Filtered By:
Specialty: Neurology
This page shows you your search results in order of date. This is page number 7.
Order by Relevance | Date
Total 80302 results found since Jan 2013.
TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction
Exp Neurol. 2023 Sep 15:114542. doi: 10.1016/j.expneurol.2023.114542. Online ahead of print.ABSTRACTAutophagy is considered a double-edged sword, with a role in the regulation of the pathophysiological processes of the central nervous system (CNS) after cerebral ischemia-reperfusion injury (CIRI). The 18-kDa translocator protein (TSPO) is a highly conserved protein, with its expression level in the nervous system closely associated with the regulation of pathophysiological processes. In addition, the ligand of TSPO reduces neuroinflammation in brain diseases, but the potential role of TSPO in CIRI is largely undiscovered. ...
Source: Experimental Neurology - September 17, 2023 Category: Neurology Authors: Yusufu Mahemuti Kaheerman Kadeer Riqing Su Abudureheman Abula Yirizhati Aili Aierpati Maimaiti Subinuer Abulaiti Maimaitiyasheng Maimaitituerxun Tong Miao Shihao Jiang Aximujiang Axier Maimaitili Aisha Yongxin Wang Xiaojiang Cheng Source Type: research
Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice
Neurobiol Dis. 2023 Sep 15:106295. doi: 10.1016/j.nbd.2023.106295. Online ahead of print.ABSTRACTThe amyloid cascade hypothesis is widely accepted as an explanation for the neuropathological changes in Alzheimer's disease (AD). However, the role of amyloid-beta (Aβ) as the sole cause of these changes is being questioned. Using the 5xFAD mouse model of AD, we investigated various factors contributing to neuropathology, including genetic load (heterozygous (HTZ) versus homozygous (HZ) condition), behavioural phenotype, neuropathology markers, metabolic physiology, and gut microbiota composition at early (5 months of age) an...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Dina Medina-Vera Emma N Zambrana-Infantes Antonio J L ópez-Gambero Julia Verheul-Campos Luis J Sant ín Elena Baixeras Juan Suarez Francisco J Pavon Cristina Rosell-Valle Fernando Rodr íguez de Fonseca Source Type: research
A murine model of BSCL2-associated Celia's encephalopathy
Neurobiol Dis. 2023 Sep 15:106300. doi: 10.1016/j.nbd.2023.106300. Online ahead of print.ABSTRACTCelia's encephalopathy or progressive encephalopathy with/without lipodystrophy is a neurodegenerative disease with a fatal prognosis in childhood. It is generally caused by the c.985C > T variant in the BSCL2 gene, leading to the skipping of exon 7 and resulting in an aberrant seipin protein (Celia-seipin). To precisely define the temporal evolution and the mechanisms involved in neurodegeneration, lipodystrophy and fatty liver in Celia's encephalopathy, our group has generated the first global knock-in murine model for the...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Silvia Cobelo-G ómez Sof ía Sánchez-Iglesias Alberto R ábano Ana Senra Pablo Aguiar Noem í Gómez-Lado Lara Garc ía-Varela Iv án Burgueño-García Laura Lamp ón-Fernández Ant ía Fernández-Pombo Everardo Josu é Díaz-López Teresa Prado-Mora ñ Source Type: research
PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions
Neurobiol Dis. 2023 Sep 15:106297. doi: 10.1016/j.nbd.2023.106297. Online ahead of print.ABSTRACTMechanosensors are emerging players responding to hemodynamic and physical inputs. Their significance in the central nervous system remains relatively uncharted. Using human-derived brain specimens or cells and a pre-clinical model of mesio-temporal lobe epilepsy (MTLE), we examined how the mRNA levels of the mechanosensitive channel PIEZO1 adjust to disease-associated pro-inflammatory trajectories. In brain tissue micro-punches obtained from 18 drug-resistant MTLE patients, PIEZO1 expression positively correlated with that of ...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Valentin Garcia Marine Blaquiere Alicia Janvier Noemie Cresto Carla Lana Athenais Genin Helene Hirbec Etienne Audinat Adele Faucherre Emmanuel L Barbier Sophie Hamelin Philippe Kahane Chris Jopling Nicola Marchi Source Type: research
Predicting seizure clustering in the epilepsy monitoring unit: A multivariable analysis
CONCLUSION: Our data showed that long-acting ASMs can be protective against seizure clustering. Furthermore, patients with temporal lobe epilepsy, and those on increased numbers of ASMs, were more likely to experience seizure clustering when undergoing medication withdrawal during an EMU evaluation.PMID:37717459 | DOI:10.1016/j.yebeh.2023.109433
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Leya Maliekal Deepti Zutshi Scott Millis Maysaa M Basha Source Type: research
A quarter-century of the Taiwan Child Neurology Society: What can we do in the future?
