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Total 1589675 results found since Jan 2013.
Retracted IQGAP1 ‑siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines
Mol Med Rep. 2023 Nov;28(5):207. doi: 10.3892/mmr.2023.13094. Epub 2023 Sep 21.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blotting data shown in Fig. 1C, and other western blotting data included in Figs. 2D and 7C and D, were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published elsewhere, prior to its s...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Bo Diao Ying Liu Yi Zhang Jing Yu Jun Xie Guo-Zheng Xu Source Type: research
Britanin inhibits titanium wear particle ‑induced osteolysis and osteoclastogenesis
Mol Med Rep. 2023 Nov;28(5):205. doi: 10.3892/mmr.2023.13092. Epub 2023 Sep 21.ABSTRACTWear particle‑induced osteolysis is a serious complication that occurs in individuals with titanium (Ti)‑based implants following long‑term usage due to loosening of the implants. The control of excessive osteoclast differentiation and inflammation is essential for protecting against wear particle‑induced osteolysis. The present study evaluated the effect of britanin, a pseudoguaianolide sesquiterpene isolated from Inula japonica, on osteoclastogenesis in vitro and Ti particle‑induced osteolysis in vivo. The effect of britanin ...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Ju Ang Kim Soomin Lim Hye Jung Ihn Jung-Eun Kim Kyungmoo Yea Jimin Moon Hyukjae Choi Eui Kyun Park Source Type: research
Oxalate ‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling < em > in  vitro < /em > and < em > in  vivo < /em >
Mol Med Rep. 2023 Nov;28(5):209. doi: 10.3892/mmr.2023.13096. Epub 2023 Sep 21.ABSTRACTCalcium oxalate kidney stone has become an urgent issue due to its high incidence and recurrence rate. Thus, it is necessary to explore for mechanisms of calcium oxalate stones formation. Previous studies demonstrated that oxalate crystals could induce the activation of nucleotide‑binding domain and leucine‑rich repeat‑containing family pyrin domain‑containing 3 (NLRP3) inflammasome and change the renal tubular epithelium adhesion. However, the type and molecular mechanism of NLRP3 inflammasome‑mediated calcium oxalate stones f...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Yue Chen Shushuai Yang Hailong Kong Qi Wang Shiqun Chen Xingyu Wang Liqun Chen Shiyong Qi Source Type: research
Alteration of relative telomere length and telomerase reverse transcriptase expression in the granulosa cells of women during aging and assessment of < em > in vitro < /em > fertilization outcomes
Mol Med Rep. 2023 Nov;28(5):206. doi: 10.3892/mmr.2023.13093. Epub 2023 Sep 21.ABSTRACTTelomere attrition plays a critical role in the reproductive aging process in humans. Telomere length (TL) is typically regulated by telomerase, the main component of which is telomerase reverse transcriptase (TERT). The aim of the present study was to investigate the changes of relative TL (RTL) and TERT expression in granulosa cells (GCs) during aging and its association with reproduction. Clinical data on the frozen‑thawed embryo transfer cycles of older (>35 year old) and younger (≤35 year old) women from a single center over ...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Yan Hao Mingrong Lv Jing Peng Dan Kuang Zhihua Zhang Zhou Zhang Tingting Wang Bo Yang Zhaolian Wei Ping Zhou Zhiguo Zhang Yunxia Cao Source Type: research
Catechin hydrate ameliorates cerulein ‑induced chronic pancreatitis via the inactivation of TGF‑β/Smad2 signaling
Mol Med Rep. 2023 Nov;28(5):208. doi: 10.3892/mmr.2023.13095. Epub 2023 Sep 21.ABSTRACTChronic pancreatitis (CP) is a pancreatic inflammatory disease associated with histological changes, including fibrosis, acinar cell loss and immune cell infiltration, and leads to damage of the pancreas, which results in pain, weight loss and loss of pancreas function. Catechin or catechin hydrate (CH) has antioxidant, anticancer and immune‑regulatory effects. However, unlike other catechins, the antifibrotic effects of (+)‑CH have not been widely studied in many diseases, including CP. Therefore, the anti‑fibrotic effects of (+)â...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Bitna Kweon Dong-Uk Kim Jin-Young Oh Sung-Joo Park Gi-Sang Bae Source Type: research
Bibliometric analysis and visualized study of research on autophagy in ischemic stroke
Conclusion: This bibliometric analysis helps us reveal the current research hotspots in the research field of autophagy in ischemic stroke and guide future research directions. Subsequent trends in this special field are likely to identify and develop novel autophagy-targeted therapy strategies to effectively prevent and treat ischemic stroke.PMID:37731738 | PMC:PMC10507179 | DOI:10.3389/fphar.2023.1232114
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Jiefang Chen Gaijie Chen Xiaojing Xu Long Chen Jiewen Zhang Feng Liu Source Type: research
Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(ii), Co(ii) and Ni(ii) complexes - combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CL < sup > Pro < /sup >
RSC Med Chem. 2023 Jan 3;14(9):1667-1697. doi: 10.1039/d2md00394e. eCollection 2023 Sep 19.ABSTRACTA novel class of bioactive complexes (1-3) [MII(L)2(bpy)], where, L = 2-(4-morpholinobenzylideneamino)phenol, bpy = 2,2'-bipyridine, MII = Mn (1), Co (2) or Ni (3), were assigned to octahedral geometry based on analytical and spectral measurements. Gel electrophoresis showed that complex (2) demonstrated significant DNA cleavage activity compared to the other complexes under the action of oxidation agent (H2O2). The DNA binding constant properties measured by various techniques were in the following sequence: (2) > (3) >...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Karunganathan Sakthikumar Bienfait Kabuyaya Isamura Rui Werner Ma çedo Krause Source Type: research
