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Total 293778 results found since Jan 2013.

SHADES Mechanistic Trial
Conditions:   Insomnia;   Insomnia Chronic;   Insomnia, Primary;   Sleep Disturbance;   Sleep Disorder;   Cardiovascular Diseases;   Heart Diseases;   Coronary Artery Disease;   Stroke;   Autonomic Dysfunction;   Systemic Inflammatory Response;   Metabolic Disease Interventions:   Behavioral: Sleep Healthy Using The Internet (SHUTi);   Behavioral: Telephonic CBT-I;   Behavioral: Face-to-Face CBT-I;   Other: Active Control: Sleep Education/Hygiene, Symptom Monitoring, and Usual Primary Care Sponsors:   Indiana University;   National Heart, Lung, and Blood Institute (NHLBI);   Eskena...
Source: ClinicalTrials.gov - September 18, 2023 Category: Research Source Type: clinical trials

Blood biomarker changes following therapeutic hypothermia in ischemic stroke
ConclusionAlthough the exact roles of MMP3, FABP, and IL-8 in hypothermia-treated stroke patients are not known, further exploration is needed to confirm their roles in brain ischemia.
Source: Brain and Behavior - September 18, 2023 Category: Neurology Authors: Elena Pal à, Anna Penalba, Alejandro Bustamante, Teresa García‐Berrocoso, Marcel Lamana‐Vallverdú, Christian Meisel, Andreas Meisel, H. Bart van der Worp, Malcolm R Macleod, Bernd Kallmünzer, Stefan Schwab, Joan Montaner Tags: BRIEF REPORT Source Type: research

Cerebral embolic protection during transcatheter heart interventions
EuroIntervention. 2023 Sep 18;19(7):549-570. doi: 10.4244/EIJ-D-23-00166.ABSTRACTStroke remains a devastating complication of transcatheter aortic valve replacement (TAVR), with the incidence of clinically apparent stroke seemingly fixed at around 3% despite TAVR's significant evolution during the past decade. Embolic showers of debris (calcium, atheroma, valve material, foreign material) are captured in the majority of patients who have TAVR using a filter-based cerebral embolic protection device (CEPD). Additionally, in systematic brain imaging studies, the majority of patients receiving TAVR exhibit new cerebral lesions...
Source: EuroIntervention - September 18, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Victor Alfonso Jimenez Diaz Samir R Kapadia Axel Linke Darren Mylotte Alexandra J Lansky Eberhard Grube Magnus Settergren Rishi Puri Source Type: research

Vasculitis associated with adenosine deaminase 2 deficiency: at the crossroads between Beh çet's disease and autoinflammation. A viewpoint
Reumatismo. 2023 Sep 18;75(3). doi: 10.4081/reumatismo.2023.1578.ABSTRACTAdenosine deaminase 2 deficiency (DADA2) is a rare monogenic vasculopathy caused by loss-of-function homozygous or compound heterozygous mutations in ADA2, formerly CECR1 (cat eye syndrome chromosome region 1) gene. The DADA2 phenotype is widely heterogeneous, and patients may present with fever, weight loss, livedo reticularis/racemosa, digital ischemia, cutaneous ulceration, peripheral neuropathy, abdominal pain, bowel perforation, and portal or nephrogenic hypertension. More specific manifestations include early-onset ischemic or hemorrhagic stroke...
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: A Colangelo F Tromby G Cafaro R Gerli E Bartoloni C Perricone Source Type: research

Perceived Level of Life Enjoyment and Risk of Developing Disabling Dementia: The Japan Public Health Center-Based Study
DISCUSSION: A higher level of life enjoyment was associated with a lower risk of disabling dementia, particularly in the low-medium mental stress group. This finding suggests the importance of having life enjoyment by managing mental stress for reducing risk of disabling dementia.PMID:37718836 | DOI:10.1093/geronb/gbad129
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Tomokazu Tajima Ai Ikeda Takeshi Tanigawa Hiroyasu Iso Kazumasa Yamagishi Takumi Matsumura Nobufumi Yasuda Manami Inoue Shoichiro Tsugane Norie Sawada Japan Public Health Center –Based Study Group Source Type: research

Single-center experience of endovascular treatment for patients with progressive posterior circulation cerebral infarction exceeding 24 h
CONCLUSION: In patients with progressive posterior circulation cerebral infarction caused by vertebral basilar artery occlusion, ET is effective and safe even if the time from onset to puncture exceeds 24 h.PMID:37719319 | PMC:PMC10505061 | DOI:10.2478/abm-2023-0046
Source: Biomed Res - September 18, 2023 Category: Research Authors: Guangfeng Zhao Xiongjun He Yajie Liu Liang Zhang Kaifeng Li Source Type: research

Reliability of tomographic 3D ultrasound in measuring internal carotid artery plaque volume
CONCLUSION: t3DUS is a reproducible imaging method and showed excellent agreement with the reference standard with respect to measuring CPV. These findings suggest that t3DUS has the potential to be a valuable non-invasive tool for assessing carotid plaque burden and predicting the risk of stroke.PMID:37722861 | DOI:10.1177/02841851231199222
Source: Acta Radiologica - September 18, 2023 Category: Radiology Authors: Adel Alzahrani Salahaden R Sultan Mohammed Aslam Source Type: research

Atherosclerosis as a Risk Factor for IBD: A Population-Based Case-Control Study
CONCLUSIONS: A history of an atherosclerotic-related condition is associated with increased odds of developing IBD, particularly among older adults. Future studies should investigate whether drugs targeting atherosclerotic-related inflammation may prevent IBD in higher-risk individuals.PMID:37721310 | DOI:10.14309/ajg.0000000000002502
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Adam S Faye Jordan Axelrad Jiangwei Sun Jonas Halfvarson Jonas S öderling Ola Ol én Jonas F Ludvigsson Source Type: research

Understanding the Link Between Adult Asthma and Coronary Artery Disease: A Narrative Review
Cureus. 2023 Aug 17;15(8):e43621. doi: 10.7759/cureus.43621. eCollection 2023 Aug.ABSTRACTAsthma is a common pathology worldwide that occurs due to chronic inflammation of the respiratory airways. Persistent pulmonary inflammation leads to low-grade systemic inflammation, influencing blood vessels and triggering coronary artery disease (CAD) events. This review's objectives include discussing the susceptible population for CAD, the mechanism underlying CAD creation in asthma patients, the characteristics of asthma, and the influence of anti-asthmatic medications on CAD development. Adult-onset asthma is strongly linked to ...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Vasudha S Garg Mihir H Sojitra Tyagi J Ubhadiya Nidhi Dubey Karan Shah Siddharth Kamal Gandhi Priyansh Patel Source Type: research

A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions
Microsyst Nanoeng. 2023 Sep 15;9:114. doi: 10.1038/s41378-023-00589-x. eCollection 2023.ABSTRACTThe ability of endothelial cells to respond to blood flow is fundamental for the correct formation and maintenance of a functional and hierarchically organized vascular network. Defective flow responses, in particular related to high flow conditions, have been associated with atherosclerosis, stroke, arteriovenous malformations, and neurodegenerative diseases. Yet, the molecular mechanisms involved in high flow response are still poorly understood. Here, we described the development and validation of a 96-wells fluidic system, w...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Catarina Gon çalves Fonseca V ânia Silvério David Barata Wolfgang Giese Holger Gerhardt Susana Cardoso Claudio Areias Franco Source Type: research

Role of TRPV1 in electroacupuncture-mediated signal to the primary sensory cortex during regulation of the swallowing function
CONCLUSION: The TRPV1 at CV23 after EA treatment might play a key role in mediating local blood perfusion but was not involved in transferring EA signals to the central nervous system (CNS). These findings collectively suggested that TRPV1 may be one of the important regulators involved in the mechanism of EA treatment for improving swallowing function in PSD.PMID:37718934 | DOI:10.1111/cns.14457
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Si Yuan Bo Qiu Ying Liang Bing Deng Jing Xu Xiaorong Tang Junshang Wu Sheng Zhou Zeli Li Hongzhu Li Qiuping Ye Lin Wang Shuai Cui Chunzhi Tang Wei Yi Lulu Yao Nenggui Xu Source Type: research

Neurophysiological characterization of stroke recovery: A  longitudinal TMS and EEG study
CONCLUSION: Our results demonstrate prominent clinical implications for individualized stroke rehabilitation based on both functional integrity of the ipsilesional corticomotor pathway and motor function.PMID:37718708 | DOI:10.1111/cns.14471
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Qian Ding Jixiang Chen Shunxi Zhang Songbin Chen Xiaotong Li Yuan Peng Yujie Chen Junhui Chen Kang Chen Guiyuan Cai Guangqing Xu Yue Lan Source Type: research

SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke
CONCLUSION: In summary, among four inflammatory biomarkers that we investigated, SERPINA3 level at baseline was associated with WMH severity, which revealed a novel biomarker for CSVD and validated its relationship with inflammation and endothelial dysfunction.PMID:37721405 | DOI:10.1111/cns.14472
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Xiao Hu Zhong-Song Xiao Yi-Qing Shen Wen-Song Yang Peng Wang Pei-Zheng Li Zi-Jie Wang Ming-Jun Pu Li-Bo Zhao Peng Xie Qi Li Source Type: research

Effectiveness of mid thoracic spine mobilization on postural balance and gait ability in subacute stroke patients: A randomized clinical trial
CONCLUSIONS: Mid-thoracic spine mobilization allows significant improvements in postural balance and gait ability in subacute stroke patients, with no differences between the SNAG and MM techniques.PMID:37718778 | DOI:10.3233/BMR-230144
Source: Journal of Back and Musculoskeletal Rehabilitation - September 18, 2023 Category: Orthopaedics Authors: Jinhong Kim Juchul Cho Source Type: research

Reliability and validity of the supine-to-stand test in people with stroke
CONCLUSION: The supine-to-stand test is a reliable, sensitive, specific and easy-to-administer clinical test for assessing the supine-to-stand ability of people with stroke.PMID:37721097 | DOI:10.2340/jrm.v55.12372
Source: Journal of Rehabilitation Medicine - September 18, 2023 Category: Rehabilitation Authors: Shamay S M Ng Peiming Chen Tony C W Chan Cherry H L Chang Regen H Y Cheng Kylie K L Chow Alex F M Yeung Tai-Wa Liu Lily Y W Ho Jerry W F Yeung Richard H Xu Mimi M Y Tse Source Type: research