Pulsed field ablation for pulmonary vein isolation: Preclinical safety and effectiveness of a novel hexaspline ablation catheter
ConclusionIn the chronic canine study, PFA-based PVI were safe and effective with demonstrable sparing of nerves and venous tissue. Compared with RFA, there was also good evidence for safety of PFA, avoiding PV stenosis and esophageal injury. This preclinical study provided the scientific basis for the first-in-human endocardial PFA studies.
Source: Journal of Cardiovascular Electrophysiology - September 15, 2023 Category: Cardiology Authors: Fengyuan Yu, Xiaonan Dong, Lei Ding, Vivek Reddy, Min Tang Tags: ORIGINAL ARTICLE Source Type: research

Label ‐Free and Colorimetric Detection of Influenza A Virus via Receptor‐Mediated Viral Fusion with Plasmonic Vesicles
This work presents a plasmonic vesicle-mediated fusogenic immunoassay (PVFIA) for the label-free and colorimetric detection of influenza A virus (IAV). PVFIA demonstrates excellent specificity in capturing the target, while the fusion assay with gold nanoparticle (GNP) encapsulating fusogenic plasmonic vesicles (PVs) enables visual detection. The results show a low detection limit (100.7919 EID50 mL−1) and good reliability (0.9901), indicating sensitivity 104.208 times higher than conventional immunoassay. AbstractThe rapid transmission and numerous re-emerging human influenza virus variants that spread via the respirato...
Source: Small - September 15, 2023 Category: Nanotechnology Authors: Yesol Moon, Sojeong Lee, Jinyoung Kim, Geunseon Park, Chaewon Park, Jong ‐Woo Lim, Minjoo Yeom, Daesub Song, Seungjoo Haam Tags: Research Article Source Type: research

Moderna CEO Pledges 15 New Products. For Now It Has 1: Its Covid Vaccine
Moderna CEO Stéphane Bancel said Wednesday that new positive data on the company’s influenza vaccine, and an aggressive plan to launch 15 products over the next five years, shows that his company will no longer be defined by the Covid-19 vaccines that made i...#moderna #stéphanebancel
Source: Reuters: Health - September 15, 2023 Category: Consumer Health News Source Type: news

Influenza A(H5N1) Virus Infections in 2 Free-Ranging Black Bears (Ursus americanus), Quebec, Canada
B. T. Jakobek et al.
Source: Emerging Infectious Diseases Journal - September 15, 2023 Category: Infectious Diseases Source Type: research

CVS MAXIMUM STRENGTH COLD AND FLU RELIEF (acetaminophen, dextromethorphan hydrobromide, guaifenesin ,phenylephrine hcl) liquid CVS PHARMACY, INC
Updated Date: Fri, 15 Sep 2023 00:00:00 EDT
Source: DailyMed Drug Label Updates - September 15, 2023 Category: Drugs & Pharmacology Source Type: alerts

CVS MAXIMUM STRENGTH COLD AND FLU RELIEF (acetaminophen, dextromethorphan hydrobromide, guaifenesin ,phenylephrine hcl) liquid CVS PHARMACY
Updated Date: Fri, 15 Sep 2023 00:00:00 EDT
Source: DailyMed Drug Label Updates - September 15, 2023 Category: Drugs & Pharmacology Source Type: alerts

Comparative analysis of clinical features of lower respiratory tract infection with respiratory syncytial virus and influenza virus in adults: a retrospective study
Respiratory syncytial virus (RSV) infection in adults remains less recognized and understood, both socially and clinically, compared to influenza virus infection. This retrospective study aims to delineate and...
Source: BMC Pulmonary Medicine - September 15, 2023 Category: Respiratory Medicine Authors: Jiahua Tian, Congyue Liu, Xunling Wang, Ling Zhang, Guoying Zhong, Guichuan Huang, Hongping Wang, Hao Hu, Ling Gong and Daishun Liu Tags: Research Source Type: research

Protocol of the process evaluation of cluster randomised control trial for estimating the effectiveness and cost-effectiveness of a complex intervention to increase care home staff influenza vaccination rates compared to usual practice (FluCare)
Influenza (flu) vaccination rates in UK care home staff are extremely low. Less than 40% of staff in care homes are vaccinated for influenza (flu), presenting risks to the health of frail residents and potenti...
Source: Trials - September 15, 2023 Category: General Medicine Authors: Linda Birt, Thando Katangwe-Chigamba, Sion Scott, David J Wright, Adam P. Wagner, Erika Sims, Veronica Bion, Carys Seeley, Faisal Alsaif, Allan Clarke, Alys Griffiths, Liz Jones, Alison Bryant and Amrish Patel Tags: Study protocol Source Type: research

Viruses, Vol. 15, Pages 1925: Bridging the Gap: Can COVID-19 Research Help Combat African Swine Fever?
hanarat African swine fever (ASF) is a highly contagious and economically devastating disease affecting domestic pigs and wild boar, caused by African swine fever virus (ASFV). Despite being harmless to humans, ASF poses significant challenges to the swine industry, due to sudden losses and trade restrictions. The ongoing COVID-19 pandemic has spurred an unparalleled global research effort, yielding remarkable advancements across scientific disciplines. In this review, we explore the potential technological spillover from COVID-19 research into ASF. Specifically, we assess the applicability of the diagnostic tools, vac...
Source: Viruses - September 15, 2023 Category: Virology Authors: Danaya Pakotiprapha Sakonwan Kuhaudomlarp Ruchanok Tinikul Sittinan Chanarat Tags: Review Source Type: research

Endovascular transmural access to carotid artery perivascular tissues: safety assessment of a novel technique
Conclusion Repeated puncture of the carotid artery to gain access to the perivascular tissues using a novel endovascular transmural approach is safe in a swine model. This represents a novel approach to various tissues in close proximity to the cervical and cranial vasculature.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Kim, W. J., Samarage, H. M., Zarrin, D., Goel, K., Wang, A. C., Johnson, J., Nael, K., Colby, G. P. Tags: New devices New devices and techniques Source Type: research

Genetic diversification patterns in swine influenza A virus (H1N2) in vaccinated and nonvaccinated animals
Influenza A viruses (IAVs) are characterized by having a segmented genome, low proofreading polymerases, and a wide host range. Consequently, IAVs are constantly evolving in nature causing a threat to animal and human health. In 2009 a new human pandemic IAV strain arose in Mexico because of a reassortment between two strains previously circulating in pigs; Eurasian “avian-like” (EA) swine H1N1 and “human-like” H1N2, highlighting the importance of swine as adaptation host of avian to human IAVs. Nowadays, although of limited use, a trivalent vaccine, which include in its formulation H1N1, H3N2, and, H1N2 swine IAV ...
Source: Frontiers in cellular and infection microbiology - September 15, 2023 Category: Microbiology Source Type: research

Molnupiravir: an antiviral drug against COVID-19
AbstractSARS-CoV-2, the virus responsible for COVID-19, has caused numerous deaths worldwide and poses significant challenges. Researchers have recently studied a new antiviral drug called molnupiravir for treating COVID-19. This review examines the causes and immunopathogenesis of COVID-19, as well as the role of molnupiravir in its treatment. Molnupiravir is a prodrug of β-D-N4-hydroxyctytidine (NHC) and has demonstrated activity against various viruses, including MERS-CoV, SARS-CoV, SARS-CoV-2, and influenza virus. The active form of molnupiravir, NHC triphosphate, acts as a nucleoside analog that disrupts viral replic...
Source: Archives of Virology - September 15, 2023 Category: Virology Source Type: research

Protocol of the process evaluation of cluster randomised control trial for estimating the effectiveness and cost-effectiveness of a complex intervention to increase care home staff influenza vaccination rates compared to usual practice (FluCare)
DiscussionAdopting this systematic and comprehensive process evaluation approach will help ensure data is captured on all aspects of the trial, enabling a full understanding of the intervention implementation and RCT findings.Trial registrationISRCTN ISRCTN22729870. Registered on 24 August 2022.
Source: Trials - September 15, 2023 Category: Research Source Type: clinical trials

PCPs Prep for ' Less Predictable ' Respiratory Virus Season PCPs Prep for ' Less Predictable ' Respiratory Virus Season
On the cusp of respiratory virus season, experts offer their guidance to primary care physicians about how to advise patients about vaccines for COVID-19, influenza, and RSV.Medscape Medical News
Source: Medscape Allergy Headlines - September 14, 2023 Category: Allergy & Immunology Tags: Family Medicine/Primary Care News Source Type: news

With the Decongestant SNAFU, the FDA Tries Something New
It’s easy to understand how a medicine like phenylephrine got onto pharmacy shelves in the first place. The common decongestant, used most often as an ingredient in multidrug cold medications like DayQuil and Sudafed PE, was initially designated as “safe and effective” by the Food and Drug Administration (FDA) in 1976, when the agency was newly—and less stringently than today—greenlighting drugs that had been on the market for years before the agency had established any efficacy standards. After a full review of 14 studies (12 unpublished and two published) from pharmaceutical companies—...
Source: TIME: Health - September 14, 2023 Category: Consumer Health News Authors: Haley Weiss Tags: Uncategorized healthscienceclimate Source Type: news

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