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Total 1589675 results found since Jan 2013.

Spirituality and heart failure: a systematic review
CONCLUSIONS: Despite the extreme heterogeneity of the populations included, of the definition of spirituality and religiosity, and of the interventions in the few studies that included it, all the studies reported some positive associations with the outcomes examined. Spirituality/religiosity is an aspect not generally taken into account in the usual practice of medicine and can potentially contribute to improving the conditions of patients with HF, a chronic disease with unfavorable prognosis.PMID:37737928 | DOI:10.1007/s40520-023-02557-x
Source: Aging Clinical and Experimental Research - September 22, 2023 Category: Geriatrics Authors: Laura Cilona Nicola Veronese Diego Lalicata Francesca Tantillo Liliana Naro Ligia J Dominguez Mario Barbagallo Source Type: research

Psoas muscle quantified muscle status and long-term mortality after cardiovascular interventions
CONCLUSIONS: Different psoas muscle measurements were significantly and very similarly associated with mortality among men but not among women. No single measurement stands out, although combining PMA and PMD seems to be a slightly stronger estimate in terms of effect size and should be considered in further studies.PMID:37738519 | DOI:10.1080/07853890.2023.2259798
Source: Annals of Medicine - September 22, 2023 Category: Internal Medicine Authors: Otto J ärvinen Juho T Tynkkynen Marko Virtanen Pasi Maaranen Iisa Lindstr öm Damir Vakhitov Jari Laurikka Niku K Oksala Jussi A Hernesniemi Source Type: research

Mobility and postural limitations perceived by transtibial amputees undertaking agricultural activities: a qualitative study
CONCLUSIONS: In conclusion, the prostheses worn by transtibial amputee farmers are not suitable for working on sloping and uneven terrain, nor for performing postures such as kneeling or squatting. These postures are very common in agricultural and livestock tasks in countries with mountainous areas such as Latin American countries. The recognition of problems reported by farmers transtibial amputees, may help to improve the design of prostheses so that they meet the needs of this population and decrease secondary injuries associated with prosthetic use. This information is useful to identify compensatory postures that fac...
Source: Annals of Medicine - September 22, 2023 Category: Internal Medicine Authors: Y Ortega Bedoya V Mej ía Londoño E Rend ón Vélez F Valencia Legarda J A Plata-Contreras Source Type: research

Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine
Annu Rev Pharmacol Toxicol. 2023 Sep 22. doi: 10.1146/annurev-pharmtox-022723-113921. Online ahead of print.ABSTRACTProteogenomics refers to the integration of comprehensive genomic, transcriptomic, and proteomic measurements from the same samples with the goal of fully understanding the regulatory processes converting genotypes to phenotypes, often with an emphasis on gaining a deeper understanding of disease processes. Although specific genetic mutations have long been known to drive the development of multiple cancers, gene mutations alone do not always predict prognosis or response to targeted therapy. The benefit of p...
Source: Pharmacological Reviews - September 22, 2023 Category: Drugs & Pharmacology Authors: Sunil K Joshi Paul Piehowski Tao Liu Sara J C Gosline Jason E McDermott Brian J Druker Elie Traer Jeffrey W Tyner Anupriya Agarwal Cristina E Tognon Karin D Rodland Source Type: research

Physical strength levels and short-term memory efficiency in primary school children: a possible match?
CONCLUSIONS: These findings suggest that physical strength can positively influence short-term memory. In addition, this impact is enhanced in older-age children. Thus, primary school programs should stimulate physical strength to help children develop cognitive abilities.PMID:37736663 | DOI:10.23736/S0022-4707.23.14996-6
Source: Methods of Information in Medicine - September 22, 2023 Category: Information Technology Authors: Samuel Agostino Michela Calandretti Franco Veglio Federico Abate Daga Source Type: research

Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine
Annu Rev Pharmacol Toxicol. 2023 Sep 22. doi: 10.1146/annurev-pharmtox-022723-113921. Online ahead of print.ABSTRACTProteogenomics refers to the integration of comprehensive genomic, transcriptomic, and proteomic measurements from the same samples with the goal of fully understanding the regulatory processes converting genotypes to phenotypes, often with an emphasis on gaining a deeper understanding of disease processes. Although specific genetic mutations have long been known to drive the development of multiple cancers, gene mutations alone do not always predict prognosis or response to targeted therapy. The benefit of p...
Source: Annual Review of Pharmacology and Toxicology - September 22, 2023 Category: Drugs & Pharmacology Authors: Sunil K Joshi Paul Piehowski Tao Liu Sara J C Gosline Jason E McDermott Brian J Druker Elie Traer Jeffrey W Tyner Anupriya Agarwal Cristina E Tognon Karin D Rodland Source Type: research

Activation of PI3K/Akt pathway by G protein ‐coupled receptor 37 promotes resistance to cisplatin‐induced apoptosis in non‐small cell lung cancer
ConclusionsIt was suggested that GPR37 acts a crucial role in promoting the occurrence and development of NSCLC. Knockdown of GPR37 significantly inhibits the occurrence and development of NSCLC. Therefore, our findings demonstrated that GPR37 may represent a viable therapeutic target for NSCLC.
Source: Cancer Medicine - September 22, 2023 Category: Cancer & Oncology Authors: Han Liu, Yingjie Zhu, Huikun Niu, Jing Jie, Shucheng Hua, Xiaoxue Bai, Shuai Wang, Lei Song Tags: RESEARCH ARTICLE Source Type: research

Determination of urinary deanol ‐N‐oxide excretion profiles after ingestion of nutritional supplements containing deanol
An analytical approach employing LC –MS/MS was developed to provide first data on urinary levels of deanol-N-oxide at baseline and after the administration of deanol or meclofenoxate in humans. After a single oral dose of deanol or meclofenoxate, considerable increases of the metabolite deanol-N-oxide are observed, reaching cmax levels at 2 –5 h post-administration. Abstract2-(Dimethylamino)ethan-1-ol (Deanol) is a widely produced chemical used by both industry and consumers in a variety of applications. Meclofenoxate, a stimulant classified on the World Anti-Doping Agency Prohibited List, metabolizes into deanol and, ...
Source: Drug Testing and Analysis - September 22, 2023 Category: Drugs & Pharmacology Authors: Oliver Krug, Sven Guddat, Christian G örgens, Thomas Piper, Tristan Möller, Mario Thevis Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research

Alleviation of ultraviolet ‐B radiation‐induced photoaging using Saussurea medusa Maxim polysaccharide
Ultraviolet B radiation from sunlight can lead to photoaging, thickening of the dermis, and deep wrinkles. It triggers the production of inflammatory factors like TNF-a and IL-1, which then activate EGFR receptors in cells. This, in turn, activates MEK1/2 and ERK1/2, eventually causing an increase in the production of MMPs. The increased MMPs then degrade collagen and other extracellular matrix components, leading to skin inflammation and damage. However, the polysaccharides present inSaussurea medusa maxim can mitigate skin damage by this pathway. AbstractSaussureamedusa polysaccharide, the polysaccharide extract ofSaussu...
Source: Photochemistry and Photobiology - September 22, 2023 Category: Science Authors: Yan Guo, Yue Kong, Juan Sun, Yang Jiao, Yan Hong, Yan Wang Tags: RESEARCH ARTICLE Source Type: research

Survey Indicates Zoomers and Millennials Are Ready for Pharmacies to Play a Bigger Role in Their Primary Care
Demand for low cost, convenient access to doctors and drugs is driving transformation to decentralized medical care, and retail pharmacy chains see opportunity in offering primary care services Retail pharmacies and pharmacists continue to play a growing role in healthcare as consumer demand for lower cost and convenience pushes the nation’s medical landscape away from […] The post Survey Indicates Zoomers and Millennials Are Ready for Pharmacies to Play a Bigger Role in Their Primary Care appeared first on Dark Daily.
Source: Dark Daily - September 22, 2023 Category: Laboratory Medicine Authors: swallask Tags: Laboratory News Laboratory Resources Laboratory Testing Molecular Diagnostics, Genetic Testing, Whole Gene Sequencing Precision Medicine Source Type: news

Kenya: KNH Specialist Salvage the Limb of a Patient With Cancer of the Bone
[Capital FM] Nairobi -- Specialists at the Kenyatta National Hospital have successfully carried a delicate procedure by salvaging the limb of a 20-year-old patient with cancer of the bone.
Source: AllAfrica News: Health and Medicine - September 22, 2023 Category: African Health Tags: East Africa Health and Medicine Kenya Source Type: news

Libya: 'The Mental Toll is Very High' - Survivors of Floods Grapple With Trauma
[UN News] Post-traumatic stress and anxiety has become a daily challenge for thousands of Libyans who survived Storm Daniel nearly two weeks ago, UN humanitarians warned on Thursday.
Source: AllAfrica News: Health and Medicine - September 22, 2023 Category: African Health Tags: Aid and Assistance External Relations Health and Medicine International Organizations and Africa Libya North Africa Source Type: news

Kenya: UNFPA-Led Alliance Unveils Financing for Adolescent-Friendly HIV Testing and Treatment
[Capital FM] Nairobi -- Three UN agencies in the country have announced a collaborative effort to promote adolescent-friendly sexual and reproductive health services in a bid to enhance HIV testing and treatment among the youth.
Source: AllAfrica News: Health and Medicine - September 22, 2023 Category: African Health Tags: HIV-Aids and STDs East Africa External Relations Health and Medicine International Organizations and Africa Kenya Source Type: news

Medication adherence in youths with CKD: habits for success
ConclusionsEvaluating patient responses to questions about adherence habits may uncover challenges with adherence habit formation, provide direction for habit-strengthening intervention focused on developing automatic cues for taking medication, and support adherence successes for youths with CKD.Clinical trial registration numberNCT03651596.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

South Africa: Aspen's Novo Nordisk Deal a 'Feather in Our Cap' and an NCD Battle Boost - Top Executive
[Daily Maverick] The success of the Danish company - Europe's second most valuable - is largely built on its weight-loss drugs.
Source: AllAfrica News: Health and Medicine - September 22, 2023 Category: African Health Tags: Economy, Business and Finance Company News Health and Medicine South Africa Southern Africa Source Type: news