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Total 80302 results found since Jan 2013.
Phosphorylation of the AMPARs regulated by protein kinase C (PKC) and protein interacting with C-kinase 1 (PICK1) contribute to orofacial neuropathic pain
In conclusion, activation of PKC and PICK1 contribute to orofacial allodynia by regulating AMPAR phosphorylation in the TG of male mice, which provides potential therapeutic targets for alleviating orofacial neuropathic pain.PMID:37709161 | DOI:10.1016/j.brainres.2023.148578
Source: Brain Research - September 14, 2023 Category: Neurology Authors: Fei Liu Yu-Han Zhang Yan-Yan Zhang Jiu Lin Ya-Jing Liu Yue-Ling Li Zhong-Han Fang Hong-Lin Liao Hang Wang Jie-Fei Shen Source Type: research
Transcranial Doppler Ultrasonography detection on cerebral infarction and blood vessels to evaluate hypoxic ischemic encephalopathy modeling
CONCLUSIONS: TCD dynamically monitored cerebral infarction after NHIE modeling, which will be potentially served as a useful auxiliary method for future animal experimental modeling evaluation in the case of less animal sacrifice.PMID:37709160 | DOI:10.1016/j.brainres.2023.148580
Source: Brain Research - September 14, 2023 Category: Neurology Authors: Rui-Fang Ma Lu-Lu Xue Jin-Xiang Liu Li Chen Liu-Lin Xiong Ting-Hua Wang Source Type: research
Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson's disease
In conclusion, our study indicates that AST had a strong protective effect on PQ-induced oxidative stress and antagonized apoptotic cell death in SH-SY5Y cells and PQ-induced mice PD model, which might provide new insights of AST for PD treatment.PMID:37708917 | DOI:10.1016/j.brainresbull.2023.110762
Source: Brain Research - September 14, 2023 Category: Neurology Authors: Lei Wang Kunliang Lu Xingyue Lou Shenghui Zhang Wenxin Song Ranran Li Lujing Geng Binfeng Cheng Source Type: research
A comparison of techniques for verifying the accuracy of precision decomposition-derived relationships between motor unit firing rates and recruitment thresholds from surface EMG signals
Exp Brain Res. 2023 Sep 14. doi: 10.1007/s00221-023-06694-7. Online ahead of print.ABSTRACTApproaches for validating motor unit firing times following surface electromyographic (EMG) signal decomposition with the precision decomposition III (PDIII) algorithm have not been agreed upon. Two approaches have been common: (1) "reconstruct-and-test" and (2) spike-triggered averaging (STA). We sought to compare motor unit results following the application of these approaches. Surface EMG signals were recorded from the vastus lateralis of 13 young males performing trapezoidal, isometric knee extensions at 50% and 80% of maximum vo...
Source: Brain Research - September 14, 2023 Category: Neurology Authors: Jonathan P Beausejour Paul Bohlen Kylie K Harmon Ryan M Girts Jason I Pagan Debbie L Hahs-Vaughn Trent J Herda Matt S Stock Source Type: research
Signatures of task learning in neural representations
Curr Opin Neurobiol. 2023 Sep 12;83:102759. doi: 10.1016/j.conb.2023.102759. Online ahead of print.ABSTRACTWhile neural plasticity has long been studied as the basis of learning, the growth of large-scale neural recording techniques provides a unique opportunity to study how learning-induced activity changes are coordinated across neurons within the same circuit. These distributed changes can be understood through an evolution of the geometry of neural manifolds and latent dynamics underlying new computations. In parallel, studies of multi-task and continual learning in artificial neural networks hint at a tradeoff between...
Source: Current Opinion in Neurobiology - September 14, 2023 Category: Neurology Authors: Harsha Gurnani N Alex Cayco Gajic Source Type: research
Response to 'Neurologists should retain diagnostic and therapeutic management of migraines'
Neurol Neurochir Pol. 2023 Sep 14. doi: 10.5603/pjnns.97421. Online ahead of print.NO ABSTRACTPMID:37706669 | DOI:10.5603/pjnns.97421
Source: Neurologia i Neurochirurgia Polska - September 14, 2023 Category: Neurology Authors: Magdalena Boczarska-Jedynak Source Type: research
Differences in diffusion tensor imaging parameters of brain white matter tracts between patients with myotonic dystrophy type 1 and type 2 - a retrospective single-centre study
CONCLUSIONS: Our results indicate diffuse disintegration of white matter pathways in DM patients, especially in the DM1 group. The damage to all types of fibres (association, commissural, and projection) may explain the diversity of clinical symptoms, which were more severe in the DM1 group of patients than in the DM2 group.CLINICAL IMPLICATIONS: DTI in patients with DM may help us to understand the neural mechanisms underlying brain involvement during the disease. In future, it may help to identify biomarkers for disease progression and treatment response.PMID:37706668 | DOI:10.5603/pjnns.95587
Source: Neurologia i Neurochirurgia Polska - September 14, 2023 Category: Neurology Authors: Edyta Maj Tomasz Wolak Joanna de Meulder Katarzyna Janiszewska Miko łaj Wojtaszek Anna Kostera-Pruszczyk Marek Go łębiowski Anna Łusakowska Source Type: research
Neurologists should retain diagnostic and therapeutic management of migraines
Neurol Neurochir Pol. 2023 Sep 14. doi: 10.5603/pjnns.96686. Online ahead of print.NO ABSTRACTPMID:37706667 | DOI:10.5603/pjnns.96686
Source: Neurologia i Neurochirurgia Polska - September 14, 2023 Category: Neurology Authors: Josef Finsterer Source Type: research
Lumateperone Monotherapy for Treatment-Resistant OCD in an Adolescent
CNS Spectr. 2023 Sep 14:1-6. doi: 10.1017/S1092852923002468. Online ahead of print.NO ABSTRACTPMID:37706369 | DOI:10.1017/S1092852923002468
Source: CNS Spectrums - September 14, 2023 Category: Neurology Authors: Ahmed Naguy Saxby Pridmore Mohamed Y Abuzeid Dalal Elsori Bibi Alamiri Source Type: research
B cell depletion modulates glial responses and enhances blood vessel integrity in a model of multiple sclerosis
Neurobiol Dis. 2023 Sep 12:106290. doi: 10.1016/j.nbd.2023.106290. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is characterized by a compromised blood-brain barrier (BBB) resulting in central nervous system (CNS) entry of peripheral lymphocytes, including T cells and B cells. While T cells have largely been considered the main contributors to neuroinflammation in MS, the success of B cell depletion therapies suggests an important role for B cells in MS pathology. Glial cells in the CNS are essential components in both disease progression and recovery, raising the possibility that they represent targets for B cell...
