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Reviewing What is Known of the Biochemistry of Klotho Relevant to Effects on Life Span
Increased klotho expression increases longevity in mice, while reduced klotho expression accelerates aging. The most well studied effects of klotho on organ function involve the kidney and brain, where in both cases it appears protective via a number of different mechanisms. Unfortunately, klotho expression declines with age. Whether treating humans with therapies that increase levels of klotho will produce effects that are as large as those observed in mice remains to be seen. Programs that might lead to treatments remain at a preclinical stage of development, though recently advanced to the point of testing in non-human ...
Source: Fight Aging! - July 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Truthfully, the Physician Shortage Doesn ’ t Exist!
Conclusion: For every hour physicians provide direct clinical face time to patients, nearly 2 additional hours is spent on EHR and desk work within the clinic day. Outside office hours, physicians spend another 1 to 2 hours of personal time each night doing additional computer and other clerical work. (Sinsky et al, 2016) If we only had the tools and the administrative support that just about every one of us has been asking for, there wouldn’t be a doctor shortage. The quote here is from 7 years ago and things have gotten even worse since then. Major league baseball players don’t handle the scoring and the st...
Source: The Health Care Blog - July 21, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Hans Duvefelt Physician Shortage Source Type: blogs

Eggs And High Blood Pressure: Decoding The Dietary Dilemma
Conclusion In navigating the winding road of managing high blood pressure, several key points emerge. Eggs, while a source of ongoing debate, can form part of a balanced diet for most people. It’s essential, though, to consider your entire dietary pattern, emphasizing heart-healthy choices like those found in the DASH and Mediterranean diets. Avoiding processed meats and sugary breakfast options, while incorporating nutrient-dense foods, can significantly impact your blood pressure management. But remember, it’s not all about diet. A comprehensive approach, involving regular physical activity, stress mana...
Source: The EMT Spot - July 21, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

5 Ways Data (and Storage) are Powering the Evolution of Healthcare
The following is a guest article by Doug McLoughlin, Regional Manager at Western Digital Healthcare technology is finally catching up with a digital revolution that’s been well underway for over a decade in other industries. The transformation was accelerated in the last three years when confined to our homes for months on end, doctors and patients alike turned to technology to try and stay healthy and connected. From medical to consumer-grade devices, millions of new endpoints emerged, generating new volumes of data. Ranging from improving individual health to better patient outcomes to enabling more advanced research, ...
Source: EMR and HIPAA - July 20, 2023 Category: Information Technology Authors: Guest Author Tags: Analytics/Big Data Health IT Company Healthcare IT IT Infrastructure and Dev Ops AI Data Storage Doug McLoughlin Healthcare Data Healthcare Data Storage Improving Patient Outcomes ML Reducing Costs RPM Western Digital Source Type: blogs

Further Work on Small Molecules that Can Induce Cell Reprogramming
In this study, we developed and utilized novel screening methods including a quantitative nucleocytoplasmic compartmentalization assay (NCC) that can readily distinguish between young, old, and senescent cells. We identify a variety of novel chemical cocktails capable of rejuvenating cells and reversing transcriptomic age to a similar extent as OSK overexpression. Thus, it is possible to reverse aspects of aging without erasing cell identity using chemical rather than genetic means.
Source: Fight Aging! - July 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Career Conversations: Q & A With Biomedical Engineer Elizabeth Wayne
Courtesy of Dr. Elizabeth Wayne. “It’s so fun to try to make meaning from a confusing experimental result and talk to other scientists who are excited by the same questions you are,” says Elizabeth Wayne, Ph.D., an assistant professor of biomedical engineering and chemical engineering at Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania. We talked to Dr. Wayne about her career trajectory, research on immune cells, and belief that scientists can change the world. Q: How did you first become interested in science? A: I was introduced to atoms during 6th grade science class. The idea that we’re ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 19, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cellular Imaging Profiles Source Type: blogs

Butterflies sleeping in the garden
A few days ago, I noticed a Holly Blue on a plant stem on the lawn at dusk. Actually, there have been hundreds of this species in the garden this year. But, this one was settled, it was at roost, in its nocturnal torpor state. Asleep, in other words. Holly Blue at roost in the middle of the lawn I put a metal basket over the top of it so that nobody would tread on it if they were mothing around the garden or counting frogs. Once it got properly dark, I took a short stroll around the garden (the only thing possible with a short garden) and shone a torch up at the overhanging ivy, ostensibly I was looking for moths, but ther...
Source: David Bradley Sciencebase - Songs, Snaps, Science - July 19, 2023 Category: Science Authors: David Bradley Tags: Lepidoptera Source Type: blogs

