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A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this.
There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Last Christmas – a Xmas Gothic
Last Christmas by David Bradley (PDF/Kindle version here)
Funnily enough, it was four years to the day since the fourth variant had emerged. So, it was Christmas Day. Four years since the death toll passed 200 million. What a gift. Four years since the last dying embers of the theory of herd immunity had burned out and even the rich and the beyond-rich were suffering.
Four years. It’s hard to believe. What started as a very localised outbreak, with a mere handful of hospitalisations had quickly thrown the global community into panic and ultimately pandemic. The present that keeps on giving. Each genetic mutation unwrappi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 29, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Last Christmas – a short story
Last Christmas by David Bradley (PDF/Kindle version here)
Funnily enough, it was four years to the day since the fourth variant had emerged. So, it was Christmas Day. Four years since the death toll passed 200 million. What a gift. Four years since the last dying embers of the theory of herd immunity had burned out and even the rich and the beyond-rich were suffering.
Four years. It’s hard to believe. What started as a very localised outbreak, with a mere handful of hospitalisations had quickly thrown the global community into panic and ultimately pandemic. The present that keeps on giving. Each genetic mutation unwrappi...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 29, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism.
Mouse Age Matters: How Age Affects the Murine Plasma Metabolome
A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Data for COVID-19 Mortality in Older People in the US
The general consensus on mortality due to COVID-19 is that it falls most heavily on people who are more impacted by aging: poor immune function when it comes to defense against pathogens; high levels of chronic inflammation that create a greater susceptibility to the way in which SARS-CoV-2 kills people; existing chronic disease; and a mortality rate that is already high even setting aside the pandemic. When younger people die due to the virus, in much smaller numbers, it is where they share these characteristics of inflammation, deficient immune systems, and chronic disease. This level of morbidity is unusual in younger i...
Source: Fight Aging! - December 23, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
3 Patient Lessons: What Cancer Patients Teach Me
By YASMIN ASVAT
An estimated 1.8 million people in this country may face a cancer diagnosis this year, in what has already been a bleak year of isolation and loss.
While news of the COVID-19 vaccine rolling out across the U.S. offers hope in a year of 311,000 deaths, 11 million people face the financial pressure of unemployment, and, approximately 43 percent of the nation reports some symptoms of anxiety or depression.
It is understandable that a cancer diagnosis now may be too much to bear. And yet, somehow, many patients cope with t...
Source: The Health Care Blog - December 22, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Patients Physicians Source Type: blogs
A word about mRNA vaccines
I note that many people are concerned that mRNA vaccine technology has never before been approved for use in humans. They worry about unknown risks and nasty surprises, and are reluctant to accept the Pfizer and Moderna vaccines.I am actually not worried about it, and I ' ll try to explain why. First I ' ll just note that this technology has been under development for decades, and has been tested extensively in animal models and experimentally in humans before the large-scale clinical trials that have led to Emergency Use Authorization. So there is a lot of evidence for safety, although it is true that the follow-up time f...
Source: Stayin' Alive - December 18, 2020 Category: American Health Source Type: blogs
Network medicine offers new insights into susceptibility to diseases such as COVID-19
In the past year, we ' ve become familiar with the factors that can make a person more vulnerable to COVID-19 infection. The elderly are more at risk, as are those who smoke and are already dealing with other diseases, such as cancer and Type 2 diabetes.At a deeper level, though, there are dozens of other factors that may come into play and influence a person ' s susceptibility to disease. A recent analysis of hospitalized COVID-19 patients in 14 states found that among patients ages 50-64 that obesity was the most prevalent underlying medical condition. Similarly, there ' s growing evidence to suggest that vitamin D defic...
Source: Life as a Healthcare CIO - December 17, 2020 Category: Information Technology Source Type: blogs
The Spectrum of Alzheimer's: An Interview With Gayatri Devi, M.D.
For years, the push to do something about Alzheimer’s disease-focused almost entirely on drug development. Find a cure. Develop a vaccine to prevent the disease. Develop a drug to “manage” people who live with Alzheimer’s and other types of dementia. What many people weren’t noticing, however, was that in tandem with this effort was a quiet revolution doggedly moving forward. Long championed by Dr. Bill Thomas of Changing Aging among others, the thinking behind this movement has always been to recognize that people living with Alzheimer’s and other dementia were first and foremost...
Source: Minding Our Elders - December 16, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Shingles: What triggers this painful, burning rash?
If you’re like 95% of American adults, you had chickenpox as a kid. Before the United States started its widespread vaccination program in 1995, there were roughly four million cases of chickenpox every year. So, most people suffered through an infection with this highly contagious virus and its itchy, whole-body rash.
But unlike many childhood viruses, the varicella-zoster virus that causes chickenpox doesn’t clear from the body when the illness ends. Instead it hangs around, taking up residence and lying dormant in the nerves, sometimes for decades, with the immune system holding it in check. In some people, it lives...
Source: Harvard Health Blog - December 14, 2020 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Health Healthy Aging Skin and Hair Care Vaccines Source Type: blogs
What I Got Wrong (and Right) about COVID19
In May, I wrote a column about COVID19 that got some attention.
My reason for writing was the change in messaging about the strategy of flatten-the-curve. We were first told to flatten-the-curve to prevent overwhelming hospitals. But then the thinking changed to flatten-the-curve to save lives.
I made eight assertions about COVID19. Let’s see how I did.
Assertion 1: The virus will not be contained. Verdict: Correct.
You might argue that New Zealand and Australia contained the virus, but I would counter that these are not fair comparisons to the US, Canada, and the EU.
Assertion 2: Tests...
Source: Dr John M - December 12, 2020 Category: Cardiology Authors: Dr John Source Type: blogs
Why are mRNA vaccines so exciting?
The very first vaccines for COVID-19 to complete Phase 3 testing are an entirely new type: mRNA vaccines. Vaccines of this type have never before been approved for use in any disease. How do they differ from traditional vaccines, and what makes them so exciting?
How traditional vaccines work
The main goal of a vaccine for a particular infectious agent, such as the virus that causes COVID-19, is to teach the immune system what that virus looks like. Once educated, the immune system will vigorously attack the actual virus, if it ever enters the body.
Viruses contain a core of genes made of DNA or RNA wrapped in a coat of pro...
Source: Harvard Health Blog - December 10, 2020 Category: Consumer Health News Authors: Anthony Komaroff, MD Tags: Coronavirus and COVID-19 Health Vaccines Source Type: blogs
Top 10 Online Medical Resources For The Patients Of The Future
There are over 1 billion health-related searches on Google every single day, according to a report. This was about 7% of all searches on the platform before, and no one will be surprised when the 2020 data massively surpasses this number. After all, the internet is likely the first source to turn to with your health-related questions.
But which hits are relevant, and which lead to straightforward la la land – even with the best intentions and the best A.I. toolset, the search giant can’t exclude the latter from among the results. And yet, doing so is especially important in the case of medicine and healthcare, s...
Source: The Medical Futurist - December 10, 2020 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research E-Patients Medical Education Medicine social media Webicina webmd gc2 online resources pharmaceutics Topol Mayo Clinic ePatients Medscape Eric Topol Smart Patients Medline Plus National Library of Source Type: blogs
Common cold, flu, or coronavirus?
In the early days of the outbreak, the novel coronavirus (COVID-19) was repeatedly compared to the flu (influenza) and even to the common cold (rhinoviruses, et al). This was due to an initial impression of shared symptoms.
The differences between these conditions are particularly important as we kick off National Influenza Vaccination Week (NIVW) and the ‘flu season’. So, how can we tell which of these diseases we are dealing with in a given patient?
Common cold
Let’s start with the common cold, a condition that can be caused by over 200 different strains of viruses. On average, an adult wil...
Source: GIDEON blog - December 8, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Diagnosis Identify News Source Type: blogs
Vaccination NOW
In a few month’s time, the first 10 million people will have been vaccinated against covid. Within two months, 4000 of those people will have a heart attack, 4000 will have a stroke, 10000 will be diagnosed with cancer, 14000 will die.
How many of those illnesses and deaths will be due to the vaccination? None of them.
But, the antivaxxers will start to claim some of those 4000 strokes, those 10000 cancers, those 14000 deaths as being caused by the vaccine. They will be wrong to do so. Why, because if we were to start counting 10 million people from today, none of them yet vaccinated against covid, within two months,...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 6, 2020 Category: Science Authors: David Bradley Tags: COVID-19 Source Type: blogs
