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Total 514633 results found since Jan 2013.
Target immobilization on glass microfiber membranes as a label-free strategy for hit identification
Anal Bioanal Chem. 2023 Sep 21. doi: 10.1007/s00216-023-04951-w. Online ahead of print.ABSTRACTThe discovery of novel chemical entities targeting G protein-coupled receptors (GPCRs) is usually guided by their receptor affinity. However, traditional affinity assay methods and hit identification procedures are usually laborious and expensive. In this work, the type-2 vasopressin receptor (V2R) was chosen as a prototypical GPCR. Membrane fragments from cells highly expressing SNAP-V2R were immobilized on the surface of a glass microfiber (GMF) coated with O6-benzylguanine (BG). This was achieved by transferring the benzyl gro...
Source: Analytical and Bioanalytical Chemistry - September 21, 2023 Category: Chemistry Authors: Yinan Wang Yan He Xiaojiao Ye Yixiao Zhang Xiuxiu Huang Hongli Liu Wenqing Dong Dongzhi Yang Dong Guo Source Type: research
Investigation on Cr(VI)-bioreduction mechanism and reduction products by a novel Microbacterium sp. strain NEAU-W11
In this study, a novel Cr(VI)-reducing strain, Microbacterium sp. NEAU-W11, was reported, and its reduction mechanism was investigated. Microbacterium sp. NEAU-W11 could effectively degrade Cr(VI) under the conditions of pH 7-10, 15-35 °C, and the coexistence of metal pollutants such as Pb and Ni, etc. In addition, both Fe3+ and Cu2+ could improve the reducing ability of strain NEAU-W11, and glucose and lactose as electron donors also had promoting effect. Heat treatment of resting cells confirmed that chromium removal was not biological sorption but biological reduction. The active reductase of strain NEAU-W11 to chromiu...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Tingting Li Dandan Du Chenxu Li Junlei Zhao Lifeng Guo Xiangjing Wang Junwei Zhao Wensheng Xiang Source Type: research
Complementarity of plasma and stool for the characterization of children's exposure to halogenated flame retardants: Update on analytical methods and application to a Canadian cohort
Chemosphere. 2023 Sep 19:140222. doi: 10.1016/j.chemosphere.2023.140222. Online ahead of print.ABSTRACTSixteen halogenated flame retardants including Polybrominated diphenyl ethers (PBDEs), Dechlorane-like compounds, and emerging halogenated flame retardants were measured in stool and plasma samples from children aged 8.9-13.8 years old. Samples were obtained from a Canadian cohort investigating the effect of contaminants on children's neurodevelopment in the Estrie region, Québec, Canada. The method for stool analysis developed for this study showed good recovery for all targeted compounds (73%-93%) with associated relat...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Guillaume Martinez Jiping Zhu Larissa Takser Andrea A Baccarelli Jean-Philippe Bellenger Source Type: research
Sustainable remediation of toxic Congo red dye pollution using bio based carbon nanocomposite: Modelling and performance evaluation
Chemosphere. 2023 Sep 19:140206. doi: 10.1016/j.chemosphere.2023.140206. Online ahead of print.ABSTRACTRemediation of synthetic dyes found in aqueous environment poses a serious challenge for treatment due to their resistance to chemical and biological degradation. This research study investigated the application of Chitosan-ZnO-Seaweed bio nanocomposite in the remediation of congo red. The novel bionanocomposite was characterised by FTIR, SEM, TEM, EDS and XRD studies. The FTIR spectra and SEM images indicated the adsorption of congo red onto the synthesized bionanocomposite. The batch wise experimental studies were done ...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Sarojini Gopalakrishnan Pownsamy Kannan Kuppusamy Balasubramani Natarajan Rajamohan Manivasagan Rajasimman Source Type: research
Performance of volatile fatty acids production from food waste at the presence of alkyl ethoxy polyglycosides and sodium dodecyl sulfate
This study investigated the performance of VFAs production from food waste at the presence of alkyl ethoxy polyglycosides (AEG) and sodium dodecyl sulfate (SDS). The highest yield of VFAs was obtained at 0.1 g AEG/g TS (14.53 g COD/L), which increased by 25.80% than the Blank. But inhibited phenomenon was observed at other reactors with relatively low yield and delayed fermentation time. The inhibition of lactate's production and bioconversion delayed the fermentation time, and SDS has changed the acidogenic fermentation type from lactate-butyrate fermentation to acetate fermentation. In addition, more organic matter disso...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Cui Quan Changxiang Chen Xinggang Li Ningbo Gao Source Type: research
Investigation on Cr(VI)-bioreduction mechanism and reduction products by a novel Microbacterium sp. strain NEAU-W11
