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Fight Aging! Newsletter, June 3rd 2019
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing. Altered Intercellular Communication It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - June 2, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Understanding Machine Learning And Deep Learning In Medicine
Algorithms, datasets, machine learning, deep learning, cognitive computing, big data, and artificial intelligence: IT expressions that took over the language of 21st-century healthcare with surprising force. If medical professionals want to get ahead of the curve, they rather get familiarized with the basics of A.I. and have an idea of what medical problems they aim to solve. So, let’s take a closer look at machine learning and deep learning in medicine. The ante-room of artificial intelligence The term “artificial intelligence” might be misleading as due to the overuse of the expression, its meaning started to...
Source: The Medical Futurist - May 30, 2019 Category: Information Technology Authors: nora Tags: Artificial Intelligence in Medicine Future of Medicine AI algorithm deep learning Health Healthcare Innovation machine learning smart smart algorithm smart health technology Source Type: blogs

Fight Aging! Newsletter, May 27th 2019
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - May 26, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Measles: The forgotten killer
As a medical student, the place I dreaded most was the ward at the children’s hospital where they kept the chronic ventilator patients. Unlike the other floors, where there was shouting and laughter and tears, and all the commotion and turbulence of youth, here it was dark and lifeless and eerie, with no sound except the hum of the ventilators, and the rattle of air being forced through plastic tubes. It was a place of failure and defeat, the desolate aftermath of some vast and tragic battle. An unexpected aftermath of measles My patient was a teenager who had been in a coma for years. His limbs had stubbornly twisted up...
Source: Harvard Health Blog - May 23, 2019 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Children's Health Infectious diseases Men's Health Vaccines Women's Health Source Type: blogs

Changes in T Cell Populations that Characterize the Progression of Immunosenescence
Immunosenescence is the name give to the age-related decline in effectiveness of the immune system. Some authors consider this to be distinct from inflammaging, the growth in chronic inflammation due to overactivation of the immune system in response to molecular damage and the presence of senescent cells, while others consider that chronic inflammation to be an aspect of immunosenescence. In today's open access paper, researchers review immunosenescence from the perspective of the adaptive immune system, here meaning detrimental changes in T cell populations. The contributing causes of these changes are given as (a) the a...
Source: Fight Aging! - May 20, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

No, the HPV vaccine isn ’t optional
A lot of parents ask me, about the HPV vaccine,“Isn’t that the optional one?” Well, let me walk you through why my answer to that question is a hard“no.” Human papillomavirus (HPV) is a virus that causes warts and several types of cancer. There are over 200 different  strains of HPV, some of which […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - May 19, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/chad-hayes" rel="tag" > Chad Hayes, MD < /a > < /span > Tags: Meds Pediatrics Source Type: blogs

Fight Aging! Newsletter, May 13th 2019
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, ...
Source: Fight Aging! - May 12, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

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(see:Startup uses phone, light and AI to detect cervical cancer)Israeli startup MobileODT has created the Eva System, which uses an Automated Visual Evaluation (AVE) algorithm that it says can detect cervical cancer by simply examining an image of the cervix (Courtesy) Israeli startup MobileODT has created the Eva System, which uses an Automated Visual Evaluation (AVE) algorithm that it says can detect cervical cancer by simply examining an image of the cervix (Courtesy) Israeli start-up MobileODT says it can detect cervical cancer more accurately and inexpensively than the standard colposcopy method used today, by creatin...
Source: Lab Soft News - April 17, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Source Type: blogs

We take requests
Someone is interested in laws regarding vaccination in the United States. There is often a tension between the liberty interest and social welfare in public health, at least from many people ' s perspective. It is a general principle that competent adults cannot be compelled to undergo any medical procedure against their will. Adults can decide to check out of the hospital against medical advice, or to treat their cancer with coffee enemas rather than surgery and chemotherapy, and the state does not get involved. As for people who are ruled not competent, that ' s a whole other discussion, but I will point out that a judge...
Source: Stayin' Alive - April 11, 2019 Category: American Health Source Type: blogs

DNA Tumour Viruses review
Excerpt from a book review of DNA Tumour Viruses: Virology, Pathogenesis and Vaccines"This book is an excellent, timely current summary of this field and provides further support for the potential clinical application of these studies ... the book hits its mark and I would recommend it as a must have ... will be of sure interest for anyone want to be informed about cancer related to viral infection." from Human Vaccines and Immunotherapeutics read more ...DNA Tumour Viruses: Virology, Pathogenesis and VaccinesEdited by: Sally RobertsA must-read book for anyone with an interest in viral tumourigenesis. read more ...
Source: Microbiology Blog: The weblog for microbiologists. - April 11, 2019 Category: Microbiology Source Type: blogs

Sen. Warren Calls for Imprisoning Executives Over Negligent Harm
Presidential candidate and Sen. Elizabeth Warren (D-Massachusetts) wants to see more business people behind bars, and she ’s not fussy about how to make that happen. In aWashington Post op-ed last week she unveiled a new Corporate Executive Accountability Act, which in her words would expand “criminal liability to any corporate executive who negligently oversees a giant company causing severe harm to U.S. families.” She says she wants top executives to know that they can be (again in her own words) “hauled out in handcuffs for failing to reasonably oversee the companies they run.”Under longstanding legal protec...
Source: Cato-at-liberty - April 9, 2019 Category: American Health Authors: Walter Olson Source Type: blogs

8 Things Autistic People Wished You Knew about April
Every April, autism takes a center stage in global awareness. All around the world, well-meaning, good-hearted people “Light it up blue” for Autism Awareness Month, and they decorate their social media with the puzzle piece frames and the jigsaw rainbow awareness ribbons. And, every March, autistic adults are already dreading April. Many of them report feeling traumatized by previous Aprils. They begin to mentally prepare for what is ahead, feeling powerless to stop it. They’re bracing themselves for what is on the horizon. What autistic people wish their neurotypical allies knew going into April: We really don’t...
Source: World of Psychology - April 8, 2019 Category: Psychiatry & Psychology Authors: Terra Vance Tags: Aspergers Autism General Personal Stigma Autism Acceptance Month Autism Awareness Month Autism Spectrum medical disability model neurodivergent neurodiversity neurotypical allies stereotyping Stigmatization Source Type: blogs

Our Visit to WIRED Health 2019 at London ’s Francis Crick Institute
WIRED Health, now in its sixth year, returned to London’s Francis Crick Institute. The event was opened by Crick Institute director Paul Nurse who introduced the institute and its mission to understand the fundamental biology of human health and d...
Source: Medgadget - April 2, 2019 Category: Medical Devices Authors: Tom Peach Tags: Exclusive Medicine Public Health Society Source Type: blogs

Fight Aging! Newsletter, March 11th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - March 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Video of Investor Jim Mellon Presenting at Abundance 360 Summit 2019
Jim Mellon's Juvenescence venture is at present one of the few major venture organizations focused on approaches to treat aging as a medical condition. Mellon and his colleagues outlined their take on the field in a 2017 book, also called Juvenescence. We are fortunate in that he is among the first few high net worth individuals to both agree with the SENS philosophy of damage repair, and then, much more importantly, follow through in action as well as word. He is not just seeing a massive market opportunity in treating aging, though that is certainly there, but is doing this because he wishes to achieve the goal of radica...
Source: Fight Aging! - March 4, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs