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Infectious Disease: Hepatitis B
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Total 12797 results found since Jan 2013.
Screening of Phyllanthus niruri Leaves Phytoconstituents for Antiviral and Antibacterial Activity by Molecular Docking Studies
Adv Exp Med Biol. 2023;1423:115-122. doi: 10.1007/978-3-031-31978-5_9.ABSTRACTThe genus Phyllanthus belongs to one of the largest plant families, the Phyllantaceae (L.). Phyllanthus niruri is an annual perennial herb that grows in tropical Asia, America, China, and the islands of the Indian Ocean. Numerous alkaloids, steroids, flavonoids, lignans, coumarins, polyphenols, and lipids are present in Phyllanthus. The effects of plants have been studied for a variety of purposes, including their antioxidant (Giribabu et al., Evid Based Complement Alternat Med, 2014), anti-inflammatory (Porto et al., Revista Brasileira de Pharma...
Source: Biomed Res - July 31, 2023 Category: Research Authors: Panjugula Manisha Kusampudi Preethi Alekhya Avulapati Tejaswini Konda Swathi K Venkat Sai Source Type: research
Clinicopathologic features and long-term prognosis of hepatitis B virus-associated glomerulonephritis: a retrospective cohort study
CONCLUSION: Hepatitis B virus-associated Glomerulonephritis has specific clinicopathologic features and should not be considered a benign disease in adults. Hypertension, hyperuricemia, glomerulosclerosis, and intrarenal arterial lesions were independent predictors of the long-term prognosis in Hepatitis B virus-associated Glomerulonephritis patients. Antiviral therapy could be effective in improving the long-term prognosis of Hepatitis B virus-associated Glomerulonephritis patients.PMID:37523106 | DOI:10.1007/s40620-023-01685-x
Source: Journal of Nephrology - July 31, 2023 Category: Urology & Nephrology Authors: Hailing Lu Yu Li Maxiu Lai Tianjun Guan Yinghao Yu Zhiyong Zheng Yongze Zhuang Source Type: research
Functional analyses of single nucleotide polymorphic variants of the DNA glycosylase NEIL1 present in sub-Saharan African populations
This study provides insight regarding the potential increased risk for early-onset HCC in human populations carrying the NEIL1 I182M variant.PMID:37517321 | DOI:10.1016/j.dnarep.2023.103544
Source: DNA Repair - July 30, 2023 Category: Genetics & Stem Cells Authors: Jamie T Zuckerman Irina G Minko Melis Kant Pawel Jaruga Michael P Stone Miral Dizdaroglu Amanda K McCullough R Stephen Lloyd Source Type: research
Analysis of hepatocellular carcinoma associated with hepatitis B virus
J Cell Mol Med. 2023 Jul 30. doi: 10.1111/jcmm.17867. Online ahead of print.ABSTRACTThe hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double-stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems...
Source: J Cell Mol Med - July 30, 2023 Category: Molecular Biology Authors: Litao Zheng Source Type: research
Comment on "Pre-operative gamma-glutamyl transferase levels predict outcomes in hepatitis B-related hepatocellular carcinoma after curative resection"
J Formos Med Assoc. 2023 Jul 28:S0929-6646(23)00287-5. doi: 10.1016/j.jfma.2023.07.013. Online ahead of print.NO ABSTRACTPMID:37516642 | DOI:10.1016/j.jfma.2023.07.013
Source: J Formos Med Assoc - July 29, 2023 Category: General Medicine Authors: Qinghua Wang Source Type: research
The Relationship between Mean Platelet Volume and Neutrophil-Lymphocyte Ratio and Liver Fibrosis in Patients with Chronic Hepatitis B
Conclusions: Regarding the outcomes of this research, a significant relationship was found between the neutrophil-lymphocyte ratio, mean platelet volume, and fibrosis.PMID:37512098 | PMC:PMC10384412 | DOI:10.3390/medicina59071287
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Mehmet Onder Ekmen Metin Uzman Source Type: research
Structure-based Design of Novel Hepatitis B Virus Capsid Assembly Modulators
Bioorg Med Chem Lett. 2023 Jul 24:129412. doi: 10.1016/j.bmcl.2023.129412. Online ahead of print.ABSTRACTSmall-molecule capsid assembly modulators (CAMs) have been recently recognized as promising antiviral agents for curing chronic hepatitis B virus (HBV) infection. A target-based in silico screening study is described, aimed towards the discovery of novel HBV CAMs. Initial optimization of four weakly active screening hits was performed via focused library synthesis. Lead compound 42 and close analogues 56 and 57 exhibited in vitro potency in the sub- and micromolar range along with good physico-chemical properties and we...
