Filtered By:
Infectious Disease: Hepatitis B
This page shows you your search results in order of date. This is page number 20.
Order by Relevance | Date
Total 12797 results found since Jan 2013.
Toward reaching hepatitis B goals: hepatitis B epidemiology and the impact of two decades of vaccination, Georgia, 2021
ConclusionsHepatitis B vaccination in Georgia had remarkable impact. In 2021, HBsAg prevalence among children was well below the 0.5% hepatitis B control target of the European Region and met the ≤ 0.1% HBsAg seroprevalence target for elimination of mother-to-child transmission of HBV. Chronic HBV infection remains a problem among adults born before vaccine introduction. Screening, treatment and preventive interventions among adults, and sustained high immunisation coverage among children, can help eliminate hepatitis B in Georgia by 2030.PMID:37498531 | PMC:PMC10375835 | DOI:10.2807/1560-7917.ES.2023.28.30.2200837
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Nino Khetsuriani Amiran Gamkrelidze Shaun Shadaker Maia Tsereteli Maia Alkhazashvili Nazibrola Chitadze Irina Tskhomelidze Lia Gvinjilia Francisco Averhoff Gavin Cloherty Qian An Giorgi Chakhunashvili Jan Drobeniuc Paata Imnadze Khatuna Zakhashvili Paige Source Type: research
Estimates of hepatitis B virus prevalence among general population and key risk groups in EU/EEA/UK countries: a systematic review
ConclusionsThe HBV prevalence is low in the general population and confined to risk populations in most European countries with some exceptions. Screening and treatment should be targeted to people in prison and migrants.PMID:37498533 | PMC:PMC10375838 | DOI:10.2807/1560-7917.ES.2023.28.30.2200738
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Sandra Bivegete Anna L McNaughton Adam Trickey Zak Thornton Becky Scanlan Aaron G Lim Lina Nerlander Hannah Fraser Josephine G Walker Matthew Hickman Peter Vickerman Helen Johnson Erika Duffell Ellen Brooks-Pollock Hannah Christensen Source Type: research
Toward reaching hepatitis B goals: hepatitis B epidemiology and the impact of two decades of vaccination, Georgia, 2021
ConclusionsHepatitis B vaccination in Georgia had remarkable impact. In 2021, HBsAg prevalence among children was well below the 0.5% hepatitis B control target of the European Region and met the ≤ 0.1% HBsAg seroprevalence target for elimination of mother-to-child transmission of HBV. Chronic HBV infection remains a problem among adults born before vaccine introduction. Screening, treatment and preventive interventions among adults, and sustained high immunisation coverage among children, can help eliminate hepatitis B in Georgia by 2030.PMID:37498531 | PMC:PMC10375835 | DOI:10.2807/1560-7917.ES.2023.28.30.2200837
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Nino Khetsuriani Amiran Gamkrelidze Shaun Shadaker Maia Tsereteli Maia Alkhazashvili Nazibrola Chitadze Irina Tskhomelidze Lia Gvinjilia Francisco Averhoff Gavin Cloherty Qian An Giorgi Chakhunashvili Jan Drobeniuc Paata Imnadze Khatuna Zakhashvili Paige Source Type: research
Estimates of hepatitis B virus prevalence among general population and key risk groups in EU/EEA/UK countries: a systematic review
ConclusionsThe HBV prevalence is low in the general population and confined to risk populations in most European countries with some exceptions. Screening and treatment should be targeted to people in prison and migrants.PMID:37498533 | PMC:PMC10375838 | DOI:10.2807/1560-7917.ES.2023.28.30.2200738
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Sandra Bivegete Anna L McNaughton Adam Trickey Zak Thornton Becky Scanlan Aaron G Lim Lina Nerlander Hannah Fraser Josephine G Walker Matthew Hickman Peter Vickerman Helen Johnson Erika Duffell Ellen Brooks-Pollock Hannah Christensen Source Type: research
Toward reaching hepatitis B goals: hepatitis B epidemiology and the impact of two decades of vaccination, Georgia, 2021
ConclusionsHepatitis B vaccination in Georgia had remarkable impact. In 2021, HBsAg prevalence among children was well below the 0.5% hepatitis B control target of the European Region and met the ≤ 0.1% HBsAg seroprevalence target for elimination of mother-to-child transmission of HBV. Chronic HBV infection remains a problem among adults born before vaccine introduction. Screening, treatment and preventive interventions among adults, and sustained high immunisation coverage among children, can help eliminate hepatitis B in Georgia by 2030.PMID:37498531 | PMC:PMC10375835 | DOI:10.2807/1560-7917.ES.2023.28.30.2200837
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Nino Khetsuriani Amiran Gamkrelidze Shaun Shadaker Maia Tsereteli Maia Alkhazashvili Nazibrola Chitadze Irina Tskhomelidze Lia Gvinjilia Francisco Averhoff Gavin Cloherty Qian An Giorgi Chakhunashvili Jan Drobeniuc Paata Imnadze Khatuna Zakhashvili Paige Source Type: research
Identification of novel tetrahydroquinoxaline derived phenyl ureas as modulators of the hepatitis B virus nucleocapsid assembly
In this study, we built upon our previous discovery of benzamide-derived HBV capsid assembly modulators by exploring fused bicyclic scaffolds with an exocyclic amide that is β, γ to the fused ring, and identified 1,2,3,4-tetrahydroquinoxaline derived phenyl ureas as a novel scaffold. Structure-activity relationship studies showed that a favorable hydrophobic substitution can be tolerated at the 2-position of the 1,2,3,4-tetrahydroquinoxaline core, and the resulting compound 88 demonstrated comparable or improved antiviral potencies in mouse and human hepatocyte-derived HBV-replicating cell lines compared to our previousl...