Epilepsy Behav. 2023 Sep 15;147:109417. doi: 10.1016/j.yebeh.2023.109417. Online ahead of print.NO ABSTRACTPMID:37717458 | DOI:10.1016/j.yebeh.2023.109417
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Yung-Ting Kuo Kun-Long Hung Wang-Tso Lee Source Type: research
Immunogenetics of autism spectrum disorder: A systematic literature review
Brain Behav Immun. 2023 Sep 15:S0889-1591(23)00274-X. doi: 10.1016/j.bbi.2023.09.010. Online ahead of print.ABSTRACTThe aetiology of autism spectrum disorder (ASD) is complex and, partly, accounted by genetic factors. Nonetheless, the genetic underpinnings of ASD are poorly defined. The presence of immune dysregulations in autistic individuals, and their families, supports a role of the immune system and its genetic regulators. Albeit immune responses belong either to the innate or adaptive arms, the overall immune system genetics is broad, and encompasses a multitude of functionally heterogenous pathways which may have di...
Source: Brain, Behavior, and Immunity - September 17, 2023 Category: Neurology Authors: Martina Arenella Rugile Matuleviciute Ryad Tamouza Marion Leboyer Grainne McAlonan Janita Bralten Declan Murphy Source Type: research
Rats have low motivation to self-administer oral methamphetamine across increasing response requirements
Behav Brain Res. 2023 Sep 16;455:114673. doi: 10.1016/j.bbr.2023.114673. Online ahead of print.ABSTRACTMethamphetamine (METH) is a psychostimulant drug that has become increasingly popular in recent years, with overdose deaths more than doubling during the second half of the 2010s. As methamphetamine use disorder rates continue to increase, finding effective treatment strategies to decrease METH dependence is important. Animal studies are well-suited for studying the neurobiological mechanisms underlying addiction-like behaviors. Although individuals can ingest METH orally, few studies have examined oral METH self-administ...
Source: Behavioural Brain Research - September 17, 2023 Category: Neurology Authors: Justin R Yates Kevin L Berling Maria R Broderick Rayah E Bako Sadie L Dillon Source Type: research
Functional neurological seizures and migraine: A systematic review and case series
CONCLUSION: Our systematic review and case series indicate that migraine attacks may trigger FND-seizures, perhaps more often that currently understood, and suggest that migraine prophylaxis may reduce FND-seizure frequency in such cases. To validate these observations, fully powered prospective investigations are required.PMID:37717461 | DOI:10.1016/j.yebeh.2023.109437
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Laura Duque Ivan Garza Gregory D Cascino Jeffrey P Staab Source Type: research
Refining of the electroclinical phenotype in familial and sporadic cases of CSNK2B-related Neurodevelopmental Syndrome
We report ten new patients with CSNK2B-related Neurodevelopmental Syndrome associated with heterozygous variants of CSNK2B. In three patients, a pathogenic variant was inherited from an affected parent. We describe both molecular and clinical features, focusing on epileptic and neurodevelopmental phenotypes. The median age at follow-up was 8.5 years (range 21 months-42 years). All patients had epilepsy, with onset at a median age of 10.5 months range 6 days-10 years). Seizures were both focal and generalized and were resistant to anti-seizure medications in two out of ten patients. Six patients had mild to moderate cogniti...
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Marina Trivisano Angela De Dominicis Fabrizia Stregapede Chiara Quintavalle Alessia Micalizzi Simona Cappelletti Maria Lisa Dentici Lorenzo Sinibaldi Costanza Calabrese Alessandra Terracciano Federico Vigevano Antonio Novelli Nicola Specchio Source Type: research
Iron chelation prevents nigrostriatal neurodegeneration in a chronic methamphetamine mice model
Neurotoxicology. 2023 Sep 15:S0161-813X(23)00122-5. doi: 10.1016/j.neuro.2023.09.006. Online ahead of print.ABSTRACTMethamphetamine (METH) has been established to selectively target and impair dopaminergic neurons through multiple pathways. Ferroptosis is a unique form of non-apoptotic cell death driven by cellular iron accumulation-induced lipid peroxidation. Nonetheless, it remains unclear whether METH can induce ferroptosis. In the present study, we sought to assess alterations in iron levels after chronic METH exposure and reveal the modulatory role of iron on METH-induced pathologies. Importantly, we demonstrated that...
