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Federal Aid Creates Central ‐​Planning Power
This study argues that Congress should repeal all federal aid-to-state programs for many reasons, including that aid comes with costly strings attached that destroy local democracy.Richard Epstein and Mario Loyolanoted about aid programs: “When Americans vote in state and local elections, they think they are voting on state and local policies. But often they are just deciding which local officials get to implement the dictates of distant and insulated federal bureaucrats, whom even Congress can’t control.”I came across a table (p. 82) in New Jersey ’s budget that lists the $15 billion the state received in 2020 fro...
Source: Cato-at-liberty - September 4, 2020 Category: American Health Authors: Chris Edwards Source Type: blogs

Back to school Mums
There’s an amusing, “Which back-to-school Mum are you?” doing the social media rounds. It sees Sue sending her kids back fully PPE’d, Trisha seriously concerned for the teachers’ safety, Betty in floods until they get home, and Mavis foreseeing burnout by the end of the week because of her newly full diary. But, they overlooked one kind of Mum… The one that will insist on her human right not to wear a mask, completely ignores social distancing everywhere, brings husband Mick and Auntie Helen to wave the kids off, storms into the Head’s office shouting her mouth off about the HPV va...
Source: David Bradley Sciencebase - Songs, Snaps, Science - September 3, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

New Cato Book: Ten Global Trends Every Smart Person Should Know: And Many Others You Will Find Interesting
In conclusion, I hope that you will buy this book and share it with your family and friends. It is meant to be a conversation piece. Instead of gathering dust on a bookshelf, it is designed to lie on a living room table (like so many architecture and interior design books), for visitors to see and discuss over a martini or glass of wine. I hope that it will alleviate some depression and anxiety, spark a fact ‐​filled discussion around the dining room table, and maybe even change some minds. Strangers things have happened. Cheers!
Source: Cato-at-liberty - August 31, 2020 Category: American Health Authors: Marian L. Tupy Source Type: blogs

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards Better Vaccines and a Lower Burden of Infectious Disease in Old People
Over a lifetime, the burden of infectious disease - and particularly persistent infections such as cytomegalovirus - influences the pace of aging via its detrimental impact on immune function in later life. The slow upward trend in life expectancy over the past two centuries is due in no small part to reductions in infectious disease that accompanied improvements in sanitation and then medicine. In addition, in old age, once the immune system declines into ineffectieness, infectious disease becomes a much more serious concern. Infections that a young person defeats with ease become life-threatening. The primary strategy to...
Source: Fight Aging! - August 17, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, August 10th 2020
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - August 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

4 Examples Of Merging Gaming & Digital Health
Pausing to check his map, Sam confirms that he is on the right track for his next delivery, only 2 kilometres left. He takes the opportunity to quench his thirst and check if his delivery load is securely attached to his back; some contain fragile vials of medicines and digital pills susceptible to damage if handled inappropriately. After making sure of the integrity of those packages, Sam takes a final look at his surroundings. “It’s quite peaceful with nobody around,” he thinks to himself and resumes his path.  Upon arrival at his destination, his gear is disinfected before he has access to the inte...
Source: The Medical Futurist - August 4, 2020 Category: Information Technology Authors: Prans Tags: Artificial Intelligence Augmented Reality Digital Health Research Healthcare Design Healthcare Policy Telemedicine & Smartphones Virtual Reality fda gamification Fitbit covid19 Apple Watch WHO gaming roche MySugr Foldit A Source Type: blogs

Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks. Sedentary Behavior Raises the Risk of Cancer Mortality https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/ Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a re...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How risky is a hug right now?
“Can I get a hug?” It’s a simple question for a simple act that’s been especially missed because of COVID-19 distancing. “Human beings need social contact,” says Dr. Eugene Beresin, executive director of The Clay Center for Young Healthy Minds at Massachusetts General Hospital, and professor of psychiatry at Harvard Medical School. “We are not hermits. We are not solo pilots. We are pack animals.” Not that it needs more promotion, but along with feeling connected, a hug has been shown to help fight off a cold and help your mood when dealing with conflict. But even as restrictions have started to loosen, the...
Source: Harvard Health Blog - June 25, 2020 Category: Consumer Health News Authors: Steve Calechman Tags: Cold and Flu Coronavirus and COVID-19 Health Risks and Prevention Safety Source Type: blogs

Blessings: How a Two-Time Cancer Survivor Copes During COVID-19
I, for one, am taking social distancing seriously. My husband and I haven’t had sex since the quarantine began. We’ve only hugged each other three times. A two-time cancer survivor, I’m afraid I’ll catch COVID-19. I’ve been working at home, but he’s been going in, and I think he’s afraid he’ll spread the disease. Not that he has it. We’re quite a pair. We always stand six feet apart. This pandemic is hard on me because I have no frame of reference for it. All I know is that danger is all around me. My mother taught me about danger when I was two and a half. We lived along the Cuyahoga River, and she’d w...
Source: World of Psychology - June 5, 2020 Category: Psychiatry & Psychology Authors: Laura Yeager Tags: Personal Trauma Cancer Survivor coronavirus COVID-19 Rape Sexual Assault social distancing Source Type: blogs

The Lack of Persuasion as a Failure Against COVID-19
By RAFAEL FONSECA, MD Reopening safely out of the current pandemic ought to be done via persuasion, not coercion. It has been more than five months since the world first learned about COVID-19. Models predicted a sharp increase in the number of cases, and a seemingly high likelihood the pandemic would overwhelm our hospitals. These models were often inaccurate, and we have all come to learn about the imprecision of epidemiological prediction.  Nevertheless, the infection is far worse than anyone initially accepted – becoming a staple of our generation. Fearing uncountable deaths and the possible need ...
Source: The Health Care Blog - June 2, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Rafael Fonseca Source Type: blogs

Fight Aging! Newsletter, June 1st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 31, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Can celiac disease affect life expectancy?
Celiac disease (CD), triggered by the ingestion of gluten, occurs in people genetically predisposed to develop the chronic autoimmune condition. During the past few decades, doctors have learned much about how the disease develops, including genetic and other risk factors. However, results from studies on whether people with CD have an increased risk of premature death linked to the condition have been mixed. A recent study shows a small but statistically significant increased mortality rate. Celiac disease can affect the entire body Until recently, CD was considered a mainly pediatric gastrointestinal disorder, associated...
Source: Harvard Health Blog - May 28, 2020 Category: Consumer Health News Authors: Maureen Leonard, MD, MMSc Tags: Allergies Autoimmune diseases Source Type: blogs

Planning for Future Pandemics Including Smallpox Outbreaks: Interview with Dr. Phil Gomez, CEO, SIGA Technologies
The COVID-19 pandemic has had significant global consequences, with healthcare systems stretched to their limits, a growing death toll, and economic devastation as economies came grinding to a halt. The pandemic and its aftereffects will be with u...
Source: Medgadget - May 27, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Public Health Source Type: blogs