Source: Bioorganic and Medicinal Chemistry Letters - July 27, 2023 Category: Chemistry Authors: Elena Detta Angelica Corcuera Andreas Urban Thomas Goldner Susanne Bonsmann Florian Engel Marina M May Helmut Buschmann Mauro Fianchini Esther Alza Miquel A Peric às Pavel A Pushkarev Anatolii O Varenyk Taras Y Yakovyuk Anton A Homon Pavlo A Sokoliuk Rad Source Type: research
Estimates of hepatitis B virus prevalence among general population and key risk groups in EU/EEA/UK countries: a systematic review
ConclusionsThe HBV prevalence is low in the general population and confined to risk populations in most European countries with some exceptions. Screening and treatment should be targeted to people in prison and migrants.PMID:37498533 | DOI:10.2807/1560-7917.ES.2023.28.30.2200738
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Sandra Bivegete Anna L McNaughton Adam Trickey Zak Thornton Becky Scanlan Aaron G Lim Lina Nerlander Hannah Fraser Josephine G Walker Matthew Hickman Peter Vickerman Helen Johnson Erika Duffell Ellen Brooks-Pollock Hannah Christensen Source Type: research
Toward reaching hepatitis B goals: hepatitis B epidemiology and the impact of two decades of vaccination, Georgia, 2021
ConclusionsHepatitis B vaccination in Georgia had remarkable impact. In 2021, HBsAg prevalence among children was well below the 0.5% hepatitis B control target of the European Region and met the ≤ 0.1% HBsAg seroprevalence target for elimination of mother-to-child transmission of HBV. Chronic HBV infection remains a problem among adults born before vaccine introduction. Screening, treatment and preventive interventions among adults, and sustained high immunisation coverage among children, can help eliminate hepatitis B in Georgia by 2030.PMID:37498531 | DOI:10.2807/1560-7917.ES.2023.28.30.2200837
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Nino Khetsuriani Amiran Gamkrelidze Shaun Shadaker Maia Tsereteli Maia Alkhazashvili Nazibrola Chitadze Irina Tskhomelidze Lia Gvinjilia Francisco Averhoff Gavin Cloherty Qian An Giorgi Chakhunashvili Jan Drobeniuc Paata Imnadze Khatuna Zakhashvili Paige Source Type: research
Estimates of hepatitis B virus prevalence among general population and key risk groups in EU/EEA/UK countries: a systematic review
ConclusionsThe HBV prevalence is low in the general population and confined to risk populations in most European countries with some exceptions. Screening and treatment should be targeted to people in prison and migrants.PMID:37498533 | PMC:PMC10375838 | DOI:10.2807/1560-7917.ES.2023.28.30.2200738
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Sandra Bivegete Anna L McNaughton Adam Trickey Zak Thornton Becky Scanlan Aaron G Lim Lina Nerlander Hannah Fraser Josephine G Walker Matthew Hickman Peter Vickerman Helen Johnson Erika Duffell Ellen Brooks-Pollock Hannah Christensen Source Type: research
Short-term treatment with risperidone ameliorated 1,2-diacetylbenzene-induced liver dysfunction
In conclusion, these findings reflect the therapeutic effects of risperidone on DAB-induced liver dysfunction after 1 week and 2 weeks exposure to DAB and risperidone, respectively.PMID:37499398 | DOI:10.1016/j.intimp.2023.110687
Source: International Immunopharmacology - July 27, 2023 Category: Allergy & Immunology Authors: Hai Duc Nguyen Won Hee Jo Ngoc Hong Minh Hoang Min-Sun Kim Source Type: research
Identification of novel tetrahydroquinoxaline derived phenyl ureas as modulators of the hepatitis B virus nucleocapsid assembly
In this study, we built upon our previous discovery of benzamide-derived HBV capsid assembly modulators by exploring fused bicyclic scaffolds with an exocyclic amide that is β, γ to the fused ring, and identified 1,2,3,4-tetrahydroquinoxaline derived phenyl ureas as a novel scaffold. Structure-activity relationship studies showed that a favorable hydrophobic substitution can be tolerated at the 2-position of the 1,2,3,4-tetrahydroquinoxaline core, and the resulting compound 88 demonstrated comparable or improved antiviral potencies in mouse and human hepatocyte-derived HBV-replicating cell lines compared to our previousl...
Source: European Journal of Medicinal Chemistry - July 27, 2023 Category: Chemistry Authors: Nicky Hwang Shuo Wu Haiqun Ban Huixin Luo Julia Ma Junjun Cheng Qiong Zhao Jessilyn A Laney Na Du Junyang Guo Manasa Suresh Liangxian Shen Gideon Tolufashe Usha Viswanathan John Kulp Patrick Lam Jinhong Chang Jason A Clement Stephan Menne Ju-Tao Guo Yanmi Source Type: research
