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Senescent Cardiomyocytes Increase the Damage Following a Heart Attack
If a heart attack is survived, it leads to long-term damage to heart tissue. Scarring, detrimental remodeling of heart muscle, and other dysfunctions result. Researchers here show that a raised burden of cellular senescence in cardiomyocytes specifically predisposes the aged heart to greater harm following a heart attack. This well illustrates that periodic senolytic treatments or related strategies that can minimize the presence of senescent cells in aged tissues are highly desirable. The presence of lingering senescent cells is harmful in many ways, directly causing organs to become less functional and more vulnerable. ...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

From darkness to healing: a urologist ’ s journey through suicidal ideation PODCAST
Subscribe to The Podcast by KevinMD. Catch up on old episodes! In this poignant podcast episode, we welcome guest William Lynes, a urologist and survivor of physician burnout, who shares his personal journey through multiple suicide attempts. Join us as we delve into the four stages of suicidal ideation and the complex evolution of thoughts Read more… From darkness to healing: a urologist’s journey through suicidal ideation [PODCAST] originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - June 25, 2023 Category: General Medicine Authors: Tags: Podcast Psychiatry Source Type: blogs

What goes on in the brain matters
I am the first to say (quite loudly at times) that pain is a whole person experience. I say this because my experience of pain is mine and utterly unable to be shared in all its complexity. The only way other people know about my pain is through my actions – both involuntary and voluntary. And even then: the way I express myself differs depending on my social context, my mood, my goals, and what I think my pain represents. Yet when I’m asleep, I don’t have pain, when I have anaesthetic for my colonoscopy, I don’t have pain – so what goes on in my brain is kinda important. Now there have bee...
Source: HealthSkills Weblog - June 25, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Pain conditions Research Therapeutic approaches Source Type: blogs

Bonus Features – June 25, 2023 – 77% of healthcare workers think burnout will cause a healthcare crisis, 62% of patients want digital communication to match the in-person experience, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. Surveys More than 75% of healthcare leaders and workers have experienced burnout in the last year, according to a Holon Solutions survey. A similar percentage believe addressing burnout should be a top priority for their organiz...
Source: EMR and HIPAA - June 25, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Health IT Company Healthcare IT 4medica Alpha Nodus Andrew Slutsky Atropos Health AvaSure AVIA Marketplace Banyan Medical Systems Carol Boston-Fleischhauer CentralReach CliniComp Datavant Dexcom DrFirst Eldermark Engage Tec Source Type: blogs

Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models. The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Concept of Immune Resilience and Its Relevance to Degenerative Aging
The aging of the immune system is widely considered a progressive loss of functional capacity, such as the ability to effectively destroy pathogens and errant cells (known as immunosenescence), coupled to rising levels of unresolved, chronic inflammation (known as inflammaging). In today's open access paper, the authors are more interested in how well the immune system brings itself back to an equilibrium state following the disruptions of an inflammatory response. They call this capacity for restoration "immune resilience". In this framework, aging brings a loss of the ability to restore normality to the immune system fol...
Source: Fight Aging! - June 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The power of liquid biopsies and the challenge of health care disparities
Laura Nuttall was diagnosed with deadly brain cancer at the age of 18 after going for a routine eye exam. She completed an incredible bucket list, which included meeting Michelle Obama, driving a monster truck, and commanding a Royal Navy warship before ultimately succumbing to her cancer this past Monday at the age of 23. Read more… The power of liquid biopsies and the challenge of health care disparities originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - June 23, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Fuse Oncology Closes Funding Round with Support from Leading Health Systems in the Southern U.S.
Fuse Oncology, an oncology software solutions company, announces that it has officially closed an oversubscribed Series A. Among the largest contributors were Cone Health Ventures, of Greensboro, N.C., and Northeast Georgia Health Ventures (NGHV), of Gainesville, Ga. Building on its established business traction, Fuse Oncology will use the investments to accelerate expansion of its first commercial product, S!GNAL, and develop additional solutions in the radiation oncology market. “As we continue to expand our reach throughout 2023, we are grateful for the interest and enthusiasm of investors who understand the si...
Source: EMR and HIPAA - June 22, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Clinical Staff Workflows Cone Health Cone Health Ventures Fuse Fuse Oncology Health IT Funding Health IT Fundings Health IT Investment James Bauler John Miller Levine Cancer Institute NGHV Northe Source Type: blogs

Dealing with Brain MRIs
Shedding light on a little-discussed aspect of having brain cancer.
Source: Depth-First - June 22, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

The inspirational journey of an 82-year-old WWII veteran battling cancer
He was 82 years old when he came into our ER, writhing in excruciating abdominal pain. After an ultrasound and a subsequent CT scan, the devastating diagnosis was revealed—end stage pancreatic and liver cancer. Despite enduring a pain level of 10, he managed to maintain his sense of humor, joking about “biting the bullet.” However, Read more… The inspirational journey of an 82-year-old WWII veteran battling cancer originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - June 21, 2023 Category: General Medicine Authors: Tags: Conditions Critical Care Nursing Oncology/Hematology Source Type: blogs

What to do about problematic medication taking?
Welcome to another episode of BDI Briefs! Our aim with BDI Briefs is to take a brief look at important issues about the emotional side of diabetes.In this short discussion, Scott, Bill, and Susan explore problematic medication taking and what you can do about it. You may be surprised by some insights – I know I was! Enjoy! And please let us know what you think and what you’d like to hear more about. And remember to subscribe to BDI’s YouTube channel! Detailed show notes and transcript ...
Source: Scott's Diabetes Blog - June 21, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

Can You Drink Green Tea With Hypertension?
Conclusion The query—can you drink green tea with hypertension—finds its answer in a blend of research and individualized healthcare advice. While green tea holds potential benefits for hypertension, its consumption should be approached responsibly, bearing in mind individual reactions, moderation, and professional guidance. Ultimately, managing hypertension involves a holistic lifestyle approach, where the tranquil, antioxidant-rich green tea might find its rightful place. Read also: Best Foods, Herbs And Spices To Lower Blood Pressure Reference Green tea consumption is associated with decreased DNA d...
Source: The EMT Spot - June 20, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Senolytic Drug Discovery as a Proving Ground for New Machine Learning Approaches
In principle, machine learning can be used to make small molecule drug discovery run more rapidly, more cost-effectively, and with a greater chance of success. The development of senolytic drugs to clear senescent cells is a good proving ground for this type of approach, and will likely accelerate investment into machine learning driven drug discovery platforms with broad application. Firstly, the state of the science shows that senescent cells are vulnerable to mechanisms that can be targeted effectively by small molecules. Secondly, it is also clear that far from all of these mechanisms are known and much remains to be d...
Source: Fight Aging! - June 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Attacking Cancer by Disabling Macrophage Recognition of CD47 " Don ' t Eat Me " Marker
CD47 is a "don't eat me" decoration found on the surface of cells. This is a necessary mechanism for the prevention of autoimmunity, but it is also subverted by cancer in order to prevent the innate immune system from attacking tumor cells. The cancer research community has investigated a range of approaches to prevent CD47 from holding back the immune response to cancerous cells. One possibility, demonstrated here, is to engineer the innate immune cells known as macrophages in order to block the CD47 interaction and thus ensure an aggressive response to cancerous cells. Cancer remains one of the leading causes of...
Source: Fight Aging! - June 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Will Success in Reversing Aging Shape the Regulatory System to Accommodate It?
A sizable fraction of the therapies produced by the medical industry are, not to put too fine a point on it, garbage. The benefit is not worth the cost of diverting the resources into the full scale production of the drug, versus those resources going towards some better form of medical research and development. Giving a cancer patient an extra month or two of life, reducing fibrosis in the liver by 10% over a year of treatment, incrementally improving mitophagy to half the degree that exercise achieves, and so forth. Small molecule development in particular excels at producing this sort out outcome, as the effects on gene...
Source: Fight Aging! - June 19, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs