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A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
We examined longevity in type 2 diabetes (T2D) patients treated with metformin therapy and compared them to matched controls and T2D patients treated with sulphonylurea therapy. Looking at individuals over a period of up to twenty years we showed that T2D patients had shorter survival times after first treatment than matched controls. When the study period was artificially truncated, we found a statistically significant benefit of metformin therapy for longevity over matched non-diabetic controls within the first three years. However, this benefit disappeared when we looked over longer periods of time (after five years). ...
Source: Fight Aging! - May 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Bonus Features – May 14, 2023 – Only 16% of organizations are using data to define clinical best practices, 84% of orgs hit with ransomware attacks lose revenue, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News In a temporary rule, the Drug Enforcement Administration (DEA) and the Substance Abuse and Mental Health Services Administration (SAMHSA) extended telemedicine flexibilities for prescribing controlled medications for six m...
Source: EMR and HIPAA - May 14, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Health IT Company Healthcare IT athenahealth AVIA Marketplace Belong.life Chris Lance Controlled Substances DEA directtrust DrFirst eClinicalWorks eCW Edifecs EPIC iO AURA ePrescribing Equiva Health Forrester Health3PT Source Type: blogs

Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species. We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Implanted Ultrasound Lets Chemo Access Brain
Researchers at Northwestern University have trailed an implanted ultrasound device in patients, which is used in combination with microbubbles to transiently open pores in the blood brain barrier, allowing chemo drugs to enter. We have reported on th...
Source: Medgadget - May 12, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Neurology Neurosurgery Oncology Radiology glioblastoma northwestern Source Type: blogs

Wearable Ultrasound Measures Tissue Stiffness Under Skin
Researchers at the University of California San Diego have developed a wearable ultrasound patch that is intended to provide information on the stiffness of underlying tissues as deep as 4 cm below the surface of the skin. The patch consists of a fle...
Source: Medgadget - May 12, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Radiology UCSD Source Type: blogs

The deadly consequences of a shortage: The Pluvicto crisis leaves metastatic prostate cancer patients in limbo
You’ve recently been diagnosed with metastatic cancer. You started the recommended first-line therapy, but it isn’t cutting it. There is another available treatment, but your hopes are crushed upon learning that you will have to wait at least three months before the life-extending medication can be produced for you and reach your location. All the Read more… The deadly consequences of a shortage: The Pluvicto crisis leaves metastatic prostate cancer patients in limbo originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - May 12, 2023 Category: General Medicine Authors: Tags: Meds Oncology/Hematology Source Type: blogs

Measures of Biological Age Largely Correlate with Cancer Risk
Cancer is an age-related condition. With age, there is a greater background of mutational damage that spreads throughout tissues. Greater inflammatory, pro-growth signaling by lingering senescent cells makes the environment more hospitable for cancerous growth once it is underway. The aging immune system becomes ever less able to destroy precancerous and cancerous cells rapidly enough to stop a cancer in its earliest stages. Thus we should expect people who show an accelerated biological age to exhibit a greater risk of cancer, and this is largely the case. Most measures of biological age have quirks, however, as th...
Source: Fight Aging! - May 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

High-Throughput Testing of Hundreds of Anti-Cancer Drug Combinations
Researchers at ETH Zurich in Switzerland have developed a high-throughput screening method for anti-cancer drugs that they have called “pharmascopy”. To date, the researchers have tested the system with multiple myeloma samples, a cancer ...
Source: Medgadget - May 11, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology ETH Zurich ethz Nature Cancer Source Type: blogs

The New Alzheimer ' s Therapies are Not What One Would Call Successful
The first batch of immunotherapies demonstrated to be capable of clearing extracellular amyloid-β from the brain have performed poorly in late stage Alzheimer's patients. Data is beginning to emerge for their ability to modestly slow down the progression of the condition at earlier stages, however. This somewhat fits with the amyloid cascade hypothesis, in that it is evidence to support the idea that amyloid-β is no longer important to disease progression once the condition has reached the stage of becoming a feedback loop involving tau aggregation, chronic inflammation, and cell death. Unfortunately, it isn't str...
Source: Fight Aging! - May 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

In an Ideal World, How Much Would We Spend on Health Care? – Part 1
BY BEN WHEATLEY We have heard it said before, and it is no longer shocking to say, that in 2021 the United States spent $4.3 trillion on health care. To put this gaudy number in some perspective, we measure it as a share of our economy and report that health care comprised 18.3% of our gross domestic product. CMS projects that health care will approach 20% of GDP in coming years—one-fifth of everything we buy and sell in this country.  In a recent report, the Health Affairs Council on Health Care Spending and Value said that “it is unclear what percentage of GDP would represent the ideal level to devote to healt...
Source: The Health Care Blog - May 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health care spending medical debt Patent Source Type: blogs

In an Ideal World, How Much Would We Spend on Health Care?
BY BEN WHEATLEY We have heard it said before, and it is no longer shocking to say, that in 2021 the United States spent $4.3 trillion on health care. To put this gaudy number in some perspective, we measure it as a share of our economy and report that health care comprised 18.3% of our gross domestic product. CMS projects that health care will approach 20% of GDP in coming years—one-fifth of everything we buy and sell in this country.  In a recent report, the Health Affairs Council on Health Care Spending and Value said that “it is unclear what percentage of GDP would represent the ideal level to devote to h...
Source: The Health Care Blog - May 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health care spending medical debt Patent Source Type: blogs

An inspiring tribute to an exceptional radiologist who made a lasting impact
“He had an intuitive gift as a physician in diagnosing and managing breast cancer. His expertise helped countless patients, and he was deeply appreciated by those he cared for. He felt an enormous sense of gratitude to be able to help his patients and be an integral part of their care.” I didn’t want to Read more… An inspiring tribute to an exceptional radiologist who made a lasting impact originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - May 11, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Capsule Delivers Electrical Current to Stomach for Appetite
This study helps establish electrical stimulation by ingestible electroceuticals as a mode of triggering hormone release via the GI tract,” said Giovanni Traverso, a researcher involved in the study. “We show one example of how we’r...
Source: Medgadget - May 10, 2023 Category: Medical Devices Authors: Conn Hastings Tags: GI Oncology cachexia mit Source Type: blogs

Career Conversations: Q & A With Biochemist Prabodhika Mallikaratchy
Credit: CUNY School of Medicine. “One of the biggest things I hope for in my career is that in 20 years, I still feel the same joy and enthusiasm for research and training that I feel now,” says Prabodhika Mallikaratchy, Ph.D., a professor in the department of molecular, cellular, and biomedical sciences at the City University of New York (CUNY) School of Medicine. Dr. Mallikaratchy talks with us about her career path, research on developing new immunotherapies and molecular tools using nucleic acids, and her belief in the importance of being passionate about your career. Q: How did you first become interested in ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 10, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques DNA Medicines Profiles Proteins Source Type: blogs

Reviewing T Cell Immunotherapies to Treat Cancer
The use of immunotherapies will most likely replace chemotherapy and radiation therapy for the treatment near all cancers over the next twenty years, and has already done so for many types of cancer. We should expect immunotherapies to in turn be replaced by approaches that target the telomere lengthening essential to all cancers. The wheel turns slowly, but this progress will lead steadily to an end to the suffering and loss of life accompanying cancer. Cancer will become a mild, annoying but controllable condition within a matter of decades, within the lifetimes of most of those reading this now. The review paper noted h...
Source: Fight Aging! - May 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs