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Navitus 2022 Drug Trend Report
   Its been many years since I posted news of a PBM Drug Trend Report. Once upon a time, PBM drug trend reports contained lots of interesting information. However, over time (in 2021, for example, when reports from the preceding year were published), CVS Caremark published only a bare-bones summary, while Prime Therapeutics, MedImpact, and other large PBMs all completelystopped publishing drug trend reports. The reason is basically because its becoming harder and harder for PBMs to present themselves as saving money when the biggest PBMs aren ' t saving any entities any money on prescription drugs anymore (I...
Source: Scott's Web Log - July 5, 2023 Category: Endocrinology Tags: 2022 2023 Drug Trend Report Navitus Navitus Health Solutions PBM Source Type: blogs

Progress Towards Rejuvenation as a Matter of Investment versus a Matter of Time
It is not hard to argue that there is too little investment in progress towards the treatment of aging as a medical condition. Collectively, the underlying mechanisms of degenerative aging are the cause of two-thirds of human mortality, and likely a somewhat greater fraction of loss of function, suffering, and pain. The cost of that mortality is vast, no matter how one likes to model the value of a human life, or a year spent alive in good health. This is much the same argument that can be made for greater investment in medical research in general. Medical research funding as a whole is a very, very tiny fraction of the co...
Source: Fight Aging! - July 4, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

The Business Reality of Healthcare AI
BY KIM BELLARD I was at the barbershop the other day and overheard one barber talking with his senior citizen customer about when – not if – robot AIs would become barbers. I kid you not. Now, I don’t usually expect to heard conversations about technology at the barber, but it illustrates that I think we are at the point with AI that we were with the Internet in the late ‘90’s/early ‘00s: people’s lives were just starting to change because of it, new companies were jumping in with ideas about how to use it, and existing companies knew they were going to have to figure out ways to incorporate it if they ...
Source: The Health Care Blog - July 4, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Healthcare AI healthcare delivery Kim Bellard Source Type: blogs

Age-Associated B Cells Correlate with Impaired Immune Response
Age-associated B cells are one of a number of dysfunctional or maladaptive immune cell subpopulations that appear in increasing numbers in later late, and which likely impair the many functions of the immune system by their presence. Clearing all B cells rather than trying to selectively clear age-associated B cells is a viable proposition, as the B cell population regenerates quite rapidly following clearance, and the new cells lack the age-associated B cell phenotype. This has been demonstrated in animal models, but has yet to make it to the clinic as a treatment to improve the aged immune system. Age-associated...
Source: Fight Aging! - July 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Unmasking physician burnout: a survivor ’ s story and solutions for a healthy medical profession
I am a physician, a urologist, but what most people don’t know about me is that I am a survivor of mental illness, physician burnout, and multiple suicide attempts. Today, I write about the condition of the medical profession, its problem with burnout, and its solutions. I began practicing general urology in 1987. My subsequent Read more… Unmasking physician burnout: a survivor’s story and solutions for a healthy medical profession originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - July 3, 2023 Category: General Medicine Authors: Tags: Physician Psychiatry Source Type: blogs

Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers. The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Gratitude: The Art of Savoring.
I was stressed this past past few weeks I finally figured in a sports injury which was supposed to be a way to de-stress my body. The many roles I acquired during the pandemic finally took its toll after almost all required physical presence and face to face activities. Face to face tasks demand full attention and physical presence. You cannot attend two conferences at the same time anymore or listen to two lectures on two different gadgets. It seems that, the technology enabled “always present, always available” does not hold true anymore post pandemic. It came to a frustrating point that I decided to give...
Source: The Orthopedic Logbook - July 1, 2023 Category: Orthopaedics Authors: Remo Aguilar Tags: Habits Productivity doctors gratitude healthcare providers Medicine physicians savoring thankful tweetchat Source Type: blogs

Gratitude: The Art of Savoring Wins.
I was stressed this past past few weeks I finally figured in a sports injury which was supposed to be a way to de-stress my body. The many roles I acquired during the pandemic finally took its toll after almost all required physical presence and face to face activities. Face to face tasks demand full attention and physical presence. You cannot attend two conferences at the same time anymore or listen to two lectures on two different gadgets. It seems that, the technology enabled “always present, always available” does not hold true anymore post pandemic. It came to a frustrating point that I decided to give...
Source: The Orthopedic Logbook - July 1, 2023 Category: Orthopaedics Authors: Remo Aguilar Tags: doctors gratitude healthcare providers Medicine physicians savoring thankful tweetchat Source Type: blogs

From never-smoker to lung cancer survivor PODCAST
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join us in this episode as we hear the inspiring story of Alice S. Y. Lee, an emergency physician diagnosed with lung cancer despite being a never-smoker. Discover the unique challenges faced by Asian American female nonsmokers, the importance of early detection, and ongoing Read more… From never-smoker to lung cancer survivor [PODCAST] originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - June 29, 2023 Category: General Medicine Authors: Tags: Podcast Oncology/Hematology Source Type: blogs

Biodegradable Ultrasound Implant Helps Chemo Reach Brain
Researchers at the University of Connecticut have developed an ultrasound implant that can assist in opening the blood brain barrier to allow chemotherapy to enter and treat brain cancer. However, unlike cumbersome ultrasound systems, this technology...
Source: Medgadget - June 28, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Neurosurgery Oncology UConn Source Type: blogs

How Automation Can Help Ease Healthcare Worker Burnout
The following is a guest article by Anna Twomey, Senior Director, Healthcare Providers – Americas at SS&C Blue Prism   With rising staffing shortages and burnout among healthcare workers, digital transformation will be key to overcoming these challenges and protecting patient care. It’s estimated that the U.S. could see a shortage of up to 124,000 physicians by 2033 and will need to hire at least 200,000 nurses per year to meet increased demand and to replace retiring nurses. The healthcare worker burnout crisis in this country began before the COVID-19 pandemic, but the public health emergency m...
Source: EMR and HIPAA - June 28, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Anna Twomey BPM Business Process Management Digital Transformation EHR Healthcare Automation Healthcare Burnout IA Intelligent Automa Source Type: blogs

Building a Digital Immune System
Credit: Courtesy of Dr. Tomas Helikar. The power of computer code has been a longtime fascination for Tomas Helikar, Ph.D., a professor of biochemistry at the University of Nebraska-Lincoln (UNL). In college, when he learned he could use that power to help researchers better understand biology and improve human health, Dr. Helikar knew he’d found his ideal career. Since then, he’s built a successful team of scientists studying the ways we can use mathematical models in biomedical research, such as creating a digital replica of the immune system that could predict how a patient will react to infectious microorganisms ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 28, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Cool Tools/Techniques Modeling Profiles Source Type: blogs

The Contribution of Transposons to Differences in Life Span Between Species
Transposable elements in the nuclear genome, also called transposons, are remnant DNA sequences left over from past, often ancient viral infections. A transposon is capable of hijacking the intricate machineries of gene expression to insert further copies of itself into the genome if not suppressed, producing what is effectively DNA damage as these haphazard insertions break existing gene sequences. Further, the transcription of transposon DNA produces viral-like RNA that can provoke an inflammatory innate immune response when present in the cell. Unfortunately, the suppression of transposons weakens with age, allowing the...
Source: Fight Aging! - June 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

From physician to survivor: My inspiring journey through burnout, mental illness, and triumph
I am a physician, specifically a urologist. However, what most people do not know about me is that I am a survivor of multiple suicide attempts. My essay attempts to tell my personal story—a story of burnout, mental illness, and suicide—and to discuss the shame that accompanied these experiences. I completed my urologic residency in Read more… From physician to survivor: My inspiring journey through burnout, mental illness, and triumph originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - June 26, 2023 Category: General Medicine Authors: Tags: Physician Psychiatry Source Type: blogs

This and that
Responding to some of the responses to my last post on global carbon emissions, yes, we agree on the facts, the issue seems to be the implications. It is correct that at this moment, the U.S. accounts for about 15% of global greenhouse gas emissions, and we have been heading downward; while China in particular has been going in the wrong direction and is the largest emitter. Maybe " fairness " is an issue here, since the U.S. is responsible for far more cumulative emissions and China ' s emissions per capita are not as large, but given the crisis facing humanity I think that ' s pretty much beside the point. What matters i...
Source: Stayin' Alive - June 26, 2023 Category: American Health Source Type: blogs