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Cancer: Adenocarcinoma
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Total 24759 results found since Jan 2013.
Socioeconomic status and cecal adenocarcinoma mortality risk: an American population-based analysis
CONCLUSION: Low socioeconomic status is associated with an increased risk of death in patients with cecal adenocarcinoma in the United States and show different distribution patterns based on population. Improving health insurance policies and strengthening psychotherapy can provide guidance for improving prognosis f cecal adenocarcinoma patients.PMID:37712280 | PMC:PMC10505572 | DOI:10.12122/j.issn.1673-4254.2023.08.20
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Z Shao J Lyu Source Type: research
Methylation of hypoxia-inducible factor 3 subunit alpha contributes to poor prognosis in lung adenocarcinoma
J Appl Genet. 2023 Sep 14. doi: 10.1007/s13353-023-00784-6. Online ahead of print.ABSTRACTHypoxia-inducible factor 3 subunit alpha (HIF3A) has been implicated in various types of cancers, while its precise role in the lung adenocarcinoma remains unclear. Our study aimed to investigate the roles of HIF3A in lung adenocarcinoma and its regulation by DNA methylation. We utilized bioinformatic tools, including UALCAN and KMPlot, to analyze the relationship between HIF3A expression, DNA methylation, and patient survival rate in lung adenocarcinoma. We also used siRNA-mediated knockdown of HIF3A and DNA-methyltransferase 1 (DNMT...
Source: J Appl Genet - September 14, 2023 Category: Genetics & Stem Cells Authors: Qin Shi Xiuxia Zheng Ying Hu Zhan Zhou Minshan Fang Xinhui Huang Source Type: research
Construction of a Diagnostic Model for Small Cell Lung Cancer Combining Metabolomics and Integrated Machine Learning
CONCLUSION: This study is the first to analyze the difference between metabolomics and lipidomics and to construct a d-model to detect SCLC using integrated machine learning. This study may be of great significance for the screening and early diagnosis of SCLC patients.PMID:37706531 | DOI:10.1093/oncolo/oyad261
Source: The Oncologist - September 14, 2023 Category: Cancer & Oncology Authors: Xiaoling Shang Chenyue Zhang Ronghua Kong Chenglong Zhao Haiyong Wang Source Type: research
Integration and deconvolution methodology deciphering prognosis-related signatures in lung adenocarcinoma
CONCLUSIONS: The constructed risk prediction model in this study offers clinicians a valuable tool for tailoring treatment strategies of LUAD and provides a comprehensive interpretation on the biological activities of PRGs in LUAD.PMID:37710052 | DOI:10.1007/s00432-023-05403-9
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Ming Yi Jiaying Shi Xiaolan Tan Xinyue Zhang Dachang Tao Yuan Yang Yunqiang Liu Source Type: research
Early immune changes support signet ring cell dormancy in CDH1-driven hereditary diffuse gastric carcinogenesis
Mol Cancer Res. 2023 Sep 14. doi: 10.1158/1541-7786.MCR-23-0122. Online ahead of print.ABSTRACTStage IA gastric adenocarcinoma, characterized by foci of intramucosal signet ring cells (SRCs), is found in nearly all asymptomatic patients with germline pathogenic CDH1 variants and hereditary diffuse gastric cancer syndrome (HDGC). The molecular steps involved in initiating malignant transformation and promoting SRC dormancy in HDGC are unknown. Here, whole-exome bulk RNA sequencing (RNAseq) of SRCs and adjacent non-SRC epithelium (NEP) was performed on laser-capture microdissected (LCM) regions of interest found in risk-redu...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Benjamin L Green Lauren A Gamble Laurence P Diggs Darryl Nousome Jesse C Patterson Brian A Joughin Billel Gasmi Stephanie C Lux Sarah G Samaranayake Markku Miettinen Martha Quezado Jonathan M Hernandez Michael B Yaffe Jeremy L Davis Source Type: research
Combined targeting of NAD biosynthesis and the NAD-dependent transcription factor C-terminal Binding Protein as a promising novel therapy for pancreatic cancer
Cancer Res Commun. 2023 Sep 13. doi: 10.1158/2767-9764.CRC-22-0521. Online ahead of print.ABSTRACTCancer therapies targeting metabolic derangements unique to cancer cells are emerging as a key strategy to address refractory solid tumors such as pancreatic ductal adenocarcinomas (PDAC) that exhibit resistance to extreme nutrient deprivation in the tumor microenvironment. Nicotinamide adenine dinucleotide (NAD) participates in multiple metabolic pathways and Nicotinamide phosphoribosyl transferase (NAMPT) is one of the key intracellular enzymes that facilitate the synthesis of NAD. C-terminal Binding Proteins 1 and 2 (CtBP) ...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: M Michael Dcona Kranthi Kumar Chougoni Diana T Dcona Jacqueline L West Sahib J Singh Keith C Ellis Steven R Grossman Source Type: research
Methylation of hypoxia-inducible factor 3 subunit alpha contributes to poor prognosis in lung adenocarcinoma
J Appl Genet. 2023 Sep 14. doi: 10.1007/s13353-023-00784-6. Online ahead of print.ABSTRACTHypoxia-inducible factor 3 subunit alpha (HIF3A) has been implicated in various types of cancers, while its precise role in the lung adenocarcinoma remains unclear. Our study aimed to investigate the roles of HIF3A in lung adenocarcinoma and its regulation by DNA methylation. We utilized bioinformatic tools, including UALCAN and KMPlot, to analyze the relationship between HIF3A expression, DNA methylation, and patient survival rate in lung adenocarcinoma. We also used siRNA-mediated knockdown of HIF3A and DNA-methyltransferase 1 (DNMT...
Source: J Appl Genet - September 14, 2023 Category: Genetics & Stem Cells Authors: Qin Shi Xiuxia Zheng Ying Hu Zhan Zhou Minshan Fang Xinhui Huang Source Type: research
Integration and deconvolution methodology deciphering prognosis-related signatures in lung adenocarcinoma
CONCLUSIONS: The constructed risk prediction model in this study offers clinicians a valuable tool for tailoring treatment strategies of LUAD and provides a comprehensive interpretation on the biological activities of PRGs in LUAD.PMID:37710052 | DOI:10.1007/s00432-023-05403-9
Source: Clinical Lung Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Ming Yi Jiaying Shi Xiaolan Tan Xinyue Zhang Dachang Tao Yuan Yang Yunqiang Liu Source Type: research
Methylation of hypoxia-inducible factor 3 subunit alpha contributes to poor prognosis in lung adenocarcinoma
J Appl Genet. 2023 Sep 14. doi: 10.1007/s13353-023-00784-6. Online ahead of print.ABSTRACTHypoxia-inducible factor 3 subunit alpha (HIF3A) has been implicated in various types of cancers, while its precise role in the lung adenocarcinoma remains unclear. Our study aimed to investigate the roles of HIF3A in lung adenocarcinoma and its regulation by DNA methylation. We utilized bioinformatic tools, including UALCAN and KMPlot, to analyze the relationship between HIF3A expression, DNA methylation, and patient survival rate in lung adenocarcinoma. We also used siRNA-mediated knockdown of HIF3A and DNA-methyltransferase 1 (DNMT...
Source: J Appl Genet - September 14, 2023 Category: Genetics & Stem Cells Authors: Qin Shi Xiuxia Zheng Ying Hu Zhan Zhou Minshan Fang Xinhui Huang Source Type: research
Design, Synthesis of Novel 1,2,3-Triazole Pendent Quinazolinones and their Cytotoxicity Against MCF-7 Cell Line
Chem Biodivers. 2023 Sep 14:e202300800. doi: 10.1002/cbdv.202300800. Online ahead of print.ABSTRACTA library of 6-(((1-(substitutedphenyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-3-methylquinazolin-4(3H)-one analogues synthesized from Isatin precursor through a series of nitration, reduction, hydrolysis, cyclization and click reaction. The structures of compounds were characterized by spectral data including IR, 1H NMR, 13C NMR and Mass. The novel quinazolinone - 1,2,3-triazoles were screened for their cytotoxicity against the human breast adenocarcinoma cell lines MCF-7 by MTT assay. 4-Isopropyl and 2-bromo substituted analog...
Source: Chemistry and Biodiversity - September 14, 2023 Category: Biochemistry Authors: Nagaraju Myakala Kotaiah Kandula Nagamani Rayala Sateesh Kuna Vishnu Thumma Durga Bhavani A K Source Type: research
Methylation of hypoxia-inducible factor 3 subunit alpha contributes to poor prognosis in lung adenocarcinoma
J Appl Genet. 2023 Sep 14. doi: 10.1007/s13353-023-00784-6. Online ahead of print.ABSTRACTHypoxia-inducible factor 3 subunit alpha (HIF3A) has been implicated in various types of cancers, while its precise role in the lung adenocarcinoma remains unclear. Our study aimed to investigate the roles of HIF3A in lung adenocarcinoma and its regulation by DNA methylation. We utilized bioinformatic tools, including UALCAN and KMPlot, to analyze the relationship between HIF3A expression, DNA methylation, and patient survival rate in lung adenocarcinoma. We also used siRNA-mediated knockdown of HIF3A and DNA-methyltransferase 1 (DNMT...
Source: J Appl Genet - September 14, 2023 Category: Genetics & Stem Cells Authors: Qin Shi Xiuxia Zheng Ying Hu Zhan Zhou Minshan Fang Xinhui Huang Source Type: research
Design, Synthesis of Novel 1,2,3-Triazole Pendent Quinazolinones and their Cytotoxicity Against MCF-7 Cell Line
Chem Biodivers. 2023 Sep 14:e202300800. doi: 10.1002/cbdv.202300800. Online ahead of print.ABSTRACTA library of 6-(((1-(substitutedphenyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-3-methylquinazolin-4(3H)-one analogues synthesized from Isatin precursor through a series of nitration, reduction, hydrolysis, cyclization and click reaction. The structures of compounds were characterized by spectral data including IR, 1H NMR, 13C NMR and Mass. The novel quinazolinone - 1,2,3-triazoles were screened for their cytotoxicity against the human breast adenocarcinoma cell lines MCF-7 by MTT assay. 4-Isopropyl and 2-bromo substituted analog...
Source: Chemistry and Biodiversity - September 14, 2023 Category: Biochemistry Authors: Nagaraju Myakala Kotaiah Kandula Nagamani Rayala Sateesh Kuna Vishnu Thumma Durga Bhavani A K Source Type: research
A study on metabolic characteristics and metabolic markers of gastrointestinal tumors
In conclusion, we identified differences among subtypes in clinical characteristics such as prognosis and revealed the potential function of metabolic subtype in response to chemotherapeutic agents and oncogene mutations. This work highlighted the potential clinical meaning of metabolic subtype and characteristics in drug therapy and prognosis assessment of malignant tumors.PMID:37705174 | DOI:10.1080/15384047.2023.2255369
Source: Cancer Biology and Therapy - September 14, 2023 Category: Cancer & Oncology Authors: Shan Cong Shanshan Bai Minghao Zhang Yanfang Bi Yu Wang Shi Jin Hui He Source Type: research
Construction of a Diagnostic Model for Small Cell Lung Cancer Combining Metabolomics and Integrated Machine Learning
CONCLUSION: This study is the first to analyze the difference between metabolomics and lipidomics and to construct a d-model to detect SCLC using integrated machine learning. This study may be of great significance for the screening and early diagnosis of SCLC patients.PMID:37706531 | DOI:10.1093/oncolo/oyad261
Source: The Oncologist - September 14, 2023 Category: Cancer & Oncology Authors: Xiaoling Shang Chenyue Zhang Ronghua Kong Chenglong Zhao Haiyong Wang Source Type: research
