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Total 80302 results found since Jan 2013.

Functional neurological seizures and migraine: A systematic review and case series
CONCLUSION: Our systematic review and case series indicate that migraine attacks may trigger FND-seizures, perhaps more often that currently understood, and suggest that migraine prophylaxis may reduce FND-seizure frequency in such cases. To validate these observations, fully powered prospective investigations are required.PMID:37717461 | DOI:10.1016/j.yebeh.2023.109437
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Laura Duque Ivan Garza Gregory D Cascino Jeffrey P Staab Source Type: research

Refining of the electroclinical phenotype in familial and sporadic cases of CSNK2B-related Neurodevelopmental Syndrome
We report ten new patients with CSNK2B-related Neurodevelopmental Syndrome associated with heterozygous variants of CSNK2B. In three patients, a pathogenic variant was inherited from an affected parent. We describe both molecular and clinical features, focusing on epileptic and neurodevelopmental phenotypes. The median age at follow-up was 8.5 years (range 21 months-42 years). All patients had epilepsy, with onset at a median age of 10.5 months range 6 days-10 years). Seizures were both focal and generalized and were resistant to anti-seizure medications in two out of ten patients. Six patients had mild to moderate cogniti...
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Marina Trivisano Angela De Dominicis Fabrizia Stregapede Chiara Quintavalle Alessia Micalizzi Simona Cappelletti Maria Lisa Dentici Lorenzo Sinibaldi Costanza Calabrese Alessandra Terracciano Federico Vigevano Antonio Novelli Nicola Specchio Source Type: research

Predicting seizure clustering in the epilepsy monitoring unit: A multivariable analysis
CONCLUSION: Our data showed that long-acting ASMs can be protective against seizure clustering. Furthermore, patients with temporal lobe epilepsy, and those on increased numbers of ASMs, were more likely to experience seizure clustering when undergoing medication withdrawal during an EMU evaluation.PMID:37717459 | DOI:10.1016/j.yebeh.2023.109433
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Leya Maliekal Deepti Zutshi Scott Millis Maysaa M Basha Source Type: research

A quarter-century of the Taiwan Child Neurology Society: What can we do in the future?
Epilepsy Behav. 2023 Sep 15;147:109417. doi: 10.1016/j.yebeh.2023.109417. Online ahead of print.NO ABSTRACTPMID:37717458 | DOI:10.1016/j.yebeh.2023.109417
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Yung-Ting Kuo Kun-Long Hung Wang-Tso Lee Source Type: research

Immunogenetics of autism spectrum disorder: A systematic literature review
Brain Behav Immun. 2023 Sep 15:S0889-1591(23)00274-X. doi: 10.1016/j.bbi.2023.09.010. Online ahead of print.ABSTRACTThe aetiology of autism spectrum disorder (ASD) is complex and, partly, accounted by genetic factors. Nonetheless, the genetic underpinnings of ASD are poorly defined. The presence of immune dysregulations in autistic individuals, and their families, supports a role of the immune system and its genetic regulators. Albeit immune responses belong either to the innate or adaptive arms, the overall immune system genetics is broad, and encompasses a multitude of functionally heterogenous pathways which may have di...
Source: Brain, Behavior, and Immunity - September 17, 2023 Category: Neurology Authors: Martina Arenella Rugile Matuleviciute Ryad Tamouza Marion Leboyer Grainne McAlonan Janita Bralten Declan Murphy Source Type: research

Predicting seizure clustering in the epilepsy monitoring unit: A multivariable analysis
CONCLUSION: Our data showed that long-acting ASMs can be protective against seizure clustering. Furthermore, patients with temporal lobe epilepsy, and those on increased numbers of ASMs, were more likely to experience seizure clustering when undergoing medication withdrawal during an EMU evaluation.PMID:37717459 | DOI:10.1016/j.yebeh.2023.109433
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Leya Maliekal Deepti Zutshi Scott Millis Maysaa M Basha Source Type: research

A quarter-century of the Taiwan Child Neurology Society: What can we do in the future?
Epilepsy Behav. 2023 Sep 15;147:109417. doi: 10.1016/j.yebeh.2023.109417. Online ahead of print.NO ABSTRACTPMID:37717458 | DOI:10.1016/j.yebeh.2023.109417
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Yung-Ting Kuo Kun-Long Hung Wang-Tso Lee Source Type: research

Metacognition and sense of agency
Cognition. 2023 Sep 14;241:105622. doi: 10.1016/j.cognition.2023.105622. Online ahead of print.ABSTRACTIntelligent agents need to understand how they can change the world, and how they cannot change it, in order to make rational decisions for their forthcoming actions, and to adapt to their current environment. Previous research on the sense of agency, based largely on subjective ratings, failed to dissociate the sensitivity of sense of agency (i.e., the extent to which individual sense of agency tracks actual instrumental control over external events) from judgment criteria (i.e., the extent to which individuals self-attr...
Source: Cognition - September 16, 2023 Category: Neurology Authors: Wen Wen Lucie Charles Patrick Haggard Source Type: research

