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Cancer: Adenocarcinoma
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Total 24759 results found since Jan 2013.
Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach
CONCLUSIONS: HSPD1 may play a role in the regulation of ribosome biogenesis and B cell-mediated immunity in LUAD. It could serve as a predictive biomarker for prognosis and immunotherapy response in LUAD.PMID:37694354 | DOI:10.3233/CBM-220442
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Siripat Aluksanasuwan Keerakarn Somsuan Jatuporn Ngoenkam Somchai Chutipongtanate Sutatip Pongcharoen Source Type: research
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach
CONCLUSIONS: HSPD1 may play a role in the regulation of ribosome biogenesis and B cell-mediated immunity in LUAD. It could serve as a predictive biomarker for prognosis and immunotherapy response in LUAD.PMID:37694354 | DOI:10.3233/CBM-220442
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Siripat Aluksanasuwan Keerakarn Somsuan Jatuporn Ngoenkam Somchai Chutipongtanate Sutatip Pongcharoen Source Type: research
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
Multi-omics data analysis reveals the biological implications of alternative splicing events in lung adenocarcinoma
J Bioinform Comput Biol. 2023 Sep 8:2350020. doi: 10.1142/S0219720023500208. Online ahead of print.ABSTRACTCancer is characterized by the dysregulation of alternative splicing (AS). However, the comprehensive regulatory mechanisms of AS in lung adenocarcinoma (LUAD) are poorly understood. Here, we displayed the AS landscape in LUAD based on the integrated analyses of LUAD's multi-omics data. We identified 13,995 AS events in 6309 genes as differentially expressed alternative splicing events (DEASEs) mainly covering protein-coding genes. These DEASEs were strongly linked to "cancer hallmarks", such as apoptosis, DNA repair,...
Source: Journal of Bioinformatics and Computational Biology - September 11, 2023 Category: Bioinformatics Authors: Fuyan Hu Bifeng Chen Qing Wang Zhiyuan Yang Man Chu Source Type: research
Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach
CONCLUSIONS: HSPD1 may play a role in the regulation of ribosome biogenesis and B cell-mediated immunity in LUAD. It could serve as a predictive biomarker for prognosis and immunotherapy response in LUAD.PMID:37694354 | DOI:10.3233/CBM-220442
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Siripat Aluksanasuwan Keerakarn Somsuan Jatuporn Ngoenkam Somchai Chutipongtanate Sutatip Pongcharoen Source Type: research
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
Construction of a prognostic model for lung adenocarcinoma based on heat shock protein-related genes and immune analysis
Cell Stress Chaperones. 2023 Sep 11. doi: 10.1007/s12192-023-01374-5. Online ahead of print.ABSTRACTLung adenocarcinoma (LUAD) represents a prevalent form of cancer, with low early diagnosis rates and high mortality rates, posing a global health challenge. Heat shock proteins (HSPs) assume a crucial role within the tumor immune microenvironment (TME) of LUAD. Here, a collection of 97 HSP-related genes (HSPGs) was assembled based on prior literature reports, of which 36 HSPGs were differentially expressed in LUAD. In The Cancer Genome Atlas (TCGA) cohort, we constructed a prognostic model for risk stratification and prognos...
Source: Cell Stress and Chaperones - September 10, 2023 Category: Cytology Authors: Wangyan Zhou Wei Zeng Dayang Zheng Xu Yang Yongcheng Qing Chunxiang Zhou Xiang Liu Source Type: research
Preparation of some new pyrazolo1,5-apyrimidines and evaluation of their antioxidant, antibacterial (MIC and ZOI) activities, and cytotoxic effect on MCF-7 cell line
This study aims to synthesize some novel pyrazolo[1,5-a]pyrimidine derivatives, and investigate their biological activities. These compounds exhibited good to high antioxidant activities [2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capabilities]. Among them, Ethyl 5-(2-ethoxy-2-oxoethyl)-7-hydroxy-2-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate (3h) showed the highest antioxidant activity [Half-maximal Inhibitory Concentration (IC50)= 15.34 μM] compared to ascorbic acid (IC50= 13.53 μM) as a standard compound. Their antibacterial activities were investigated against two Gram-positive bacteria (Bacillus subtil...
Source: Chemistry and Biodiversity - September 10, 2023 Category: Biochemistry Authors: Mohammad Mehdi Vahedi Sakineh Asghari Mahmood Tajbakhsh Mojtaba Mohseni Source Type: research
