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Dermatological Issues Among Individuals Receiving Palliative Care - A Review
Am J Hosp Palliat Care. 2023 Aug 25:10499091231198752. doi: 10.1177/10499091231198752. Online ahead of print.ABSTRACTSkin disorders among individuals receiving palliative care may be associated with the primary condition or underlying comorbidities and patients may experience pruritus, discomfort or pain. Common conditions include xerosis, pressure ulcers, intertrigo, superficial fungal infections, telogen effluvium, pruritus, herpes zoster, eczematous disorders and edema. During end-of-life care, there is reduced skin perfusion and metabolism hence leading to susceptibility to infection, pressure and injury. Other factors...
Source: The American Journal of Hospice and Palliative Care - August 25, 2023 Category: Palliative Care Authors: Zhenli Kwan Winn Hui Han Shin Shen Yong Nik Aimee Azizah Faheem Rebecca Kai Jan Choong Sheriza Izwa Zainuddin Chee Loong Lam Maw Pin Tan David Paul Capelle Source Type: research
Always Enough but Never Too Much: The How and Why of Down Regulating Tissue Oxygenation
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00449.2023. Online ahead of print.ABSTRACTCardiovascular regulation of tissue oxygenation is generally viewed as an anti-drop process that prevents tissue oxygen concentration from falling below some minimum. I propose that cardiovascular regulation is predominately an anti-rise process designed to down-regulate oxygen delivery. This maintains an evolutionarily-conserved, reduced intracellular environment to prevent oxidation of redox-sensitive regulatory protein thiols. A number of points support this hypothesis. 1) Oxygen is the only nutrient with a posi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Kenneth R Olson Source Type: research
The Impact of Aging on Vascular Ion Channels: Perspectives and Knowledge Gaps Across Major Organ Systems
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00288.2023. Online ahead of print.ABSTRACTIndividuals aged ≥65 years will comprise approximately 20% of the global population by 2030. Cardiovascular disease remains the leading cause of death in the world with age-related endothelial "dysfunction" as a key risk factor. As an organ in and of itself, vascular endothelium courses throughout the mammalian body to coordinate blood flow to all other organs and tissues (e.g., brain, heart, lung, skeletal muscle, gut, kidney, skin) in accord with metabolic demand. In turn, emerging evidence demonstrates that va...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Erik J Behringer Source Type: research
Always Enough but Never Too Much: The How and Why of Down Regulating Tissue Oxygenation
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00449.2023. Online ahead of print.ABSTRACTCardiovascular regulation of tissue oxygenation is generally viewed as an anti-drop process that prevents tissue oxygen concentration from falling below some minimum. I propose that cardiovascular regulation is predominately an anti-rise process designed to down-regulate oxygen delivery. This maintains an evolutionarily-conserved, reduced intracellular environment to prevent oxidation of redox-sensitive regulatory protein thiols. A number of points support this hypothesis. 1) Oxygen is the only nutrient with a posi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Kenneth R Olson Source Type: research
The Impact of Aging on Vascular Ion Channels: Perspectives and Knowledge Gaps Across Major Organ Systems
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00288.2023. Online ahead of print.ABSTRACTIndividuals aged ≥65 years will comprise approximately 20% of the global population by 2030. Cardiovascular disease remains the leading cause of death in the world with age-related endothelial "dysfunction" as a key risk factor. As an organ in and of itself, vascular endothelium courses throughout the mammalian body to coordinate blood flow to all other organs and tissues (e.g., brain, heart, lung, skeletal muscle, gut, kidney, skin) in accord with metabolic demand. In turn, emerging evidence demonstrates that va...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Erik J Behringer Source Type: research
Dermatological Issues Among Individuals Receiving Palliative Care - A Review
Am J Hosp Palliat Care. 2023 Aug 25:10499091231198752. doi: 10.1177/10499091231198752. Online ahead of print.ABSTRACTSkin disorders among individuals receiving palliative care may be associated with the primary condition or underlying comorbidities and patients may experience pruritus, discomfort or pain. Common conditions include xerosis, pressure ulcers, intertrigo, superficial fungal infections, telogen effluvium, pruritus, herpes zoster, eczematous disorders and edema. During end-of-life care, there is reduced skin perfusion and metabolism hence leading to susceptibility to infection, pressure and injury. Other factors...
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Zhenli Kwan Winn Hui Han Shin Shen Yong Nik Aimee Azizah Faheem Rebecca Kai Jan Choong Sheriza Izwa Zainuddin Chee Loong Lam Maw Pin Tan David Paul Capelle Source Type: research
Always Enough but Never Too Much: The How and Why of Down Regulating Tissue Oxygenation
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00449.2023. Online ahead of print.ABSTRACTCardiovascular regulation of tissue oxygenation is generally viewed as an anti-drop process that prevents tissue oxygen concentration from falling below some minimum. I propose that cardiovascular regulation is predominately an anti-rise process designed to down-regulate oxygen delivery. This maintains an evolutionarily-conserved, reduced intracellular environment to prevent oxidation of redox-sensitive regulatory protein thiols. A number of points support this hypothesis. 1) Oxygen is the only nutrient with a posi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Kenneth R Olson Source Type: research
The Impact of Aging on Vascular Ion Channels: Perspectives and Knowledge Gaps Across Major Organ Systems
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00288.2023. Online ahead of print.ABSTRACTIndividuals aged ≥65 years will comprise approximately 20% of the global population by 2030. Cardiovascular disease remains the leading cause of death in the world with age-related endothelial "dysfunction" as a key risk factor. As an organ in and of itself, vascular endothelium courses throughout the mammalian body to coordinate blood flow to all other organs and tissues (e.g., brain, heart, lung, skeletal muscle, gut, kidney, skin) in accord with metabolic demand. In turn, emerging evidence demonstrates that va...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Erik J Behringer Source Type: research
Dermatological Issues Among Individuals Receiving Palliative Care - A Review
Am J Hosp Palliat Care. 2023 Aug 25:10499091231198752. doi: 10.1177/10499091231198752. Online ahead of print.ABSTRACTSkin disorders among individuals receiving palliative care may be associated with the primary condition or underlying comorbidities and patients may experience pruritus, discomfort or pain. Common conditions include xerosis, pressure ulcers, intertrigo, superficial fungal infections, telogen effluvium, pruritus, herpes zoster, eczematous disorders and edema. During end-of-life care, there is reduced skin perfusion and metabolism hence leading to susceptibility to infection, pressure and injury. Other factors...
Source: The American Journal of Hospice and Palliative Care - August 25, 2023 Category: Palliative Care Authors: Zhenli Kwan Winn Hui Han Shin Shen Yong Nik Aimee Azizah Faheem Rebecca Kai Jan Choong Sheriza Izwa Zainuddin Chee Loong Lam Maw Pin Tan David Paul Capelle Source Type: research
Always Enough but Never Too Much: The How and Why of Down Regulating Tissue Oxygenation
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00449.2023. Online ahead of print.ABSTRACTCardiovascular regulation of tissue oxygenation is generally viewed as an anti-drop process that prevents tissue oxygen concentration from falling below some minimum. I propose that cardiovascular regulation is predominately an anti-rise process designed to down-regulate oxygen delivery. This maintains an evolutionarily-conserved, reduced intracellular environment to prevent oxidation of redox-sensitive regulatory protein thiols. A number of points support this hypothesis. 1) Oxygen is the only nutrient with a posi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Kenneth R Olson Source Type: research
Year in review: Highlights in ECLS Innovation and Technology, Anno 2022-2023
CONCLUSIONS: The manuscript underscores the critical role of collaboration between clinicians, researchers, and industry in driving recent technological innovations within the ECLS field. It emphasizes the necessity of open communication about technological limitations and the potential for repurposing established technologies in novel ways. However, the resourcefulness of physicians in repurposing devices requires validation through comprehensive scientific and technical investigation. Thus, fostering broader collaboration among stakeholders is recommended to ensure the rigorous evaluation and validation of new applicatio...
Source: Perfusion - August 25, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Leen Vercaemst Source Type: research
Always Enough but Never Too Much: The How and Why of Down Regulating Tissue Oxygenation
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00449.2023. Online ahead of print.ABSTRACTCardiovascular regulation of tissue oxygenation is generally viewed as an anti-drop process that prevents tissue oxygen concentration from falling below some minimum. I propose that cardiovascular regulation is predominately an anti-rise process designed to down-regulate oxygen delivery. This maintains an evolutionarily-conserved, reduced intracellular environment to prevent oxidation of redox-sensitive regulatory protein thiols. A number of points support this hypothesis. 1) Oxygen is the only nutrient with a posi...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Kenneth R Olson Source Type: research
Vascularization of the adult mouse lung grafted onto the chick chorioallantoic membrane
Microvasc Res. 2023 Aug 23:104596. doi: 10.1016/j.mvr.2023.104596. Online ahead of print.ABSTRACTIn the later stages of angiogenesis, the vascular sprout transitions into a functional vessel by fusing with a target vessel. Although this process appears to routinely occur in embryonic tissue, the biologic rules for sprout fusion and lumenization in adult regenerating tissue are unknown. To investigate this process, we grafted portions of the regenerating post-pneumonectomy lung onto the chick chorioallantoic membrane (CAM). Grafts from all 4 lobes of the post-pneumonectomy right lung demonstrated peri-graft angiogenesis as ...
Source: Cell Research - August 25, 2023 Category: Cytology Authors: Kenji Chamoto Barry C Gibney Willi L Wagner Maximilian Ackermann Hassan A Khalil Steven J Mentzer Source Type: research
The Impact of Aging on Vascular Ion Channels: Perspectives and Knowledge Gaps Across Major Organ Systems
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00288.2023. Online ahead of print.ABSTRACTIndividuals aged ≥65 years will comprise approximately 20% of the global population by 2030. Cardiovascular disease remains the leading cause of death in the world with age-related endothelial "dysfunction" as a key risk factor. As an organ in and of itself, vascular endothelium courses throughout the mammalian body to coordinate blood flow to all other organs and tissues (e.g., brain, heart, lung, skeletal muscle, gut, kidney, skin) in accord with metabolic demand. In turn, emerging evidence demonstrates that va...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Erik J Behringer Source Type: research
