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Infectious Disease: Hepatitis B
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Total 12797 results found since Jan 2013.
Development and validation of a risk prediction algorithm for evaluating the efficacy of postoperative adjuvant TACE therapy for hepatocellular carcinoma
CONCLUSION: This model may be an easy-to-use tool for screening patients suitable for PA-TACE treatment and guiding the selection of clinical protocols. But further research and external validation are required.PMID:37622693 | DOI:10.2174/1386207326666230824090204
Source: Combinatorial Chemistry and High Throughput Screening - August 25, 2023 Category: Chemistry Authors: Jie Tao Xiaoli Shi Xu Feng Xinhua Wu Shiguai Qi Guoying Feng Xu Yang Yufei Zhao Hangjia Zuo Zhengrong Shi Source Type: research
Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis
CONCLUSION: MTX is a promising chemotherapeutic agent for β-catenin hyperactive liver cancer. Since repurposing MTX has the advantages of lower risk, shorter timelines, and less investment in drug discovery and development, a clinical trial is warranted to test its efficacy in the treatment of β-catenin mutant liver cancer.PMID:37612257 | DOI:10.1097/CM9.0000000000002816
Source: Chinese Medical Journal - August 23, 2023 Category: General Medicine Authors: Fangming Liu Yuting Wu Baohui Zhang Shuhui Yang Kezhuo Shang Jie Li Pengju Zhang Weiwei Deng Linlin Chen Liang Zheng Xiaochen Gai Hongbing Zhang Source Type: research
Serum Expression Level of MicroRNA-122 and its Significance in different Stages of Hepatitis B Virus Infection
This study aims to determine the serum expression level of miRNA-122 and its significance in the different stages of Hepatitis B virus infection. The study subjects were recruited and grouped for Hepatitis B associated with Chronic Hepatitis B infection, hepatic sclerosis, hepatocellular carcinoma, and healthy controls were also considered. Venous blood was collected from the participants including the controls and routine blood tests and quantification of miRNA-122 were done and analyzed in each case of hepatitis B infection and compared with that of healthy controls. The miRNA-122 was determined, which came to be highest...
Source: Mol Biol Cell - August 22, 2023 Category: Molecular Biology Authors: Shashi Prabha Singh Vandana Maurya Krishan Kumar Durgesh Singh Poonam Verma Dipan Samanta Manish Kumar Verma Source Type: research
The transmission of hepatitis B virus (HBV) infection from mother-to-infant (MTI) and the susceptibility of offspring to hepatitis B under intrauterine exposure to HBsAg
CONCLUSIONS: Therefore, we speculated that these signaling pathways and the genes within may be closely related to hepatitis B susceptibility and maternal hepatitis B inheritance. In this study, we showed that differentially expressed genes and signaling pathways may be valuable in preventing MTI transmission of HBV.PMID:37606146 | DOI:10.26355/eurrev_202308_33309
Source: Pharmacological Reviews - August 22, 2023 Category: Drugs & Pharmacology Authors: M-M Zhang X Liao H Wang Source Type: research
Serum Expression Level of MicroRNA-122 and its Significance in different Stages of Hepatitis B Virus Infection
This study aims to determine the serum expression level of miRNA-122 and its significance in the different stages of Hepatitis B virus infection. The study subjects were recruited and grouped for Hepatitis B associated with Chronic Hepatitis B infection, hepatic sclerosis, hepatocellular carcinoma, and healthy controls were also considered. Venous blood was collected from the participants including the controls and routine blood tests and quantification of miRNA-122 were done and analyzed in each case of hepatitis B infection and compared with that of healthy controls. The miRNA-122 was determined, which came to be highest...
Source: Mol Biol Cell - August 22, 2023 Category: Molecular Biology Authors: Shashi Prabha Singh Vandana Maurya Krishan Kumar Durgesh Singh Poonam Verma Dipan Samanta Manish Kumar Verma Source Type: research
Trends of Mortality in End-Stage Liver Disease - China, 2008-2020
CONCLUSIONS: The mortality rate associated with ESLDs in China decreased between 2008 and 2020. Nevertheless, the death burden attributable to ESLD continues to be alarmingly high. Future initiatives should prioritize the reduction of ESLD mortality in particular populations: males, elderly individuals, and those residing in rural regions of South and Southwest China. The emphasis of future interventions should be placed on antiviral therapy for adults diagnosed with viral hepatitis, and on the prevention of hepatitis B virus (HBV) infection across all demographics.PMID:37593126 | PMC:PMC10427498 | DOI:10.46234/ccdcw2023.128
Source: Cancer Control - August 18, 2023 Category: Cancer & Oncology Authors: Xiaoxiao Wang Huixin Liu Jinlei Qi Fangfang Zeng Lijun Wang Peng Yin Feng Liu Hongbo Li Yunning Liu Jiangmei Liu Lai Wei Xiaofeng Liang Yu Wang Huiying Rao Maigeng Zhou Source Type: research
Apolipoprotein E and viral infection: Risks and Mechanisms
Mol Ther Nucleic Acids. 2023 Jul 28;33:529-542. doi: 10.1016/j.omtn.2023.07.031. eCollection 2023 Sep 12.ABSTRACTApolipoprotein E (ApoE) is a multifunctional protein critical for lipid metabolism and cholesterol homeostasis. In addition to being a well known genetic determinant of both neurodegenerative and cardiovascular diseases, ApoE is frequently involved in various viral infection-related diseases. Human ApoE protein is functionally polymorphic with three isoforms, namely, ApoE2, ApoE3, and ApoE4, with markedly altered protein structures and functions. ApoE4 is associated with increased susceptibility to infection wit...
Source: Herpes - August 17, 2023 Category: Infectious Diseases Authors: Feng Chen Qiongwei Ke Wenyan Wei Lili Cui Yan Wang Source Type: research
Viral Hepatitis in Pregnancy: ACOG Clinical Practice Guideline No. 6
Obstet Gynecol. 2023 Sep 1;142(3):745-759. doi: 10.1097/AOG.0000000000005300.ABSTRACTPURPOSE: The purpose of this document is to describe the specific types of viral hepatitis, their implications during pregnancy, the risk of perinatal transmission, and issues related to both treatment and prevention of infection.TARGET POPULATION: Pregnant or postpartum women and individuals who screen positive for viral hepatitis infection. The onset of these conditions may have predated the perinatal period or may have occurred for the first time in pregnancy or the first year postpartum.METHODS: This guideline was developed using an a ...
Source: Obstetrics and Gynecology - August 17, 2023 Category: OBGYN Source Type: research