Transplanting Regulatory T Cells Alongside Neurons Improves Cell Survival in Parkinson ' s Disease
The most evident symptoms of Parkinson's disease result from the loss of dopamine generating neurons in the brain, a population of cells uniquely vulnerable to the underlying biochemistry of the condition. Researchers have long worked towards therapies based on transplanting new neurons to replace those lost to cell death, and clinical trials have taken place in human patients, but the survival of these cells is a challenge. The process of transplantation, as noted here, has consequences. Suppressing the local immune response to the transplantation procedure may improve matters, however. The specific loss of midbr...
Source: Fight Aging! - July 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Sweet Spot of Health Care Cost Containment
BY BEN WHEATLEY As health care continues to move in the direction of unaffordability, policy makers are considering a range of options to bring down health care costs. The Health Affairs Committee on Health Care Spending and Value has identified four broad areas for reform, including administrative savings, price regulation and supports for competition, spending growth targets, and value-based payment. These measures appropriately target health care’s supply side and the excesses that exist in the health care system. In this blog, I would like to highlight another avenue for savings: one that focuses on the demand ...
Source: The Health Care Blog - July 19, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health Care Cost Containment Health care spending Source Type: blogs

How Alcohol Affects Blood Pressure: A Detailed Insight
Conclusion In this guide, we’ve explored the complex relationship between alcohol and blood pressure. We’ve seen that alcohol, whether consumed moderately, heavily, or in a binge pattern, can impact blood pressure. We also delved into the biological mechanisms at play, the role of various drinking patterns, and the sobering revelations of recent research. While the pleasure of a drink might be fleeting, its effects on our body, particularly on our blood pressure, can be long-lasting. The key takeaway? Moderation. Even a small reduction in alcohol intake can have significant health benefits, partic...
Source: The EMT Spot - July 18, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Why oncology is ripe for digital innovation
In every aspect of our lives, whether it is online banking or shopping, we rely on technology to make things better, more convenient, and more efficient. Yet in health care, and particularly cancer care, that is not the case. Oncology has been revolutionized in recent decades by therapies targeted to specific biomarkers and immunotherapy. Despite Read more… Why oncology is ripe for digital innovation originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - July 18, 2023 Category: General Medicine Authors: Tags: Tech Health IT Oncology/Hematology Source Type: blogs

No, the Poor Don ’ t Always Have to Be With Us
BY KIM BELLARD OK, for you amateur (or professional) epidemiologists among us: what are the leading causes of death in the U.S.?  Let’s see, most of us would probably cite heart disease and cancer.  After that, we might guess smoking, obesity, or, in recent years, COVID.  But a new study has a surprising contender: poverty.    It’s the kind of thing you might expect to find in developing countries, not in the world’s leading economy, the most prosperous country in the world. But amidst all that prosperity, the U.S. has the highest rates of poverty among developed countries, which accounts in no small part ...
Source: The Health Care Blog - July 18, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Anti-Poverty Medicine Kim Bellard TANF Source Type: blogs

Bonus Features – July 16, 2023 – 95% of patients are concerned about data breaches affecting their medical records, 81% incorrectly assume PHI collected by digital health apps is protected under HIPAA
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News The Sequoia Project and AHIMA are co-sponsoring the Data Usability Taking Root initiative, which will aim to implement data usability guidance published by a Sequoia Project workgroup with input form more than 260 organizat...
Source: EMR and HIPAA - July 16, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Accelecom Arcadia AT&T Availity Brightside Health Cerner Christine Swisher ClearDATA CMS CommonWell Health Alliance Cotiviti CVS CareMark Dave Wichmann Dr. Amy Compton-Philips eClinicalWorks eCW eLovu Health Source Type: blogs

Cancer: The Popular Vitamin Linked To 91% Higher Risk Of Disease
These supplements found to increase cancer risk at doses above recommended daily intake.
Source: PsyBlog | Psychology Blog - July 16, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Cancer Source Type: blogs

Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs