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Total 514633 results found since Jan 2013.

Exosome-hijacking drug delivery system with branched arginine linker effectively deliver antisense oligonucleotides into lung adenocarcinoma cells
In this study, we modified ExomiR-Tracker by incorporating branched nona-D-arginines (9 + 9 mer) molecules (referred to as Branch ExomiR-Tracker) and evaluated its efficacy in lung adenocarcinoma cells (A549 cells). The improved complex formation ability and enhanced cellular uptake of anti-miR, demonstrated by our findings, highlight the advantages of incorporating branched oligoarginine peptides into the ExomiR-Tracker platform. These results represent significant progress in revealing the effectiveness of Branch ExomiR-Tracker against adhesive cancer cells, which has not been shown to be effective with the conventional ...
Source: Chemical and Pharmaceutical Bulletin - September 20, 2023 Category: Drugs & Pharmacology Authors: Shota Oyama Mao Tomita Moeka Hata Yu Mikame Tsuyoshi Yamamoto Eishi Ashihara Asako Yamayoshi Source Type: research

Insight into the effect of particulate organic matter on sludge granulation at the low organic load: Sludge characteristics, extracellular polymeric substances and microbial communities response
Bioresour Technol. 2023 Sep 18:129791. doi: 10.1016/j.biortech.2023.129791. Online ahead of print.ABSTRACTThis paper investigated the effect of particulate organic matter (POM) on sludge granulation under low organic load. The results showed that POM promoted the formation of aerobic granular sludge (AGS) with a chemical oxygen demand (COD) fraction of 25%, and POM also enhanced the sludge settleability and biomass retention. However, when the COD fraction of POM increased to 50% and 75%, the AGS performance deteriorated. The analysis of extracellular polymeric substances revealed that the POM (accounted for ≤ 50% of COD...
Source: Bioresource Technology - September 20, 2023 Category: Biotechnology Authors: Zhe Liu Rushuo Yang Dan Zhang Jiaxuan Wang Min Gao Aining Zhang Wenlong Liu Yongjun Liu Source Type: research

Exploring Highly Efficient Broadband Self-Trapped-Exciton Luminophors: from 0D to 3D Materials
Chem Rec. 2023 Sep 20:e202300241. doi: 10.1002/tcr.202300241. Online ahead of print.ABSTRACTThe review summarizes our recent reports on brightly-emitting materials with varied dimensionality (3D, 2D, 0D) synthesized using "green" chemistry and exhibiting highly efficient photoluminescence (PL) originating from self-trapped exciton (STE) states. The discussion starts with 0D emitters, in particular, ternary indium-based colloidal quantum dots, continues with 2D materials, focusing on single-layer polyheptazine carbon nitride, and further evolves to 3D luminophores, the latter exemplified by lead-free double halide perovskit...
Source: Chemical Record - September 20, 2023 Category: Chemistry Authors: Oleksandr Stroyuk Oleksandra Raievska Dietrich R T Zahn Christoph J Brabec Source Type: research

Advance Technologies in Biodegradable Flexible Solid-State Supercapacitors: A Mini Review on Clean and Sustainable Energy
Chem Rec. 2023 Sep 20:e202300226. doi: 10.1002/tcr.202300226. Online ahead of print.ABSTRACTIn the recent times research towards solid state supercapacitors (SSS) have increased drastically due to the promising performance in futuristic technologies particularly in portable and flexible electronics like smart watches, smart fabrics, foldable smartphones and tablets. Also, when compared to supercapacitors using liquid electrolyte, solid electrolyte has several advantages like high energy density, safety, high cycle life, flexible form factor, and less environmental impact. The crucial factor determining the sustainability o...
Source: Chemical Record - September 20, 2023 Category: Chemistry Authors: Himadri Tanaya Das Elango Balaji T Subhashree Mohapatra Swapnamoy Dutta Nigamananda Das Mohammed A Assiri Source Type: research

Comparative Studies of Essential Oil Composition and Biological Activities of Callistemon citrinus from western Himalaya
Chem Biodivers. 2023 Sep 20:e202301129. doi: 10.1002/cbdv.202301129. Online ahead of print.ABSTRACTThis work described a comprehensive study to estimate chemical constituents of essential oils (EOs) extracted from different parts of the Callistemon citrinus viz: fruits, leaves and aerial part. The EOs were characterized using physicochemical parameters, and GC-FID/MS. It was observed that among different parts, aerial part has the highest oil yield (0.90%) followed by leaves and fruits. Further, seventeen compounds were characterized, and represented total amount (97.2-99.5%) with domination of monoterpenes (12.5-34.6%) an...
Source: Chemistry and Biodiversity - September 20, 2023 Category: Biochemistry Authors: Sachin Vashisath Smita Kapoor Vandana Kumari Shabana Butt Dinesh Kumar Source Type: research

Structures, Bonding Analyses and Reactivity of a Dicationic Digallene and Diindene Mimicking trans-bent Ditetrylenes
Angew Chem Int Ed Engl. 2023 Sep 20:e202311648. doi: 10.1002/anie.202311648. Online ahead of print.ABSTRACTThe reaction of bisdicyclohexylphosphinoethane (dcpe) and the subvalent MI sources [MI(PhF)2][pf] (M = Ga+, In+; [pf]- = [Al(ORF)4]-; RF = C(CF3)3) yielded the salts [{M(dcpe)}2][pf]2, containing the first dicationic, trans-bent digallene and diindene structures reported so far. The non-classical MI⇆MI double bonds are surprisingly short and display a ditetrylene-like structure. The bonding situation was extensively analyzed by quantum chemical calculations, QTAIM (Quantum Theory of Atoms in Molecules) and EDA-NOCV ...
Source: Angewandte Chemie - September 20, 2023 Category: Chemistry Authors: Antoine Barth élemy Harald Scherer Michael Daub Alexis Bugnet Ingo Krossing Source Type: research

Continuous magnetic separation microfluidic chip for tumor cell < em > in vivo < /em > detection
Chem Commun (Camb). 2023 Sep 20. doi: 10.1039/d3cc04062c. Online ahead of print.ABSTRACTContinuously recording the dynamic changes of circulating tumor cells (CTCs) is crucial for tumor metastasis. This paper creates a continuous magnetic separation microfluidic chip that enables rapid and continuous in vivo cell detection. The chip shows its potential to study tumor cell circulation in the blood, offering a new platform for studying the cellular mechanism of tumor metastasis.PMID:37727113 | DOI:10.1039/d3cc04062c
Source: Chemical Communications - September 20, 2023 Category: Chemistry Authors: Man Tang Jiao Feng Hou-Fu Xia Chun-Miao Xu Ling-Ling Wu Min Wu Shao-Li Hong Gang Chen Zhi-Ling Zhang Source Type: research

Stereochemical modulation of ketyl radical cyclization enabled by pyridine-boryl radicals: catalytic diastereoselective synthesis of < em > trans < /em > -2-alkyl-1-indanols
In this report, stereochemical modulation was accomplished by taking advantage of the pyridine-boryl radical, which leaves the synthetically modifiable boronate moiety on the carbonyl oxygen near the reacting center during the stereo-determining cyclization step. In consequence, a catalytic diastereoselective synthesis of trans-2-substituted-1-indanols was achieved in the presence of a sterically congested six-membered diboronic ester and an efficient hydrogen atom donor.PMID:37727049 | DOI:10.1039/d3cc02248j
Source: Chemical Communications - September 20, 2023 Category: Chemistry Authors: Somi Kim Junhyuk Jo Sunggi Lee Won-Jin Chung Source Type: research

Target-mediated rolling circle transcription coupling with CRISPR/Cas12a-Cas13a for simultaneous detection of HPV16 and HPV18
Chem Commun (Camb). 2023 Sep 20. doi: 10.1039/d3cc04223e. Online ahead of print.ABSTRACTSimultaneous detection of multiple targets can provide important data support for clinical diagnosis and treatment. Here, we report a facile isothermal assay based on target-mediated rolling circle transcription coupling with CRISPR/Cas12a-Cas13a (TM-RCT/Cas12a-Cas13a). Through facile one-step amplification (TM-RCT), two target DNAs are converted to RNA amplified products. The simultaneous detection of HPV16 and HPV18 is then achieved by combining two CRISPR/Cas systems. This system shows excellent sensing performance and provides a uni...
Source: Chemical Communications - September 20, 2023 Category: Chemistry Authors: Shiying Zhou Shuyu Zhu Zhen Huang Jian Chen Jiawei Li Mei Yang Liang Jin Danqun Huo Changjun Hou Source Type: research

Aza-Michael Addition in Explicit Solvent: A Relative Energy Gradient - Interacting Quantum Atoms Study
Chemphyschem. 2023 Sep 20:e202300529. doi: 10.1002/cphc.202300529. Online ahead of print.ABSTRACTAza-Michael additions are key reactions in organic synthesis. We investigate, from a theoretical and computational point of view, several examples ranging from weak to strong electrophiles in dimethylsulfoxide treated as explicit solvent. We use the REG-IQA method, which is a quantum topological energy decomposition (Interacting Quantum Atoms, IQA) coupled to a chemical-interpretation calculator (Relative Energy Gradient, REG). We focus on the rate-limiting addition step in order to unravel the different events taking place in ...
Source: Chemphyschem - September 20, 2023 Category: Chemistry Authors: A ël Cador Vincent Tognetti Laurent Joubert Paul Popelier Source Type: research

Adsorption performance and kinetics of Cr(VI) onto activated carbons derived from the waste leaves of invasive plants Rhus typhina and Amorpha fruticosa
Environ Sci Pollut Res Int. 2023 Sep 20. doi: 10.1007/s11356-023-29833-7. Online ahead of print.ABSTRACTTo maximize the potential of biomass from invasive plants, waste leaves from Rhus typhina (RT) and Amorpha fruticosa (AF) were used to prepare activated carbons (ACs) for the efficient removal of chromium from wastewater. Six ACs were prepared by CO2 activation at 850 °C with varying flow rates (500, 1000, and 1500 mL/min) and characterized by yield, pH, N2 adsorption isotherm, FTIR, SEM, TG, and XPS. The adsorption isotherm and kinetics for chromium removal were analyzed. The outcomes showed that the ACs had mesoporous...
Source: Environmental Science and Pollution Research International - September 20, 2023 Category: Environmental Health Authors: Tuerxun Tuerhong Zaituniguli Kuerban Maryamgul Abdurahman Cai Xinbin Amanula Yimingniyazi Source Type: research

Metagenome meta-analysis reveals an increase in the abundance of some multidrug efflux pumps and mobile genetic elements in chemically polluted environments
The objective of the present study was to examine existing metagenomes from chemically polluted environments and evaluate whether there is evidence that pollution increases the relative abundance of genes and mobile genetic elements that are associated with antibiotic resistance. The key finding is that for some types of pollution, particularly in environments exposed to petroleum, efflux pumps are enriched, and these efflux pumps can confer resistance to multiple classes of medically important antibiotics that are typically associated with Pseudomonas spp. or other Gram-negative bacteria. This finding makes clear the need...
Source: Applied and Environmental Microbiology - September 20, 2023 Category: Microbiology Authors: Jessica Subirats Hannah Sharpe Vera Tai Michael Fruci Edward Topp Source Type: research

Biodegradability enhancement of waste lubricating oil regeneration wastewater using electrocoagulation pretreatment
Environ Sci Pollut Res Int. 2023 Sep 20. doi: 10.1007/s11356-023-29841-7. Online ahead of print.ABSTRACTAs a sustainable management of fossil fuel resources and ecological environment protection, recycling used lubricating oil has received widespread attention. However, large amounts of waste lubricating-oil regeneration wastewater (WLORW) are inevitably produced in the recycling process, and challenges are faced by traditional biological treatment of WLORW. Thus, this study investigated the effectiveness of electrocoagulation (EC) as pretreatment and its removal mechanism. The electrolysis parameters (current density, ini...
Source: Environmental Science and Pollution Research International - September 20, 2023 Category: Environmental Health Authors: Li-Li Shan Zhao Tan Yu Chen Ruo-Shan Wang Meng Zhang Chang-Long Pang Yu-Hong Cui Zhi-Min Liao Hong-Qiang Ma Ze-Bing Zhu Source Type: research

Real-time characterization of chemical threat agent aerosols for improvement of inhalation studies
CONCLUSIONS: In summary, the present work demonstrates the utility of the ELPI technology, in combination with off-line analysis, for characterizing aerosols with various size, shape, charge, and composition. This makes the aerosol generation and analysis suite described a promising tool for quantitative inhalation exposure studies.PMID:37729079 | DOI:10.1080/08958378.2023.2254323
Source: Inhalation Toxicology - September 20, 2023 Category: Respiratory Medicine Authors: Mirjam de Bruin-Hoeg ée Duurt P W Alkema Ruud W Busker Marloes J A Joosen Arjan L van Wuijckhuijse Source Type: research

Elucidating the Reaction Mechanism of Mn2+ Electrolyte Additives in Aqueous Zinc Batteries (Small 38/2023)
Aqueous Zinc BatteriesIn article number2301770, Yueliang Gu, Xiaochuan Ren, Daming Zhu, Jianxin Zou, and co-workers elucidate the reaction mechanism of Mn2+ electrolyte additives in aqueous zinc batteries (ZIBs) via operando synchrotron X-ray diffraction, ex situ X-ray absorption spectroscopy and electrochemical analyses. A reversible Mn2+/MnO2 deposition/dissolution reaction occurred at the cathode, in which the change in the electrolyte environment enabled Zn2+/Zn4SO4(OH)6•5H2O deposition/dissolution. The chemical reaction of Zn2+/Zn4SO4(OH)6•5H2O contributes no capacity and hinders the diffusion kinetics of the Mn2+...
Source: Small - September 20, 2023 Category: Nanotechnology Authors: Zhao Li, Yi Li, Xiaochuan Ren, Yuanxin Zhao, Zhiguo Ren, Zeyin Yao, Wei Zhang, Hao Xu, Zhong Wang, Nian Zhang, Yueliang Gu, Xiaolong Li, Daming Zhu, Jianxin Zou Tags: Frontispiece Source Type: research