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Why poor diets are contributing to a surge in colorectal cancer cases among young people
An alarming trend has emerged in my medical practice in recent years: I’m seeing more and more young adults with colorectal cancer. When I began practicing as a family physician 21 years ago, I never saw patients in their 40s and 50s with the disease, much less ones in their 30s. Now, I diagnose two Read more… Why poor diets are contributing to a surge in colorectal cancer cases among young people originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 26, 2023 Category: General Medicine Authors: Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs

In Memoriam: Mighty Casey has moved on
Casey Quinlan, our friend and frequent THCB Gang member, died today. She may have gone quietly but she for sure lived her life way out loud. It’s not unexpected; she was diagnosed with a recurrent stage 4 cancer two years back, and I was lucky enough to have dinner with her on a rare east coast trip last June. She was hoping to come to the West Coast late last Fall but was too sick to make it. It looked like things were getting better and she was on THCBGang in February but soon things turned and she spent the last few weeks in hospice. She leaves a huge hole in the patient advocacy movement and a huge wave of love f...
Source: The Health Care Blog - April 25, 2023 Category: Consumer Health News Authors: matthew holt Tags: THCB Gang Casey Quinlan Source Type: blogs

HIMSS Takeaways: Size Doesn ’t (Always) Count, Johnny Appleseed and MomGPT
By MICHAEL L. MILLENSON Live and in-person once again, HIMSS 2023 attracted more than 30,000 attendees to the exhibit halls and meeting rooms of Chicago’s sprawling McCormick Place. Although no one person could possibly absorb it all, below are some harbingers of the health care future that stayed with me. Size Doesn’t Count. Exploring the remote byways of the cavernous exhibition areas, it became clear that it’s not the size of the booth, but the impact of the product that counts. At a pavilion highlighting Turkish companies, for instance, R. Serdar Gemici stood in front of a kiosk that might fit into a walk-i...
Source: The Health Care Blog - April 24, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Best Buy Clarify Health Solutions Dedalus Epic Systems Eyal Zimlichman HealthPartners HIMSS HIMSS2023 Intermountain Healthcare Medeanalytics Michael Millenson NCQA Pangea Tim Barry VillageMD Source Type: blogs

Extrachromosomal Circular DNA Implicated in Early Development of Cancer
The abnormal generation of circular DNA as a mechanism of cancer, operating by greatly increasing the expression of genes that favor the growth and development of a particular type of cancer. It is a feature of established tumor tissue, but researchers here note that the early presence of extracellular circular DNA in precancerous tissue is a strong marker for the later development of cancer, in that study participants lacking circular DNA in tissue biopsies near all did not go on to develop cancer. The research is focused on one particular tissue and cancer type, but is likely broadly applicable across many varieties of c...
Source: Fight Aging! - April 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved. Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A veteran ’ s battle against possible lung cancer
During my night shift at the emergency department, I encountered a 72-year-old decorated war veteran named Mr. Sun. Accompanied by his concerned wife, he came to address a year-long struggle with fatigue and a non-productive cough he’d been experiencing in recent weeks. Initially resistant to seeking medical attention, Mr. Sun finally gave in to his Read more… A veteran’s battle against possible lung cancer originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 22, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Senescent Cells Induce Dedifferentiation in Salamander Regeneration
Regeneration from injury is an intricate dance of many different cell types: stem cells, somatic cells, cells that become senescent, and innate immune cells such as macrophages. This is true of every higher species, but what is the meaningful difference between species capable of regenerating entire limbs and internal organs, such as salamanders, and species that scar and exhibit only partial regeneration of lost tissue, such as near all mammals? In recent years, researchers have discovered that senescent cells and macrophages behave differently in injured tissues in species capable of proficient regeneration. Clearance of...
Source: Fight Aging! - April 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

50 year old with acute chest pain, with ‘normal’ ECG and falling troponin
Written by Jesse McLaren, with comments from SmithA 50-year old patient on the medical wards developed acute chest pain, with an ECG labeled (see computer interpretation at the top) and confirmed as normal. What do you think? There ’s normal sinus rhythm, normal conduction, normal axis, normal R wave progression, and normal voltages. Lead aVL jumps out as abnormal because there is a discordant T wave inversion and mild ST depression. This is reciprocal to inferior mild ST elevation and hyperacute T waves (wide based, bulky, and symmetric, and in III taller than the QRS complex), and adjacent to ST depression in...
Source: Dr. Smith's ECG Blog - April 21, 2023 Category: Cardiology Authors: Jesse McLaren Source Type: blogs

The Vitamin That Reduces Cancer Risk By 40%
Taking this supplement can fight cancer and greatly reduce the risk of dying from the disease.
Source: PsyBlog | Psychology Blog - April 20, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Nutrition Source Type: blogs

Wednesday Bible Study: Literary Complilcations
What are now considered the Book of Ezra and the Book of Nehemiah were originally a single document. Medieval monks separated them and Rabbinical tradition accepted the separation in the 16th Century. Scholars used to attribute Ezra/Nehemiah to the Chronicler, and while composition of the book(s) probably began around 400 BC and may have been associated with Chronicles, it was revised and amended over the next 250 years before being translated into Koine Greek as part of the Septuagint. It contains interpolated documents in Aramaic as well as the main narrative in Hebrew.  It is organized around theological conce...
Source: Stayin' Alive - April 19, 2023 Category: American Health Source Type: blogs

Wednesday Bible Study: Literary Complications
What are now considered the Book of Ezra and the Book of Nehemiah were originally a single document. Medieval monks separated them and Rabbinical tradition accepted the separation in the 16th Century. Scholars used to attribute Ezra/Nehemiah to the Chronicler, and while composition of the book(s) probably began around 400 BC and may have been associated with Chronicles, it was revised and amended over the next 250 years before being translated into Koine Greek as part of the Septuagint. It contains interpolated documents in Aramaic as well as the main narrative in Hebrew.  It is organized around theological conce...
Source: Stayin' Alive - April 19, 2023 Category: American Health Source Type: blogs

Longer Genes May Be More Disrupted than Shorter Genes by Random DNA Damage Occuring with Age
Random mutational damage to nuclear DNA occurs constantly. While near all of it is restored by the highly efficient suite of DNA repair mechanisms present in the cell, some is not. This damage accumulates over time. Fortunately, near all of it occurs in DNA that is unused in that cell type, or occurs in genes that are not all that important, or occurs in somatic cells that have few replications remaining before hitting the Hayflick limit. In other words, most DNA damage isn't all that important, and even where it sticks, it will be cleared from the body via the normal processes of replacement of cells in a tissue. H...
Source: Fight Aging! - April 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Reviewing the Aging of the Gut Microbiome
Researchers here take a high level tour of what is known of age-related changes in the gut microbiome and how they influence health. Accumulating evidence shows a loss of beneficial populations that generate useful metabolites such as butyrate, accompanied by an increase in harmful populations that can provoke chronic inflammation. This is a likely a meaningful contribution to the onset and development age-related conditions, making it a priority to develop ways to reset the balance of populations in the gut microbiome. The best of the available approaches, given the evidence to date, is fecal microbiota transplantation fr...
Source: Fight Aging! - April 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The insurance denial process: one oncologist ’ s fight against a broken system
It is 4:15 p.m. in my clinic, and I’m running an hour behind. One of my morning patients arrived acutely ill and thus required more of my time and attention than the schedule allotted for. Accordingly, every patient after that has ended up waiting for me. And, as I’m a cancer physician, each of them Read more… The insurance denial process: one oncologist’s fight against a broken system originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - April 16, 2023 Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs

Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context. Glycine Supplementation as a Methionine Restriction Mimetic https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/ Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restrictio...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs