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Total 1589675 results found since Jan 2013.
Interaction between N < sup > 6 < /sup > -methyladenosine modification and the tumor microenvironment in colorectal cancer
Mol Med. 2023 Sep 22;29(1):129. doi: 10.1186/s10020-023-00726-2.ABSTRACTThe incidence and mortality of colorectal cancer (CRC) are rapidly increasing worldwide. Recently, there has been significant attention given to N6-methyladenosine (m6A), the most common mRNA modification, especially for its effects on CRC development. It is important to note that the progression of CRC would be greatly hindered without the tumor microenvironment (TME). The interaction between CRC cells and their surroundings can activate and influence complex signaling mechanisms of epigenetic changes to affect the survival of tumor cells with a malig...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Jiali Yao Yeke Song Xiaoping Yu Zhijie Lin Source Type: research
The prognostic significance of a negative PSMA-PET scan prior to salvage radiotherapy following radical prostatectomy
CONCLUSION: Favorable bRFS after SRT in patients with BR and negative PSMA-PET following RP was achieved. These data support the usage of early SRT for patients with negative PSMA-PET findings.PMID:37736808 | DOI:10.1007/s00259-023-06438-3
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Sonja Adebahr Alexander Althaus Sophia Scharl Iosif Strouthos Andrea Farolfi Francesca Serani Helena Lanzafame Christian Trapp Stefan A Koerber Jan C Peeken Marco M E Vogel Alexis Vrachimis Simon K B Spohn Anca-Ligia Grosu Stephanie G C Kroeze Matthias Gu Source Type: research
Automated radiosynthesis of < sup > 18 < /sup > FFMPEP- < em > d < /em > < sub > 2 < /sub > for cannabinoid receptor PET imaging
Am J Nucl Med Mol Imaging. 2023 Aug 15;13(4):171-178. eCollection 2023.ABSTRACTThe cannabinoid subtype 1 receptor (CB1R) is highly expressed in the central nervous system and abnormalities in regional CB1R density are associated with neurodegenerative disorders. The PET tracer [18F]FMPEP-d2 is an inverse CB1R agonist which was shown to be suitable for non-invasive PET imaging. In this work, we reported the fully automated radiosynthesis of [18F]FMPEP-d2 on a Synthra RNplus research module. In a total synthesis time of 70 min, [18F]FMPEP-d2 was obtained in 2.2 ± 0.1 GBq (n = 3) with excellent radiochemical and chemical pur...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Huailei Jiang Yan Guo Otto Muzik Source Type: research
Investigation of tumor assessment between two PET systems using various indices: comparison between PET/CT and PET/MRI systems
This study aimed to determine the comparability of tumor-uptake indices of 18F-FDG in positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) PET/CT and PET/MRI were performed on 55 patients with confirmed primary malignancies. PET/CT preceded PET/MRI in all examinations. Accumulation of 18F-FDG in lesions and normal organs (brain, liver) was measured. Maximum and peak standardized uptake values (SUVs; SUVmax and SUVpeak, respectively), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) with ...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Hirotoshi Hotsumi Shirou Ishii Hiroki Suenaga Shigeyasu Sugawara Kenji Fukushima Hiroshi Ito Source Type: research
Duodenal-type follicular lymphoma in < sup > 18 < /sup > F-FDG PET/CT imaging: a case report
We report a case of a 36-year-old male patient with multiple, small, gray polypoid lesions in the descending duodenum which were detected by esophagogastroduodenoscopy. The pathological diagnosis was low-grade D-FL. 18F-FDG PET/CT was performed for staging and revealed the pancreas and peripheral lymph nodes were involved by FL, with a clinical IV stage. The patient underwent a bone marrow smear cytology, which revealed no bone marrow abnormalities, and excluded bone marrow involvement. He was treated with six cycles of chemotherapy using the R-CHOP regimen and reached complete remission.PMID:37736494 | PMC:PMC10509290
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Wenpeng Huang Fangfang Chao Yushuo Peng Xiaoyue Zhang Qi Yang Lele Song Liming Li Lei Kang Source Type: research
Evaluation of enhanced permeability effect and different linear energy transfer of radionuclides in a prostate cancer xenograft model
In conclusion, we found that specific targeting might negatively influence normal organ uptake when targeting secreted antigens. Furthermore, different energy deposition i.e. linear energy transfer of a radionuclide might have diverse effects on receptor expression and cell proliferation in tumors.PMID:37736493 | PMC:PMC10509292
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Oskar Vilhelmsson Timmermand Marcella Safi Bo Holmqvist Joanna Strand Source Type: research
The role of 18F-fluorodeoxyglucose PET/computed tomography in the diagnosis and monitoring of large vessel vasculitides - a review article
Am J Nucl Med Mol Imaging. 2023 Aug 15;13(4):127-135. eCollection 2023.ABSTRACTIn the last two decades, advancements in positron emission tomography (PET) technology have increased the diagnostic accuracy of patients with large-vessel vasculitis (LVV). Numerous systematic reviews and meta-analyses have been conducted, and patients suspected of having LVV can be diagnosed earlier with 18F-FDG PET. Two subtypes, giant cell arteritis (GCA) and Takayasu arteritis (TA), will progress when their response to corticosteroids and enhanced immunosuppression is inadequate. In the majority of patients, disease activity cannot be monit...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Mahshid Bahrami Hossein Mohammadi Hannaneh Mirgaloyebayat Zahra Mohajeri Pooya Fazeli Azad Mojahedi Ali Afsharirad Reza Tavakoli Amirhossein Sadeghian Sayed Mohammad Amin Nourian Source Type: research
Novel technique of detecting inflammatory and osseous changes in the glenohumeral joint associated with patient age and weight using FDG- and NaF-PET imaging
CONCLUSION: Our study demonstrates the varying effect of limb laterality and BMI on FDG and NaF uptake at the GH joint. Adoption of molecular imaging will require future studies that correlate tracer uptake with relevant medical and illness history as well as degenerative change evident on traditional imaging.PMID:37736491 | PMC:PMC10509288
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Peter Sang Uk Park Lori Jia William Y Raynor Om H Gandhi Mia Mijung Park Thomas J Werner Poul Flemming H øilund-Carlsen Abass Alavi Source Type: research
Associated Factors of Tophaceous Gout: A Study Involving 20 Primary Care Clinics in an Urbanized State in Malaysia
CONCLUSIONS: Tophaceous gout is associated with longer disease duration, higher baseline serum uric acid level, and younger age at symptoms onset. Hence, early initiation of urate-lowering therapy with a treat-to-target approach is crucial to prevent tophi formation.PMID:37736055 | PMC:PMC10509634 | DOI:10.5001/omj.2023.87
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Syang Pyng Gan Mollyza Mohd Zain Shereen Suyin Ch'ng Hasliza Hassan Wan Farzihan Wan Adib Anizah Muzaid Ing Soo Lau Habibah Yusoof Azmillah Rosman Hazlyna Baharuddin Source Type: research
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01105-5. Online ahead of print.ABSTRACTSubstrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic process. So far, how any ubiquitin ligase builds a proteasomal degradation signal, which is canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic electron microscopy studies of the ...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Tatyana Bodrug Kaeli A Welsh Derek L Bolhuis Ethan Paul аkonis Raquel C Martinez-Chacin Bei Liu Nicholas Pinkin Thomas Bonacci Liying Cui Pengning Xu Olivia Roscow Sascha Josef Amann Irina Grishkovskaya Michael J Emanuele Joseph S Harrison Joshua P Steim Source Type: research
Italian status update on physical activity levels, sports, and sedentariness: how should we turn the tide?
J Sports Med Phys Fitness. 2023 Sep 22. doi: 10.23736/S0022-4707.23.15136-X. Online ahead of print.NO ABSTRACTPMID:37736665 | DOI:10.23736/S0022-4707.23.15136-X
Source: Journal of Sports Medicine and Physical Fitness - September 22, 2023 Category: Sports Medicine Authors: Antonio LA Torre Luca Filipas Roberto Codella Source Type: research
Effect of integrative neuromuscular training and detraining on performance indices in young female volleyball players
CONCLUSIONS: Concluding, INT may cause improvements in specific power and skill performance indices during in season training in young female volleyball players which may be maintained or even improved for at least 8-week detraining when players remain active through volleyball training.PMID:37736664 | DOI:10.23736/S0022-4707.23.15108-5
Source: Journal of Sports Medicine and Physical Fitness - September 22, 2023 Category: Sports Medicine Authors: Maria Gavala Eleni Bassa Eleni Zetou Ilias Smilios Helen Douda Source Type: research
Physical strength levels and short-term memory efficiency in primary school children: a possible match?
CONCLUSIONS: These findings suggest that physical strength can positively influence short-term memory. In addition, this impact is enhanced in older-age children. Thus, primary school programs should stimulate physical strength to help children develop cognitive abilities.PMID:37736663 | DOI:10.23736/S0022-4707.23.14996-6
Source: Journal of Sports Medicine and Physical Fitness - September 22, 2023 Category: Sports Medicine Authors: Samuel Agostino Michela Calandretti Franco Veglio Federico Abate Daga Source Type: research
Non-vaccination against COVID-19 Among Venezuelan Refugees and Adult Migrants Adults in Peru: A Cross-sectional Study from, 2022
CONCLUSIONS: The primary governmental and non-governmental institutions responsible for supporting and protecting the Venezuelan migrant and refugee population should improve vaccination access by issuing migration permits and providing health insurance.PMID:37735835 | DOI:10.3961/jpmph.23.078
Source: Journal of Preventive Medicine and Public Health - September 22, 2023 Category: International Medicine & Public Health Authors: Akram Hern ández-Vásquez Rodrigo Vargas-Fern ánde Source Type: research
Health Behaviors before and After the Implementation of a Health Community Organization: Gangwon's Health-Plus Community Program
CONCLUSIONS: The HCO seems to have contributed to improving community health indicators. In the future, a follow-up study that analyzes only the effectiveness of the HCO through structured quasi-experimental studies will be needed.PMID:37735834 | DOI:10.3961/jpmph.23.121
Source: Journal of Preventive Medicine and Public Health - September 22, 2023 Category: International Medicine & Public Health Authors: Joon-Hyeong Kim Nam-Jun Kim Im-Sun Seo Soo-Hyeong Kim Woong-Sub Park Source Type: research
