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Procedure: Liver Transplant
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Total 13525 results found since Jan 2013.
Metronomic capecitabine with rapamycin exerts an immunosuppressive effect by inducing ferroptosis of CD4 < sup > + < /sup > T cells after liver transplantation in rat
In conclusion, the autophagy inducer RAPA improved the mCAP-induced ferroptosis in CD4+ T cells. Our results support the concept of ferroptosis as an autophagy-dependent cell death and suggest that the combination of ferroptosis inducers and autophagy inducers is a new research direction for improving immunosuppressive regimens after liver transplantation.PMID:37625370 | DOI:10.1016/j.intimp.2023.110810
Source: International Immunopharmacology - August 25, 2023 Category: Allergy & Immunology Authors: Hao Wang Ruining Yang Zhenglu Wang Lei Cao Dejun Kong Qian Sun Sei Yoshida Jiashu Ren Tao Chen Jinliang Duan Jianing Lu Zhongyang Shen Hong Zheng Source Type: research
CSF-1R+ Macrophages Control the Gut Microbiome-enhanced Liver Invariant NKT Function through IL-18
In this study, we found that altering the gut microbiome by oral vancomycin increases liver invariant NKT (iNKT) cell function. Enhanced iNKT cytokine production and activation marker expression were observed in vancomycin-treated mice following both Ag-specific and Ag-independent in vivo iNKT stimulations, with a more prominent effect in the liver than in the spleen. Fecal transplantation studies demonstrated that the iNKT functional regulation is mediated by altering the gut microbiome but uncoupled from the modulation of iNKT cell population size. Interestingly, when stimulated in vitro, iNKT cells from vancomycin-treat...
Source: Journal of Immunology - August 25, 2023 Category: Allergy & Immunology Authors: Chi Ma Justin McCallen John C McVey Rajiv Trehan Kylynda Bauer Qianfei Zhang Benjamin Ruf Sophie Wang Chunwei Walter Lai Giorgio Trinchieri Jay A Berzofsky Firouzeh Korangy Tim F Greten Source Type: research
Safety analysis of co-administering tacrolimus and omeprazole in renal transplant recipients - A review
Biomed Pharmacother. 2023 Aug 22;166:115149. doi: 10.1016/j.biopha.2023.115149. Online ahead of print.ABSTRACTTacrolimus is a calcineurin inhibitor used to prevent rejection in allogenic solid organ transplant recipients, which is metabolized in the liver with cytochrome P450 isoforms 3A4 and 3A5 (CYP3A4, CYP3A5). In turn, proton pump inhibitors (PPIs), such as Omeprazole - a substrate and inhibitor of CYP2C19 and CYP3A4 enzymes - are administered to kidney transplant patients in order to prevent duodenal and gastric ulcer disease, associated with the glucocorticoid treatment. Simultaneous administration of both drugs in r...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 24, 2023 Category: Drugs & Pharmacology Authors: Mi łosz Miedziaszczyk Ilona Idasiak-Piechocka Source Type: research
Extracorporeal albumin dialysis in critically ill patients with liver failure: Comparison of four different devices-A retrospective analysis
CONCLUSIONS: From this clinical perspective ADVOS and OPAL may provide higher reduction capabilities of liver solutes (i.e. bilirubin and ammonia) in comparison to MARS and SPAD. However, further prospective studies comparing the effectiveness of the devices to support liver impairment (i.e. bile acid clearance or albumin binding capacity) as well as markers of renal recovery are warranted.PMID:37609875 | DOI:10.1177/03913988231191952
Source: The International Journal of Artificial Organs - August 23, 2023 Category: Transplant Surgery Authors: Oliver Sommerfeld Caroline Neumann Jan Becker Christian von Loeffelholz Johannes Roth Andreas Kortgen Michael Bauer Christoph Sponholz Source Type: research
Cancers, Vol. 15, Pages 4221: Mutational Landscape and Precision Medicine in Hepatocellular Carcinoma
awlik
Hepatocellular carcinoma (HCC) is the fourth most common malignancy worldwide and exhibits a universal burden as the incidence of the disease continues to rise. In addition to curative-intent therapies such as liver resection and transplantation, locoregional and systemic therapy options also exist. However, existing treatments carry a dismal prognosis, often plagued with high recurrence and mortality. For this reason, understanding the tumor microenvironment and mutational pathophysiology has become the center of investigation for disease control. The use of precision medicine and genetic analysis can supplement...
Source: Cancers - August 23, 2023 Category: Cancer & Oncology Authors: Leva Gorji Zachary J. Brown Timothy M. Pawlik Tags: Review Source Type: research
Albumin and fibrinogen synthesis rates in advanced chronic liver disease
Am J Physiol Gastrointest Liver Physiol. 2023 Aug 22. doi: 10.1152/ajpgi.00072.2023. Online ahead of print.ABSTRACTSynthesis of plasma proteins is an important function of the liver that has sparsely been investigated by modern techniques in patients with advanced chronic liver disease (CLD). Twenty-eight well-characterized patients with CLD under evaluation for liver transplantation were included. Albumin and fibrinogen synthesis rates were measured by the flooding dose technique using stable isotope labelled phenylalanine. Transcapillary escape rate of albumin and plasma volume were assessed by radio-iodinated human seru...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - August 22, 2023 Category: Physiology Authors: Mariam Amouzandeh Anna Sundstr öm Staffan Wahlin Jan Wernerman Olav Rooyackers Åke Norberg Source Type: research
