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Infectious Disease: Hepatitis B
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Total 12797 results found since Jan 2013.
Biological Roles of Hepatitis B Viral X Protein in the Viral Replication and Hepatocarcinogenesis
Acta Med Okayama. 2023 Aug;77(4):341-345. doi: 10.18926/AMO/65739.ABSTRACTHepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral r...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Motoyuki Otsuka Source Type: research
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506
Bioorg Med Chem Lett. 2023 Aug 24:129456. doi: 10.1016/j.bmcl.2023.129456. Online ahead of print.ABSTRACTDisruption of the HBV capsid assembly process through small-molecule interaction with HBV core protein is a validated target for the suppression of hepatitis B viral replication and the development of new antivirals. Through combination of key structural features associated with two distinct series of capsid assembly modulators, a novel aminochroman-based chemotype was identified. Optimization of anti-HBV potency through generation of SAR in addition to further core modifications provided a series of related functionali...
Source: Bioorganic and Medicinal Chemistry Letters - August 26, 2023 Category: Chemistry Authors: Andrew G Cole Steven G Kultgen Nagraj Mani Jorge G Quintero Kristi Yi Fan Andrzej Ardzinski Kim Stever Bruce D Dorsey Janet R Phelps Amy C H Lee Emily P Thi Tim Chiu Sunny Tang Peter S Horanyi Stephen J Mayclin Troy O Harasym Michael J Sofia Source Type: research