Hyperbaric oxygen therapy suppresses hypoxia and reoxygenation injury to retinal pigment epithelial cells through activating peroxisome proliferator activator receptor-alpha signalling
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17963. Online ahead of print.ABSTRACTRetinal ischemia followed by reperfusion (IR) is a common cause of many ocular disorders, such as age-related macular degeneration (AMD), which leads to blindness in the elderly population, and proper therapies remain unavailable. Retinal pigment epithelial (RPE) cell death is a hallmark of AMD. Hyperbaric oxygen (HBO) therapy can improve IR tissue survival by inducing ischemic preconditioning responses. We conducted an in vitro study to examine the effects of HBO preconditioning on oxygen-glucose deprivation (OGD)-induced IR-injured RPE ce...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Tzong-Bor Sun Kuo-Feng Huang Ko-Chi Niu Cheng-Hsien Lin Wen-Pin Liu Chao-Hung Yeh Shu-Chun Kuo Ching-Ping Chang Source Type: research
Transcriptome analysis of six tissues obtained post-mortem from sepsis patients
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17938. Online ahead of print.ABSTRACTSeptic shock is a life-threatening clinical condition characterized by a robust immune inflammatory response to disseminated infection. Little is known about its impact on the transcriptome of distinct human tissues. To address this, we performed RNA sequencing of samples from the prefrontal cortex, hippocampus, heart, lung, kidney and colon of seven individuals who succumbed to sepsis and seven uninfected controls. We identified that the lungs and colon were the most affected organs. While gene activation dominated, strong inhibitory signa...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Fabiano Pinheiro da Silva Andr é Nicolau Aquime Gonçalves Amaro Nunes Duarte-Neto Thomaz L üscher Dias Hermes Vieira Barbeiro Cristiane Naffah Souza Breda Leandro Carvalho Dantas Breda Niels Olsen Saraiva C âmara Helder I Nakaya Source Type: research
Author Correction: Diversity and complexity of cell death: a historical review
Exp Mol Med. 2023 Sep 20. doi: 10.1038/s12276-023-01107-9. Online ahead of print.NO ABSTRACTPMID:37731035 | DOI:10.1038/s12276-023-01107-9
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Wonyoung Park Shibo Wei Bo-Sung Kim Bosung Kim Sung-Jin Bae Young Chan Chae Dongryeol Ryu Ki-Tae Ha Source Type: research
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases
Trends Mol Med. 2023 Sep 19:S1471-4914(23)00190-9. doi: 10.1016/j.molmed.2023.08.005. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDs) are commonly observed and while no therapy is universally applicable, cell-based therapies are promising. Stem cell transplantation has been investigated, but endogenous neural stem cells (eNSCs), despite their potential, especially with the development of bioelectronic medicine and biomaterials, remain understudied. Here, we compare stem cell transplantation therapy with eNSC-based therapy and summarize the combined use of eNSCs and developing technologies. The rapid developm...
Source: Trends in Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Maifu Yu Pin Sun Changkai Sun Wei-Lin Jin Source Type: research
Recreational Runners Gain Physiological and Biomechanical Benefits From Super Shoes at Marathon Paces
CONCLUSIONS: There was a physiological benefit to running in the super shoes even at the slower speed. There were also spatiotemporal and global stiffness improvements indicating that recreational runners benefit from wearing super shoes.PMID:37734742 | DOI:10.1123/ijspp.2023-0115
Source: International Journal of Sports Physiology and Performance - September 21, 2023 Category: Sports Medicine Authors: Giorgos P Paradisis Elias Zacharogiannis Athanassios Bissas Brian Hanley Source Type: research
Benefits of Training the Iron Cross With Herdos Devices and External Load Added to Body Weight for Young Nonachiever Gymnasts
CONCLUSION: sEMG activity of PM and BB was particularly sensitive between situations, independently of the level of achievement. We recommend training the IC by adding external load in the herdos situation to increase muscle activity to levels closer to the rings situation but avoiding the potential factor of injuries.PMID:37734741 | DOI:10.1123/ijspp.2023-0183
Source: International Journal of Sports Physiology and Performance - September 21, 2023 Category: Sports Medicine Authors: Michel Marina Priscila Torrado Blai Ferrer-Uris Albert Busquets Source Type: research
Erratum. Determinants of 1500-m Front-Crawl Swimming Performance in Triathletes: Influence of Physiological and Biomechanical Variables
Int J Sports Physiol Perform. 2023 Sep 21:1. doi: 10.1123/ijspp.2023-0362. Online ahead of print.NO ABSTRACTPMID:37734740 | DOI:10.1123/ijspp.2023-0362
Source: International Journal of Sports Physiology and Performance - September 21, 2023 Category: Sports Medicine Authors: International Journal of Sports Physiology and Performance Source Type: research
Uptake of a Universal Sports Subsidy Program for School-Aged Children: A Population Data Analysis
CONCLUSIONS: Future work is needed to understand how Sports Voucher, and sport participation rates have changed over time, and to improve voucher uptake among girls, city dwellers, and low SES children.PMID:37734744 | DOI:10.1123/jpah.2022-0204
Source: Journal of Physical Activity and Health - September 21, 2023 Category: Sports Medicine Authors: Rachel G Curtis Michelle Crisp Simone Licari Rosa Virgara Catherine E M Simpson Carol A Maher Source Type: research
