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Total 514633 results found since Jan 2013.
Advance in vasculogenic mimicry in ovarian cancer (Review)
Oncol Lett. 2023 Sep 5;26(4):456. doi: 10.3892/ol.2023.14043. eCollection 2023 Oct.ABSTRACTOvarian cancer (OC) is a common and highly prevalent malignant tumor in women, associated with a high mortality rate, easy recurrence and easy metastasis, which is predominantly at an advanced stage when detected in patients. This renders the cancer more difficult to treat, and consequently it is also associated with a low survival rate, being the malignancy with the highest mortality rate among the various gynecological tumors. As an important factor affecting the development and metastasis of OC, understanding the underlying mechan...
Source: Oncology Letters - September 22, 2023 Category: Cancer & Oncology Authors: Xinyuan Tian Qin Si Menghe Liu Jianping Shi Rongwei Zhao Yang Xiong Lei Yu Hongwei Cui Haibin Guan Source Type: research
Preparation of poly(acrylic acid)/tricalcium phosphate nanoparticles scaffold: Characterization and releasing UC-MSCs derived exosomes for bone differentiation
CONCLUSION: The current research is the first study fabricating a multiscale scaffold using triCaPNPs in the substrate of PPA polymer using a cross-linker and freeze-drying process. This scaffold could mimic the nanoscale structure and chemical combination of native bone minerals. In addition, our results suggest that the PAA/triCaPNPs scaffold could be beneficial to achieve controlled exosome release for exosome-based therapy in bone tissue engineering.PMID:37736343 | PMC:PMC10509736 | DOI:10.34172/bi.2022.24142
Source: BioImpacts - September 22, 2023 Category: Research Authors: Nahid Moradi Saeid Kaviani Mina Soufizomorrod Simzar Hosseinzadeh Masoud Soleimani Source Type: research
Autophagy induced macrophages by α-alumina(α-AL2O3) conjugated cysteine peptidase, enhances the cytotoxic activity of CD8 < sup > + < /sup > T lymphocytes against < em > Leishmania major < /em >
CONCLUSION: α-AL2O3 nanoparticles enhance the cross-presentation of L. major antigens to CD8+ T cells by inducing autophagy. This finding supports the positive role of autophagy and encourages the use of α-AL2O3 in vaccine design.PMID:37736336 | PMC:PMC10509742 | DOI:10.34172/bi.2023.25282
Source: BioImpacts - September 22, 2023 Category: Research Authors: Fatemeh Beyzay Ahmad Zavaran Hosseini Ali Hazrati Mozhdeh Karimi Sara Soudi Source Type: research
Determination of urinary deanol ‐N‐oxide excretion profiles after ingestion of nutritional supplements containing deanol
An analytical approach employing LC –MS/MS was developed to provide first data on urinary levels of deanol-N-oxide at baseline and after the administration of deanol or meclofenoxate in humans. After a single oral dose of deanol or meclofenoxate, considerable increases of the metabolite deanol-N-oxide are observed, reaching cmax levels at 2 –5 h post-administration. Abstract2-(Dimethylamino)ethan-1-ol (Deanol) is a widely produced chemical used by both industry and consumers in a variety of applications. Meclofenoxate, a stimulant classified on the World Anti-Doping Agency Prohibited List, metabolizes into deanol and, ...
Source: Drug Testing and Analysis - September 22, 2023 Category: Drugs & Pharmacology Authors: Oliver Krug,
Sven Guddat,
Christian G örgens,
Thomas Piper,
Tristan Möller,
Mario Thevis Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
High ytterbium concentration Yb/Al/P/Ce co-doped silica fiber for 1- µ m ultra-short cavity fiber laser application
We demonstrate a high ytterbium concentration Yb/Al/P/Ce co-doped silica fiber by conventional modified chemical vapor deposition (MCVD) ...
