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Procedure: Liver Transplant
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Total 13525 results found since Jan 2013.
Use of gelatin sponge to seal the biliary tract after percutaneous transhepatic biliary drainage in patients with liver transplants
Diagn Interv Radiol. 2023 Aug 31. doi: 10.4274/dir.2023.232344. Online ahead of print.ABSTRACTPercutaneous transhepatic biliary drainage (PTBD) is commonly used in the treatment of malign and benign biliary pathologies. Certain complications after PTBD may occur, such as biliary fistula, biliary leakage, bilioma, and hematoma. The purpose of this study was to evaluate the safety and effectiveness of using a sterile gelatin sponge to seal the biliary tract after PTBD in patients with liver transplants to prevent complications. A total of 131 biliary drainages were introduced in 97 patients, and a sterile gelatin sponge was ...
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - August 31, 2023 Category: Radiology Authors: Ali Özgen Source Type: research
Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver
CONCLUSION: Our study provides a comprehensive atlas of liver EC development and documents VESC-like cell lineage commitment at single-cell resolution.PMID:37649114 | PMC:PMC10468894 | DOI:10.1186/s13287-023-03460-y
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Fitriana N Rahmawati Tomohiro Iba Hisamichi Naito Shota Shimizu Hirotaka Konishi Weizhen Jia Nobuyuki Takakura Source Type: research
Toll-interacting protein may affect doxorubicin resistance in hepatocellular carcinoma cell lines
CONCLUSIONS: Our results showed for the first time that silencing TOLLIP in hepatocellular carcinoma cells may help sensitize these cells to doxorubicin and increase the efficacy of chemotherapeutic regimens where doxorubicin is used.PMID:37644370 | DOI:10.1007/s11033-023-08737-2
Source: Mol Biol Cell - August 29, 2023 Category: Molecular Biology Authors: Ayse Banu Demir Elif Baris Umay Bengi Kaner Hani Alotaibi Nese Atabey Ahmet Koc Source Type: research
Pachymic acid protects hepatic cells against oxygen-glucose deprivation/reperfusion injury by activating sirtuin 1 to inhibit HMGB1 acetylation and inflammatory signaling
In this study, liver cells were subjected to oxygen-glucose deprivation/reperfusion (OGD/R) to simulate a hepatic ischemia-reperfusion injury model. The binding relationship between PA and sirtuin 1 (SIRT1) was analyzed by molecular docking. Cell viability was detected by Cell Counting Kit-8. Expression levels of SIRT1 and high mobility group box 1 (HMGB1) were detected by western blot. Subsequent levels of inflammatory factors were detected by related kits and western blot. Meanwhile, related kits were used to examine levels of oxidative stress markers including reactive oxygen species, malondialdehyde, superoxide dismuta...
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Chengbiao Xue Zhigao Xu Zhongzhong Liu Cheng Zeng Qifa Ye Source Type: research
Ultrasound-mediated multifunctional magnetic microbubbles for drug delivery of celastrol in VX2 liver transplant tumors
Drug Deliv Transl Res. 2023 Aug 28. doi: 10.1007/s13346-023-01421-9. Online ahead of print.ABSTRACTCelastrol (CST) has positive pharmacological effects on various cancers, but clinical application is limited because of poor water solubility and systemic toxicity. Ferric oxide (Fe3O4) has a large specific surface area and can be functionalized by inorganic modification to form complex magnetic drug delivery systems. Herein, Fe3O4 was surface-modified with citric acid and polyethylene glycol (PEG) (via) the Mitsunobu reaction and then covalently bound to CST. Finally, magnetic microbubbles (MMBs) containing perfluoropropane ...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Jian Huang Zhengji Wang Zihe Chen Chunxin Huang Ying Wang Xing Li Weiyang Lv Guiqiang Qi Huilin Liu Source Type: research
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants in...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CSF-1R+ Macrophages Control the Gut Microbiome-enhanced Liver Invariant NKT Function through IL-18
In this study, we found that altering the gut microbiome by oral vancomycin increases liver invariant NKT (iNKT) cell function. Enhanced iNKT cytokine production and activation marker expression were observed in vancomycin-treated mice following both Ag-specific and Ag-independent in vivo iNKT stimulations, with a more prominent effect in the liver than in the spleen. Fecal transplantation studies demonstrated that the iNKT functional regulation is mediated by altering the gut microbiome but uncoupled from the modulation of iNKT cell population size. Interestingly, when stimulated in vitro, iNKT cells from vancomycin-treat...
Source: Cancer Control - August 25, 2023 Category: Cancer & Oncology Authors: Chi Ma Justin McCallen John C McVey Rajiv Trehan Kylynda Bauer Qianfei Zhang Benjamin Ruf Sophie Wang Chunwei Walter Lai Giorgio Trinchieri Jay A Berzofsky Firouzeh Korangy Tim F Greten Source Type: research
Metronomic capecitabine with rapamycin exerts an immunosuppressive effect by inducing ferroptosis of CD4 < sup > + < /sup > T cells after liver transplantation in rat
In conclusion, the autophagy inducer RAPA improved the mCAP-induced ferroptosis in CD4+ T cells. Our results support the concept of ferroptosis as an autophagy-dependent cell death and suggest that the combination of ferroptosis inducers and autophagy inducers is a new research direction for improving immunosuppressive regimens after liver transplantation.PMID:37625370 | DOI:10.1016/j.intimp.2023.110810
Source: International Immunopharmacology - August 25, 2023 Category: Allergy & Immunology Authors: Hao Wang Ruining Yang Zhenglu Wang Lei Cao Dejun Kong Qian Sun Sei Yoshida Jiashu Ren Tao Chen Jinliang Duan Jianing Lu Zhongyang Shen Hong Zheng Source Type: research
