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Procedure: Liver Transplant
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Total 13525 results found since Jan 2013.
Albumin and fibrinogen synthesis rates in advanced chronic liver disease
Am J Physiol Gastrointest Liver Physiol. 2023 Aug 22. doi: 10.1152/ajpgi.00072.2023. Online ahead of print.ABSTRACTSynthesis of plasma proteins is an important function of the liver that has sparsely been investigated by modern techniques in patients with advanced chronic liver disease (CLD). Twenty-eight well-characterized patients with CLD under evaluation for liver transplantation were included. Albumin and fibrinogen synthesis rates were measured by the flooding dose technique using stable isotope labelled phenylalanine. Transcapillary escape rate of albumin and plasma volume were assessed by radio-iodinated human seru...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - August 22, 2023 Category: Physiology Authors: Mariam Amouzandeh Anna Sundstr öm Staffan Wahlin Jan Wernerman Olav Rooyackers Åke Norberg Source Type: research
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Busulfan-induced hepatic sinusoidal endothelial cell injury: Modulatory role of pirfenidone for therapeutic purposes
The objective of this study is to investigate the potential protective effect of Pirfenidone against Busulfan-induced damage to hepatic sinusoidal endothelial cells and to preliminarily explore the mechanisms underlying this protective effect. Our results indicate that Pirfenidone has a great protective effect on the injury induced by Busulfan. In addition, Busulfan increased the relative mRNA expression of transforming growth factor-β1 (TGF-β1), collagen and tissue inhibitor of metalloproteinase-1 in HSECs. After pretreatment with Pirfenidone, the expression level of TGF-β1 was down-regulated. Mechanically, Pirfenidone...
Source: Toxicology in Vitro - August 19, 2023 Category: Toxicology Authors: Xiangyu Ma Jinjie Yuan Xinyu Liu Jiamin Xu Jiaqi Han Xiaoling Wang Libo Zhao Source Type: research
Pharmaceutical care model in precision medicine in China
Farm Hosp. 2023 Aug 17:S1130-6343(23)00095-8. doi: 10.1016/j.farma.2023.07.004. Online ahead of print.ABSTRACTPharmacy service is to provide individualized pharmaceutical care for patients, which should follow the current evidence-based pharmacy, and constantly verify the evidence and then produce new evidence. In pharmaceutical care, differences are often found in the efficacy and adverse reactions of drugs among individuals, even within individuals, which are closely related to patients' genetics, liver and kidney functions, disease states, and drug interactions. Back in the 1980s, therapeutic drug monitoring (TDM) has b...
Source: Farmacia Hospitalaria - August 19, 2023 Category: Drugs & Pharmacology Authors: Ping Zheng Liqian Mo Boxin Zhao Liren Li Baihong Cen Zhongyuan Xu Yilei Li Source Type: research
Virtual screening of novel mTOR inhibitors for the potential treatment of human colorectal cancer
In this study, a rational virtual screening strategy has been established and MT-5, a novel mTOR inhibitor with a quinoline scaffold, was obtained from the ChemDiv database. MT-5 showed potent kinase inhibitory activity (IC50: 8.90 μM) and antiproliferative effects against various cancer cell lines, especially HCT-116 cells (IC50: 4.61 μM), and this was 2.2-fold more potent than that of the cisplatin control (IC50: 9.99 μM). Western blot, cell migration, cycle arrest, and apoptosis assays were performed with HCT-116 cells to investigate the potential anticancer mechanism of MT-5. Metabolic stability results in vitro ind...
Source: Bioorganic Chemistry - August 19, 2023 Category: Chemistry Authors: Na-Na Zhang Yu-Juan Ban Yu-Jie Wang Si-Yu He Pan-Pan Qi Ting Bi Yi-Fei Ma Yong-Xi Dong Bing Guo Jiang Weng Hong-Liang Li Lei Tang Ji-Quan Zhang Source Type: research
Post-operative increased glucose variability was a predictor of mortality for recipients after liver transplantation
Asian J Surg. 2023 Aug 17:S1015-9584(23)01216-2. doi: 10.1016/j.asjsur.2023.08.034. Online ahead of print.NO ABSTRACTPMID:37597986 | DOI:10.1016/j.asjsur.2023.08.034
Source: Asian Journal of Surgery - August 19, 2023 Category: Surgery Authors: Jiangli Cheng Yongfang Zhou Zhongwei Zhang Source Type: research
Busulfan-induced hepatic sinusoidal endothelial cell injury: Modulatory role of pirfenidone for therapeutic purposes
The objective of this study is to investigate the potential protective effect of Pirfenidone against Busulfan-induced damage to hepatic sinusoidal endothelial cells and to preliminarily explore the mechanisms underlying this protective effect. Our results indicate that Pirfenidone has a great protective effect on the injury induced by Busulfan. In addition, Busulfan increased the relative mRNA expression of transforming growth factor-β1 (TGF-β1), collagen and tissue inhibitor of metalloproteinase-1 in HSECs. After pretreatment with Pirfenidone, the expression level of TGF-β1 was down-regulated. Mechanically, Pirfenidone...
Source: Toxicology in Vitro - August 19, 2023 Category: Toxicology Authors: Xiangyu Ma Jinjie Yuan Xinyu Liu Jiamin Xu Jiaqi Han Xiaoling Wang Libo Zhao Source Type: research
Post-operative increased glucose variability was a predictor of mortality for recipients after liver transplantation
Asian J Surg. 2023 Aug 17:S1015-9584(23)01216-2. doi: 10.1016/j.asjsur.2023.08.034. Online ahead of print.NO ABSTRACTPMID:37597986 | DOI:10.1016/j.asjsur.2023.08.034
Source: Asian Journal of Surgery - August 19, 2023 Category: Surgery Authors: Jiangli Cheng Yongfang Zhou Zhongwei Zhang Source Type: research