Source: Optics Express - September 22, 2023 Category: Physics Authors: Qiubai Yang Yafei Wang Chunlei Yu Fan Wang Mengting Guo Lei Zhang Chongyun Shao Meng Wang Hui Shen Yunfeng Qi Lili Hu Source Type: research
Non-chemical signalling between mitochondria
A wide variety of studies have reported some form of non-chemical or non-aqueous communication between physically isolated organisms, eliciting changes in cellular proliferation, morphology, and/or metabolism. The sources and mechanisms of such signalling pathways are still unknown, but have been postulated to involve vibration, volatile transmission, or light through the phenomenon of ultraweak photon emission. Here, we report non-chemical communication between isolated mitochondria from MCF7 (cancer) and MCF10A (non-cancer) cell lines. We found that mitochondria in one cuvette stressed by an electron transport chain inhi...
Source: Frontiers in Physiology - September 22, 2023 Category: Physiology Source Type: research
Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct
Introduction
Multiple chemical sensitivity (MCS) has been characterised by reported adverse responses to environmental exposures of common chemical agents (eg, perfumes, paint, cleaning products and other inhaled or ingested agents) in low doses considered non-toxic for the general population. There is currently no consensus on whether MCS can be established as a distinct disorder.
Methods and analysis
The scoping review of the literature will be guided by five questions: How is MCS defined and which diagnostic criteria have been proposed? What methods are used to report prevalence and incidence estimates of MCS? What are...
Source: BMJ Open - September 22, 2023 Category: General Medicine Authors: Hempel, S., Danz, M., Robinson, K. A., Bolshakova, M., Rodriguez, J., Mears, A., Pham, C., Yagyu, S., Motala, A., Tolentino, D., Akbari, O., Johnston, J. Tags: Open access, Diagnostics Source Type: research
Antimicrobial efficacy of different herbal extracts against root canal pathogens - An in vitro study
Conclusion: There was a greater efficacy of Eucalyptus galbie extract than other extracts.
Source: Indian Journal of Dental Research - September 22, 2023 Category: Dentistry Authors: Maryam Raoof Mohammad H Zadeh Zahra E Nejad Fariba Sharififar Mansooreh Khodashenas Rahim Fereidooni Source Type: research
Molecules, Vol. 28, Pages 6771: Longitudinal Plant Health Monitoring via High-Resolution Mass Spectrometry Screening Workflows: Application to a Fertilizer Mediated Tomato Growth Experiment
omaidis
Significant efforts have been spent in the modern era towards implementing environmentally friendly procedures like composting to mitigate the negative effects of intensive agricultural practices. In this context, a novel fertilizer was produced via the hydrolysis of an onion-derived compost, and has been previously comprehensively chemically characterized. In order to characterize its efficacy, the product was applied to tomato plants at five time points to monitor plant health and growth. Control samples were also used at each time point to eliminate confounding parameters due to the plant&rsquo;s nor...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Anthi Panara Evagelos Gikas Anastasia Koupa Nikolaos S. Thomaidis Tags: Article Source Type: research
Molecules, Vol. 28, Pages 6770: Chemical Characterization of Polysaccharide Extracts Obtained from Pomace By-Products of Different White Grape Varieties
ariño
Grape pomace is one of the main by-products in the wine industry and contains some high-added-value compounds, such as polysaccharides. Considering the wide application possibilities of polysaccharides in wine and in the food industry, the revalorization of grape pomace to extract polysaccharides presents itself as an opportunity for by-product management. Therefore, the aim of this study was to characterize polysaccharide extracts obtained from pomace by-products of different white grape varieties. The type and content of polysaccharides, proteins and phenols were analyzed. Statistically significant differences...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Mar ía Curiel-Fernández Marta Bueno-Herrera Zenaida Guadalupe Bel én Ayestarán Silvia P érez-Magariño Tags: Article Source Type: research
Molecules, Vol. 28, Pages 6767: Antioxidant Properties and Secondary Metabolites Profile of Hyptis colombiana at Various Phenological Stages
In this study, H. colombiana plants at different phenological stages (vegetative, flowering, and post-flowering) were harvested to obtain essential oils (EOs) and extracts (from fresh plant materials or post-distillation waste) whose chemical compositions and antioxidant activities were determined. H. colombiana EOs distilled by microwave-assisted hydrodistillation were analyzed by GC/MS/FID, and hydroalcoholic extracts obtained from fresh plant materials or post-distillation waste were analyzed by UHPLC-ESI+/&minus;-Orbitrap-MS. The antioxidant activity was evaluated by the ABTS+&bull; and ORAC assays. The...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Sheila B. Beltr án Lady J. Sierra Jos é L. Fernández-Alonso Angie K. Romero Jairo R. Mart ínez Elena E. Stashenko Tags: Article Source Type: research
Molecules, Vol. 28, Pages 6749: Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using Dendrobium anosmum and Its Effect on Acne Vulgaris
In this study, biogenically synthesized zinc oxide nanoparticles using Dendrobium anosum are used as a reducing and capping agent for topical anti-acne nanogels, and the antimicrobial effect of the nanogel is assessed on Cutibacterium acne and Staphylococcus aureus. Dendrobium anosmum leaf extract was examined for the presence of secondary metabolites and its total amount of phenolic and flavonoid content was determined. Both the biogenically and chemogenic-synthesized zinc oxide nanoparticles were compared using UV-Visible spectrophotometer, FE-SEM, XRD, and FTIR. To produce the topical nanogel, the biogenic and chemogeni...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Yu Yang Tan Ling Shing Wong Kar Lin Nyam Kitiyaporn Wittayanarakul Nurliyana Ahmad Zawawi Kavitha Rajendran Sinovassane Djearamane Anto Cordelia Tanislaus Antony Dhanapal Tags: Article Source Type: research
Molecules, Vol. 28, Pages 6761: Substrate-Controlled Diversity-Oriented Synthesis of Novel Polycyclic Frameworks via 4 + 2 and 3 + 2 Annulations of Ninhydrin-Derived MBH Adducts with 3,4-Dihydroisoquinolines
Rongxiang Chen
Substrate-controlled diversity-oriented synthesis of polycyclic frameworks via [4 + 2] and [3 + 2] annulations between ninhydrin-derived Morita&ndash;Baylis&ndash;Hillman (MBH) adducts and 3,4-dihydroisoquinolines under similar reaction conditions have been developed. The reaction provides diversity-oriented synthesis of a series of novel and structurally complex spiro multi heterocyclic skeletons in good yields (up to 87% and 90%, respectively) with excellent diastereoselectivities (up to &gt;25:1 dr). In particular, the switchable [4 + 2] and [3 + 2] annulation reactions are co...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Kaikai Wang Wenwen Zhou Jun Jia Junwei Ye Mengxin Yuan Jie Yang Yonghua Qi Rongxiang Chen Tags: Article Source Type: research
Evaluation of probiotic growth stimulation using prebiotic ingredients to optimize compounds for in ovo delivery
In this study, we analyzed 7 poultry probiotics (Lactobacillus plantarum – B1 and B4, Lactobacillus rhamnosus – B3, Bifidobacterium lactis – B2, Carnobacterium divergens – B5, Propionibacterium thoenii – B6, Clostridium butyricum – B7) and 12 prebiotics, differing in chemical composition and source of origin (fungi, algae, animal, etc.). The main goal of our research was to select the most promising candidates to develop synbiotic combinations. We determined the growth kinetics of all probiotics in the presence of prebiotics in a series of in vitro studies to select optimal combinations. Five out of seven inves...
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
Effects of a novel microbial fermentation medium produced by Tremella aurantialba SCT-F3 on cigar filler leaf
ConclusionThis research provides not only a new microbial fermentation medium that utilizes edible and medicinal fungi to improve the quality of fermented CFLs, but also new ideas for the development and application of other edible medicinal fungi to improve the quality of cigar tobacco leaves.
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