Source: Neurobiology of Disease - September 14, 2023 Category: Neurology Authors: Julie J Ahn Yusra Islam Cheryl Clarkson-Paredes Molly T Karl Robert H Miller Source Type: research
Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking
Neurobiol Dis. 2023 Sep 12:106293. doi: 10.1016/j.nbd.2023.106293. Online ahead of print.ABSTRACTSpastic paraplegia type 11 (SPG11) is a common autosomal recessive form of hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor neuron axons, leading to muscle spasticity and weakness. Impaired lipid trafficking is an emerging pathology in neurodegenerative diseases including SPG11, though its role in axonal degeneration of human SPG11 neurons remains unknown. Here, we established a pluripotent stem cell-based SPG11 model by knocking down the SPG11 gene in human embryonic stem cells (hESCs). T...
Source: Neurobiology of Disease - September 14, 2023 Category: Neurology Authors: Eric Chai Zhenyu Chen Yongchao Mou Gitika Thakur Weihai Zhan Xue-Jun Li Source Type: research
Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson's disease
In conclusion, our study indicates that AST had a strong protective effect on PQ-induced oxidative stress and antagonized apoptotic cell death in SH-SY5Y cells and PQ-induced mice PD model, which might provide new insights of AST for PD treatment.PMID:37708917 | DOI:10.1016/j.brainresbull.2023.110762
Source: Brain Research Bulletin - September 14, 2023 Category: Neurology Authors: Lei Wang Kunliang Lu Xingyue Lou Shenghui Zhang Wenxin Song Ranran Li Lujing Geng Binfeng Cheng Source Type: research
Masked priming under the Bayesian microscope: Exploring the integration of local elements into global shape through Bayesian model comparison
Conscious Cogn. 2023 Sep 12;115:103568. doi: 10.1016/j.concog.2023.103568. Online ahead of print.ABSTRACTTo investigate whether local elements are grouped into global shapes in the absence of awareness, we introduced two different masked priming designs (e.g., the classic dissociation paradigm and a trial-wise probe and prime discrimination task) and collected both objective (i.e., performance based) and subjective (using the perceptual awareness scale [PAS]) awareness measures. Prime visibility was manipulated using three different prime-mask stimulus onset asynchronies (SOAs) and an unmasked condition. Our results showed...
Source: Consciousness and Cognition - September 14, 2023 Category: Neurology Authors: Mikel Jimenez Antonio Prieto Pablo G ómez Jos é Antonio Hinojosa Pedro R Montoro Source Type: research
Aphantasia within the framework of neurodivergence: Some preliminary data and the curse of the confidence gap
Conscious Cogn. 2023 Sep 12;115:103567. doi: 10.1016/j.concog.2023.103567. Online ahead of print.ABSTRACTAphantasia is a neurocognitive phenomenon affecting voluntary visual imagery, such that it is either entirely absent, or markedly impaired. Using both the social and medical models of disability, this article discusses the extent to which aphantasia can be understood as a disorder or just a form of neutral neurodivergence, given that imagery plays a central role in thinking and memory for most other people. Preliminary school performance data are presented, showing that low imagery does not necessarily complicate life, ...
Source: Consciousness and Cognition - September 14, 2023 Category: Neurology Authors: Merlin Monzel Carla Dance Elena Aza ñón Julia Simner Source Type: research
Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline
Brain Behav Immun. 2023 Sep 12:S0889-1591(23)00273-8. doi: 10.1016/j.bbi.2023.09.009. Online ahead of print.ABSTRACTAging is associated with a significant shift in immune system reactivity ("inflammaging"), as basal inflammation increases but protective responses to infection are compromised. The immune system exhibits considerable sex differences, which may influence the process of inflammaging, including immune cell activation and behavioral consequences of immune signaling (i.e., impaired memory). Here, we test the hypothesis that sex differences in immune aging may mediate sex differences in cognitive decline. Aged mal...
Source: Brain, Behavior, and Immunity - September 14, 2023 Category: Neurology Authors: Louise M Ince Jeffrey S Darling Kevin Sanchez Kiersten S Bell Jennifer K Melbourne Lourdes K Davis Kimberly Nixon Andrew D Gaudet Laura K Fonken Source Type: research
