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Cancer: Adenocarcinoma
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Total 24759 results found since Jan 2013.
PD-1 blockade induces reactivation of non-productive T cell responses characterized by NF-kB signaling in patients with pancreatic cancer
CONCLUSIONS: Cytotoxic T cells in the blood of PDAC patients remain sensitive to reinvigoration by PD-1 blockade and some have tumor-recognizing potential. Although these T cells proliferate and have a signature of IFN exposure, they also upregulate NF-κB signaling, which potentially counteracts the beneficial effects of anti-PD-1 reinvigoration and marks these T cells as non-productive contributors to anti-tumor immunity.PMID:37733830 | DOI:10.1158/1078-0432.CCR-23-1444
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Lestat R Ali Patrick J Lenehan Victoire Cardot-Ruffino Andressa Dias Costa Matthew H G Katz Todd W Bauer Jonathan A Nowak Brian M Wolpin Thomas A Abrams Anuj Patel Thomas E Clancy Jiping Wang Joseph D Mancias Matthew J Reilley Chee-Chee H Stucky Tanios S Source Type: research
Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon diagnosed by molecular pathology: A case report and literature review
CONCLUSION: Based on pathological and genetic analysis, surgery combined with chemotherapy or chemoradiotherapy may have good therapeutic effects for collision tumor.PMID:37731579 | PMC:PMC10507543 | DOI:10.12998/wjcc.v11.i26.6289
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Meng Jiang Xiao-Ping Yuan Source Type: research
PD-1 blockade induces reactivation of non-productive T cell responses characterized by NF-kB signaling in patients with pancreatic cancer
CONCLUSIONS: Cytotoxic T cells in the blood of PDAC patients remain sensitive to reinvigoration by PD-1 blockade and some have tumor-recognizing potential. Although these T cells proliferate and have a signature of IFN exposure, they also upregulate NF-κB signaling, which potentially counteracts the beneficial effects of anti-PD-1 reinvigoration and marks these T cells as non-productive contributors to anti-tumor immunity.PMID:37733830 | DOI:10.1158/1078-0432.CCR-23-1444
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Lestat R Ali Patrick J Lenehan Victoire Cardot-Ruffino Andressa Dias Costa Matthew H G Katz Todd W Bauer Jonathan A Nowak Brian M Wolpin Thomas A Abrams Anuj Patel Thomas E Clancy Jiping Wang Joseph D Mancias Matthew J Reilley Chee-Chee H Stucky Tanios S Source Type: research
Mesonephric-like adenocarcinoma of the endometrium
Asian J Surg. 2023 Sep 19:S1015-9584(23)01463-X. doi: 10.1016/j.asjsur.2023.09.029. Online ahead of print.NO ABSTRACTPMID:37730504 | DOI:10.1016/j.asjsur.2023.09.029
Source: Asian Journal of Surgery - September 20, 2023 Category: Surgery Authors: Guowu Wang Weishan Zhang Baian Lai Siyi Luo Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Technology in Cancer Research and Treatment - September 20, 2023 Category: Cancer & Oncology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
Synchronous rectal adenocarcinoma and intestinal mantle cell lymphoma: A case report
CONCLUSION: Synchronous rectal adenocarcinoma and intestinal MCL presenting as multiple lymphomatous polyposis are extremely rare. MCL is often discovered fortuitously when rectal cancer is diagnosed. The coexistence of these tumors poses treatment challenges.PMID:37727717 | PMC:PMC10506007 | DOI:10.12998/wjcc.v11.i24.5772
Source: Clinical Colorectal Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Kim-Van Vu Nguyen-Van Trong Nguyen-Thi Khuyen Do Huyen Nga Hoang Anh Nguyen Tien Trung Pham Trung Thong Nguyen Minh Duc Source Type: research
Analysis of Prognoses according to Breast MRI Results in Patients with Axillary Lymph Node Metastases from an Unknown Primary Origin
CONCLUSION: The prognoses of MR-negative patients with ACUPax who received ALND and WBRT followed by chemotherapy were as good as those of patients with MRI-detected primary breast cancers.PMID:37727923 | DOI:10.3349/ymj.2023.0181
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: E-Ryung Choi Ok Hee Woo Eun Young Ko Boo-Kyung Han Ji Soo Choi Eun Sook Ko Haejung Kim Myoung Kyoung Kim Jeong Eon Lee Source Type: research
Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma
CONCLUSIONS: The results indicate that promoting infiltration and activation of B cell populations could improve the long-term survival of LUAD patients, thereby offering a potential novel immunotherapeutic approach for LUAD. Besides, the promotion of cancer cell ferroptosis and upregulation of WDFY4 expression have been shown to induce the infiltration and activation of B cell populations. Furthermore, the overexpression of WDFY4 can significantly inhibit the growth of lung adenocarcinoma in vitro and in vivo, highlighting its potential as a target for immunotherapy in LUAD.PMID:37728413 | DOI:10.18632/aging.205042
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Ling Huang Lifan Zhong Ruxin Cheng Limei Chang Mingyan Qin Huaping Liang Zhongkai Liao Source Type: research
Exosome-hijacking drug delivery system with branched arginine linker effectively deliver antisense oligonucleotides into lung adenocarcinoma cells
In this study, we modified ExomiR-Tracker by incorporating branched nona-D-arginines (9 + 9 mer) molecules (referred to as Branch ExomiR-Tracker) and evaluated its efficacy in lung adenocarcinoma cells (A549 cells). The improved complex formation ability and enhanced cellular uptake of anti-miR, demonstrated by our findings, highlight the advantages of incorporating branched oligoarginine peptides into the ExomiR-Tracker platform. These results represent significant progress in revealing the effectiveness of Branch ExomiR-Tracker against adhesive cancer cells, which has not been shown to be effective with the conventional ...
Source: Chemical and Pharmaceutical Bulletin - September 20, 2023 Category: Drugs & Pharmacology Authors: Shota Oyama Mao Tomita Moeka Hata Yu Mikame Tsuyoshi Yamamoto Eishi Ashihara Asako Yamayoshi Source Type: research
Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma
CONCLUSIONS: The results indicate that promoting infiltration and activation of B cell populations could improve the long-term survival of LUAD patients, thereby offering a potential novel immunotherapeutic approach for LUAD. Besides, the promotion of cancer cell ferroptosis and upregulation of WDFY4 expression have been shown to induce the infiltration and activation of B cell populations. Furthermore, the overexpression of WDFY4 can significantly inhibit the growth of lung adenocarcinoma in vitro and in vivo, highlighting its potential as a target for immunotherapy in LUAD.PMID:37728413 | DOI:10.18632/aging.205042
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Ling Huang Lifan Zhong Ruxin Cheng Limei Chang Mingyan Qin Huaping Liang Zhongkai Liao Source Type: research
Metastatic competency and tumor spheroid formation are independent cell states governed by RB in lung adenocarcinoma
Cancer Res Commun. 2023 Sep 20. doi: 10.1158/2767-9764.CRC-23-0172. Online ahead of print.ABSTRACTInactivation of the retinoblastoma (RB) tumor suppressor in lung adenocarcinoma is associated with the rapid acquisition of metastatic ability and the loss of lung cell lineage commitment. We previously showed that restoration of RB in advanced lung adenocarcinomas in the mouse was correlated with a decreased frequency of lineage de-committed tumors and overt metastases. To identify a causal relationship for RB and its role in reprogramming lineage commitment and reducing metastatic competency in lung adenocarcinoma, we develo...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Nelson F Freeburg Nia Peterson Dain A Ruiz Amy C Gladstein David M Feldser Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells
Lung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important. Lawsone (2-hydroxy-1,4-naphtoquinone) is a naphthoquinone found in plants ...
Source: BMC Complementary and Alternative Medicine - September 20, 2023 Category: Complementary Medicine Authors: Edmilson Willian Propheta dos Santos, Rauan Cruz de Sousa, Mariana Nobre Farias de Franca, Jileno Ferreira Santos, Flaviano Melo Ottoni, Raquel Geralda Isid ório, Waldecy de Lucca Junior, Ricardo José Alves, Ricardo Scher and Cristiane Bani Corrêa Tags: Research Source Type: research
