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Specialty: Neurology
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Total 80302 results found since Jan 2013.
Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human
CONCLUSIONS: This study is the first report of haploinsufficiency of two GABR epilepsy genes and visual impairment due to altered axonal myelination and resultant optic nerve atrophy. The study suggests the far-reaching impact of GABR mutations and the translational significance of animal models with the same etiology.PMID:37703949 | DOI:10.1016/j.expneurol.2023.114537
Source: Experimental Neurology - September 13, 2023 Category: Neurology Authors: Qi Zhang Cynthia Forster-Gibson Eduard Bercovici Alexandra Bernardo Fei Ding Wangzhen Shen Katherine Langer Tonia Rex Jing-Qiong Kang Source Type: research
Parkinson's disease pathology is directly correlated to SIRT3 in human subjects and animal models: Implications for AAV.SIRT3-myc as a disease-modifying therapy
In this study, to determine whether there is a link between PD pathology and SIRT3, we analysed SIRT3 levels in human subjects with PD, and compared to age-matched controls. In the SNc of PD subjects, SIRT3 was reduced by 56.8 ± 15.5% compared to control, regardless of age (p < 0.05, R = 0.6539). Given that age is the primary risk factor for PD, this finding suggests that reduced SIRT3 may contribute to PD pathology. Next, we measured whether there was a correlation between α-synuclein and SIRT3. In a parallel study, we assessed the disease-modifying potential of SIRT3 over-expression in a seeding model of α-synuclei...
Source: Neurobiology of Disease - September 13, 2023 Category: Neurology Authors: Dennison Trinh Ahmad R Israwi Harsimar Brar Jose E A Villafuerte Ruella Laylo Humaiyra Patel Sabika Jafri Lina Al Halabi Shaumia Sinnathurai Kiran Reehal Alyssa Shi Vayisnavei Gnanamanogaran Natalie Garabedian Drake Thrasher Philippe P Monnier Laura A Vol Source Type: research
Expanding the function of oligodendrocytes to brain energy metabolism
Curr Opin Neurobiol. 2023 Sep 11;83:102782. doi: 10.1016/j.conb.2023.102782. Online ahead of print.ABSTRACTOligodendrocytes are best known for wrapping myelin, a unique specialization that enables energy-efficient and fast axonal impulse propagation in white matter tracts and fibers of the cortical circuitry. However, myelinating oligodendrocytes have additional metabolic functions that are only gradually understood, including the regulated release of pyruvate/lactate and extracellular vesicles, both of which are in support of the axonal energy balance. The axon-supportive functions of glial cells are older than myelin in ...
Source: Current Opinion in Neurobiology - September 13, 2023 Category: Neurology Authors: Klaus-Armin Nave Ebrahim Asadollahi Andrew Sasmita Source Type: research
Elevated susceptibility to exogenous seizure triggers and impaired interneuron excitability in a mouse model of Leigh syndrome epilepsy
Neurobiol Dis. 2023 Sep 11:106288. doi: 10.1016/j.nbd.2023.106288. Online ahead of print.ABSTRACTMutations in the NADH dehydrogenase (ubiquinone reductase) iron‑sulfur protein 4 (NDUFS4) gene, which encodes for a key structural subunit of the OXFOS complex I (CI), lead to the most common form of mitochondrial disease in children known as Leigh syndrome (LS). As in other mitochondrial diseases, epileptic seizures constitute one of the most significant clinical features of LS. These seizures are often very difficult to treat and are a sign of poor disease prognosis. Mice with whole-body Ndufs4 KO are a well-validated model...
Source: Neurobiology of Disease - September 13, 2023 Category: Neurology Authors: Arena Manning Victor Han Alexa Stephens Rose Wang Nicholas Bush Michelle Bard Jan M Ramirez Franck Kalume Source Type: research
Patients' long-term perspectives on gains and losses after temporal lobe resection for epilepsy
CONCLUSIONS: Presurgical hopes go beyond seizure freedom and memory and naming problems are experienced lasting many years after surgery in the temporal lobe. Better preoperative information, particularly about unwanted cognitive effects, is of prime importance. By exploring patientś presurgical hopes, a common ground for expectations on surgery may be found along with strategies on how to cope with cognitive difficulties and possible negative life changes.PMID:37703614 | DOI:10.1016/j.yebeh.2023.109400
Source: Epilepsy and Behaviour - September 13, 2023 Category: Neurology Authors: Eli B Kyte Annette Holth Skogan Åsne Bjøråsen Baklid Kristina Malmgren Anneli Ozanne Kristin Å Alfstad Source Type: research
Mitteilungen der DGPPN 9/2023
Nervenarzt. 2023 Sep;94(9):870-872. doi: 10.1007/s00115-023-01545-w.NO ABSTRACTPMID:37702767 | DOI:10.1007/s00115-023-01545-w
Source: Der Nervenarzt - September 13, 2023 Category: Neurology Source Type: research
Mental illnesses in the postpartum period: an interdisciplinary and intersectoral challenge
Nervenarzt. 2023 Sep;94(9):777-778. doi: 10.1007/s00115-023-01509-0. Epub 2023 Sep 13.NO ABSTRACTPMID:37702766 | DOI:10.1007/s00115-023-01509-0
Source: Der Nervenarzt - September 13, 2023 Category: Neurology Authors: Sarah Kittel-Schneider Source Type: research
Glial-derived neuroinflammation induced with amyloid-beta-peptide plus fibrinogen injection in rat hippocampus
CONCLUSION: The findings suggest the utility of combining peptide plus fibrinogen as a potent and understudied neuroinflammatory stimulus for the induction of glial-derived neurotoxic factors in BBB-compromised AD brain.PMID:37702232 | DOI:10.2174/1567205020666230912113501
Source: Current Alzheimer Research - September 13, 2023 Category: Neurology Authors: James G McLarnon Source Type: research
Plasma proteomics show altered inflammatory and mitochondrial proteins in patients with neurologic symptoms of post-acute sequelae of SARS-CoV-2 infection
Brain Behav Immun. 2023 Sep 11:S0889-1591(23)00253-2. doi: 10.1016/j.bbi.2023.08.022. Online ahead of print.ABSTRACTPersistent symptoms of COVID-19 survivors constitute long COVID syndrome, also called post-acute sequelae of SARS-CoV-2 infection (PASC). Neurologic manifestations of PASC (Neuro-PASC) are particularly debilitating, long lasting, and poorly understood. To gain insight into the pathogenesis of PASC, we leveraged a well-characterized group of Neuro-PASC (NP) patients seen at our Neuro-COVID-19 clinic who had mild acute COVID-19 and never required hospitalization, to investigate their plasma proteome. Using the ...