Source: European Journal of Medicinal Chemistry - July 27, 2023 Category: Chemistry Authors: Nicky Hwang Shuo Wu Haiqun Ban Huixin Luo Julia Ma Junjun Cheng Qiong Zhao Jessilyn A Laney Na Du Junyang Guo Manasa Suresh Liangxian Shen Gideon Tolufashe Usha Viswanathan John Kulp Patrick Lam Jinhong Chang Jason A Clement Stephan Menne Ju-Tao Guo Yanmi Source Type: research
Structure-based Design of Novel Hepatitis B Virus Capsid Assembly Modulators
Bioorg Med Chem Lett. 2023 Jul 24:129412. doi: 10.1016/j.bmcl.2023.129412. Online ahead of print.ABSTRACTSmall-molecule capsid assembly modulators (CAMs) have been recently recognized as promising antiviral agents for curing chronic hepatitis B virus (HBV) infection. A target-based in silico screening study is described, aimed towards the discovery of novel HBV CAMs. Initial optimization of four weakly active screening hits was performed via focused library synthesis. Lead compound 42 and close analogues 56 and 57 exhibited in vitro potency in the sub- and micromolar range along with good physico-chemical properties and we...
Source: Bioorganic and Medicinal Chemistry Letters - July 27, 2023 Category: Chemistry Authors: Elena Detta Angelica Corcuera Andreas Urban Thomas Goldner Susanne Bonsmann Florian Engel Marina M May Helmut Buschmann Mauro Fianchini Esther Alza Miquel A Peric às Pavel A Pushkarev Anatolii O Varenyk Taras Y Yakovyuk Anton A Homon Pavlo A Sokoliuk Rad Source Type: research
Estimates of hepatitis B virus prevalence among general population and key risk groups in EU/EEA/UK countries: a systematic review
ConclusionsThe HBV prevalence is low in the general population and confined to risk populations in most European countries with some exceptions. Screening and treatment should be targeted to people in prison and migrants.PMID:37498533 | PMC:PMC10375838 | DOI:10.2807/1560-7917.ES.2023.28.30.2200738
Source: Euro Surveill - July 27, 2023 Category: Infectious Diseases Authors: Sandra Bivegete Anna L McNaughton Adam Trickey Zak Thornton Becky Scanlan Aaron G Lim Lina Nerlander Hannah Fraser Josephine G Walker Matthew Hickman Peter Vickerman Helen Johnson Erika Duffell Ellen Brooks-Pollock Hannah Christensen Source Type: research
The hepatic GABAergic system promotes liver macrophage M2 polarization and mediates HBV replication in mice
Antiviral Res. 2023 Jul 24:105680. doi: 10.1016/j.antiviral.2023.105680. Online ahead of print.ABSTRACTMacrophages display functional phenotypic plasticity. Hepatitis B virus (HBV) infection induces polarizations of liver macrophages either to M1-like pro-inflammatory phenotype or to M2-like anti-inflammatory phenotype. Gamma-aminobutyric acid (GABA) signaling exists in various non-neuronal cells including hepatocytes and some immune cells. Here we report that macrophages express functional GABAergic signaling components and activation of type A GABA receptors (GABAARs) promotes M2-polarization thus advancing HBV replicati...
Source: Antiviral Research - July 26, 2023 Category: Virology Authors: Ziyou Bao Xiaotong Chen Yan Li Wenshan Jiang Di Pan Lushun Ma Yunxiao Wu Yunling Chen Chaojia Chen Liyuan Wang Songbo Zhao Tixiao Wang Wei-Yang Lu Chunhong Ma Shuanglian Wang Source Type: research
Advances in isothermal nucleic acid amplification methods for hepatitis B virus detection
Analyst, 2023, Advance Article DOI: 10.1039/D3AN00700F, Critical ReviewHuilin Li, Wenjun Song, Hongying Li, Jiaqi Cui, Yuchen Xie, Bo Wu, Rong Chen A schematic diagram of the main methods for hepatitis B detection. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - July 25, 2023 Category: Chemistry Authors: Huilin Li Source Type: research
Hypoxia-inducible factor affects hepatitis B virus transcripts and genome levels as well as the expression and subcellular location of the hepatitis B virus core protein
Virology. 2023 Jul 16;586:76-90. doi: 10.1016/j.virol.2023.06.013. Online ahead of print.ABSTRACTGlobally, a chronic-hepatitis B virus (HBV) infection is the leading cause of hepatocellular carcinoma (HCC). The transcription factor hypoxia-inducible factor 1 (HIF1) is often elevated in HCC, including HBV-associated HCC. Previous studies have suggested that the expression of the HIF1 subunit, HIF1α, is elevated in HBV-infected hepatocytes; however, whether HIF1 activity affects the HBV lifecycle has not been fully explored. We used a liver-derived cell line and ex vivo cultured primary hepatocytes as models to determine ho...
Source: Virology - July 25, 2023 Category: Virology Authors: Nicholas J Duchemin Ronak Loonawat Kyle Yeakle Andrea Rosenkranz Michael J Bouchard Source Type: research