Source: Neurotoxicology - September 17, 2023 Category: Neurology Authors: Shanshan Hu Xiaorong Huang Jian Huang Ying Qian Yingbiao Tian Ye Xiao Xiaolan Qi Xiaoxian Zhou Zhusheng Yang Zehui Chen Source Type: research
Transcranial photobiomodulation mitigates learning and memory impairments induced by hindlimb unloading in a mouse model of microgravity exposure by suppression of oxidative stress and neuroinflammation signaling pathways
Brain Res. 2023 Sep 15:148583. doi: 10.1016/j.brainres.2023.148583. Online ahead of print.ABSTRACTProlonged microgravity exposure causes cognitive impairment. Evidence shows that oxidative stress and neuroinflammation are involved in the causation. Here, we explore the effectiveness of transcranial near-infrared photobiomodulation (PBM) on cognitive deficits in a mouse model of simulated microgravity. 24 adult male C57BL/6 mice were assigned into three groups (8 in each); control, hindlimb unloading (HU), and HU+PBM groups. After surgery to fit the suspension fixing, the animals were housed either in HU cages or in their n...
Source: Brain Research - September 17, 2023 Category: Neurology Authors: Sareh Kazmi Fereshteh Farajdokht Reza Meynaghizadeh-Zargar Saeed Sadigh-Eteghad Amir Pasokh Mohammad Farzipour Narmin Farazi Michael R Hamblin Javad Mahmoudi Source Type: research
Breastfeeding promotes oligodendrocyte precursor cells in a demyelinated region of the corpus callosum
Brain Res. 2023 Sep 15:148584. doi: 10.1016/j.brainres.2023.148584. Online ahead of print.ABSTRACTDemyelination alters the conduction of neuronal signals and hampers sensory-motor functions. Experimental and clinical evidence suggest that breastfeeding exerts a promyelinating impact on the maternal brain. The mechanism underlying this neuroprotective effect is not well-understood. In the present paper, we assessed the impact of rat lactation on lysolecithin-induced demyelination injury within the corpus callosum of lactating and non-lactating postpartum rats. We show that lactation enhanced the cell density of oligodendroc...
Source: Brain Research - September 17, 2023 Category: Neurology Authors: Abdeslam Mouihate Samah Kalakh Source Type: research
Where in the brain do internally generated and externally presented visual information interact?
Brain Res. 2023 Sep 15:148582. doi: 10.1016/j.brainres.2023.148582. Online ahead of print.ABSTRACTConscious experiences normally result from the flow of external input into our sensory systems. However, we can also create conscious percepts independently of sensory stimulation. These internally generated percepts are referred to as mental images, and they have many similarities with real visual percepts. Consequently, mental imagery is often referred to as "seeing in the mind's eye". While the neural basis of imagery has been widely studied, the interaction between internal and external sources of visual information has re...
Source: Brain Research - September 17, 2023 Category: Neurology Authors: Jussi Alho Athanasios Gotsopoulos Juha Silvanto Source Type: research
Rats have low motivation to self-administer oral methamphetamine across increasing response requirements
Behav Brain Res. 2023 Sep 16;455:114673. doi: 10.1016/j.bbr.2023.114673. Online ahead of print.ABSTRACTMethamphetamine (METH) is a psychostimulant drug that has become increasingly popular in recent years, with overdose deaths more than doubling during the second half of the 2010s. As methamphetamine use disorder rates continue to increase, finding effective treatment strategies to decrease METH dependence is important. Animal studies are well-suited for studying the neurobiological mechanisms underlying addiction-like behaviors. Although individuals can ingest METH orally, few studies have examined oral METH self-administ...
Source: Brain Research - September 17, 2023 Category: Neurology Authors: Justin R Yates Kevin L Berling Maria R Broderick Rayah E Bako Sadie L Dillon Source Type: research