Divergences in color perception between deep neural networks and humans
Cognition. 2023 Sep 14;241:105621. doi: 10.1016/j.cognition.2023.105621. Online ahead of print.ABSTRACTDeep neural networks (DNNs) are increasingly proposed as models of human vision, bolstered by their impressive performance on image classification and object recognition tasks. Yet, the extent to which DNNs capture fundamental aspects of human vision such as color perception remains unclear. Here, we develop novel experiments for evaluating the perceptual coherence of color embeddings in DNNs, and we assess how well these algorithms predict human color similarity judgments collected via an online survey. We find that stat...
Source: Cognition - September 16, 2023 Category: Neurology Authors: Ethan O Nadler Elise Darragh-Ford Bhargav Srinivasa Desikan Christian Conaway Mark Chu Tasker Hull Douglas Guilbeault Source Type: research

Multiple predictions during language comprehension: Friends, foes, or indifferent companions?
Cognition. 2023 Sep 14;241:105602. doi: 10.1016/j.cognition.2023.105602. Online ahead of print.ABSTRACTTo comprehend language, we continually use prior context to pre-activate expected upcoming information, resulting in facilitated processing of incoming words that confirm these predictions. But what are the consequences of disconfirming prior predictions? To address this question, most previous studies have examined unpredictable words appearing in contexts that constrain strongly for a single continuation. However, during natural language processing, it is far more common to encounter contexts that constrain for multiple...
Source: Cognition - September 16, 2023 Category: Neurology Authors: Trevor Brothers Emily Morgan Anthony Yacovone Gina Kuperberg Source Type: research

Cognitive function and the longitudinal hippocampal axis in mesial temporal sclerosis
CONCLUSIONS: Ipsilateral hippocampal head and tail seem more vulnerable to injury than the body in both the left and right mTLE. Our study suggests there may be functional differences along the hippocampal longitudinal axis, particularly for the left hippocampal tail with verbal memory. Our findings are consistent with material-specific right-left differences in memory processing.PMID:37716331 | DOI:10.1016/j.yebeh.2023.109413
Source: Epilepsy and Behaviour - September 16, 2023 Category: Neurology Authors: L Reppert L N Sepeta D Panjeti-Moore E Akinsoji C Sherer A Hamidullah-Thiam W H Theodore Source Type: research

The value of continuing research on epidemiology of cerebral palsy (CP) - What have we learned?
Eur J Paediatr Neurol. 2023 Sep 9:S1090-3798(23)00137-X. doi: 10.1016/j.ejpn.2023.09.004. Online ahead of print.NO ABSTRACTPMID:37716822 | DOI:10.1016/j.ejpn.2023.09.004
Source: European Journal of Paediatric Neurology - September 16, 2023 Category: Neurology Authors: Antigone S Papavasiliou Dimitrios Zafeiriou Source Type: research

Microvascular blood-brain barrier alterations in isolated brain capillaries of mice over-expressing alpha-synuclein (Thy1-aSyn line 61)
Neurobiol Dis. 2023 Sep 14:106298. doi: 10.1016/j.nbd.2023.106298. Online ahead of print.ABSTRACTDysfunction of the blood-brain barrier (BBB) is suggested to play a critical role in the pathological mechanisms of Parkinson's disease (PD). PD-related pathology such as alpha-synuclein accumulation and inflammatory processes potentially affect the integrity of the BBB early in disease progression, which in turn may alter the crosstalk of the central and peripheral immune response. Importantly, BBB dysfunction could also affect drug response in PD. Here we analyzed microvascular changes in isolated brain capillaries and brain ...
Source: Neurobiology of Disease - September 16, 2023 Category: Neurology Authors: Kristina Lau Lisa T Porschen Franziska Richter Birthe Gericke Source Type: research

Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs
In this study, HTT exon1 production was examined in the HD knock-in (KI) pig model, which more closely recapitulates neuropathology seen in HD patient brains than HD mouse models. The study revealed that aberrant spliced HTT exon1 is also present in the brains of HD pigs, but it is expressed at a much lower level than the normally spliced HTT exon products. These findings suggest that careful consideration is needed when assessing the contribution of aberrantly spliced mHTT exon1 to HD pathogenesis, and further rigorous investigation is required.PMID:37716514 | DOI:10.1016/j.nbd.2023.106291
Source: Neurobiology of Disease - September 16, 2023 Category: Neurology Authors: Huichun Tong Tianqi Yang Li Liu Caijuan Li Yize Sun Qingqing Jia Yiyang Qin Laiqiang Chen Xianxian Zhao Gongke Zhou Sen Yan Xiao-Jiang Li Shihua Li Source Type: research