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Procedure: Perfusion
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In Vivo Electron Paramagnetic Resonance Molecular Profiling of Tumor Microenvironment upon Tumor Progression to Malignancy in an Animal Model of Breast Cancer
CONCLUSION: Molecular TME profiling informs on alteration of tumor redox and metabolism during tumor staging. Early elevation of interstitial Pi at S1 may reflect tumor metabolic alterations that demand elevated phosphorus supply in accordance with the high rate growth hypothesis. These metabolic changes are supported by the following decrease of pHe due to a high tumor reliance on glycolysis and increase of intracellular GSH, a major intracellular redox buffer. The appreciable decrease in TME pO2 was observed only at malignant S4, apparently as a consequence of tumor mass growth and corresponding decrease in perfusion eff...
Source: Mol Biol Cell - August 23, 2023 Category: Molecular Biology Authors: Timothy D Eubank Andrey A Bobko E Hannah Hoblitzell Marieta Gencheva Benoit Driesschaert Valery V Khramtsov Source Type: research
Saline bolus for negative contrast perfusion imaging in magnetic particle imaging
Phys Med Biol. 2023 Aug 22;68(17). doi: 10.1088/1361-6560/ace309.ABSTRACTObjective.Magnetic particle imaging (MPI) is capable of high temporal resolution measurements of the spatial distribution of magnetic nanoparticles and therefore well suited for perfusion imaging, which is an important tool in medical diagnosis. Perfusion imaging in MPI usually requires a fresh bolus of tracer material to capture the key signal dynamics. Here, we propose a method to decouple the imaging sequence from the injection of additional tracer material, without further increasing the administered iron dose in the body with each image.Approach....
Source: Physics in Medicine and Biology - August 23, 2023 Category: Physics Authors: Fabian Mohn Miriam Exner Patryk Szwargulski Martin M öddel Tobias Knopp Matthias Graeser Source Type: research
Re-Dosing del Nido cardioplegia in adult cardiac surgery: Perfusion characteristics and outcomes--Is there an optimal redosing strategy?
CONCLUSIONS: In this retrospective study, variations in re-dosing strategy for del Nido cardioplegia do not affect postoperative outcomes and increased CPB time is associated with increased operative mortality, myocardial infarction, need for post-operative CSDs, and reduced postoperative EF, and increased VIS, irrespective of the re-dosing strategy. Further studies are warranted to to identify additional patient and operative characteristics that predispose to complications.PMID:37608700 | DOI:10.1177/02676591231197524
Source: Perfusion - August 23, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Alexander P Kossar Samantha Nemeth Yaagnik D Kosuri Brigitte E Kazzi Emily Honzel Alex D'Angelo Jessica Spellman Koji Takeda Hiroo Takayama Vinayak Bapat Michael Argenziano James Beck Craig R Smith Paul Kurlansky Isaac George Source Type: research
Efficacy of the Hepcon system in reducing hemorrhagic and thrombotic complications in antiphospholipid syndrome patients undergoing cardiac surgery
CONCLUSION: There was no difference in the composite outcome of thrombotic or hemorrhagic complications in patients monitored by Hepcon versus those monitored by ACT.PMID:37608561 | DOI:10.1177/02676591231197990
Source: Perfusion - August 23, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Sheu Michael Molina Garcia Sofia Wei Wei Grady Patrick Apostolakis John Angelini Dana Source Type: research
Saline bolus for negative contrast perfusion imaging in magnetic particle imaging
Phys Med Biol. 2023 Aug 22;68(17). doi: 10.1088/1361-6560/ace309.ABSTRACTObjective.Magnetic particle imaging (MPI) is capable of high temporal resolution measurements of the spatial distribution of magnetic nanoparticles and therefore well suited for perfusion imaging, which is an important tool in medical diagnosis. Perfusion imaging in MPI usually requires a fresh bolus of tracer material to capture the key signal dynamics. Here, we propose a method to decouple the imaging sequence from the injection of additional tracer material, without further increasing the administered iron dose in the body with each image.Approach....
Source: Physics in Medicine and Biology - August 23, 2023 Category: Physics Authors: Fabian Mohn Miriam Exner Patryk Szwargulski Martin M öddel Tobias Knopp Matthias Graeser Source Type: research
Re-Dosing del Nido cardioplegia in adult cardiac surgery: Perfusion characteristics and outcomes--Is there an optimal redosing strategy?
CONCLUSIONS: In this retrospective study, variations in re-dosing strategy for del Nido cardioplegia do not affect postoperative outcomes and increased CPB time is associated with increased operative mortality, myocardial infarction, need for post-operative CSDs, and reduced postoperative EF, and increased VIS, irrespective of the re-dosing strategy. Further studies are warranted to to identify additional patient and operative characteristics that predispose to complications.PMID:37608700 | DOI:10.1177/02676591231197524
Source: Perfusion - August 23, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Alexander P Kossar Samantha Nemeth Yaagnik D Kosuri Brigitte E Kazzi Emily Honzel Alex D'Angelo Jessica Spellman Koji Takeda Hiroo Takayama Vinayak Bapat Michael Argenziano James Beck Craig R Smith Paul Kurlansky Isaac George Source Type: research
Efficacy of the Hepcon system in reducing hemorrhagic and thrombotic complications in antiphospholipid syndrome patients undergoing cardiac surgery
CONCLUSION: There was no difference in the composite outcome of thrombotic or hemorrhagic complications in patients monitored by Hepcon versus those monitored by ACT.PMID:37608561 | DOI:10.1177/02676591231197990
Source: Perfusion - August 23, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Sheu Michael Molina Garcia Sofia Wei Wei Grady Patrick Apostolakis John Angelini Dana Source Type: research
Methadone as an opioid and sedative weaning strategy in adults receiving extracorporeal membrane oxygenation
Perfusion. 2023 Aug 22:2676591231195303. doi: 10.1177/02676591231195303. Online ahead of print.NO ABSTRACTPMID:37606232 | DOI:10.1177/02676591231195303
Source: Perfusion - August 22, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Christopher Remmington Victor Liew Fraser Hanks Luigi Camporota Oliver Stubbs Angelo Sousa Nicholas A Barrett Source Type: research
An adapted liver perfusion in a shark species, < em > Squalus suckleyi < /em > : investigation of energy mobilization
Am J Physiol Regul Integr Comp Physiol. 2023 Aug 21. doi: 10.1152/ajpregu.00132.2023. Online ahead of print.ABSTRACTThe liver is an essential energy storage organ in vertebrates. In teleosts and elasmobranchs, previous studies examining hepatic energy balance have used isolated hepatocytes. While these studies have been informative the high fat content in the elasmobranch liver limits isolation of hepatocytes and therefore the utility of this method to understand hepatic metabolic processes. In the present study we developed an in situ liver perfusion in the North Pacific spiny dogfish, Squalus suckleyi. Perfusions were co...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 21, 2023 Category: Physiology Authors: Alexandra N Schoen Alyssa M Weinrauch Ian A Bouyoucos W Gary Anderson Source Type: research
Application of ultrasound microbubble contrast to evaluate the effect of sitaxentan on renal microvascular perfusion in beagles undergoing cardiopulmonary bypass
CONCLUSIONS: Ultrasound microbubble contrast could be effectively used to evaluate renal microvascular perfusion peri-CPB in beagles, which was prone to decrease and could be improved via pretreatment with sitaxentan.PMID:37599525 | DOI:10.3233/CH-221600
Source: Clinical Hemorheology and Microcirculation - August 21, 2023 Category: Hematology Authors: Lu Yang Liqun Mo Fuyu Li Fuzu Zhu Yiping Bai Source Type: research
An adapted liver perfusion in a shark species, < em > Squalus suckleyi < /em > : investigation of energy mobilization
Am J Physiol Regul Integr Comp Physiol. 2023 Aug 21. doi: 10.1152/ajpregu.00132.2023. Online ahead of print.ABSTRACTThe liver is an essential energy storage organ in vertebrates. In teleosts and elasmobranchs, previous studies examining hepatic energy balance have used isolated hepatocytes. While these studies have been informative the high fat content in the elasmobranch liver limits isolation of hepatocytes and therefore the utility of this method to understand hepatic metabolic processes. In the present study we developed an in situ liver perfusion in the North Pacific spiny dogfish, Squalus suckleyi. Perfusions were co...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 21, 2023 Category: Physiology Authors: Alexandra N Schoen Alyssa M Weinrauch Ian A Bouyoucos W Gary Anderson Source Type: research
Application of ultrasound microbubble contrast to evaluate the effect of sitaxentan on renal microvascular perfusion in beagles undergoing cardiopulmonary bypass
CONCLUSIONS: Ultrasound microbubble contrast could be effectively used to evaluate renal microvascular perfusion peri-CPB in beagles, which was prone to decrease and could be improved via pretreatment with sitaxentan.PMID:37599525 | DOI:10.3233/CH-221600
Source: Clinical Hemorheology and Microcirculation - August 21, 2023 Category: Hematology Authors: Lu Yang Liqun Mo Fuyu Li Fuzu Zhu Yiping Bai Source Type: research