Source: Brain, Behavior, and Immunity - September 13, 2023 Category: Neurology Authors: Barbara A Hanson Lavanya Visvabharathy Zachary S Orban Millenia Jimenez Ayush Batra Eric M Liotta Robert K DeLisle Jeffrey D Klausner Pinchas Cohen Advait S Padhye George Tachas Igor J Koralnik Source Type: research
Partner relationship quality and IL-6:IL-10 trajectories from pregnancy to a year after-birth
CONCLUSION: Lower partner support may be associated with reduced moderation of IL-6 by IL-10 between pregnancy and a year postpartum, with possible consequences for maternal health and well-being.PMID:37704011 | DOI:10.1016/j.bbi.2023.09.007
Source: Brain, Behavior, and Immunity - September 13, 2023 Category: Neurology Authors: Alexandria Lozowchuk Judith E Carroll Calvin Hobel Mary Coussons-Read Christine Dunkel Schetter Kharah M Ross Source Type: research
Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models
This study revealed the anti-inflammatory properties of UCMSC-CM and its regulatory effect on glial activation in the treatment of neuroinflammation in ALS, providing strong evidence for the clinical application of UCMSC-CM.PMID:37704056 | DOI:10.1016/j.brainresbull.2023.110760
Source: Brain Research Bulletin - September 13, 2023 Category: Neurology Authors: Jingshu Tang Yuying Kang Yujun Zhou Qiuyu Chen Jiaqi Lan Xuebin Liu Ying Peng Source Type: research
EEG cortical network reveals the temporo-spatial mechanism of visual search
This study aims to explore a method based on brain networks for implicit attention by using wavelet coherence as feature to identify individual targets in the visual field, find the optimal classification rhythm and time window, and investigate the relationship between the optimal rhythm and N2pc event-related potential. The study uses a weighted minimum norm estimate to locate the sources of the scalp EEG and reconstructs the source time series. The functional connectivity between brain areas during the visual search process is evaluated using wavelet coherence analysis, and a lateral difference network is constructed bas...
Source: Brain Research Bulletin - September 13, 2023 Category: Neurology Authors: Rui Qiao Haiyong Zhang Yin Tian Source Type: research
Characterizing, classifying, and collecting spells in paroxysmal disorders - A need as targeted therapies approach for childhood neurological disorders
Eur J Paediatr Neurol. 2023 Sep 9:S1090-3798(23)00136-8. doi: 10.1016/j.ejpn.2023.09.003. Online ahead of print.NO ABSTRACTPMID:37704551 | DOI:10.1016/j.ejpn.2023.09.003
Source: European Journal of Paediatric Neurology - September 13, 2023 Category: Neurology Authors: Phillip L Pearl Source Type: research
Hippocampal alterations after SARS-CoV-2 infection: a systematic review
Behav Brain Res. 2023 Sep 11:114662. doi: 10.1016/j.bbr.2023.114662. Online ahead of print.ABSTRACTSARS-CoV-2 infection produces a wide range of symptoms. Some of the structural changes caused by the virus in the nervous system are found in the medial temporal lobe, and several neuropsychological sequelae of COVID-19 are related to the function of the hippocampus. The main objective of the systematic review is to update and further analyze the existing evidence of hippocampal and related cortices' structural and functional alterations due to SARS-CoV-2 infection. Both clinical and preclinical studies that used different me...
Source: Behavioural Brain Research - September 13, 2023 Category: Neurology Authors: Candela Zorzo Luc ía Solares Marta Mendez Magdalena Mendez-Lopez Source Type: research
Sex and estrous cycle-linked differences in the effect of cannabidiol on panic-like responding in rats and mice
Behav Brain Res. 2023 Sep 11:114663. doi: 10.1016/j.bbr.2023.114663. Online ahead of print.ABSTRACTClinical and preclinical studies point towards anxiolytic actions of cannabidiol (CBD), but its effect in panic disorder has been less explored and few studies consider effects in females. We here compared the effect of CBD on the response of male and female rats and mice to a panicogenic challenge; exposure to low O2 (rats) or high CO2 (mice) paying attention in females to possible effects of estrous cycle phase. Male and female Sprague-Dawley rats and C57BL/6J mice were exposed to 7% O2 for 5min (rats) or 20% CO2 (mice) and...
Source: Behavioural Brain Research - September 13, 2023 Category: Neurology Authors: Paloma Molina Hernandes Matheus Fitipaldi Batistela Jefferson Manoel Nascimento-Silva Alana Tercino Frias Melina Matthiesen Alline Cristina Campos Thelma Anderson Lovick Helio Zangrossi Source Type: research
