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An mRNA Vaccine to Treat Cancer
by Gertrud U. Rey There are several highly effective vaccines that block infection by human papillomaviruses (HPVs) and thereby prevent the cervical, anogenital, and head and neck cancers caused by these viruses. However, none of these vaccines are effective for the treatment of established HPV-induced tumors. The success of the COVID-19 messenger RNA (mRNA) vaccines … An mRNA Vaccine to Treat Cancer Read More »
Source: virology blog - April 7, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey cancer cancer mRNA vaccines cytotoxic T cells helper T cells HPV HPV E7 human papillomavirus tumor Source Type: blogs

Modeling the Contribution of Cellular Senescence to the Tradeoff Between Cancer Risk and Aging
Researchers consider that the state of late life health in humans, and the mechanisms involved, are a balance between risk of death by cancer and risk of death by loss of tissue function. Cancer risk is increased by the activity of damaged cells, particularly stem cells, in a dysfunctional tissue environment, while loss of tissue function is accelerated by suppressing that activity. Tissue must be maintained, such as via a supply of new cells to replace losses, and cells must be active in order for that maintenance to occur. Cellular senescence is a part of this balance of benefit and harm. Cellular senescence is a ...
Source: Fight Aging! - April 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Farm Bill 2023 and Obesity
This study found U.S. farm policies “have generally small and mixed effects on farm commodity prices, which in turn have even smaller and still mixed effects on the relative prices of more‐ and less‐​fattening foods.”Farm subsidy/ ​nutrition issues are hotly debated, and I have not done a detailed research review. If Congress withdrew subsidies from corn, wheat, soybeans, and rice, would U.S. farming shift toward healthier fruits and vegetables? Are the subsidized crops and related oils a cause of obesity, and has the go vernment given Americans bad nutrition advice about these products for decades, asNina T...
Source: Cato-at-liberty - April 6, 2023 Category: American Health Authors: Chris Edwards Source Type: blogs

An mRNA Vaccine to Treat Cancer
by Gertrud U. Rey There are several highly effective vaccines that block infection by human papillomaviruses (HPVs) and thereby prevent the cervical, anogenital, and head and neck cancers caused by these viruses. However, none of these vaccines are effective for the treatment of established HPV-induced tumors. The success of the COVID-19 messenger RNA (mRNA) vaccines […]
Source: virology blog - April 6, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey cancer cancer vaccine cervical cancer cytotoxic T cells helper T cells HPV HPV E7 human papillomavirus mRNA mRNA vaccine non-replicating mRNA vaccine self-replicating mRNA vaccine tumor Source Type: blogs

Triggering the STING Pathway Suppresses Cancer Metastasis
Most cancers would become manageable if metastasis could be eliminated. A robust way to fully suppress metastasis across all forms of cancer would not be a cure in and of itself, but it would greatly reduce mortality and allow cancers to be managed or eliminated more readily, and with less trauma for the patient. On the way to a hypothetical end to metastasis, researchers are making inroads towards approaches that may at least reduce metastasis to some degree. These approaches often, as here, involve ways to enlist the immune system to more aggressively target and destroy metastatic cells before they can build a new tumor....
Source: Fight Aging! - April 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The heartbreaking story of Jimmy Carter: a call for Medicare reform in end-of-life care
The purpose of the serious illness conversation is to offer patients a clear choice between treating and not treating an incurable disease like liver cancer. The goal is to give the person permission to alleviate pain and suffering. The individual might decide to be treated as a patient or honored as a person if given Read more… The heartbreaking story of Jimmy Carter: a call for Medicare reform in end-of-life care originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 4, 2023 Category: General Medicine Authors: Tags: Conditions Palliative Care Source Type: blogs

I ’ m a medical oncologist. Here ’ s why AI isn ’ t going to cure cancer.
As a cancer physician, the amount of data I obtain on my patients is ever-increasing, along with options for cancer therapies. This is, as the saying goes, a good problem to have, but the amount of data management oncologists must do after hours (because there isn’t enough time in the clinic day) to keep up Read more… I’m a medical oncologist. Here’s why AI isn’t going to cure cancer. originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 4, 2023 Category: General Medicine Authors: Tags: Tech Health IT Source Type: blogs

Accelerating Personalized Health With Healthcare Digital Twins
The following is a guest article by Steve Lazer, Global Healthcare & Life Sciences CTO at Dell Technologies. One rapidly advancing trend in healthcare and life sciences is the shift from inefficient, expensive physical models to digital models tested in the virtual world. This is especially critical when time to value and cost are of the essence, as in the case of a global pandemic. One way to address this challenge, is to create a digital replica of a physical system or environment, accumulate data with sensors and collectors to monitor performance, and identify anomalies and trends to predict problems before they oc...
Source: EMR and HIPAA - April 4, 2023 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Artificial Intelligence Dell Technologies Digital Twin Consortium Digital Twins Healthcare AI Healthcare Digital Twins Source Type: blogs

I Have No Mouth, Yet Still I Scream
BY KIM BELLARD In light of the recent open letter from AI leaders for a moratorium on AI development, I’m declaring a temporary moratorium on writing about it too, although I doubt either one will last long (and this week’s title is, if you hadn’t noticed, an homage to Harlan Ellison’s classic dystopian AI short story).  Instead, this week I want to write about plants. Specifically, the new research that suggests that plants can, in their own way, scream.  Bear with me. To be fair, the researchers don’t use the word “scream;” they talk about “ultrasonic airborne sounds,” but just about every ac...
Source: The Health Care Blog - April 4, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Kim Bellard Microbiome Plants Source Type: blogs

Breaking Bad: the antihero ’ s journey through cancer
An excerpt from From Whispers to Shouts: The Ways We Talk About Cancer. “Walt, is that you?” Skyler asks her husband in the final scene of the Breaking Bad pilot. They’re in bed, she’s pregnant, and he’s come toward her in a new way. He’s changed, and she doesn’t yet know why. In this acclaimed Read more… Breaking Bad: the antihero’s journey through cancer originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 2, 2023 Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs

Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Complicating the Relationship Between Cellular Senescence and Late Life Depression
Inflammatory signaling may be influential in major depressive disorder. For any condition in which inflammation is important, attention should be given to the possible role of cellular senescence, given the advent of senolytic therapies to clear these cells. Senescent cells grow in number throughout the body with age, and while never a large fraction of all cells, they energetically generate pro-inflammatory signals. Here, researchers discuss the sometimes there, sometimes not correlation between burden of senescent cells and incidence of major depressive disorder in later life. Previous studies suggested the role...
Source: Fight Aging! - March 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Aggrephagy in Hematopoietic Stem Cell Aging
Autophagy is the name given to a complex, varied set of processes that tag and recycle broken or excess proteins and structures in the cell. The destination for materials to be recycled is the lysosome, a membrane-wrapped collection of enzymes capable of breaking down near all of the proteins and other molecules a cell is likely to encounter. How materials are selected and how exactly they make their way to the lysosome varies considerably. Alongside autophagy, the ubiquitin-proteasome system is another way for cells to identify problem proteins, such as those that misfold into toxic configurations, and then break them dow...
Source: Fight Aging! - March 29, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

In Other Words: Not All Bases Are in the Ballpark
You might first think about sports when you hear the word base, but not all bases are on the baseball diamond. In chemistry, a base is a molecule that reacts with an acid, often by accepting a proton from the acid or from water. Baking soda and dish soap are common bases. Credit: NIGMS. A Building Block for Life Bases are found throughout biological systems and in many molecules critical to life. The pH scale measures how acidic or basic (“alkaline”) liquids, such as water or blood, are. Liquids with a pH less than 7 are acidic, while liquids with a pH greater than 7 are basic. Electrolytes, like sodium, ca...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 29, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Molecular Structures DNA In Other Words RNA Source Type: blogs

So We Have Hallmarks of Aging: What Now?
The influential hallmarks of aging paper is now nearly ten years old. It has been twenty years since the Strategies for Engineered Negligible Senescence (SENS) categorization of causative mechanisms of aging was first put forward, an effort that inspired the hallmarks. Time moves on relentlessly! Are you feeling old yet? Unlike SENS, the hallmarks of aging made no attempt to be a to-do list of research and development approaches that we should be undertaking in order to effectively treat aging. They are, as it says on the label, hallmarks, observations of old cells and tissues. Nonetheless, a to-do list is somewhat the way...
Source: Fight Aging! - March 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs