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Browsing New comments
Any comments on this blog are moderated by me.  If they are a question related to the subject of the post, I will answer it (not always very quickly, I have to confess).But most are not related at all.   For example:Very complementary about my writing style, but included a link to private tutoring service.  Actually there were three at least like this;Opportunities to buy medications - separate offers of NSAIDs, pain medications, benzodiazepines, opioids, barbiturates...;Links to a homoeopathy clinic (as all these comments are, on posts not related to the subject of the comment);Recommendation...
Source: Browsing - August 13, 2023 Category: Databases & Libraries Source Type: blogs

Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health." « Back to Top Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis? https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/ Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't n...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The future of medicine: Advancements and greed collide
In the future, I foresee a world without pandemics, cancer becoming a thing of the past, and advancements that enable bionic adaptations to our bodies, leading to a life expectancy of easily over one hundred years. While some of these advancements may seem distant, we are on the cusp of making them a reality within Read more… The future of medicine: Advancements and greed collide originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - August 12, 2023 Category: General Medicine Authors: Tags: Tech Health IT Source Type: blogs

Removal of the Thymus Illustrates the Importance of Thymic Atrophy in Aging
This study demonstrates just how vital the thymus is to maintaining adult health." Link: https://news.harvard.edu/gazette/story/2023/08/turns-out-lowly-thymus-may-be-saving-your-life/
Source: Fight Aging! - August 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

In the Long Run, Even Baseline Humans Will Live for a Very, Very Long Time
It is at present somewhat out of style to point out that, yes, obviously, it will be possible in the future to ensure that humans live for a very, very long time. That will be true for even baseline humans lacking all of the various genetic modifications one might propose a future scientific community to be capable of, modifications to introduce the numerous distinct forms of resilience to the mechanisms of mammalian aging exhibited by naked mole-rats, whales, elephants, bats and so forth. Control over aging is a subset of control over molecules and their positions. To be as reductionist as possible, degenerative aging is ...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Selective Disruption of Replication in Cancerous Cells by Targeting PCNA
The future of cancer therapy will involve the targeting of mechanisms found broadly in many or all different types of cancer, that cancer cells cannot dispense with as they evolve rapidly within a tumor, and which have little to no effect on non-cancerous cells. Targeting telomerase to prevent the lengthening of telomeres can check the first two of those boxes, leaving the question of how best to effectively restrict the treatment to tumor cells. Targeting alternative lengthening of telomeres can check the second and third boxes, but the mechanism only operates in a minority of cancers. The research community is engaged in...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Biomaterial Injection Combines T Cell and Cancer Vaccine Treatments
Researchers at the Harvard Wyss Institute have developed an anti-cancer biomaterial treatment that combines adoptive T cell therapy and cancer vaccine technology to treat solid tumors. The researchers have called their technique SIVET, which is short...
Source: Medgadget - August 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology harvard wyssinstitute Source Type: blogs

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Strategy and Tactics: Two Essential Keys to Success
I recently read Outlive by Peter Attia. It’s a book about longevity that I found insightful. It contains many lessons about different aspects of health. However, what I’d like to share with you here isn’t the health lessons from the book. Instead, it’s a quote by Sun Tzu that I found there: Strategy without tactics is the slowest route to victory. Tactics without strategy is the noise before defeat. Interesting quote, isn’t it? Strategy without tactics might lead you to victory, but it’s the slowest route to get there. You will waste a lot of resources along the way. On the other hand, tactics without ...
Source: Life Optimizer - August 5, 2023 Category: Consumer Health News Authors: Donald Latumahina Tags: Productivity Thinking Source Type: blogs

Visually Guided Uterine Biopsies in Physician ’s Office: Interview with Allison London Brown, CEO of LUMINELLE
LUMINELLE, a medtech company based in North Carolina, has developed a suite of endoscopic tools that allow clinicians to perform visually guided gynecological procedures right from their office. At present, the majority of uterine biopsies taken to i...
Source: Medgadget - August 4, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Ob/Gyn Source Type: blogs

The ultimate sanction
Some while back I discussed the death penalty here, in response to a couple of atrocious crimes that happened in Connecticut and provoked a lot of controversy. The first person to be executed in the state following the Supreme Court moratorium was a man named Michael Ross, who raped and murdered young women in what is now my neck of the woods as it were, a bit before I moved out here. He asked his attorneys to stop trying to prevent it, in other words he went to his death willingly, evidently preferring it to life in prison. So in that situation one has to ask, what ' s the point? One element of controversy was whether his...
Source: Stayin' Alive - August 3, 2023 Category: American Health Source Type: blogs

Phreesia Acquires MediFind, Reinforcing its Commitment to Patient-Centered Care and Expanding its Offerings to Consumers
Phreesia, a leader in patient intake, outreach, and activation, is pleased to announce it has acquired Comsort, Inc. d/b/a MediFind (MediFind), a health technology company that uses advanced analytics to help patients—especially those with serious, chronic, and rare diseases—find better care faster. MediFind uses machine learning and proprietary algorithms to continuously review medical information across a wide range of datasets, identifying leading doctors in specific conditions and fields based on factors such as their research output, the volume of patients, and standing among their peers. MediFind assigns four lev...
Source: EMR and HIPAA - August 3, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Chronic Care Comsort Inc. David Linetsky Health IT Acquisitions Healthcare M&A MediFind Patrick Howie Phreesia Rare Diseases Rob Weker Source Type: blogs

Republican Misbehavior Promoted Health Professional Activism
By MIKE MAGEE If you wanted to create a motto for the summer of 2023 – one that would stand the test of time from the medical exam room of Ohio to the gilded bathroom of Mar-a-lago – it would have to be Jack Smith’s “Facts matter!” If that is true on a national scale, it is equally true in states across the nation where doctors increasingly are coming out from behind a self-imposed clinical curtain and going public. As reported in ProPublica last week, “Doctors who previously never mixed work with politics are jumping into the abortion debate by lobbying state lawmakers, campaigning, forming polit...
Source: The Health Care Blog - August 2, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Abortion Activism health care providers Mike Magee Physicians Trump Source Type: blogs

Rutin Suppresses the SASP of Senescent Cells
Senescent cells accumulate with age and cause harm via a sustained, energetic production of signal molecules, the senescence-associated secretory phenotype (SASP), that disrupts tissue structure and function. In addition to the search for senolytic drugs that can selectively destroy senescent cells by pushing them into programmed cell death, researchers are also looking for senomorphic drugs that can suppress some or most of the SASP by interfering in its regulatory mechanisms. This seems to me a poor alternative to clearance of senescent cells, as a senomorphic drug must be taken continually, but nonetheless a great many ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Investigating the Secrets of Cancer-Causing Viruses
Credit: Courtesy of Dr. Mandy Muller. While she was in graduate school, Mandy Muller, Ph.D., became intrigued with viruses that are oncogenic, meaning they can cause cancer. At the time, she was researching human papillomaviruses (HPVs), which can lead to cervical and throat cancer, among other types. Now, as an assistant professor of microbiology at the University of Massachusetts (UMass) Amherst, Dr. Muller studies Kaposi sarcoma-associated herpesvirus (KSHV), which causes the rare AIDS-associated cancer Kaposi sarcoma. A Continental Change Dr. Muller has come a long way, both geographically and professionally, s...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 1, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Infectious Diseases Microbes Profiles RNA Viruses Source Type: blogs