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Infectious Disease: Endemics
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Total 16462 results found since Jan 2013.
Outbreak of Locally Acquired Mosquito-Transmitted (Autochthonous) Malaria - Florida and Texas, May-July 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 8;72(36):973-978. doi: 10.15585/mmwr.mm7236a1.ABSTRACTEight cases of locally acquired, mosquito-transmitted (i.e., autochthonous) Plasmodium vivax malaria, which has not been reported in the United States since 2003, were reported to CDC from state health departments in Florida and Texas during May 18-July 17, 2023. As of August 4, 2023, case surveillance, mosquito surveillance and control activities, and public outreach and education activities continue in both states. U.S. clinicians need to consider a malaria diagnosis in patients with unexplained fever, especially in areas where auto...
Source: MMWR Morb Mortal Wkl... - September 7, 2023 Category: Epidemiology Authors: Dawn Blackburn Michael Drennon Kelly Broussard Andrea M Morrison Danielle Stanek Elizabeth Sarney Christina Ferracci Steve Huard Wade Brennan John Eaton Sara Nealeigh Natalie Barber Rebecca A Zimler Jeremy N Adams Carina Blackmore Manuel Gordillo Robert M Source Type: research
Crystal structure of Methionyl-tRNA synthetase from Rickettsia typhi in complex with its cognate amino acid
Biochimie. 2023 Sep 4:S0300-9084(23)00210-9. doi: 10.1016/j.biochi.2023.09.001. Online ahead of print.ABSTRACTRickettsia typhi is the causative agent of murine typhus (endemic typhus), a febrile illness that can be self-contained, though in some cases it can progress to death. The three dimensional structure of Methionyl-tRNA Synthetase from R. typhi (RtMetRS) in complex with its substrate l-methionine was solved by molecular replacement and refined at 2.30 Å resolution in space group P1 from one X-ray diffraction dataset. Processing and refinement trials were decisive to establish the lower symmetry space group and indic...
Source: Biochimie - September 6, 2023 Category: Biochemistry Authors: Renato Ferras Penteado Jorge Iulek Source Type: research
Case report of scrub typhus with bilateral acute sensorineural hearing loss and cerebral salt-wasting disease
We present a 65-year-old male from Sri Lanka who presented with fever, bilateral acute sensorineural hearing loss, and confusion. On examination, he was dehydrated. Significant orthostatic hypotension and an eschar were noted. Investigations revealed hyponatremia with elevated urine sodium, reduced serum osmolality, and normal urine osmolality suggestive of cerebral salt wasting. After initial hydration with 0.9% NaCl, hyponatremia was corrected with 3% NaCl. Oral doxycycline was prescribed, and he showed dramatic clinical improvement. A diagnosis of typhus must be considered in a patient presenting with a febrile illness ...
Source: Tropical Doctor - September 6, 2023 Category: Tropical Medicine Authors: Asitha Goonetilleke Shehan Silva Source Type: research
Limitation of primers used in pcr for the characterization of leishmania infantum
This study evaluates 3 pairs of primers described for the identification and characterization of Leishmania infantum. Primers RV1/RV2, LEISH1/LEISH2, and FLC2/RLC2 were used with the DNA of L. infantum, Leishmania amazonensis, and Leishmania braziliensis. An initial temperature curve was performed (52-62 C) to determine the optimal annealing temperature, followed by a dilution curve of Leishmania DNA (500 pg/μl, 50 pg/μl, 5 pg/μl, 500 fg/μl, 50 fg/μl, 5 fg/μl, and 0.5 fg/μl) to be used for analytical sensitivity. RV1/RV2 PCR amplified L. infantum and L. amazonensis at all analyzed temperatures; LEISH1/LEISH2 PCR amp...
Source: The Journal of Parasitology - September 5, 2023 Category: Parasitology Authors: Helton Krisman de Ara újo Silvana de Oliveira Castro Maria Joelma Alves da Silva Valejo Manoel Sebasti ão da Costa Lima Junior Herintha Coeto Neitzke-Abreu Source Type: research
Limitation of primers used in pcr for the characterization of leishmania infantum
This study evaluates 3 pairs of primers described for the identification and characterization of Leishmania infantum. Primers RV1/RV2, LEISH1/LEISH2, and FLC2/RLC2 were used with the DNA of L. infantum, Leishmania amazonensis, and Leishmania braziliensis. An initial temperature curve was performed (52-62 C) to determine the optimal annealing temperature, followed by a dilution curve of Leishmania DNA (500 pg/μl, 50 pg/μl, 5 pg/μl, 500 fg/μl, 50 fg/μl, 5 fg/μl, and 0.5 fg/μl) to be used for analytical sensitivity. RV1/RV2 PCR amplified L. infantum and L. amazonensis at all analyzed temperatures; LEISH1/LEISH2 PCR amp...
Source: The Journal of Parasitology - September 5, 2023 Category: Parasitology Authors: Helton Krisman de Ara újo Silvana de Oliveira Castro Maria Joelma Alves da Silva Valejo Manoel Sebasti ão da Costa Lima Junior Herintha Coeto Neitzke-Abreu Source Type: research
Eliminating hepatitis B vaccination disparities for West African immigrants
Vaccine. 2023 Sep 3:S0264-410X(23)01012-5. doi: 10.1016/j.vaccine.2023.08.058. Online ahead of print.ABSTRACTBACKGROUND: Hepatitis B virus (HBV) infection is endemic in West Africa. There has been a significant increase in the Bronx West African (WA) community. To achieve HBV elimination, vaccination of non-immune individuals is important. Unfortunately, vaccine uptake in immigrant populations is at this time very limited.METHODS: An educational program was conducted by medical providers of WA origin in collaboration with local faith-based organizations, after which free HBV screening was offered. Non-immune individuals we...
Source: Vaccine - September 5, 2023 Category: Allergy & Immunology Authors: Jessie A Birnbaum Daniel Guttman Mugdha Parulekar Fatima Omarufilo Emmanuel U Emeasoba Julie Nguyen Oluwadara Tokunboh Jared Coe Matthew J Akiyama Samuel H Sigal Source Type: research
Limitation of primers used in pcr for the characterization of leishmania infantum
This study evaluates 3 pairs of primers described for the identification and characterization of Leishmania infantum. Primers RV1/RV2, LEISH1/LEISH2, and FLC2/RLC2 were used with the DNA of L. infantum, Leishmania amazonensis, and Leishmania braziliensis. An initial temperature curve was performed (52-62 C) to determine the optimal annealing temperature, followed by a dilution curve of Leishmania DNA (500 pg/μl, 50 pg/μl, 5 pg/μl, 500 fg/μl, 50 fg/μl, 5 fg/μl, and 0.5 fg/μl) to be used for analytical sensitivity. RV1/RV2 PCR amplified L. infantum and L. amazonensis at all analyzed temperatures; LEISH1/LEISH2 PCR amp...
Source: The Journal of Parasitology - September 5, 2023 Category: Parasitology Authors: Helton Krisman de Ara újo Silvana de Oliveira Castro Maria Joelma Alves da Silva Valejo Manoel Sebasti ão da Costa Lima Junior Herintha Coeto Neitzke-Abreu Source Type: research
Limitation of primers used in pcr for the characterization of leishmania infantum
This study evaluates 3 pairs of primers described for the identification and characterization of Leishmania infantum. Primers RV1/RV2, LEISH1/LEISH2, and FLC2/RLC2 were used with the DNA of L. infantum, Leishmania amazonensis, and Leishmania braziliensis. An initial temperature curve was performed (52-62 C) to determine the optimal annealing temperature, followed by a dilution curve of Leishmania DNA (500 pg/μl, 50 pg/μl, 5 pg/μl, 500 fg/μl, 50 fg/μl, 5 fg/μl, and 0.5 fg/μl) to be used for analytical sensitivity. RV1/RV2 PCR amplified L. infantum and L. amazonensis at all analyzed temperatures; LEISH1/LEISH2 PCR amp...
Source: The Journal of Parasitology - September 5, 2023 Category: Parasitology Authors: Helton Krisman de Ara újo Silvana de Oliveira Castro Maria Joelma Alves da Silva Valejo Manoel Sebasti ão da Costa Lima Junior Herintha Coeto Neitzke-Abreu Source Type: research
Limitation of primers used in pcr for the characterization of leishmania infantum
This study evaluates 3 pairs of primers described for the identification and characterization of Leishmania infantum. Primers RV1/RV2, LEISH1/LEISH2, and FLC2/RLC2 were used with the DNA of L. infantum, Leishmania amazonensis, and Leishmania braziliensis. An initial temperature curve was performed (52-62 C) to determine the optimal annealing temperature, followed by a dilution curve of Leishmania DNA (500 pg/μl, 50 pg/μl, 5 pg/μl, 500 fg/μl, 50 fg/μl, 5 fg/μl, and 0.5 fg/μl) to be used for analytical sensitivity. RV1/RV2 PCR amplified L. infantum and L. amazonensis at all analyzed temperatures; LEISH1/LEISH2 PCR amp...
Source: The Journal of Parasitology - September 5, 2023 Category: Parasitology Authors: Helton Krisman de Ara újo Silvana de Oliveira Castro Maria Joelma Alves da Silva Valejo Manoel Sebasti ão da Costa Lima Junior Herintha Coeto Neitzke-Abreu Source Type: research
Limitation of primers used in pcr for the characterization of leishmania infantum
This study evaluates 3 pairs of primers described for the identification and characterization of Leishmania infantum. Primers RV1/RV2, LEISH1/LEISH2, and FLC2/RLC2 were used with the DNA of L. infantum, Leishmania amazonensis, and Leishmania braziliensis. An initial temperature curve was performed (52-62 C) to determine the optimal annealing temperature, followed by a dilution curve of Leishmania DNA (500 pg/μl, 50 pg/μl, 5 pg/μl, 500 fg/μl, 50 fg/μl, 5 fg/μl, and 0.5 fg/μl) to be used for analytical sensitivity. RV1/RV2 PCR amplified L. infantum and L. amazonensis at all analyzed temperatures; LEISH1/LEISH2 PCR amp...
Source: The Journal of Parasitology - September 5, 2023 Category: Parasitology Authors: Helton Krisman de Ara újo Silvana de Oliveira Castro Maria Joelma Alves da Silva Valejo Manoel Sebasti ão da Costa Lima Junior Herintha Coeto Neitzke-Abreu Source Type: research
Social construction of risk and prevention practices related to Aedes mosquito-borne disease in an endemic municipality in Colombia
CONCLUSION: The findings show a multisituated risk that refers to the inside and outside of homes; and the prevention practices mentioned by different actors, in which a continuity of tensions between lay people, leaders and government officials can be observed.PMID:37666503 | DOI:10.22605/RRH7695
Source: Rural Remote Health - September 4, 2023 Category: Rural Health Authors: Claudia Margarita Cort és García Claudia Milena Hormiga S ánchez Johan Sebasti án Ariza Abril Yaneth Stefania Becerra Fajardo Source Type: research
GMP manufacture of Shigella flexneri 2a Artificial Invaplex (Invaplex < sub > AR < /sub > ) and evaluation in a Phase 1 Open-label, dose escalating study administered intranasally to healthy, adult volunteers
Vaccine. 2023 Sep 2:S0264-410X(23)00995-7. doi: 10.1016/j.vaccine.2023.08.051. Online ahead of print.ABSTRACTShigella species cause severe disease among travelers to, and children living in, endemic countries. Although significant efforts have been made to improve sanitation, increased antibiotic resistance and other factors suggest an effective vaccine is a critical need. Artificial Invaplex (InvaplexAR) is a subunit vaccine approach complexing Shigella LPS with invasion plasmid antigens. In pre-clinical studies, the InvaplexAR vaccine demonstrated increased immunogenicity as compared to the first generation product and w...
Source: Vaccine - September 4, 2023 Category: Allergy & Immunology Authors: Christopher Duplessis Kristen A Clarkson K Ross Turbyfill Ashley N Alcala Ramiro Gutierrez Mark S Riddle Tida Lee Kristopher Paolino Hailey P Weerts Amanda Lynen Edwin V Oaks Chad K Porter Robert Kaminski Source Type: research
Social construction of risk and prevention practices related to Aedes mosquito-borne disease in an endemic municipality in Colombia
CONCLUSION: The findings show a multisituated risk that refers to the inside and outside of homes; and the prevention practices mentioned by different actors, in which a continuity of tensions between lay people, leaders and government officials can be observed.PMID:37666503 | DOI:10.22605/RRH7695
Source: Rural Remote Health - September 4, 2023 Category: Rural Health Authors: Claudia Margarita Cort és García Claudia Milena Hormiga S ánchez Johan Sebasti án Ariza Abril Yaneth Stefania Becerra Fajardo Source Type: research
