TWiV 1044: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 southern hemisphere influenza vaccines in preventing Influenza-associated hospitalizations, genome-wide association study of susceptibility to RSV hospitalization in young children
Source: This Week in Virology - MP3 Edition - September 16, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Viruses, Vol. 15, Pages 1939: Developing an Indirect ELISA for the Detection of African Swine Fever Virus Antibodies Using a Tag-Free p15 Protein Antigen
Xia Shanyuan Zhu African swine fever (ASF) is one of the most severe diseases caused by the ASF virus (ASFV), causing massive economic losses to the global pig industry. Serological tests are important in ASF epidemiological surveillance, and more antigen targets are needed to meet market demand for ASFV antibody detection. In the present study, ASFV p15 protein was fusion-expressed in Escherichia coli (E. coli) with elastin-like polypeptide (ELP), and the ELP-p15 protein was purified using a simple inverse transition cycling (ITC) process. The ELP tag was cleaved off using tobacco etch virus protease (TEVp), result...
Source: Viruses - September 16, 2023 Category: Virology Authors: Zhi Wu Huipeng Lu Dewei Zhu Jun Xie Fan Sun Yan Xu Hua Zhang Zhijun Wu Wenlong Xia Shanyuan Zhu Tags: Article Source Type: research

Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
AbstractNeurological manifestations of coronavirus disease 2019 (COVID-19) are less noticeable than the respiratory symptoms, but they may be associated with disability and mortality in COVID-19. Even though Omicron caused less severe disease than Delta, the incidence of neurological manifestations is similar. More than 30% of patients experienced “brain fog”, delirium, stroke, and cognitive impairment, and over half of these patients presented abnormal neuroimaging outcomes. In this review, we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with ...
Source: Neuroscience Bulletin - September 16, 2023 Category: Neuroscience Source Type: research

NIH Clinical Trial of Universal Flu Vaccine Candidate FluMos-v2 Begins
September 15, 2023 -- Enrollment in a Phase 1 trial of a new investigational universal influenza vaccine candidate has begun at the National Institutes of Health’s Clinical Center in Bethesda, Maryland. The trial is sponsored by the National...
Source: Drugs.com - Clinical Trials - September 15, 2023 Category: Pharmaceuticals Source Type: clinical trials

CDC warns of another 'tripledemic' this winter: Agency says Covid, RSV and flu could overwhelm hospitals again - after mask-wearing and lockdowns weakened people's immune systems
While the spread of the respiratory viruses is low at the moment, the CDC has started to see an uptick in positive Covid tests and Covid-related emergency department visits across the US.
Source: the Mail online | Health - September 15, 2023 Category: Consumer Health News Source Type: news

NIH clinical trial of universal flu vaccine candidate begins
Vaccine targets six flu strains.
Source: National Institutes of Health (NIH) News Releases - September 15, 2023 Category: American Health Source Type: news

Notice to Inform the Extramural Influenza Research Community of the Availability of Materials for Controlled Human Influenza Virus Infection Model (CHIVIM) Clinical Studies and Trials
Notice NOT-AI-23-067 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 15, 2023 Category: Research Source Type: funding

Flu-Like Symptoms, Then Amputation; Docs Charge for Emails; Wait List for Psilocybin
(MedPage Today) -- Note that some links may require registration or subscription. A Tennessee teenager's flu-like symptoms turned out to be a rare bacterial infection that led to the amputation of his hands and feet. (USA Today) In Arkansas...
Source: MedPage Today Psychiatry - September 15, 2023 Category: Psychiatry Source Type: news

It ' s Time to Start Preparing Against Flu, RSV & COVID-19
FRIDAY, Sept. 15, 2023 – Kids are back in school and it’s time to think about viruses, for both yourself and them. It could be an early flu season in the United States, if what happened in the Southern Hemisphere offers any insight, according to...
Source: Drugs.com - Daily MedNews - September 15, 2023 Category: General Medicine Source Type: news

Methods for virus recovery from environmental surfaces to monitor infectious viral contamination
Environ Int. 2023 Sep 9;180:108199. doi: 10.1016/j.envint.2023.108199. Online ahead of print.ABSTRACTAccurate quantification of infectious contaminants on environmental surfaces, particularly infectious viruses, is essential for contact transmission risk assessment; however, difficulties in recovering viruses from surfaces using swabs complicates this quantification process. Herein, we identified the factors that significantly affected virus recovery rates and developed an ideal swab method that yielded the highest rate of virus recovery. We comprehensively analyzed the effects of swab type (cotton/polyester), swab water c...
Source: Environment International - September 15, 2023 Category: Environmental Health Authors: Hajime Miyazaki Ryohei Hirose Mikako Ichikawa Hiroki Mukai Katsuma Yamauchi Takaaki Nakaya Yoshito Itoh Source Type: research

Concurrent determination of cyanide and thiocyanate in human and swine antemortem and postmortem blood by high-performance liquid chromatography-tandem mass spectrometry
Anal Bioanal Chem. 2023 Sep 15. doi: 10.1007/s00216-023-04939-6. Online ahead of print.ABSTRACTCyanide (in the form of cyanide anion (CN-) or hydrogen cyanide (HCN), inclusively represented as CN) can be a rapidly acting and deadly poison, but it is also a common chemical component of a variety of natural and anthropogenic substances. The main mechanism of acute CN toxicity is based on blocking terminal electron transfer by inhibiting cytochrome c oxidase, resulting in cellular hypoxia, cytotoxic anoxia, and potential death. Due to the well-established link between blood CN concentrations and the manifestation of symptoms,...
Source: Analytical and Bioanalytical Chemistry - September 15, 2023 Category: Chemistry Authors: Abdullah H Alluhayb Carter Severance Tara Hendry-Hofer Vikhyat S Bebarta Brian A Logue Source Type: research

Association of vaccine-specific regulatory T cells with reduced antibody response to repeated influenza vaccination
This article is protected by copyright. All rights reserved.PMID:37713727 | DOI:10.1002/eji.202350525
Source: European Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Pin-Hung Lin Po-Ju Hsiao Ching-Fu Pan Ming-Tsan Liu Jann-Tay Wang Chi Ching Fang-Yi Wu Yi-Hsuan Lin Yu-Chan Yang Le-Yin Hsu Hung-Chih Yang Un-In Wu Source Type: research

Mentha pulegium: A Plant With Several Medicinal Properties
Endocr Metab Immune Disord Drug Targets. 2023 Sep 14. doi: 10.2174/1871530323666230914103731. Online ahead of print.ABSTRACTThe species Mentha pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Drugs & Pharmacology Authors: Smail Amtaghri Miloudia Slaoui Mohamed Eddouks Source Type: research

Association of vaccine-specific regulatory T cells with reduced antibody response to repeated influenza vaccination
This article is protected by copyright. All rights reserved.PMID:37713727 | DOI:10.1002/eji.202350525
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Pin-Hung Lin Po-Ju Hsiao Ching-Fu Pan Ming-Tsan Liu Jann-Tay Wang Chi Ching Fang-Yi Wu Yi-Hsuan Lin Yu-Chan Yang Le-Yin Hsu Hung-Chih Yang Un-In Wu Source Type: research

Mentha pulegium: A Plant With Several Medicinal Properties
Endocr Metab Immune Disord Drug Targets. 2023 Sep 14. doi: 10.2174/1871530323666230914103731. Online ahead of print.ABSTRACTThe species Mentha pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Smail Amtaghri Miloudia Slaoui Mohamed Eddouks Source Type: research

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