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Association Between Calcium Supplementation and the Risk of Cardiovascular Disease and Stroke: A  Systematic Review and Meta-Analysis
Some observational studies and randomised controlled trials (RCTs) have reported an association between calcium supplementation and increased risk of cardiovascular disease. Previous meta-analyses on the topic, based on data from RCTs and observational studies, have contradictory findings. This meta-analysis was conducted to determine the difference in associated risks of calcium supplementation with cardiovascular disease and stroke in RCTs.
Source: Heart, Lung and Circulation - September 22, 2023 Category: Cardiology Authors: Ming Gin Sim, Yao Neng Teo, Yao Hao Teo, Nicholas L. Syn, Tony Y.W. Li, Leonard L.L. Yeo, William K.F. Kong, Benjamin Y.Q. Tan, James W. Yip, Raymond C.C. Wong, Kian Keong Poh, Tiong-Cheng Yeo, Vijay Kumar Sharma, Ping Chai, Mark Y. Chan, Ching-Hui Sia Tags: Original Article Source Type: research

Refining the Detection of Systemic Congestion in Severe Tricuspid Regurgitation: Echocardiography May Be  the Key
A growing number of studies have shown the independent prognostic value of tricuspid regurgitation (TR) and the direct link between TR severity and adverse outcomes.1-4 However, TR not only affects prognosis but has also a negative impact on quality of life,5-7 decreasing functional capacity and increasing systemic congestion.7,8 The systolic blood backflow through the incompetent tricuspid valve reduces the forward stroke volume and cardiac output of the right ventricle (RV). Therefore, as TR worsens, pulmonary perfusion decreases, as does the venous return of oxygenated blood from the pulmonary circulation into the left ...
Source: Journal of the American Society of Echocardiography - September 22, 2023 Category: Cardiology Authors: Federico Fortuni, Nina Ajmone Marsan Tags: Editorial Source Type: research

Perceived performance of activities of daily living by stroke patients: key in decision to call EMS and outcomes
ConclusionPerception of unimpaired performance of ADL is a crucial barrier to appropriate help-seeking behavior after acute stroke, leading to undertreatment and less improvement in clinical symptoms. Thus, beyond improving the public’s knowledge of stroke symptoms, future public education campaigns should focus on the need for calling the EMS in case of stroke symptoms even if daily activities do not seem to be severely impaired.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research

Prospective analysis of video head impulse tests in patients with acute posterior circulation stroke
ConclusionSignificantly abnormal vHIT results were rare in patients with acute PCS, even in the presence of DBS. Moreover, vHIT effectively differentiated dizziness between PCS and VN, highlighting its potential for aiding differential diagnosis of acute dizziness.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research

Alterations in the preferred direction of individual arm muscle activation after stroke
DiscussionThese findings imply that alterations in the preferred direction of individual muscle activation contribute to various aspects of motor deficit following stroke. This insight may serve as a foundation for the development of innovative stroke neurorehabilitation approaches that take into account specific attributes of individual muscle activation, including their preferred activation direction.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research

Protocol for a single-blind randomized clinical trial to test the efficacy of bilateral transcranial magnetic stimulation on upper extremity motor function in patients recovering from stroke
This study is currently in progress.Graphical Abstract
Source: Trials - September 22, 2023 Category: Research Source Type: clinical trials

Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk
Introduction Current efforts to reduce dementia focus on prevention and risk reduction by targeting modifiable risk factors. As dementia and cardiometabolic non-communicable diseases (NCDs) share risk factors, a single risk-estimating tool for dementia and multiple NCDs could be cost-effective and facilitate concurrent assessments as compared with a conventional single approach. The aim of this study is to develop and validate a new risk tool that estimates an individual’s risk of developing dementia and other NCDs including diabetes mellitus, stroke and myocardial infarction. Once validated, it could be used by the ...
Source: BMJ Open - September 22, 2023 Category: General Medicine Authors: Kootar, S., Huque, M. H., Kiely, K. M., Anderson, C. S., Jorm, L., Kivipelto, M., Lautenschlager, N. T., Matthews, F., Shaw, J. E., Whitmer, R. A., Peters, R., Anstey, K. J. Tags: Open access, Public health Source Type: research

To block or not to block: Targeting SK channels in diseased hearts
Atrial fibrillation (AF) is the most common arrhythmia, affecting more than 1% of general population and reaching over 10% in advanced age in the USA. Atrial fibrillation drastically increases the risk of stroke and promotes development of cardiomyopathy and congestive heart failure. Existing pharmacological approaches using β-blockers and inhibitors of Na+, Ca2+ and K+ channels to treat AF are effective only in 50% of cases. Furthermore, these drugs could affect ventricular tissue promoting proarrhythmic changes in electrical conduction, intracellular Ca2+ homeostasis, or action potential duration (APD).
Source: Journal of Molecular and Cellular Cardiology - September 22, 2023 Category: Cytology Authors: Dmitry Terentyev, Andriy E. Belevych, Bum-Rak Choi, Shanna Hamilton Source Type: research

The TICE Pathway: Mechanisms and Potential Clinical Applications
This article focuses on the research progress of the TICE pathway in the last few years, including the discovery process of the TICE pathway, its molecular mechanism, and potential clinical applications.Recent FindingsCholesterol homeostasis is vital for cardiovascular diseases, stroke, and neurodegenerative diseases. Beyond the cholesterol excretion via hepatobiliary pathway, TICE contributes significantly to reverse cholesterol transport ex vivo and in vivo. Nuclear receptors are ligand-activated transcription factors that regulate cholesterol metabolism. The farnesoid X receptor (FXR) and liver X receptor (LXR) activate...
Source: Current Atherosclerosis Reports - September 22, 2023 Category: Cardiology Source Type: research

Health-related quality of life in stroke survivors: a 5-year follow-up of The Fall Study of Gothenburg (FallsGOT)
There are limited data on long-term prevalence and predictors of health-related quality of life (HRQoL) in stroke survivors. Therefore, the aim was to describe the prevalence of impaired HRQoL, and to identify...
Source: BMC Geriatrics - September 22, 2023 Category: Geriatrics Authors: M årten Segerdahl, Per-Olof Hansson, Carina M. Samuelsson and Carina U. Persson Tags: Research Source Type: research

Hemispheric Asymmetry in TMS-Induced Effects on Spatial Attention: A Meta-Analysis
AbstractHemispheric asymmetry is a fundamental principle in the functional architecture of the brain. It plays an important role in attention research where right hemisphere dominance is core to many attention theories. Lesion studies seem to confirm such hemispheric dominance with patients being more likely to develop left hemineglect after right hemispheric stroke than vice versa. However, the underlying concept of hemispheric dominance is still not entirely clear. Brain stimulation studies using transcranial magnetic stimulation (TMS) might be able to illuminate this concept. To examine the putative hemispheric asymmetr...
Source: Neuropsychology Review - September 22, 2023 Category: Neuroscience Source Type: research

Protocol for a single-blind randomized clinical trial to test the efficacy of bilateral transcranial magnetic stimulation on upper extremity motor function in patients recovering from stroke
No consensus currently exists regarding the optimal protocol for repetitive transcranial magnetic stimulation (rTMS) treatment of upper-extremity motor dysfunction after stroke. Studies have shown that combine...
Source: Trials - September 22, 2023 Category: General Medicine Authors: Yuan Huang, Ruizhu Lin, Hongyu Li, Yujuan Xu, Fubao Tian, Liangchen Ma, Xiaoli Liu, Shuming Ma, Xiaolong Li, Zheying Lai, Chuanping Bai, Weichun He, Qi Ma, Jingkai Wang and Ning Zhu Tags: Study protocol Source Type: research

Fox News Host Emily Compagno Questions If Fetterman Has ‘Ability’ To Put On A Suit After Stroke
Fox News host Emily Compagno hammered Sen. John Fetterman (D-PA) for his choice to wear sloppy clothes while on Capitol Hill by questioning if he had the “ability” to put on a suit after his stroke. During the November midterm election, Fetterman had suffered a stroke in May 2022 which impaired…#emilycompagno #johnfetterman #capitolhill #pennsylvania #fetterman #foxnewshost #mediaite
Source: Reuters: Health - September 21, 2023 Category: Consumer Health News Source Type: news

Factors Affecting Physical Activity in Stroke
Condition:   Stroke Intervention:   Diagnostic Test: physical activity in stroke Sponsor:   Kırıkkale University Completed
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Tele-physiotherapy on Post-stroke Hemiplegia Patients
Conditions:   Hemiplegia;   Muscle Spasticity Intervention:   Other: Conventional Physiotherapy + telephysiotherapty Sponsors:   Universidad Católica San Antonio de Murcia;   Hermanas Hospitalarias del Sagrado Corazón de Jesús;   Hospital Universitario Virgen de la Arrixaca Completed
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials