistry Letters - September 21, 2023 Category: Chemistry Authors: Albert W Garofalo Jacob Schwarz Kerry Zobel Claudia Beato Silvia Bernardi Federica Budassi Laura Caberlotto Peng Gao Cristiana Griffante Xinying Liu Marco Migliore Feifei Qiao Fabio Maria Sabbatini Anna Sava Mingliang Zhang Holly J Carlisle Source Type: research
A Review on the Antimutagenic and Anticancer Effects of Cysteamine
In conclusion, regarding the high safety profile of cysteamine and the current literature data presented in this article, cysteamine might be considered as an interesting molecule for the prevention and the treatment of cancer. Further clinical studies should be performed to support these data in humans.PMID:37731680 | PMC:PMC10508993 | DOI:10.1155/2023/2419444
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Chun-Man Lee Source Type: research
Long-Term Doxycycline Therapy for Stable COPD: Do the Benefits Outweigh the Drawbacks?
Am J Respir Crit Care Med. 2023 Sep 21. doi: 10.1164/rccm.202307-1301LE. Online ahead of print.NO ABSTRACTPMID:37734069 | DOI:10.1164/rccm.202307-1301LE
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2023 Category: Respiratory Medicine Authors: Jingcun Wang Qiming Gan Haojie Zhang Qiuyun Xing Yanjuan Wu Xiaofen Su Nuofu Zhang Kang Wu Source Type: research
Microbiological Monitoring in Therapeutic Trials in COPD
Am J Respir Crit Care Med. 2023 Sep 21. doi: 10.1164/rccm.202307-1214LE. Online ahead of print.NO ABSTRACTPMID:37734068 | DOI:10.1164/rccm.202307-1214LE
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2023 Category: Respiratory Medicine Authors: Miguel Angel Martinez-Garcia Alvar Agusti Source Type: research
The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation
CONCLUSIONS: Donor smoking associates with a modest increase in PGD risk but not with increased recipient mortality. Use of lungs from smokers is likely safe and may increase lung donor availability.PMID:37734031 | DOI:10.1164/rccm.202303-0358OC
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2023 Category: Respiratory Medicine Authors: Joshua M Diamond Edward Cantu Carolyn S Calfee Michaela R Anderson Emily S Clausen Michael G S Shashaty Andrew M Courtwright Laurel Kalman Michelle Oyster Maria M Crespo Christian A Bermudez Luke Benvenuto Scott M Palmer Laurie D Snyder Matthew G Hartwig Source Type: research
Win Statistics in Pulmonary Arterial Hypertension Clinical Trials
Am J Respir Crit Care Med. 2023 Sep 21. doi: 10.1164/rccm.202305-0800LE. Online ahead of print.NO ABSTRACTPMID:37734029 | DOI:10.1164/rccm.202305-0800LE
Source: American Journal of Respiratory and Critical Care Medicine - September 21, 2023 Category: Respiratory Medicine Authors: Jason Weatherald Jude Moutchia Nadine Al-Naamani Robyn L McClelland Corey E Ventetuolo Harold I Palevsky Michael O Harhay Steven M Kawut Source Type: research
Reducing the risk of hallucinations with interpretable deep learning models for low-dose CT denoising: comparative performance analysis
In this study, we aim to use qualitative reader studies and quantitative radiomics studies to assess the perceived quality, signal preservation and statistical feature preservation of LDCT volumes denoised by deep learning. We aim to compare interpretable deep learning methods with classical deep neural networks in clinical de-
noising performance.
Approach: We conducted an image quality analysis (IQA) study to assess the image quality of the denoised volumes based on four criteria to assess the perceived image quality. We subsequently conduct a lesion detection/segmentation study to assess the impact of de...
Source: Physics in Medicine and Biology - September 21, 2023 Category: Physics Authors: Mayank Patwari Ralf Gutjahr Roy Marcus Yannick Thali Adria Font Calvarons Rainer Raupach Andreas Maier Source Type: research
3D phantom for image quality assessment of mammography systems
Phys Med Biol. 2023 Sep 21. doi: 10.1088/1361-6560/acfc10. Online ahead of print.ABSTRACTOBJECTIVE: To present an innovative approach for the design of a 3D mammographic phantom for medical equipment quality assessment, estimation of the glandular tissue percentage in the patient's breast, and emulation of microcalcification ($\mu$C) breast lesions.APPROACH: Contrast-to noise ratio (CNR) measurements, as well as spatial resolution and intensity-to-glandularity calibrations under mammography conditions were performed to assess the effectiveness of the phantom. CNR measurements were applied to different groups of calcium hyd...
Source: Physics in Medicine and Biology - September 21, 2023 Category: Physics Authors: Jes ús David Bermúdez Sánchez Gerardo Alfonso Roque Juan Sebasti án Calderón García Paula Andrea Pardo Ramos Manuel Fernando S ánchez Alarcón Victor Alfonso Ramos Correa Carlos Arturo Ávila Bernal Source Type: research
Evaluating COVID-19 Response Within a Tribal Health Care Organization
Conclusion Our evaluation approach captured areas of importance to the tribal health organization and may be pertinent for other indigenous organizations and rural communities. It is especially important to consider tribal perspectives in response to COVID-19 because of the prior history with Western medicine and infectious diseases, and health care limitations experienced due to rurality.PMID:37731363 | DOI:10.7812/TPP/23.039
Source: The Permanente journal - September 21, 2023 Category: General Medicine Authors: Krista R Schaefer Brianna Triplett Olivia Lorenzo Michelle Aregood Donna Galbreath Denise A Dillard Ann Futterman Collier Source Type: research
Brain Injury: How Dietary Patterns Impact Long-Term Outcomes
We examined Mediterranean, Dietary Approaches to Stop Hypertension, plant-based, ketogenic, and intermittent fasting dietary patterns through publications of clinical trials and systematic reviews. While many reviews had significant positive findings, some were limited by generalizability.SUMMARY: While there is extensive literature on the immediate nutrition goals in the inpatient setting following an acute TBI exposure, there is limited literature discussing the nature of diet and nutrition in the post-acute setting. Fortunately, most individuals with TBI exposure survive their initial injury and continue into the recove...
Source: Health Physics - September 21, 2023 Category: Physics Authors: Palak R Patel Patrick Armistead-Jehle Nicholas R Eltman Kelly M Heath David X Cifu Randel L Swanson Source Type: research
Addressing the paradox: Health expansion threatening sustainable healthcare
Eur J Intern Med. 2023 Sep 19:S0953-6205(23)00332-1. doi: 10.1016/j.ejim.2023.09.012. Online ahead of print.ABSTRACTWe need to address the paradox that health expansion threatens sustainable healthcare as anti-aging drugs are on the trail from trial to the market and come together with health enhancement measures changing demography and the health of populations. This poses global, social, and professional problems, and challenges clinical medicine as well as health policy. To handle the emerging challenges, we need to address four crucial issues: (1) injustice (access), (2) sustainability, (3) basic human rights, and (4) ...
Source: European Journal of Internal Medicine - September 21, 2023 Category: Internal Medicine Authors: Bj ørn Hofmann Source Type: research