In this study, a novel Cr(VI)-reducing strain, Microbacterium sp. NEAU-W11, was reported, and its reduction mechanism was investigated. Microbacterium sp. NEAU-W11 could effectively degrade Cr(VI) under the conditions of pH 7-10, 15-35 °C, and the coexistence of metal pollutants such as Pb and Ni, etc. In addition, both Fe3+ and Cu2+ could improve the reducing ability of strain NEAU-W11, and glucose and lactose as electron donors also had promoting effect. Heat treatment of resting cells confirmed that chromium removal was not biological sorption but biological reduction. The active reductase of strain NEAU-W11 to chromiu...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Tingting Li Dandan Du Chenxu Li Junlei Zhao Lifeng Guo Xiangjing Wang Junwei Zhao Wensheng Xiang Source Type: research
Complementarity of plasma and stool for the characterization of children's exposure to halogenated flame retardants: Update on analytical methods and application to a Canadian cohort
Chemosphere. 2023 Sep 19:140222. doi: 10.1016/j.chemosphere.2023.140222. Online ahead of print.ABSTRACTSixteen halogenated flame retardants including Polybrominated diphenyl ethers (PBDEs), Dechlorane-like compounds, and emerging halogenated flame retardants were measured in stool and plasma samples from children aged 8.9-13.8 years old. Samples were obtained from a Canadian cohort investigating the effect of contaminants on children's neurodevelopment in the Estrie region, Québec, Canada. The method for stool analysis developed for this study showed good recovery for all targeted compounds (73%-93%) with associated relat...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Guillaume Martinez Jiping Zhu Larissa Takser Andrea A Baccarelli Jean-Philippe Bellenger Source Type: research
Sustainable remediation of toxic Congo red dye pollution using bio based carbon nanocomposite: Modelling and performance evaluation
Chemosphere. 2023 Sep 19:140206. doi: 10.1016/j.chemosphere.2023.140206. Online ahead of print.ABSTRACTRemediation of synthetic dyes found in aqueous environment poses a serious challenge for treatment due to their resistance to chemical and biological degradation. This research study investigated the application of Chitosan-ZnO-Seaweed bio nanocomposite in the remediation of congo red. The novel bionanocomposite was characterised by FTIR, SEM, TEM, EDS and XRD studies. The FTIR spectra and SEM images indicated the adsorption of congo red onto the synthesized bionanocomposite. The batch wise experimental studies were done ...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Sarojini Gopalakrishnan Pownsamy Kannan Kuppusamy Balasubramani Natarajan Rajamohan Manivasagan Rajasimman Source Type: research
Chemical biology tools for protein labelling: insights into cell-cell communication
Biochem J. 2023 Sep 27;480(18):1445-1457. doi: 10.1042/BCJ20220309.ABSTRACTMulticellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell-cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to unders...
Source: The Biochemical Journal - September 21, 2023 Category: Biochemistry Authors: Megan H Wright Source Type: research
Performance of volatile fatty acids production from food waste at the presence of alkyl ethoxy polyglycosides and sodium dodecyl sulfate
This study investigated the performance of VFAs production from food waste at the presence of alkyl ethoxy polyglycosides (AEG) and sodium dodecyl sulfate (SDS). The highest yield of VFAs was obtained at 0.1 g AEG/g TS (14.53 g COD/L), which increased by 25.80% than the Blank. But inhibited phenomenon was observed at other reactors with relatively low yield and delayed fermentation time. The inhibition of lactate's production and bioconversion delayed the fermentation time, and SDS has changed the acidogenic fermentation type from lactate-butyrate fermentation to acetate fermentation. In addition, more organic matter disso...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Cui Quan Changxiang Chen Xinggang Li Ningbo Gao Source Type: research
Recent advances and future perspective on lignocellulose-based materials as adsorbents in diverse water treatment applications
Int J Biol Macromol. 2023 Sep 19:126984. doi: 10.1016/j.ijbiomac.2023.126984. Online ahead of print.ABSTRACTThe growing shortage of non-renewable resources and the burden of toxic pollutants in water have gradually become stumbling blocks in the path of sustainable human development. To this end, there has been great interest in finding renewable and environmentally friendly materials to promote environmental sustainability and combat harmful pollutants in wastewater. Of the many options, lignocellulose, as an abundant, biocompatible and renewable material, is the most attractive candidate for water remediation due to the ...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Weidong Xiao Ran Sun Sihai Hu Chengzhen Meng Bin Xie Mengying Yi Yaoguo Wu Source Type: research
Design and Synthesis of a Library of C2-Substituted Sulfamidoadenosines to Probe Bacterial Permeability
Bioorg Med Chem Lett. 2023 Sep 19:129486. doi: 10.1016/j.bmcl.2023.129486. Online ahead of print.ABSTRACTAntibiotic resistance is a major threat to public health, and Gram-negative bacteria pose a particular challenge due to their combination of a low permeability cell envelope and efflux pumps. Our limited understanding of the chemical rules for overcoming these barriers represents a major obstacle in antibacterial drug discovery. Several recent efforts to address this problem have involved screening compound libraries for accumulation in bacteria in order to understand the structural properties required for Gram-negative...
Source: Bioorganic and Medicinal Chemistry Letters - September 21, 2023 Category: Chemistry Authors: Shibin Zhao Julian Maceren Mia Chung Samantha Stone Raphael Gei ßen Melissa S Boby Bradley S Sherborne Derek S Tan Source Type: research
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties
Eur J Med Chem. 2023 Sep 12;261:115803. doi: 10.1016/j.ejmech.2023.115803. Online ahead of print.ABSTRACTNeurodegenerative processes characterizing Alzheimer's disease (AD) are strictly related to the impairment of cholinergic and glutamatergic neurotransmitter systems which provoke synaptic loss. These experimental evidences still represent the foundation of the actual standard-of-care treatment for AD, albeit palliative, consisting on the coadministration of an acetylcholinesterase inhibitor and the NMDAR antagonist memantine. In looking for more effective treatments, we previously developed a series of galantamine-meman...
Source: European Journal of Medicinal Chemistry - September 21, 2023 Category: Chemistry Authors: Filippo Basagni Jose A Ortega Sine M Bertozzi Andrea Armirotti Maria Summa Rosalia Bertorelli Manuela Bartolini Ian R Mellor Martina Bedeschi Giovanni Bottegoni Vittorio Lembo Anna Minarini Andrea Cavalli Michela Rosini Source Type: research
Carbon-Based Electron Buffer Layer on ZnOx-Fe5C2-Fe3O4 Boosts Ethanol Synthesis from CO2 Hydrogenation
Angew Chem Int Ed Engl. 2023 Sep 21:e202311786. doi: 10.1002/anie.202311786. Online ahead of print.ABSTRACTThe conversion of CO2 into ethanol with renewable H2 has attracted tremendous attention due to its integrated functions of carbon elimination and chemical synthesis, but still being challenging. The electronic property of catalyst is essential to determine the adsorption strength and configuration of the key intermediates, therefore altering the reaction network for targeted synthesis. Here, a carbon buffer layer is employed to tailor the electronic property of the ternary ZnOx-Fe5C2-Fe3O4, in which the electron trans...
Source: Angewandte Chemie - September 21, 2023 Category: Chemistry Authors: Yang Wang Wenhang Wang Ruosong He Meng Li Jinqiang Zhang Fengliang Cao Jianxin Liu Shiyuan Lin Xinhua Gao Guohui Yang Mingqing Wang Tao Xing Tao Liu Qiang Liu Han Hu Noritatsu Tsubaki Mingbo Wu Source Type: research
Organocatalytic C-H Functionalization of Simple Alkanes
Angew Chem Int Ed Engl. 2023 Sep 20:e202310072. doi: 10.1002/anie.202310072. Online ahead of print.ABSTRACTThe direct functionalization of inert C(sp3)-H bonds to form carbon-carbon and carbon-heteroatom bonds offers vast potential for chemical synthesis and therefore receives intense attention. At present, most successes come from strategies using metal catalysts/reagents or photo/electrochemical processes. The use of organocatalysis for this purpose remains very limited or even unexplored especially when dealing with challenging C-H bonds such as those from simple alkanes. Here we disclose the first organocatalytic direc...
Source: Angewandte Chemie - September 21, 2023 Category: Chemistry Authors: Fen Su Fengfei Lu Kun Tang Xiaokang Lv Zhongfu Luo Fengrui Che Hongyan Long Xingxing Wu Yonggui Robin Chi Source Type: research
