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Total 514633 results found since Jan 2013.

Graph Attention Network based mapping of knowledge relations between chemical spaces of Nuclear factor kappa B and Centella asiatica
This study aims to explore the regulatory nature of the molecules from the inhibition and activation of the NF-κB bioassay data set and map this information for a knowledge-based analysis against the molecules of CA, a low-growing tropical plant. This finding has led to a new direction in the field, transitioning from the conventional active-inactive framework to a more comprehensive active-inactive-regulatory model. This approach can be thoroughly explored by leveraging a graph-based deep learning system. The study presents an innovative approach using a Graph Attention Network (GAT) to rank CA molecules in chemical spac...
Source: Computational Biology and Chemistry - September 21, 2023 Category: Bioinformatics Authors: Vivek P Mithun Mohanan Shajil U K Sandesh E Pa Jaleel U C A Source Type: research

Toxicological profiling of a de novo synthesized benzimidazole derivative with potent and selective proapoptotic potentials against breast cancer
This study aimed to investigate the toxicological profile of 1-(6-(1H-benzo[d]imidazole-2-yl)-2-methylpyridin-3-yl) ethanone (BMPE), both in vitro and in vivo. The proapoptotic/necrotic and cell cycle arrest potentials of BMPE were assessed in MCF-7 cell line. The in vivo toxicology was assessed in female Balb/c mice by repeated dosing of 5, 25, and 50 mg/kg for 21 consecutive days, then different biochemical, inflammatory, and oxidative markers were assessed in sera/tissue homogenates of treated animals. The new derivative showed a potent selective cytotoxicity against malignant cell lines with IC50 value 0.2 μM/mL, whil...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Ebtehal K Farrag Wessam M Aziz Sylvia E Shaker Heba Shawky Dalia B Fayed Source Type: research

Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells
Bioorg Chem. 2023 Sep 18;141:106873. doi: 10.1016/j.bioorg.2023.106873. Online ahead of print.ABSTRACTMetastasis is the leading cause of cancer-related mortality, targeting angiogenesis emerges as a therapeutic strategy for the treatment of melanoma metastasis. Discovery of new antiangiogenic compounds with specific mechanism of action is still desired. In present study, a bioassay-guidance uncovers the EtOAc extract of a marine-derived fungus Aspergillus clavutus LZD32-24 with significant inhibitory activity against the angiogenesis in Tg (fli1a: EGFP) zebrafish model. Extensive chromatographic fractionation led to the is...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Xingchen Guo Aili Fan Xinyi Qi Dong Liu Jian Huang Wenhan Lin Source Type: research

In vitro, in vivo, and in silico evaluation of the glucocorticoid receptor antagonist activity of 3,6-dibromocarbazole
Food Chem Toxicol. 2023 Sep 19:114048. doi: 10.1016/j.fct.2023.114048. Online ahead of print.ABSTRACT3,6-Dibromocarbazole is a novel environmental contaminant which is currently detected in several environmental media worldwide. This work aims to investigate the anti-glucocorticoid potency and endocrine disrupting effects of 3,6-dibromocarbazole. In vitro experiments indicated that 3,6-dibromocarbazole possessed glucocorticoid receptor (GR) antagonistic activity and inhibited dexamethasone-induced GR nuclear translocation. 3,6-Dibromocarbazole reduced the expression levels of glucocorticoid responsive genes including gluco...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Haoyang Zou Jia Yu Zhuolin Li Yao Liu Tuoyi Wang Tiezhu Li Chengyu Lv Jie Zhang Source Type: research

Piperlongumine induces apoptosis and autophagy via the PI3K/Akt/mTOR pathway in KB human cervical cancer cells
Food Chem Toxicol. 2023 Sep 19:114051. doi: 10.1016/j.fct.2023.114051. Online ahead of print.ABSTRACTNatural products are continuously being researched to develop safe and effective treatment options for cervical cancer, the fourth most common cancer in women. Piperlongumine (PL), an amide alkaloid mainly present in long pepper, exhibits neuroprotective and anti-cancer properties. However, the specific effect of PL in cervical cancer and the relationship between the anti-cancer pathway and autophagy remain unclear. Therefore, we aimed to investigate PL-induced apoptosis in KB human cervical cancer cells and the relationshi...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Eun-Ji Han Eun-Young Choi Su-Ji Jeon Sang-Woo Lee Jun-Mo Moon Soo-Hyun Jung Bumseok Kim Sung-Dae Cho Jeong-Seok Nam Changsun Choi Jeong-Hwan Che Ji-Youn Jung Source Type: research

Oridonin ameliorates doxorubicin induced-cardiotoxicity via the E2F1/Sirt6/PGC1 α pathway in mice
This study investigates the protective effect of Ori against DIC and elucidates its underlying molecular mechanisms. The results demonstrate that Ori significantly alleviated DIC by improving myocardial structure, reducing the proportion of apoptotic cells, and alleviating the myocardial oxidative damage and mitochondrial dysfunction both in vivo and in vitro. Doxorubicin significantly decreased Sirt6 and PGC1α levels in cardiac tissues, which was reversed by Ori. Furthermore, Sirt6 overexpression significantly improved myocardial structure and reduced the proportion of apoptotic cells by reducing oxidative stress and imp...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Dongsheng Yu Jiye Li Yu Wang Danfeng Guo Chunsheng Zhu Bao Sun Zheng Zhou Source Type: research

On the evaluation of the antimicrobial effect of grape seed extract and cold atmospheric plasma on the dynamics of Listeria monocytogenes in novel multiphase 3D viscoelastic models
Int J Food Microbiol. 2023 Sep 12;406:110395. doi: 10.1016/j.ijfoodmicro.2023.110395. Online ahead of print.ABSTRACTThe demand for products that are minimally processed and produced in a sustainable way, without the use of chemical preservatives or antibiotics have increased over the last years. Novel non-thermal technologies such as cold atmospheric plasma (CAP) and natural antimicrobials such as grape seed extract (GSE) are attractive alternatives to conventional food decontamination methods as they can meet the above demands. The aim of this study was to investigate the microbial inactivation potential of GSE, CAP (in t...
Source: International Journal of Food Microbiology - September 21, 2023 Category: Food Science Authors: Melina Kitsiou Lisa Purk Christina Ioannou Thomas Wantock Gavin Sandison Thomas Harle Jorge Gutierrez-Merino Oleksiy V Klymenko Eirini Velliou Source Type: research

Liquid chromatographic retention time prediction models to secure and improve the feature annotation process in high-resolution mass spectrometry
Talanta. 2023 Sep 17;267:125214. doi: 10.1016/j.talanta.2023.125214. Online ahead of print.ABSTRACTThe development of quantitative structure-retention relationship (QSRR) models has, until recently, required an adequate selection of molecular descriptors necessarily obtained based on a known chemical structure. However, these complex descriptors are not always available nor calculable when the high-resolution mass spectrometry (HRMS) annotation process is underway. Depending on the level of annotation, many structures or even various molecular formulas could be candidates. To secure and improve the annotation process and t...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Julien Parinet Yassine Makni Thierno Diallo Thierry Gu érin Source Type: research

Mutagenic sensitivity, effectiveness and efficiency of gamma rays and ethyl methane sulphonate on soft and semi-hard bread wheat ( < em > Triticum aestivum < /em > L.) varieties in the north-western Himalayan climate
CONCLUSIONS: It was found that semi-hard textured varieties showed higher sensitivity to chemical mutagens as compared to soft-textured varieties. Gamma irradiation dose of 250-300 Gy and ethyl methane sulphonate concentration of 0.7-1.3% were found to be most effective and efficient across four bread wheat varieties and can be used in large scale mutagenesis programmes.PMID:37734005 | DOI:10.1080/09553002.2023.2261527
Source: International Journal of Radiation Biology - September 21, 2023 Category: Radiology Authors: Amit Rana Vijay Rana Vinod Kumar Sood Suman Bakshi None Priyanka Source Type: research

Development of Thiol-Ene Reaction-Based HA Hydrogel with Sustained Release of EGF for Enhanced Skin Wound Healing
This study develops a novel drug delivery system using a hyaluronic acid (HA) hydrogel for controlled release of epidermal growth factor (EGF) to enhance skin wound healing. Conventional hydrogel-based methods suffer from a burst release and limited drug delivery times. To address this, we employ bioconjugation to introduce an acrylate group to EGF, enabling chemical bonding to the HA hydrogel matrix through thiol-ene cross-linking. This approach results in sustained-release delivery of EGF based on the degradation rate of the HA matrix, overcoming diffusion-based limitations. We confirm the introduction of the acrylate gr...
Source: Biomacromolecules - September 21, 2023 Category: Biochemistry Authors: Yerin Lee Saebin Lim Ji An Kim Yoon Hong Chun Hyun Jong Lee Source Type: research

Tannin-Assisted Synthesis of Nanocomposites Loaded with Silver Nanoparticles and Their Multifunctional Applications
Biomacromolecules. 2023 Sep 21. doi: 10.1021/acs.biomac.3c00737. Online ahead of print.ABSTRACTNanocomposites have been widely used in many important areas due to their particular physical/chemical properties; however, just though a simple technology, endowing multiple functions into a single nanomaterial for realizing their multifunctional applications is still a challenge. Here, we report a robust method for the facile synthesis of Ag-based multifunctional nanocomposites via using tannin-coated phenol-formaldehyde resin nanospheres (TA-PFRN) as silver nanoparticle (Ag NP) carriers. The thickness of the tannin coating is ...
Source: Biomacromolecules - September 21, 2023 Category: Biochemistry Authors: Mengyao Xia Weikun Jiang Chen Wu Chao Wang Chang Geun Yoo Yu Liu Gaojin Lyu Source Type: research

Phenomenological interpretations of the mechanism for the concentration-dependent positive effect of antibiotic lincomycin on < em > Streptomyces coelicolor < /em > A3(2)
Appl Environ Microbiol. 2023 Sep 21:e0113323. doi: 10.1128/aem.01133-23. Online ahead of print.ABSTRACTThe antibiotic lincomycin binds to the 23S ribosomal RNA peptidyl transferase loop region to inhibit protein synthesis. However, lincomycin can also stimulate the growth and secondary metabolism of actinomycetes in a concentration-dependent manner. In Streptomyces coelicolor A3(2), lincomycin stimulates the production of the blue-pigmented antibiotic actinorhodin at concentrations below the minimum inhibitory concentration. To better understand the molecular mechanism underlying these concentration-dependent positive effe...
Source: Applied and Environmental Microbiology - September 21, 2023 Category: Microbiology Authors: Keiichiro Mukai Tomoko Shibayama Yu Imai Takeshi Hosaka Source Type: research

Progress advances in the production of bio-sourced methionine and its hydroxyl analogues
Biotechnol Adv. 2023 Sep 19:108259. doi: 10.1016/j.biotechadv.2023.108259. Online ahead of print.ABSTRACTThe essential sulphur-containing amino acid, methionine, is becoming a mass-commodity product with an annual production that exceeded 1,500,000 tons in 2018. This amino acid is today almost exclusively produced by chemical process from fossil resources. The environmental problems caused by this industrial process, and the expected scarcity of oil resources in the coming years, have recently accelerated the development of bioprocesses for producing methionine from renewable carbon feedstock. After a brief description of ...
Source: Biotechnology Advances - September 21, 2023 Category: Biotechnology Authors: Jean Marie Fran çois Source Type: research

Magnetic Nanoparticles: A Review on Synthesis, Characterization, Functionalization, and Biomedical Applications
This review outlines diverse magnetic nanoparticle (MNP) designs, materials, morphologies, and characterization methods. It assesses various MNP synthesis techniques, their pros and cons, and explores inorganic and organic surface coatings. Biomedical MNP applications are covered, spanning hyperthermia, MRI, drug delivery, biosensors, and magnetic particle imaging. Future MNP structure trends and novel biomedical prospects are also discussed. AbstractNowadays, magnetic nanoparticles (MNPs)  are applied in numerous fields, especially in biomedical applications. Since biofluidic samples and biological tissues are nonmagneti...
Source: Small - September 21, 2023 Category: Nanotechnology Authors: Bahareh Rezaei, Parsa Yari, Sean M. Sanders, Haotong Wang, Vinit Kumar Chugh, Shuang Liang, Shahriar Mostufa, Kanglin Xu, Jian ‐Ping Wang, Jenifer Gómez‐Pastora, Kai Wu Tags: Review Source Type: research

Graphene ‐Coated Ni–Cu Alloys for Durable Degradation Resistance of Bi‐Polar Plates for Proton Exchange Membrane Fuel Cells: Remarkable Role of Alloy Composition
This study demonstrates graphene coating developed by chemical vapor deposition on a pure Ni-Cu alloy to provide remarkably superior corrosion resistance in 0.5m H2SO4 than the coating on a commercial Ni-Cu alloy. AbstractBipolar plates, a critical component of proton exchange membrane fuel cell (PEMFC), are constructed out of alloys of Ti, Pt, Cr, or graphitic materials that have limitations. Electrical conductivity, cost, and corrosion resistance are among the critical considerations for bi-polar plate material. Graphene, which possesses impressive conductivity and toughness, is an attractive option as coating on metalli...
Source: Small - September 21, 2023 Category: Nanotechnology Authors: Abhishek Kumar Arya, R.K. Singh Raman, Rahul Parmar, Matteo Amati, Luca Gregoratti, Sumit Saxena Tags: Research Article Source Type: research